Reviewed, UniProtKB/Swiss-Prot P46585 (KPR1_CANAL)

Names and origin

Protein names

Recommended name:
    Ribose-phosphate pyrophosphokinase 1
    EC=2.7.6.1
Alternative name(s):
    Phosphoribosyl pyrophosphate synthetase 1

Gene names

Name:

PRS1

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.
Sequence similarities	Belongs to the ribose-phosphate pyrophosphokinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW ribose phosphate diphosphokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Ribose-phosphate pyrophosphokinase 1		PRO_0000141085
Sites
	Metal binding	131	1	Magnesium Potential
	Metal binding	133	1	Magnesium Potential
	Metal binding	142	1	Magnesium Potential
	Metal binding	146	1	Magnesium Potential

Sequences

	Sequence		Length	Mass (Da)
	P46585-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: AC70534163AA5BEB	FASTA	321	35,278
	10 20 30 40 50 60 MSTNSIKLLA SDVHRGLAEL VSKRLGLRLT PSELKRESTG EVQFSIGESV RDEDIFIICQ 70 80 90 100 110 120 IGSGEVNDRV FELMIMINAC KTASARRITV ILPNFPYARQ DRKDKSRAPI TAKLMADMLT 130 140 150 160 170 180 TAGCDHVITM DLHASQIQGF FDVPVDNLYA EPSVVRYIKE TIDYSEAIII SSDAGGAKRA 190 200 210 220 230 240 AGLADRLDLN FELIHKERAR ANEVSRMVLV VDVTDKICVI VDDMADTCGT LAKAAEVLLD 250 260 270 280 290 300 NNAKDVIAIV THGILSGNAI KNINNSKLKK VVCTNTVPFE DKLKLCLKLD TIDISAVIAE 310 320 SIRRLHNGES ISYLFKNAPC K

References

[1]	"Isolation of phosphoribosylpyrophosphate synthetase (PRS1) gene from Candida albicans." Payne T.L., Calderone R.A. Yeast 11:1295-1302(1995) [PubMed: 8553701] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 4918.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U23934 Genomic DNA. Translation: AAA97558.1.
PIR	S60393.
3D structure databases
HSSP	HSSP built from PDB template 1DKR based on UniProtKB P14193.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.6.1. 1124.
Family and domain databases
InterPro	IPR000842. PRib-PP_synthetase_CS. IPR000836. PRibTrfase. IPR005946. PRPP_kinase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01251. ribP_PPkin. 1 hit.
PROSITE	PS00114. PRPP_SYNTHETASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPR1_CANAL

Accession

Primary (citable) accession number: P46585

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	September 22, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)