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P46593

- HWP1_CANAL

UniProt

P46593 - HWP1_CANAL

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Protein

Hyphal wall protein 1

Gene

HWP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence factors and host inflammatory responses when protective immunity is absent.16 Publications

GO - Molecular functioni

  1. cell adhesion molecule binding Source: CGD

GO - Biological processi

  1. adhesion of symbiont to host Source: CGD
  2. cell adhesion Source: CGD
  3. cell adhesion involved in biofilm formation Source: CGD
  4. cell adhesion involved in single-species biofilm formation in or on host organism Source: CGD
  5. cellular response to drug Source: CGD
  6. filamentous growth Source: CGD
  7. fungal-type cell wall organization Source: CGD
  8. growth of symbiont in host Source: CGD
  9. pathogenesis Source: CGD
  10. single organismal cell-cell adhesion Source: CGD
  11. single-species biofilm formation in or on host organism Source: CGD
  12. single-species biofilm formation on inanimate substrate Source: CGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Hyphal wall protein 1
Alternative name(s):
Cell elongation protein 2
Gene namesi
Name:HWP1
Synonyms:ECE2
ORF Names:CaO19.1321, CaO19.8901
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003753. HWP1.

Subcellular locationi

Secretedcell wall. Membrane; Lipid-anchorGPI-anchor
Note: Hyphal surface. Localizes to the a/a Portion of the conjugation bridge during mating.

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell surface Source: CGD
  3. extracellular region Source: CGD
  4. fungal-type cell wall Source: CGD
  5. hyphal cell wall Source: CGD
  6. mating projection Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Reduces the overall mating frequency in both liquid and solid media. Impairs stable attachments to human buccal epithelial cells and reduces capacity to cause systemic candidiasis in mice. Produces a thin biofilm that lacks much of the hyphal mass found in the wild type cell.6 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi613 – 6131G → D, N or S: Still allows localization to the cell surface. 1 Publication
Mutagenesisi613 – 6131G → E, Q, R or T: Impairs cell surface localization and localizes exclusively to internal ER-like structures. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 613586Hyphal wall protein 1PRO_0000084097Add
BLAST
Propeptidei614 – 63421Removed in mature formPRO_0000425596Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi601 – 6011N-linked (GlcNAc...)Sequence Analysis
Lipidationi613 – 6131GPI-anchor amidated glycine1 Publication

Post-translational modificationi

The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer.
Serves as a substrate for mammalian transglutaminases which are necessary for cross-linking between HWP1 and host epithelial cells. Also predicted to be a substrate for cleavage by KEX2.
N- and O-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Developmental stagei

Found in hyphal but not yeast forms.

Inductioni

The promoter contains a 368 bp region, the HWP1 control region (HCR), which is target of transcription factors and is critical for activation under hypha-inducing conditions. Expression is positively regulated by BCR1, EFG1, FLO8, GPA2, GPR1, MSS11, RBF1, and RFG1; and negatively regulated by NRG1 and TUP1. Transcription is induced in an adhesion-dependent manner and in presence of human serum or hemoglobin. Expression is down-regulated by hypoxic conditions, allicine, ethylenediaminetetra-acetic acid (EDTA), farnesol, linalool, riccardin D, purpurin, filastatin, phorbasin H, Ocimum sanctum essential oil (OSEO), as well as many substances belonging to chemical classes such as methyl aryl-oxazoline carboxylates, dihydrobenzo-d-isoxazolones, and thiazolo-4,5-e-benzoisoxazoles. Moreover, the competitors Saccharomyces boulardii or Streptococcus mutans secrete respectively capric acid and trans-2-decenoic acid (SDSF) which also suppress HWP1 expression.35 Publications

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0003753.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati46 – 58131; approximateAdd
BLAST
Repeati59 – 69112; approximateAdd
BLAST
Repeati70 – 81123; approximateAdd
BLAST
Repeati82 – 91104
Repeati92 – 101105
Repeati102 – 111106
Repeati112 – 121107
Repeati122 – 131108
Repeati132 – 141109
Repeati142 – 1511010
Repeati152 – 1611011
Repeati162 – 1711012
Repeati172 – 179813; truncated
Repeati180 – 187814; truncated

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 18714214 X 10 AA tandem repeats of [EVIQ]-P-[CDT]-D-[YNW]-P-[PQ]-[QI]-[QP]-[QDN]Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi53 – 586Poly-Gln
Compositional biasi65 – 695Poly-Gln
Compositional biasi204 – 2074Poly-Thr
Compositional biasi208 – 22013Poly-SerAdd
BLAST
Compositional biasi291 – 2944Poly-Thr
Compositional biasi304 – 3074Poly-Thr
Compositional biasi398 – 4014Poly-Val

Sequence similaritiesi

Belongs to the HWP1 family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
InParanoidiP46593.
OrthoDBiEOG718KPF.

Family and domain databases

InterProiIPR025928. Flocculin_t3_rpt.
[Graphical view]
PfamiPF13928. Flocculin_t3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46593-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLSTAQLIA IAYYMLSIGA TVPQVDGQGE TEEALIQKRS YDYYQEPCDD
60 70 80 90 100
YPQQQQQQEP CDYPQQQQQE EPCDYPQQQP QEPCDYPQQP QEPCDYPQQP
110 120 130 140 150
QEPCDYPQQP QEPCDNPPQP DVPCDNPPQP DVPCDNPPQP DIPCDNPPQP
160 170 180 190 200
DIPCDNPPQP DQPDDNPPIP NIPTDWIPNI PTDWIPDIPE KPTTPATTPN
210 220 230 240 250
IPATTTTSES SSSSSSSSSS TTPKTSASTT PESSVPATTP NTSVPTTSSE
260 270 280 290 300
STTPATSPES SVPVTSGSSI LATTSESSSA PATTPNTSVP TTTTEAKSSS
310 320 330 340 350
TPLTTTTEHD TTVVTVTSCS NSVCTESEVT TGVIVITSKD TIYTTYCPLT
360 370 380 390 400
ETTPVSTAPA TETPTGTVST STEQSTTVIT VTSCSESSCT ESEVTTGVVV
410 420 430 440 450
VTSEETVYTT FCPLTENTPG TDSTPEASIP PMETIPAGSE SSMPAGETSP
460 470 480 490 500
AVPKSDVPAT ESAPVPEMTP AGSQPSIPAG ETSPAVPKSD VPATESAPAP
510 520 530 540 550
EMTPAGTETK PAAPKSSAPA TEPSPVAPGT ESAPAGPGAS SSPKSSVLAS
560 570 580 590 600
ETSPIAPGAE TAPAGSSGAI TIPESSAVVS TTEGAIPTTL ESVPLMQPSA
610 620 630
NYSSVAPIST FEGAGNNMRL TFGAAIIGIA AFLI
Length:634
Mass (Da):65,342
Last modified:October 19, 2011 - v4
Checksum:i05B7ACBD44D7ADF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411D → DVPCDNPPQPD in AAC49209. (PubMed:8626424)Curated
Sequence conflicti296 – 2961A → T in AAC96368. (PubMed:9639315)Curated
Sequence conflicti441 – 4411S → P in AAB64014. (PubMed:10464197)Curated
Sequence conflicti492 – 4921P → S in AAB64014. (PubMed:10464197)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U64206 Genomic DNA. Translation: AAC96368.1.
AF001978 Genomic DNA. Translation: AAB64014.1.
AACQ01000139 Genomic DNA. Translation: EAK93836.1.
AACQ01000138 Genomic DNA. Translation: EAK93868.1.
U29369 mRNA. Translation: AAC49209.1.
RefSeqiXP_709961.1. XM_704869.1.
XP_712998.1. XM_707905.1.

Genome annotation databases

GeneIDi3645372.
3645386.
KEGGical:CaO19.1321.
cal:CaO19.8901.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U64206 Genomic DNA. Translation: AAC96368.1 .
AF001978 Genomic DNA. Translation: AAB64014.1 .
AACQ01000139 Genomic DNA. Translation: EAK93836.1 .
AACQ01000138 Genomic DNA. Translation: EAK93868.1 .
U29369 mRNA. Translation: AAC49209.1 .
RefSeqi XP_709961.1. XM_704869.1.
XP_712998.1. XM_707905.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3645372.
3645386.
KEGGi cal:CaO19.1321.
cal:CaO19.8901.

Organism-specific databases

CGDi CAL0003753. HWP1.

Phylogenomic databases

eggNOGi NOG12793.
InParanoidi P46593.
OrthoDBi EOG718KPF.

Family and domain databases

InterProi IPR025928. Flocculin_t3_rpt.
[Graphical view ]
Pfami PF13928. Flocculin_t3. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic organization and sequence analysis of the hypha-specific cell wall protein gene HWP1 of Candida albicans."
    Staab J.F., Sundstrom P.
    Yeast 14:681-686(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. "HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1."
    Sharkey L.L., McNemar M.D., Saporito-Irwin S.M., Sypherd P.S., Fonzi W.A.
    J. Bacteriol. 181:5273-5279(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
    Strain: SC5314 / ATCC MYA-2876.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  4. "Developmental expression of a tandemly repeated, proline- and glutamine-rich amino acid motif on hyphal surfaces on Candida albicans."
    Staab J.F., Ferrer C.A., Sundstrom P.
    J. Biol. Chem. 271:6298-6305(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-225, INDUCTION, SUBCELLULAR LOCATION.
    Strain: SC5314 / ATCC MYA-2876.
  5. "Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1."
    Staab J.F., Bradway S.D., Fidel P.L., Sundstrom P.
    Science 283:1535-1538(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  6. "TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans."
    Braun B.R., Johnson A.D.
    Genetics 155:57-67(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "Identification and characterization of TUP1-regulated genes in Candida albicans."
    Braun B.R., Head W.S., Wang M.X., Johnson A.D.
    Genetics 156:31-44(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  8. "Reduced virulence of HWP1-deficient mutants of Candida albicans and their interactions with host cells."
    Tsuchimori N., Sharkey L.L., Fonzi W.A., French S.W., Edwards J.E. Jr., Filler S.G.
    Infect. Immun. 68:1997-2002(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  9. "Efg1, a morphogenetic regulator in Candida albicans, is a sequence-specific DNA binding protein."
    Leng P., Lee P.R., Wu H., Brown A.J.
    J. Bacteriol. 183:4090-4093(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  10. "Rfg1, a protein related to the Saccharomyces cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in Candida albicans."
    Kadosh D., Johnson A.D.
    Mol. Cell. Biol. 21:2496-2505(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  11. "Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1."
    Murad A.M., d'Enfert C., Gaillardin C., Tournu H., Tekaia F., Talibi D., Marechal D., Marchais V., Cottin J., Brown A.J.
    Mol. Microbiol. 42:981-993(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  12. "Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule."
    Ramage G., Saville S.P., Wickes B.L., Lopez-Ribot J.L.
    Appl. Environ. Microbiol. 68:5459-5463(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  13. "Reevaluation of the role of HWP1 in systemic candidiasis by use of Candida albicans strains with selectable marker URA3 targeted to the ENO1 locus."
    Sundstrom P., Cutler J.E., Staab J.F.
    Infect. Immun. 70:3281-3283(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Inactivation of Kex2p diminishes the virulence of Candida albicans."
    Newport G., Kuo A., Flattery A., Gill C., Blake J.J., Kurtz M.B., Abruzzo G.K., Agabian N.
    J. Biol. Chem. 278:1713-1720(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PREDICTION AS A SUBSTRATE FOR KEX2 CLEAVAGE.
  15. "Essential role of the Candida albicans transglutaminase substrate, hyphal wall protein 1, in lethal oroesophageal candidiasis in immunodeficient mice."
    Sundstrom P., Balish E., Allen C.M.
    J. Infect. Dis. 185:521-530(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  16. "The adhesin Hwp1 and the first daughter cell localize to the a/a portion of the conjugation bridge during Candida albicans mating."
    Daniels K.J., Lockhart S.R., Staab J.F., Sundstrom P., Soll D.R.
    Mol. Biol. Cell 14:4920-4930(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  17. "Use of green fluorescent protein fusions to analyse the N- and C-terminal signal peptides of GPI-anchored cell wall proteins in Candida albicans."
    Mao Y., Zhang Z., Wong B.
    Mol. Microbiol. 50:1617-1628(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GPI-ANCHOR AT GLY-613, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-613.
  18. "Genome-wide identification of fungal GPI proteins."
    De Groot P.W., Hellingwerf K.J., Klis F.M.
    Yeast 20:781-796(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PREDICTION OF GPI-ANCHOR.
  19. "Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans."
    Miwa T., Takagi Y., Shinozaki M., Yun C.W., Schell W.A., Perfect J.R., Kumagai H., Tamaki H.
    Eukaryot. Cell 3:919-931(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  20. "Expression of transglutaminase substrate activity on Candida albicans germ tubes through a coiled, disulfide-bonded N-terminal domain of Hwp1 requires C-terminal glycosylphosphatidylinositol modification."
    Staab J.F., Bahn Y.S., Tai C.H., Cook P.F., Sundstrom P.
    J. Biol. Chem. 279:40737-40747(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GLYCOSYLATION, GPI-ANCHOR, CELL WALL ANCHORAGE.
  21. "Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p."
    Nobile C.J., Mitchell A.P.
    Curr. Biol. 15:1150-1155(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  22. "Function of Candida albicans adhesin Hwp1 in biofilm formation."
    Nobile C.J., Nett J.E., Andes D.R., Mitchell A.P.
    Eukaryot. Cell 5:1604-1610(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  23. "An in vitro assay to study the transcriptional response during adherence of Candida albicans to different human epithelia."
    Sohn K., Senyurek I., Fertey J., Konigsdorfer A., Joffroy C., Hauser N., Zelt G., Brunner H., Rupp S.
    FEMS Yeast Res. 6:1085-1093(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  24. "Candida albicans HWP1 gene expression and host antibody responses in colonization and disease."
    Naglik J.R., Fostira F., Ruprai J., Staab J.F., Challacombe S.J., Sundstrom P.
    J. Med. Microbiol. 55:1323-1327(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  25. "Expression of firefly luciferase in Candida albicans and its use in the selection of stable transformants."
    Doyle T.C., Nawotka K.A., Purchio A.F., Akin A.R., Francis K.P., Contag P.R.
    Microb. Pathog. 40:69-81(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  26. "The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans."
    Cao F., Lane S., Raniga P.P., Lu Y., Zhou Z., Ramon K., Chen J., Liu H.
    Mol. Biol. Cell 17:295-307(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  27. "Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo."
    Nobile C.J., Andes D.R., Nett J.E., Smith F.J., Yue F., Phan Q.T., Edwards J.E., Filler S.G., Mitchell A.P.
    PLoS Pathog. 2:E63-E63(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  28. "Diagnosis of invasive candidiasis by enzyme-linked immunosorbent assay using the N-terminal fragment of Candida albicans hyphal wall protein 1."
    Lain A., Elguezabal N., Brena S., Garcia-Ruiz J.C., Del Palacio A., Moragues M.D., Ponton J.
    BMC Microbiol. 7:35-35(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DIAGNOSTIC TOOL.
  29. "A 368-base-pair cis-acting HWP1 promoter region, HCR, of Candida albicans confers hypha-specific gene regulation and binds architectural transcription factors Nhp6 and Gcf1p."
    Kim S., Wolyniak M.J., Staab J.F., Sundstrom P.
    Eukaryot. Cell 6:693-709(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  30. "State of differentiation defines buccal epithelial cell affinity for cross-linking to Candida albicans Hwp1."
    Ponniah G., Rollenhagen C., Bahn Y.S., Staab J.F., Sundstrom P.
    J. Oral Pathol. Med. 36:456-467(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBSTRATE FOR HOST TRANSGLUTAMINASES.
  31. "Hemoglobin is an effective inducer of hyphal differentiation in Candida albicans."
    Pendrak M.L., Roberts D.D.
    Med. Mycol. 45:61-71(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  32. "Inhibition on Candida albicans biofilm formation using divalent cation chelators (EDTA)."
    Ramage G., Wickes B.L., Lopez-Ribot J.L.
    Mycopathologia 164:301-306(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  33. "Candida albicans Tup1 is involved in farnesol-mediated inhibition of filamentous-growth induction."
    Kebaara B.W., Langford M.L., Navarathna D.H., Dumitru R., Nickerson K.W., Atkin A.L.
    Eukaryot. Cell 7:980-987(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  34. "C-terminal signals regulate targeting of glycosylphosphatidylinositol-anchored proteins to the cell wall or plasma membrane in Candida albicans."
    Mao Y., Zhang Z., Gast C., Wong B.
    Eukaryot. Cell 7:1906-1915(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, GPI-ANCHOR.
  35. "Expression of ALS1, HWP1 and SAP4 genes in Candida albicans strains isolated from women with vaginitis."
    Nas T., Kalkanci A., Fidan I., Hizel K., Bolat S., Yolbakan S., Yilmaz E., Ozkan S., Kustimur S.
    Folia Microbiol. (Praha) 53:179-183(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  36. "Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivity."
    Plaine A., Walker L., Da Costa G., Mora-Montes H.M., McKinnon A., Gow N.A., Gaillardin C., Munro C.A., Richard M.L.
    Fungal Genet. Biol. 45:1404-1414(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  37. "Beta-1,2 oligomannose adhesin epitopes are widely distributed over the different families of Candida albicans cell wall mannoproteins and are associated through both N- and O-glycosylation processes."
    Fradin C., Slomianny M.C., Mille C., Masset A., Robert R., Sendid B., Ernst J.F., Michalski J.C., Poulain D.
    Infect. Immun. 76:4509-4517(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION.
  38. "Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions."
    Sosinska G.J., de Groot P.W., Teixeira de Mattos M.J., Dekker H.L., de Koster C.G., Hellingwerf K.J., Klis F.M.
    Microbiology 154:510-520(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION.
  39. "Synthetic glycopeptide vaccines combining beta-mannan and peptide epitopes induce protection against candidiasis."
    Xin H., Dziadek S., Bundle D.R., Cutler J.E.
    Proc. Natl. Acad. Sci. U.S.A. 105:13526-13531(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRODUCTION OF VACCINES.
  40. "The inhibitory effect of a macrocyclic bisbibenzyl riccardin D on the biofilms of Candida albicans."
    Cheng A., Sun L., Wu X., Lou H.
    Biol. Pharm. Bull. 32:1417-1421(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  41. "Mss11, a transcriptional activator, is required for hyphal development in Candida albicans."
    Su C., Li Y., Lu Y., Chen J.
    Eukaryot. Cell 8:1780-1791(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  42. "Hwp1 and related adhesins contribute to both mating and biofilm formation in Candida albicans."
    Ene I.V., Bennett R.J.
    Eukaryot. Cell 8:1909-1913(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  43. "Trifluoromethanesulfonic acid-based proteomic analysis of cell wall and secreted proteins of the ascomycetous fungi Neurospora crassa and Candida albicans."
    Maddi A., Bowman S.M., Free S.J.
    Fungal Genet. Biol. 46:768-781(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, INDUCTION.
  44. "Interaction of Candida albicans biofilms with antifungals: transcriptional response and binding of antifungals to beta-glucans."
    Vediyappan G., Rossignol T., d'Enfert C.
    Antimicrob. Agents Chemother. 54:2096-2111(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  45. "Heterologous expression of Candida albicans cell wall-associated adhesins in Saccharomyces cerevisiae Reveals differential specificities in adherence and biofilm formation and in binding oral Streptococcus gordonii."
    Nobbs A.H., Vickerman M.M., Jenkinson H.F.
    Eukaryot. Cell 9:1622-1634(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  46. "Streptococcus mutans inhibits Candida albicans hyphal formation by the fatty acid signaling molecule trans-2-decenoic acid (SDSF)."
    Vilchez R., Lemme A., Ballhausen B., Thiel V., Schulz S., Jansen R., Sztajer H., Wagner-Dobler I.
    ChemBioChem 11:1552-1562(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  47. "Capric acid secreted by S. boulardii inhibits C. albicans filamentous growth, adhesion and biofilm formation."
    Murzyn A., Krasowska A., Stefanowicz P., Dziadkowiec D., Lukaszewicz M.
    PLoS ONE 5:E12050-E12050(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  48. "Mass spectrometric quantification of the adaptations in the wall proteome of Candida albicans in response to ambient pH."
    Sosinska G.J., de Koning L.J., de Groot P.W., Manders E.M., Dekker H.L., Hellingwerf K.J., de Koster C.G., Klis F.M.
    Microbiology 157:136-146(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION.
  49. "Comparison between allicin and fluconazole in Candida albicans biofilm inhibition and in suppression of HWP1 gene expression."
    Khodavandi A., Harmal N.S., Alizadeh F., Scully O.J., Sidik S.M., Othman F., Sekawi Z., Ng K.P., Chong P.P.
    Phytomedicine 19:56-63(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  50. "Role of Bcr1-activated genes Hwp1 and Hyr1 in Candida albicans oral mucosal biofilms and neutrophil evasion."
    Dwivedi P., Thompson A., Xie Z., Kashleva H., Ganguly S., Mitchell A.P., Dongari-Bagtzoglou A.
    PLoS ONE 6:E16218-E16218(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  51. "Purpurin suppresses Candida albicans biofilm formation and hyphal development."
    Tsang P.W., Bandara H.M., Fong W.P.
    PLoS ONE 7:E50866-E50866(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  52. "Inhibition of yeast-to-hypha transition in Candida albicans by phorbasin H isolated from Phorbas sp."
    Lee S.H., Jeon J.E., Ahn C.H., Chung S.C., Shin J., Oh K.B.
    Appl. Microbiol. Biotechnol. 97:3141-3148(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  53. "Identification of inhibitors of yeast-to-hyphae transition in Candida albicans by a reporter screening assay."
    Heintz-Buschart A., Eickhoff H., Hohn E., Bilitewski U.
    J. Biotechnol. 164:137-142(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  54. "The inhibitory activity of linalool against the filamentous growth and biofilm formation in Candida albicans."
    Hsu C.C., Lai W.L., Chuang K.C., Lee M.H., Tsai Y.C.
    Med. Mycol. 51:473-482(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  55. "Ocimum sanctum essential oil inhibits virulence attributes in Candida albicans."
    Khan A., Ahmad A., Xess I., Khan L.A., Manzoor N.
    Phytomedicine 21:448-452(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  56. "Human serum promotes Candida albicans biofilm growth and virulence gene expression on silicone biomaterial."
    Samaranayake Y.H., Cheung B.P., Yau J.Y., Yeung S.K., Samaranayake L.P.
    PLoS ONE 8:E62902-E62902(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  57. "Niche-specific requirement for hyphal wall protein 1 in virulence of Candida albicans."
    Staab J.F., Datta K., Rhee P.
    PLoS ONE 8:E80842-E80842(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  58. "Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis."
    Fazly A., Jain C., Dehner A.C., Issi L., Lilly E.A., Ali A., Cao H., Fidel P.L. Jr., Rao R.P., Kaufman P.D.
    Proc. Natl. Acad. Sci. U.S.A. 110:13594-13599(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiHWP1_CANAL
AccessioniPrimary (citable) accession number: P46593
Secondary accession number(s): O13424, P87019, Q59TL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 58 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

As a major cell surface protein expressed during infection, HWP1 detection can be used for diagnosis of invasive candidiasis. HWP1 epitopes can also be used to develop vaccines for protection against candidiasis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3