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P46593 (HWP1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyphal wall protein 1
Alternative name(s):
Cell elongation protein 2
Gene names
Name:HWP1
Synonyms:ECE2
ORF Names:CaO19.1321, CaO19.8901
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length634 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence factors and host inflammatory responses when protective immunity is absent. Ref.2 Ref.5 Ref.8 Ref.13 Ref.15 Ref.20 Ref.22 Ref.24 Ref.27 Ref.30 Ref.35 Ref.36 Ref.42 Ref.45 Ref.50 Ref.57

Subcellular location

Secretedcell wall. Membrane; Lipid-anchorGPI-anchor. Note: Hyphal surface. Localizes to the a/a Portion of the conjugation bridge during mating. Ref.4 Ref.16 Ref.17 Ref.18 Ref.20 Ref.34 Ref.38 Ref.43 Ref.48

Developmental stage

Found in hyphal but not yeast forms.

Induction

The promoter contains a 368 bp region, the HWP1 control region (HCR), which is target of transcription factors and is critical for activation under hypha-inducing conditions. Expression is positively regulated by BCR1, EFG1, FLO8, GPA2, GPR1, MSS11, RBF1, and RFG1; and negatively regulated by NRG1 and TUP1. Transcription is induced in an adhesion-dependent manner and in presence of human serum or hemoglobin. Expression is down-regulated by hypoxic conditions, allicine, ethylenediaminetetra-acetic acid (EDTA), farnesol, linalool, riccardin D, purpurin, filastatin, phorbasin H, Ocimum sanctum essential oil (OSEO), as well as many substances belonging to chemical classes such as methyl aryl-oxazoline carboxylates, dihydrobenzo-d-isoxazolones, and thiazolo-4,5-e-benzoisoxazoles. Moreover, the competitors Saccharomyces boulardii or Streptococcus mutans secrete respectively capric acid and trans-2-decenoic acid (SDSF) which also suppress HWP1 expression. Ref.2 Ref.4 Ref.6 Ref.7 Ref.9 Ref.10 Ref.11 Ref.12 Ref.19 Ref.21 Ref.23 Ref.24 Ref.25 Ref.26 Ref.29 Ref.31 Ref.32 Ref.33 Ref.35 Ref.38 Ref.40 Ref.41 Ref.43 Ref.44 Ref.46 Ref.47 Ref.48 Ref.49 Ref.51 Ref.52 Ref.53 Ref.54 Ref.55 Ref.56 Ref.58

Post-translational modification

The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer. Ref.14

Serves as a substrate for mammalian transglutaminases which are necessary for cross-linking between HWP1 and host epithelial cells. Also predicted to be a substrate for cleavage by KEX2.

N- and O-glycosylated. Ref.20 Ref.37

Disruption phenotype

Reduces the overall mating frequency in both liquid and solid media. Impairs stable attachments to human buccal epithelial cells and reduces capacity to cause systemic candidiasis in mice. Produces a thin biofilm that lacks much of the hyphal mass found in the wild type cell. Ref.5 Ref.8 Ref.15 Ref.22 Ref.42 Ref.57

Miscellaneous

As a major cell surface protein expressed during infection, HWP1 detection can be used for diagnosis of invasive candidiasis. HWP1 epitopes can also be used to develop vaccines for protection against candidiasis.

Sequence similarities

Belongs to the HWP1 family.

Ontologies

Keywords
   Biological processCell adhesion
Virulence
   Cellular componentCell wall
Membrane
Secreted
   DomainRepeat
Signal
   PTMGlycoprotein
GPI-anchor
Lipoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadhesion of symbiont to host

Inferred from mutant phenotype Ref.5Ref.20PubMed 20869222. Source: CGD

cell adhesion

Inferred from mutant phenotype PubMed 17416898Ref.45. Source: CGD

cell adhesion involved in biofilm formation

Inferred from mutant phenotype Ref.45. Source: CGD

cell adhesion involved in single-species biofilm formation in or on host organism

Inferred from mutant phenotype Ref.22. Source: CGD

cellular response to drug

Inferred from mutant phenotype Ref.36. Source: CGD

filamentous growth

Inferred from mutant phenotype PubMed 19616419. Source: CGD

fungal-type cell wall organization

Inferred from direct assay PubMed 19383685. Source: CGD

growth of symbiont in host

Inferred from mutant phenotype PubMed 22544909. Source: CGD

pathogenesis

Inferred from mutant phenotype Ref.5Ref.7Ref.13PubMed 19616419. Source: CGD

single organismal cell-cell adhesion

Inferred from direct assay PubMed 17416898. Source: CGD

single-species biofilm formation in or on host organism

Inferred from mutant phenotype PubMed 17416898. Source: CGD

single-species biofilm formation on inanimate substrate

Inferred from mutant phenotype PubMed 17416898PubMed 19798425PubMed 20869222. Source: CGD

   Cellular_componentanchored component of plasma membrane

Inferred from sequence or structural similarity PubMed 14665461. Source: CGD

cell surface

Inferred from direct assay PubMed 18712765Ref.34Ref.4. Source: CGD

extracellular region

Inferred from direct assay PubMed 20641015. Source: CGD

fungal-type cell wall

Inferred from direct assay Ref.17PubMed 17416898Ref.38Ref.34PubMed 19383685PubMed 21602216. Source: CGD

hyphal cell wall

Inferred from direct assay Ref.16Ref.20PubMed 18712765Ref.43PubMed 21602216. Source: CGD

mating projection

Inferred from direct assay Ref.16. Source: CGD

   Molecular_functioncell adhesion molecule binding

Inferred from mutant phenotype Ref.45. Source: CGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 613586Hyphal wall protein 1
PRO_0000084097
Propeptide614 – 63421Removed in mature form
PRO_0000425596

Regions

Repeat46 – 58131; approximate
Repeat59 – 69112; approximate
Repeat70 – 81123; approximate
Repeat82 – 91104
Repeat92 – 101105
Repeat102 – 111106
Repeat112 – 121107
Repeat122 – 131108
Repeat132 – 141109
Repeat142 – 1511010
Repeat152 – 1611011
Repeat162 – 1711012
Repeat172 – 179813; truncated
Repeat180 – 187814; truncated
Region46 – 18714214 X 10 AA tandem repeats of [EVIQ]-P-[CDT]-D-[YNW]-P-[PQ]-[QI]-[QP]-[QDN]
Compositional bias53 – 586Poly-Gln
Compositional bias65 – 695Poly-Gln
Compositional bias204 – 2074Poly-Thr
Compositional bias208 – 22013Poly-Ser
Compositional bias291 – 2944Poly-Thr
Compositional bias304 – 3074Poly-Thr
Compositional bias398 – 4014Poly-Val

Amino acid modifications

Lipidation6131GPI-anchor amidated glycine Ref.17 Ref.18 Ref.20 Ref.34
Glycosylation2411N-linked (GlcNAc...) Potential
Glycosylation2861N-linked (GlcNAc...) Potential
Glycosylation6011N-linked (GlcNAc...) Potential

Experimental info

Mutagenesis6131G → D, N or S: Still allows localization to the cell surface. Ref.17
Mutagenesis6131G → E, Q, R or T: Impairs cell surface localization and localizes exclusively to internal ER-like structures. Ref.17
Sequence conflict1411D → DVPCDNPPQPD in AAC49209. Ref.4
Sequence conflict2961A → T in AAC96368. Ref.1
Sequence conflict4411S → P in AAB64014. Ref.2
Sequence conflict4921P → S in AAB64014. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P46593 [UniParc].

Last modified October 19, 2011. Version 4.
Checksum: 05B7ACBD44D7ADF5

FASTA63465,342
        10         20         30         40         50         60 
MRLSTAQLIA IAYYMLSIGA TVPQVDGQGE TEEALIQKRS YDYYQEPCDD YPQQQQQQEP 

        70         80         90        100        110        120 
CDYPQQQQQE EPCDYPQQQP QEPCDYPQQP QEPCDYPQQP QEPCDYPQQP QEPCDNPPQP 

       130        140        150        160        170        180 
DVPCDNPPQP DVPCDNPPQP DIPCDNPPQP DIPCDNPPQP DQPDDNPPIP NIPTDWIPNI 

       190        200        210        220        230        240 
PTDWIPDIPE KPTTPATTPN IPATTTTSES SSSSSSSSSS TTPKTSASTT PESSVPATTP 

       250        260        270        280        290        300 
NTSVPTTSSE STTPATSPES SVPVTSGSSI LATTSESSSA PATTPNTSVP TTTTEAKSSS 

       310        320        330        340        350        360 
TPLTTTTEHD TTVVTVTSCS NSVCTESEVT TGVIVITSKD TIYTTYCPLT ETTPVSTAPA 

       370        380        390        400        410        420 
TETPTGTVST STEQSTTVIT VTSCSESSCT ESEVTTGVVV VTSEETVYTT FCPLTENTPG 

       430        440        450        460        470        480 
TDSTPEASIP PMETIPAGSE SSMPAGETSP AVPKSDVPAT ESAPVPEMTP AGSQPSIPAG 

       490        500        510        520        530        540 
ETSPAVPKSD VPATESAPAP EMTPAGTETK PAAPKSSAPA TEPSPVAPGT ESAPAGPGAS 

       550        560        570        580        590        600 
SSPKSSVLAS ETSPIAPGAE TAPAGSSGAI TIPESSAVVS TTEGAIPTTL ESVPLMQPSA 

       610        620        630 
NYSSVAPIST FEGAGNNMRL TFGAAIIGIA AFLI 

« Hide

References

« Hide 'large scale' references
[1]"Genetic organization and sequence analysis of the hypha-specific cell wall protein gene HWP1 of Candida albicans."
Staab J.F., Sundstrom P.
Yeast 14:681-686(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"HWP1 functions in the morphological development of Candida albicans downstream of EFG1, TUP1, and RBF1."
Sharkey L.L., McNemar M.D., Saporito-Irwin S.M., Sypherd P.S., Fonzi W.A.
J. Bacteriol. 181:5273-5279(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION.
Strain: SC5314 / ATCC MYA-2876.
[3]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[4]"Developmental expression of a tandemly repeated, proline- and glutamine-rich amino acid motif on hyphal surfaces on Candida albicans."
Staab J.F., Ferrer C.A., Sundstrom P.
J. Biol. Chem. 271:6298-6305(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-225, INDUCTION, SUBCELLULAR LOCATION.
Strain: SC5314 / ATCC MYA-2876.
[5]"Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1."
Staab J.F., Bradway S.D., Fidel P.L., Sundstrom P.
Science 283:1535-1538(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[6]"TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans."
Braun B.R., Johnson A.D.
Genetics 155:57-67(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[7]"Identification and characterization of TUP1-regulated genes in Candida albicans."
Braun B.R., Head W.S., Wang M.X., Johnson A.D.
Genetics 156:31-44(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[8]"Reduced virulence of HWP1-deficient mutants of Candida albicans and their interactions with host cells."
Tsuchimori N., Sharkey L.L., Fonzi W.A., French S.W., Edwards J.E. Jr., Filler S.G.
Infect. Immun. 68:1997-2002(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[9]"Efg1, a morphogenetic regulator in Candida albicans, is a sequence-specific DNA binding protein."
Leng P., Lee P.R., Wu H., Brown A.J.
J. Bacteriol. 183:4090-4093(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[10]"Rfg1, a protein related to the Saccharomyces cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in Candida albicans."
Kadosh D., Johnson A.D.
Mol. Cell. Biol. 21:2496-2505(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[11]"Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1."
Murad A.M., d'Enfert C., Gaillardin C., Tournu H., Tekaia F., Talibi D., Marechal D., Marchais V., Cottin J., Brown A.J.
Mol. Microbiol. 42:981-993(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[12]"Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule."
Ramage G., Saville S.P., Wickes B.L., Lopez-Ribot J.L.
Appl. Environ. Microbiol. 68:5459-5463(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[13]"Reevaluation of the role of HWP1 in systemic candidiasis by use of Candida albicans strains with selectable marker URA3 targeted to the ENO1 locus."
Sundstrom P., Cutler J.E., Staab J.F.
Infect. Immun. 70:3281-3283(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[14]"Inactivation of Kex2p diminishes the virulence of Candida albicans."
Newport G., Kuo A., Flattery A., Gill C., Blake J.J., Kurtz M.B., Abruzzo G.K., Agabian N.
J. Biol. Chem. 278:1713-1720(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PREDICTION AS A SUBSTRATE FOR KEX2 CLEAVAGE.
[15]"Essential role of the Candida albicans transglutaminase substrate, hyphal wall protein 1, in lethal oroesophageal candidiasis in immunodeficient mice."
Sundstrom P., Balish E., Allen C.M.
J. Infect. Dis. 185:521-530(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[16]"The adhesin Hwp1 and the first daughter cell localize to the a/a portion of the conjugation bridge during Candida albicans mating."
Daniels K.J., Lockhart S.R., Staab J.F., Sundstrom P., Soll D.R.
Mol. Biol. Cell 14:4920-4930(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[17]"Use of green fluorescent protein fusions to analyse the N- and C-terminal signal peptides of GPI-anchored cell wall proteins in Candida albicans."
Mao Y., Zhang Z., Wong B.
Mol. Microbiol. 50:1617-1628(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GPI-ANCHOR AT GLY-613, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-613.
[18]"Genome-wide identification of fungal GPI proteins."
De Groot P.W., Hellingwerf K.J., Klis F.M.
Yeast 20:781-796(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PREDICTION OF GPI-ANCHOR.
[19]"Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans."
Miwa T., Takagi Y., Shinozaki M., Yun C.W., Schell W.A., Perfect J.R., Kumagai H., Tamaki H.
Eukaryot. Cell 3:919-931(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[20]"Expression of transglutaminase substrate activity on Candida albicans germ tubes through a coiled, disulfide-bonded N-terminal domain of Hwp1 requires C-terminal glycosylphosphatidylinositol modification."
Staab J.F., Bahn Y.S., Tai C.H., Cook P.F., Sundstrom P.
J. Biol. Chem. 279:40737-40747(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, GLYCOSYLATION, GPI-ANCHOR, CELL WALL ANCHORAGE.
[21]"Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p."
Nobile C.J., Mitchell A.P.
Curr. Biol. 15:1150-1155(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[22]"Function of Candida albicans adhesin Hwp1 in biofilm formation."
Nobile C.J., Nett J.E., Andes D.R., Mitchell A.P.
Eukaryot. Cell 5:1604-1610(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[23]"An in vitro assay to study the transcriptional response during adherence of Candida albicans to different human epithelia."
Sohn K., Senyurek I., Fertey J., Konigsdorfer A., Joffroy C., Hauser N., Zelt G., Brunner H., Rupp S.
FEMS Yeast Res. 6:1085-1093(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[24]"Candida albicans HWP1 gene expression and host antibody responses in colonization and disease."
Naglik J.R., Fostira F., Ruprai J., Staab J.F., Challacombe S.J., Sundstrom P.
J. Med. Microbiol. 55:1323-1327(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[25]"Expression of firefly luciferase in Candida albicans and its use in the selection of stable transformants."
Doyle T.C., Nawotka K.A., Purchio A.F., Akin A.R., Francis K.P., Contag P.R.
Microb. Pathog. 40:69-81(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[26]"The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans."
Cao F., Lane S., Raniga P.P., Lu Y., Zhou Z., Ramon K., Chen J., Liu H.
Mol. Biol. Cell 17:295-307(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[27]"Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo."
Nobile C.J., Andes D.R., Nett J.E., Smith F.J., Yue F., Phan Q.T., Edwards J.E., Filler S.G., Mitchell A.P.
PLoS Pathog. 2:E63-E63(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[28]"Diagnosis of invasive candidiasis by enzyme-linked immunosorbent assay using the N-terminal fragment of Candida albicans hyphal wall protein 1."
Lain A., Elguezabal N., Brena S., Garcia-Ruiz J.C., Del Palacio A., Moragues M.D., Ponton J.
BMC Microbiol. 7:35-35(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: DIAGNOSTIC TOOL.
[29]"A 368-base-pair cis-acting HWP1 promoter region, HCR, of Candida albicans confers hypha-specific gene regulation and binds architectural transcription factors Nhp6 and Gcf1p."
Kim S., Wolyniak M.J., Staab J.F., Sundstrom P.
Eukaryot. Cell 6:693-709(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[30]"State of differentiation defines buccal epithelial cell affinity for cross-linking to Candida albicans Hwp1."
Ponniah G., Rollenhagen C., Bahn Y.S., Staab J.F., Sundstrom P.
J. Oral Pathol. Med. 36:456-467(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBSTRATE FOR HOST TRANSGLUTAMINASES.
[31]"Hemoglobin is an effective inducer of hyphal differentiation in Candida albicans."
Pendrak M.L., Roberts D.D.
Med. Mycol. 45:61-71(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[32]"Inhibition on Candida albicans biofilm formation using divalent cation chelators (EDTA)."
Ramage G., Wickes B.L., Lopez-Ribot J.L.
Mycopathologia 164:301-306(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[33]"Candida albicans Tup1 is involved in farnesol-mediated inhibition of filamentous-growth induction."
Kebaara B.W., Langford M.L., Navarathna D.H., Dumitru R., Nickerson K.W., Atkin A.L.
Eukaryot. Cell 7:980-987(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[34]"C-terminal signals regulate targeting of glycosylphosphatidylinositol-anchored proteins to the cell wall or plasma membrane in Candida albicans."
Mao Y., Zhang Z., Gast C., Wong B.
Eukaryot. Cell 7:1906-1915(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, GPI-ANCHOR.
[35]"Expression of ALS1, HWP1 and SAP4 genes in Candida albicans strains isolated from women with vaginitis."
Nas T., Kalkanci A., Fidan I., Hizel K., Bolat S., Yolbakan S., Yilmaz E., Ozkan S., Kustimur S.
Folia Microbiol. (Praha) 53:179-183(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[36]"Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivity."
Plaine A., Walker L., Da Costa G., Mora-Montes H.M., McKinnon A., Gow N.A., Gaillardin C., Munro C.A., Richard M.L.
Fungal Genet. Biol. 45:1404-1414(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[37]"Beta-1,2 oligomannose adhesin epitopes are widely distributed over the different families of Candida albicans cell wall mannoproteins and are associated through both N- and O-glycosylation processes."
Fradin C., Slomianny M.C., Mille C., Masset A., Robert R., Sendid B., Ernst J.F., Michalski J.C., Poulain D.
Infect. Immun. 76:4509-4517(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION.
[38]"Hypoxic conditions and iron restriction affect the cell-wall proteome of Candida albicans grown under vagina-simulative conditions."
Sosinska G.J., de Groot P.W., Teixeira de Mattos M.J., Dekker H.L., de Koster C.G., Hellingwerf K.J., Klis F.M.
Microbiology 154:510-520(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INDUCTION.
[39]"Synthetic glycopeptide vaccines combining beta-mannan and peptide epitopes induce protection against candidiasis."
Xin H., Dziadek S., Bundle D.R., Cutler J.E.
Proc. Natl. Acad. Sci. U.S.A. 105:13526-13531(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PRODUCTION OF VACCINES.
[40]"The inhibitory effect of a macrocyclic bisbibenzyl riccardin D on the biofilms of Candida albicans."
Cheng A., Sun L., Wu X., Lou H.
Biol. Pharm. Bull. 32:1417-1421(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[41]"Mss11, a transcriptional activator, is required for hyphal development in Candida albicans."
Su C., Li Y., Lu Y., Chen J.
Eukaryot. Cell 8:1780-1791(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[42]"Hwp1 and related adhesins contribute to both mating and biofilm formation in Candida albicans."
Ene I.V., Bennett R.J.
Eukaryot. Cell 8:1909-1913(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[43]"Trifluoromethanesulfonic acid-based proteomic analysis of cell wall and secreted proteins of the ascomycetous fungi Neurospora crassa and Candida albicans."
Maddi A., Bowman S.M., Free S.J.
Fungal Genet. Biol. 46:768-781(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, INDUCTION.
[44]"Interaction of Candida albicans biofilms with antifungals: transcriptional response and binding of antifungals to beta-glucans."
Vediyappan G., Rossignol T., d'Enfert C.
Antimicrob. Agents Chemother. 54:2096-2111(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[45]"Heterologous expression of Candida albicans cell wall-associated adhesins in Saccharomyces cerevisiae Reveals differential specificities in adherence and biofilm formation and in binding oral Streptococcus gordonii."
Nobbs A.H., Vickerman M.M., Jenkinson H.F.
Eukaryot. Cell 9:1622-1634(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[46]"Streptococcus mutans inhibits Candida albicans hyphal formation by the fatty acid signaling molecule trans-2-decenoic acid (SDSF)."
Vilchez R., Lemme A., Ballhausen B., Thiel V., Schulz S., Jansen R., Sztajer H., Wagner-Dobler I.
ChemBioChem 11:1552-1562(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[47]"Capric acid secreted by S. boulardii inhibits C. albicans filamentous growth, adhesion and biofilm formation."
Murzyn A., Krasowska A., Stefanowicz P., Dziadkowiec D., Lukaszewicz M.
PLoS ONE 5:E12050-E12050(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[48]"Mass spectrometric quantification of the adaptations in the wall proteome of Candida albicans in response to ambient pH."
Sosinska G.J., de Koning L.J., de Groot P.W., Manders E.M., Dekker H.L., Hellingwerf K.J., de Koster C.G., Klis F.M.
Microbiology 157:136-146(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INDUCTION.
[49]"Comparison between allicin and fluconazole in Candida albicans biofilm inhibition and in suppression of HWP1 gene expression."
Khodavandi A., Harmal N.S., Alizadeh F., Scully O.J., Sidik S.M., Othman F., Sekawi Z., Ng K.P., Chong P.P.
Phytomedicine 19:56-63(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[50]"Role of Bcr1-activated genes Hwp1 and Hyr1 in Candida albicans oral mucosal biofilms and neutrophil evasion."
Dwivedi P., Thompson A., Xie Z., Kashleva H., Ganguly S., Mitchell A.P., Dongari-Bagtzoglou A.
PLoS ONE 6:E16218-E16218(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[51]"Purpurin suppresses Candida albicans biofilm formation and hyphal development."
Tsang P.W., Bandara H.M., Fong W.P.
PLoS ONE 7:E50866-E50866(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[52]"Inhibition of yeast-to-hypha transition in Candida albicans by phorbasin H isolated from Phorbas sp."
Lee S.H., Jeon J.E., Ahn C.H., Chung S.C., Shin J., Oh K.B.
Appl. Microbiol. Biotechnol. 97:3141-3148(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[53]"Identification of inhibitors of yeast-to-hyphae transition in Candida albicans by a reporter screening assay."
Heintz-Buschart A., Eickhoff H., Hohn E., Bilitewski U.
J. Biotechnol. 164:137-142(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[54]"The inhibitory activity of linalool against the filamentous growth and biofilm formation in Candida albicans."
Hsu C.C., Lai W.L., Chuang K.C., Lee M.H., Tsai Y.C.
Med. Mycol. 51:473-482(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[55]"Ocimum sanctum essential oil inhibits virulence attributes in Candida albicans."
Khan A., Ahmad A., Xess I., Khan L.A., Manzoor N.
Phytomedicine 21:448-452(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[56]"Human serum promotes Candida albicans biofilm growth and virulence gene expression on silicone biomaterial."
Samaranayake Y.H., Cheung B.P., Yau J.Y., Yeung S.K., Samaranayake L.P.
PLoS ONE 8:E62902-E62902(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[57]"Niche-specific requirement for hyphal wall protein 1 in virulence of Candida albicans."
Staab J.F., Datta K., Rhee P.
PLoS ONE 8:E80842-E80842(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[58]"Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis."
Fazly A., Jain C., Dehner A.C., Issi L., Lilly E.A., Ali A., Cao H., Fidel P.L. Jr., Rao R.P., Kaufman P.D.
Proc. Natl. Acad. Sci. U.S.A. 110:13594-13599(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U64206 Genomic DNA. Translation: AAC96368.1.
AF001978 Genomic DNA. Translation: AAB64014.1.
AACQ01000139 Genomic DNA. Translation: EAK93836.1.
AACQ01000138 Genomic DNA. Translation: EAK93868.1.
U29369 mRNA. Translation: AAC49209.1.
RefSeqXP_709961.1. XM_704869.1.
XP_712998.1. XM_707905.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0003753.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3645372.
3645386.
KEGGcal:CaO19.1321.
cal:CaO19.8901.

Organism-specific databases

CGDCAL0003753. HWP1.

Phylogenomic databases

eggNOGNOG12793.
OrthoDBEOG718KPF.

Family and domain databases

InterProIPR025928. Flocculin_t3_rpt.
[Graphical view]
PfamPF13928. Flocculin_t3. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHWP1_CANAL
AccessionPrimary (citable) accession number: P46593
Secondary accession number(s): O13424, P87019, Q59TL7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 19, 2011
Last modified: July 9, 2014
This is version 56 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names