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Protein

Tryptophan--tRNA ligase, mitochondrial

Gene

wars-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei232 – 2321ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. tryptophan-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase, mitochondrial (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:wars-2
Synonyms:wrs-2
ORF Names:C34E10.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC34E10.4a; CE29032; WBGene00006946; wars-2.
C34E10.4b; CE37710; WBGene00006946; wars-2.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 360Tryptophan--tRNA ligase, mitochondrialPRO_0000136746
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PaxDbiP46579.
PRIDEiP46579.

Interactioni

Protein-protein interaction databases

IntActiP46579. 1 interaction.
STRINGi6239.C34E10.4a.

Structurei

3D structure databases

ProteinModelPortaliP46579.
SMRiP46579. Positions 34-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 479"HIGH" region
Motifi229 – 2335"KMSKS" region

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG5574.
GeneTreeiENSGT00510000047425.
HOGENOMiHOG000022014.
InParanoidiP46579.
OMAiGWGQFKP.
OrthoDBiEOG73JKWD.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFSGKFTSH LLNYGFKPNN LRLLSTSTHP TIYFTGIQPT GIPHLGNFFG
60 70 80 90 100
SIEPWTELQN SVDKNILMML SVVDQHAISL GPLPANELRQ NTHQMTASLI
110 120 130 140 150
ACGVDPNRTL LFRQSDVPQI AQISWILGSL QTTSKLARLP QYKEKKERFK
160 170 180 190 200
KGDIPVGLLT YPLLQAADVL TFKATTVPVG EDQSQHLNLL GGLAYAFNKT
210 220 230 240 250
YETEIFPIPK QLTRESHARI RSLREPEKKM SKSSGGPRSR IEITDSRSTI
260 270 280 290 300
IEKCQKAQSD NAGKVTYDKE NRLAVSNLLD LYSAVTKTQT SEIDFSNWTT
310 320 330 340 350
LDLKMNLAEA VDKRLAPIRQ KFEELQNTGE VDKVLTENGE KAREIAEKNL
360
EEIRRTIGFL
Length:360
Mass (Da):40,474
Last modified:January 25, 2012 - v3
Checksum:iE73230D906FA1E7A
GO

Sequence cautioni

The sequence CCD66656.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080774 Genomic DNA. Translation: CCD66648.1.
FO080774 Genomic DNA. Translation: CCD66656.1. Sequence problems.
AB096634 mRNA. Translation: BAC76734.1.
PIRiT15761.
RefSeqiNP_001021200.2. NM_001026029.3.
NP_001021201.1. NM_001026030.3.
UniGeneiCel.23360.
Cel.39087.

Genome annotation databases

EnsemblMetazoaiC34E10.4b; C34E10.4b; WBGene00006946.
GeneIDi175719.
KEGGicel:CELE_C34E10.4.
UCSCiC34E10.4a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080774 Genomic DNA. Translation: CCD66648.1.
FO080774 Genomic DNA. Translation: CCD66656.1. Sequence problems.
AB096634 mRNA. Translation: BAC76734.1.
PIRiT15761.
RefSeqiNP_001021200.2. NM_001026029.3.
NP_001021201.1. NM_001026030.3.
UniGeneiCel.23360.
Cel.39087.

3D structure databases

ProteinModelPortaliP46579.
SMRiP46579. Positions 34-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP46579. 1 interaction.
STRINGi6239.C34E10.4a.

Proteomic databases

PaxDbiP46579.
PRIDEiP46579.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC34E10.4b; C34E10.4b; WBGene00006946.
GeneIDi175719.
KEGGicel:CELE_C34E10.4.
UCSCiC34E10.4a. c. elegans.

Organism-specific databases

CTDi175719.
WormBaseiC34E10.4a; CE29032; WBGene00006946; wars-2.
C34E10.4b; CE37710; WBGene00006946; wars-2.

Phylogenomic databases

eggNOGiCOG5574.
GeneTreeiENSGT00510000047425.
HOGENOMiHOG000022014.
InParanoidiP46579.
OMAiGWGQFKP.
OrthoDBiEOG73JKWD.

Miscellaneous databases

NextBioi889350.
PROiP46579.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "C. elegans mitochondrial aminoacyl-tRNA synthetases."
    Ohtsuki T.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSYWM_CAEEL
AccessioniPrimary (citable) accession number: P46579
Secondary accession number(s): Q5TYM1, Q7Z259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 25, 2012
Last modified: January 7, 2015
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.