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P46579

- SYWM_CAEEL

UniProt

P46579 - SYWM_CAEEL

Protein

Tryptophan--tRNA ligase, mitochondrial

Gene

wars-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 3 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei232 – 2321ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. tryptophan-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligase, mitochondrial (EC:6.1.1.2)
    Alternative name(s):
    Tryptophanyl-tRNA synthetase
    Short name:
    TrpRS
    Gene namesi
    Name:wars-2
    Synonyms:wrs-2
    ORF Names:C34E10.4
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiC34E10.4a; CE29032; WBGene00006946; wars-2.
    C34E10.4b; CE37710; WBGene00006946; wars-2.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 360Tryptophan--tRNA ligase, mitochondrialPRO_0000136746
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiP46579.
    PRIDEiP46579.

    Interactioni

    Protein-protein interaction databases

    IntActiP46579. 1 interaction.
    STRINGi6239.C34E10.4a.

    Structurei

    3D structure databases

    ProteinModelPortaliP46579.
    SMRiP46579. Positions 34-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi39 – 479"HIGH" region
    Motifi229 – 2335"KMSKS" region

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG5574.
    GeneTreeiENSGT00510000047425.
    HOGENOMiHOG000022014.
    InParanoidiP46579.
    OMAiSHILHRP.
    OrthoDBiEOG73JKWD.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P46579-1 [UniParc]FASTAAdd to Basket

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    MIFSGKFTSH LLNYGFKPNN LRLLSTSTHP TIYFTGIQPT GIPHLGNFFG    50
    SIEPWTELQN SVDKNILMML SVVDQHAISL GPLPANELRQ NTHQMTASLI 100
    ACGVDPNRTL LFRQSDVPQI AQISWILGSL QTTSKLARLP QYKEKKERFK 150
    KGDIPVGLLT YPLLQAADVL TFKATTVPVG EDQSQHLNLL GGLAYAFNKT 200
    YETEIFPIPK QLTRESHARI RSLREPEKKM SKSSGGPRSR IEITDSRSTI 250
    IEKCQKAQSD NAGKVTYDKE NRLAVSNLLD LYSAVTKTQT SEIDFSNWTT 300
    LDLKMNLAEA VDKRLAPIRQ KFEELQNTGE VDKVLTENGE KAREIAEKNL 350
    EEIRRTIGFL 360
    Length:360
    Mass (Da):40,474
    Last modified:January 25, 2012 - v3
    Checksum:iE73230D906FA1E7A
    GO

    Sequence cautioni

    The sequence CCD66656.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080774 Genomic DNA. Translation: CCD66648.1.
    FO080774 Genomic DNA. Translation: CCD66656.1. Sequence problems.
    AB096634 mRNA. Translation: BAC76734.1.
    PIRiT15761.
    RefSeqiNP_001021200.2. NM_001026029.3.
    NP_001021201.1. NM_001026030.3.
    UniGeneiCel.23360.
    Cel.39087.

    Genome annotation databases

    EnsemblMetazoaiC34E10.4b; C34E10.4b; WBGene00006946.
    GeneIDi175719.
    KEGGicel:CELE_C34E10.4.
    UCSCiC34E10.4a. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080774 Genomic DNA. Translation: CCD66648.1 .
    FO080774 Genomic DNA. Translation: CCD66656.1 . Sequence problems.
    AB096634 mRNA. Translation: BAC76734.1 .
    PIRi T15761.
    RefSeqi NP_001021200.2. NM_001026029.3.
    NP_001021201.1. NM_001026030.3.
    UniGenei Cel.23360.
    Cel.39087.

    3D structure databases

    ProteinModelPortali P46579.
    SMRi P46579. Positions 34-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P46579. 1 interaction.
    STRINGi 6239.C34E10.4a.

    Proteomic databases

    PaxDbi P46579.
    PRIDEi P46579.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C34E10.4b ; C34E10.4b ; WBGene00006946 .
    GeneIDi 175719.
    KEGGi cel:CELE_C34E10.4.
    UCSCi C34E10.4a. c. elegans.

    Organism-specific databases

    CTDi 175719.
    WormBasei C34E10.4a ; CE29032 ; WBGene00006946 ; wars-2.
    C34E10.4b ; CE37710 ; WBGene00006946 ; wars-2.

    Phylogenomic databases

    eggNOGi COG5574.
    GeneTreei ENSGT00510000047425.
    HOGENOMi HOG000022014.
    InParanoidi P46579.
    OMAi SHILHRP.
    OrthoDBi EOG73JKWD.

    Miscellaneous databases

    NextBioi 889350.
    PROi P46579.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "C. elegans mitochondrial aminoacyl-tRNA synthetases."
      Ohtsuki T.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSYWM_CAEEL
    AccessioniPrimary (citable) accession number: P46579
    Secondary accession number(s): Q5TYM1, Q7Z259
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 109 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3