Reviewed, UniProtKB/Swiss-Prot P46581 (NDF1_CAEEL)

Names and origin

Protein names

Recommended name:
    Neurogenic differentiation factor 1
Alternative name(s):
    NeuroD

Gene names

Name:	cnd-1
ORF Names:	C34E10.7

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acts as a transcriptional regulator whose activity is required for several aspects of motor neuron fate specification, including cell division patterns, proper spatiotemporal expression of fate-specific markers, and normal axonal morphology and pathfinding. Ref.1
Subcellular location	Nucleus Potential.
Tissue specificity	Expressed in neuroblasts of the AB lineage. More specifically in precursors of the embryonic ventral cord motor neurons. Expressed to a lesser degree in the EMS lineage which generates mostly endoderm and mesoderm tissues. Ref.1 Ref.3
Developmental stage	Expressed at the 14 cell embryo stage. Ref.1
Disruption phenotype	Defects in axonal morphology and synaptic connectivity of the ventral cord motor neurons. Ref.1
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	axonal fasciculation Inferred from mutant phenotype. Source: WormBase oviposition Inferred from mutant phenotype. Source: WormBase regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW transcription regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Neurogenic differentiation factor 1		PRO_0000127508
Regions
	Domain	32 – 72	41	Helix-loop-helix motif
	DNA binding	22 – 31	10	Basic motif
	Compositional bias	139 – 151	13	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	P46581-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: B1BCFEAF6C7310F1	FASTA	192	21,845
	10 20 30 40 50 60 MRPTDTSNFA PAEISKRKVR RVKANGRERA RMHGLNNALD MLREYIPITT QHQKLSKIET 70 80 90 100 110 120 LRLARNYIDA LQRMLQTNEQ PTPLEYAHTL ANGLSQTTTN MLANLLQVQP RQLLPPSQFD 130 140 150 160 170 180 IFSDPSHHQL HPSHPPPHSS FSSSSPSSSC SPPQYYYSPT QPSAAPLQGS CDPQYQQMYH 190 QHSHQNTFNY SP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The C. elegans NeuroD homolog cnd-1 functions in multiple aspects of motor neuron fate specification." Hallam S., Singer E., Waring D., Jin Y. Development 127:4239-4252(2000) [PubMed: 10976055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[3]	"Automated analysis of embryonic gene expression with cellular resolution in C. elegans." Murray J.I., Bao Z., Boyle T.J., Boeck M.E., Mericle B.L., Nicholas T.J., Zhao Z., Sandel M.J., Waterston R.H. Nat. Methods 5:703-709(2008) [PubMed: 18587405] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U10402 Genomic DNA. Translation: AAA19069.1.
PIR	T15764.
RefSeq	NP_498115.1.
UniGene	Cel.10756
3D structure databases
SMR	P46581. Positions 20-76.
ModBase	Search...
Protein-protein interaction databases
IntAct	P46581. 1 interaction.
STRING	P46581.
Genome annotation databases
Ensembl	C34E10.7; C34E10.7; C34E10.7; Caenorhabditis elegans. [Genome view]
GeneID	183212.
KEGG	cel:C34E10.7.
NMPDR	fig|6239.3.peg.9725.
Organism-specific databases
CTD	183212.
WormBase	WBGene00000561. cnd-1.
WormPep	C34E10.7. CE01187. [WorfDB]
Phylogenomic databases
eggNOG	meNOG08444.
InParanoid	P46581.
OMA	VKANGRE.
Gene expression databases
ArrayExpress	P46581.
Family and domain databases
InterPro	IPR001092. HLH_DNA-bd_dom. IPR011598. HLH_DNA_bd. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	920322.

Entry information

Entry name

NDF1_CAEEL

Accession

Primary (citable) accession number: P46581

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	February 9, 2010
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project