Reviewed, UniProtKB/Swiss-Prot P46580 (ANM5_CAEEL)

Names and origin

Protein names

Recommended name:
    Protein arginine N-methyltransferase 5
    EC=2.1.1.125
    EC=2.1.1.-

Gene names

Name:	prmt-5
Synonyms:	tag-251
ORF Names:	C34E10.5

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	734 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Methylates arginine residues in proteins such as small nuclear ribonucleoproteins or histone H2A/H4 By similarity.
Catalytic activity	S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N(omega)-methyl-arginine.
Sequence similarities	Belongs to the protein arginine N-methyltransferase family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	histone-arginine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 734	734	Protein arginine N-methyltransferase 5		PRO_0000212348

Sequences

	Sequence		Length	Mass (Da)
	P46580-1 [UniParc]. Last modified March 1, 2004. Version 2. Checksum: 415AAC571206DB2C	FASTA	734	83,292
	10 20 30 40 50 60 MSNRTYADNL FPQQVAEQHE EQMSSGSSPK SNSPSRSISS VEAANSRIHI GWMATTLDVA 70 80 90 100 110 120 ENLDRHVATF CTRLGEFKYN FVVYPIGGVV RAFWTPNGSA ENHPPVIDLP DVQLRNDLWE 130 140 150 160 170 180 SYVVGKISPW IDCDSSDPAF ASLSEEHLLK ELSYICYLGL QTMAIELTRI SSPRTAAILK 190 200 210 220 230 240 KWIWTRNSRF TVWVQLPSAI EKCKDYDAFT IEHVDLWTIW ADFRKNCGNF SGVYFQVALT 250 260 270 280 290 300 ISSELPDELT ELKLVDRWKA EPLAAFVIES GLFISGRNGE ASIPSAHINL LKHLWTTDAL 310 320 330 340 350 360 RIVLRATTDT FKYNTSIKSE YSQALRHAVR NVNYRSRPDV GEGSNDSTHY LNVIEYKDVL 370 380 390 400 410 420 QAPLQPLSEN LDSGVYNTFE QDQIKYDVYG EAVVGALKDL GADGRKTVVI YLLGGGRGPI 430 440 450 460 470 480 GTKILKSERE YNNTFRQGQE SLKVKLYIVE KNPNAIVTLK YMNVRTWKRR VTIIESDMRS 490 500 510 520 530 540 LPGIAKDRGF EQPDIIVSEL LGSFGDNELS PECLDGVTGF LKPTTISIPQ KYTSYVKPIM 550 560 570 580 590 600 STHIHQTIKA QSIPYLSRAI PSHGRGEPEL DEDEMWIQKY PQGHVRNNMD QIYVVYLSKY 610 620 630 640 650 660 IPLAETTKPV FTFEHPNFMN SSNERSDSIE FVMDRNADLM GFAGYFDLQL YKTVMLSIEP 670 680 690 700 710 720 STHTPGMVSW FPAVIPLRDQ LRVGEGDRIS LKIDRKVDNT GVWYEWHVEK KKTNGESVST 730 PIQNPNGESY YMRM

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U10402 Genomic DNA. Translation: AAK95874.1.
PIR	T15762.
RefSeq	NP_498112.1.
UniGene	Cel.16951
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P46580.
Genome annotation databases
Ensembl	C34E10.5.1; C34E10.5.1; C34E10.5; Caenorhabditis elegans. [Genome view] C34E10.5.2; C34E10.5.2; C34E10.5; Caenorhabditis elegans. [Genome view] C34E10.5.3; C34E10.5.3; C34E10.5; Caenorhabditis elegans. [Genome view]
GeneID	175717.
KEGG	cel:C34E10.5.
UCSC	C34E10.5.3. c. elegans.
Organism-specific databases
CTD	175717.
WormBase	WBGene00016408. prmt-5.
WormPep	C34E10.5. CE29033. [WorfDB]
Phylogenomic databases
OMA	TWELWNT.
Gene expression databases
ArrayExpress	P46580.
Family and domain databases
InterPro	IPR007857. Skb1_MeTrfase. [Graphical view]
PANTHER	PTHR10738. Skb1_mtfrase. 1 hit.
Pfam	PF05185. PRMT5. 1 hit. [Graphical view]
PIRSF	PIRSF015894. Skb1_MeTrfase. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	889342.

Entry information

Entry name

ANM5_CAEEL

Accession

Primary (citable) accession number: P46580
Secondary accession number(s): Q8T8N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	March 1, 2004
Last modified:	November 3, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project