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P46579 (SYWM_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase, mitochondrial

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:wars-2
Synonyms:wrs-2
ORF Names:C34E10.4
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence CCD66656.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 360Tryptophan--tRNA ligase, mitochondrialPRO_0000136746

Regions

Motif39 – 479"HIGH" region
Motif229 – 2335"KMSKS" region

Sites

Binding site2321ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P46579 [UniParc].

Last modified January 25, 2012. Version 3.
Checksum: E73230D906FA1E7A

FASTA36040,474
        10         20         30         40         50         60 
MIFSGKFTSH LLNYGFKPNN LRLLSTSTHP TIYFTGIQPT GIPHLGNFFG SIEPWTELQN 

        70         80         90        100        110        120 
SVDKNILMML SVVDQHAISL GPLPANELRQ NTHQMTASLI ACGVDPNRTL LFRQSDVPQI 

       130        140        150        160        170        180 
AQISWILGSL QTTSKLARLP QYKEKKERFK KGDIPVGLLT YPLLQAADVL TFKATTVPVG 

       190        200        210        220        230        240 
EDQSQHLNLL GGLAYAFNKT YETEIFPIPK QLTRESHARI RSLREPEKKM SKSSGGPRSR 

       250        260        270        280        290        300 
IEITDSRSTI IEKCQKAQSD NAGKVTYDKE NRLAVSNLLD LYSAVTKTQT SEIDFSNWTT 

       310        320        330        340        350        360 
LDLKMNLAEA VDKRLAPIRQ KFEELQNTGE VDKVLTENGE KAREIAEKNL EEIRRTIGFL 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"C. elegans mitochondrial aminoacyl-tRNA synthetases."
Ohtsuki T.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080774 Genomic DNA. Translation: CCD66648.1.
FO080774 Genomic DNA. Translation: CCD66656.1. Sequence problems.
AB096634 mRNA. Translation: BAC76734.1.
PIRT15761.
RefSeqNP_001021200.2. NM_001026029.3.
NP_001021201.1. NM_001026030.3.
UniGeneCel.23360.
Cel.39087.

3D structure databases

ProteinModelPortalP46579.
SMRP46579. Positions 34-359.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP46579. 1 interaction.
STRING6239.C34E10.4a.

Proteomic databases

PaxDbP46579.
PRIDEP46579.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC34E10.4b; C34E10.4b; C34E10.4.
GeneID175719.
KEGGcel:CELE_C34E10.4.
UCSCC34E10.4a. c. elegans.

Organism-specific databases

CTD175719.
WormBaseC34E10.4a; CE29032; WBGene00006946; wars-2.
C34E10.4b; CE37710; WBGene00006946; wars-2.

Phylogenomic databases

eggNOGCOG5574.
HOGENOMHOG000022014.
InParanoidP46579.
OMAGWGQFKP.
OrthoDBEOG73JKWD.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio889350.
PROP46579.

Entry information

Entry nameSYWM_CAEEL
AccessionPrimary (citable) accession number: P46579
Secondary accession number(s): Q5TYM1, Q7Z259
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 25, 2012
Last modified: April 16, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries