Reviewed, UniProtKB/Swiss-Prot P46590 (ALS1_CANAL)

Names and origin

Protein names

Recommended name:
    Agglutinin-like protein 1

Gene names

Name:

ALS1

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	1260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted.

General annotation (Comments)

Function	May play a role in adhesion and pathogenesis.
Post-translational modification	N-glycosylated and O-glycosylated Potential.
Sequence similarities	To yeast SAG1.

Ontologies

Keywords
Biological process	Cell adhesion
Domain	Repeat Signal
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 1260	1243	Agglutinin-like protein 1		PRO_0000020691
Regions
	Repeat	433 – 468	36	1-1
	Repeat	469 – 504	36	1-2
	Repeat	505 – 540	36	1-3
	Repeat	541 – 576	36	1-4
	Repeat	577 – 612	36	1-5
	Repeat	613 – 648	36	1-6
	Repeat	649 – 684	36	1-7
	Repeat	685 – 720	36	1-8
	Repeat	721 – 756	36	1-9
	Repeat	757 – 792	36	1-10
	Repeat	983 – 1043	61	2-1
	Repeat	1092 – 1152	61	2-2
	Region	433 – 792	360	10 X 36 AA tandem repeats
	Region	983 – 1152	170	2 X 26 AA approximate repeats
	Compositional bias	399 – 404	6	Poly-Thr
	Compositional bias	408 – 418	11	Poly-Thr
	Compositional bias	450 – 455	6	Poly-Thr
	Compositional bias	486 – 491	6	Poly-Thr
	Compositional bias	522 – 527	6	Poly-Thr
	Compositional bias	558 – 563	6	Poly-Thr
	Compositional bias	594 – 599	6	Poly-Thr
	Compositional bias	630 – 635	6	Poly-Thr
	Compositional bias	666 – 671	6	Poly-Thr
	Compositional bias	702 – 707	6	Poly-Thr
	Compositional bias	738 – 743	6	Poly-Thr
	Compositional bias	774 – 779	6	Poly-Thr
	Compositional bias	874 – 877	4	Poly-Ser
Amino acid modifications
	Glycosylation	471	1	N-linked (GlcNAc...) Potential
	Glycosylation	579	1	N-linked (GlcNAc...) Potential
	Glycosylation	615	1	N-linked (GlcNAc...) Potential
	Glycosylation	687	1	N-linked (GlcNAc...) Potential
	Glycosylation	723	1	N-linked (GlcNAc...) Potential
	Glycosylation	820	1	N-linked (GlcNAc...) Potential
	Glycosylation	886	1	N-linked (GlcNAc...) Potential
	Glycosylation	918	1	N-linked (GlcNAc...) Potential
	Glycosylation	973	1	N-linked (GlcNAc...) Potential
	Glycosylation	1045	1	N-linked (GlcNAc...) Potential
	Glycosylation	1068	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P46590-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 763D1063A2354C24	FASTA	1,260	132,641
	10 20 30 40 50 60 MLQQFTLLFL YLSIASAKTI TGVFDSFNSL TWSNAANYAF KGPGYPTWNA VLGWSLDGTS 70 80 90 100 110 120 ANPGDTFTLN MPCVFKYTTS QTSVDLTADG VKYATCQFYS GEEFTTFSTL TCTVNDALKS 130 140 150 160 170 180 SIKAFGTVTL PIAFNVGGTG SSTDLEDSKC FTAGTNTVTF NDGDKDISID VEFEKSTVDP 190 200 210 220 230 240 SAYLYASRVM PSLNKVTTLF VAPQCENGYT SGTMGFSSSN GDVAIDCSNI HIGITKGLND 250 260 270 280 290 300 WNYPVSSESF SYTKTCTSNG IQIKYQNVPA GYRPFIDAYI SATDVNQYTL AYTNDYTCAG 310 320 330 340 350 360 SRSQSKPFTL RWTGYKNSDA GSNGIVIVAT TRTVTDSTTA VTTLPFNPSV DKTKTIEILQ 370 380 390 400 410 420 PIPTTTITTS YVGVTTSYST KTAPIGETAT VIVDVPYHTT TTVTSEWTGT ITTTTTRTNP 430 440 450 460 470 480 TDSIDTVVVQ VPSPNPTVST TEYWSQSFAT TTTVTAPPGG TDTVIIREPP NHTVTTTEYW 490 500 510 520 530 540 SQSFATTTTV TAPPGGTDSV IIREPPNPTV TTTEYWSQSF ATTTTVTAPP GGTDSVIIRE 550 560 570 580 590 600 PPNPTVTTTE YWSQSYATTT TVTAPPGGTD SVIIREPPNH TVTTTEYWSQ SYATTTTVTA 610 620 630 640 650 660 PPGGTDTVII REPPNHTVTT TEYWSQSFAT TTTVTGPPSG TDTVIIREPP NPTVTTTEYW 670 680 690 700 710 720 SQSYATTTTI TAPPGETDTV LIREPPNHTV TTTEYWSQSY ATTTTVTAPP GETDTVLIRE 730 740 750 760 770 780 PPNHTVTTTE YWSQSYATTT TVTAPPGGTD TVIIREPPNP TVTTTEYWSQ SFATTTTVTA 790 800 810 820 830 840 PPGGTDTVII YESMSSSKIS TSSNDITSII PSFSRPHYVN STTSDLSTFE SSSMNTPTSI 850 860 870 880 890 900 SSDGMLLSST TLVTESETTT ESICSDGKEC SRLSSSSGIV TNPDSNESSI VTSTVPTAST 910 920 930 940 950 960 MSDSLSSTDG ISATSSDNVS KSGVSVTTET SVTTIQTTPN PLSSSVTSLT QLSSIPSVSE 970 980 990 1000 1010 1020 SESKVTFTSN GDNQSGTHDS QSTSTEIEIV TTSSTKVLPP VVSSNTDLTS EPTNTREQPT 1030 1040 1050 1060 1070 1080 TLSTTSNSIT EDITTSQPTG DNGDNTSSTN PVPTVATSTL ASASEEDNKS GSHESASTSL 1090 1100 1110 1120 1130 1140 KPSMGENSGL TTSTEIEATT TSPTEAPSPA VSSGTDVTTE PTDTREQPTT LSTTSKTNSE 1150 1160 1170 1180 1190 1200 SVATTQATNE NGGKSPSTDL TSSLTTGTSA STSANSELVT SGSVTGGAVA SASNDQSHST 1210 1220 1230 1240 1250 1260 SVTNSNSIVS NTPQTTLSQQ VTSSSPSTNT FIASTYDGSG SIIQHSTWLY GLITLLSLFI

References

[1]

"Candida albicans ALS1: domains related to a Saccharomyces cerevisiae sexual agglutinin separated by a repeating motif." Hoyer L.L., Scherer S., Shatzman A.R., Livi G.P. Mol. Microbiol. 15:39-54(1995) [PubMed: 7752895] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 11651 / B792 / 171D.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L25902 Genomic DNA. Translation: AAC41649.2.
PIR	S60896.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR008966. Adhesion_bac. IPR008440. Candida_ALS. [Graphical view]
Pfam	PF05792. Candida_ALS. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALS1_CANAL

Accession

Primary (citable) accession number: P46590

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)