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P46579

- SYWM_CAEEL

UniProt

P46579 - SYWM_CAEEL

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Protein

Tryptophan--tRNA ligase, mitochondrial

Gene

wars-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei232 – 2321ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. tryptophan-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase, mitochondrial (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:wars-2
Synonyms:wrs-2
ORF Names:C34E10.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC34E10.4a; CE29032; WBGene00006946; wars-2.
C34E10.4b; CE37710; WBGene00006946; wars-2.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 360Tryptophan--tRNA ligase, mitochondrialPRO_0000136746
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PaxDbiP46579.
PRIDEiP46579.

Interactioni

Protein-protein interaction databases

IntActiP46579. 1 interaction.
STRINGi6239.C34E10.4a.

Structurei

3D structure databases

ProteinModelPortaliP46579.
SMRiP46579. Positions 34-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 479"HIGH" region
Motifi229 – 2335"KMSKS" region

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG5574.
GeneTreeiENSGT00510000047425.
HOGENOMiHOG000022014.
InParanoidiP46579.
OMAiSHILHRP.
OrthoDBiEOG73JKWD.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46579-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIFSGKFTSH LLNYGFKPNN LRLLSTSTHP TIYFTGIQPT GIPHLGNFFG
60 70 80 90 100
SIEPWTELQN SVDKNILMML SVVDQHAISL GPLPANELRQ NTHQMTASLI
110 120 130 140 150
ACGVDPNRTL LFRQSDVPQI AQISWILGSL QTTSKLARLP QYKEKKERFK
160 170 180 190 200
KGDIPVGLLT YPLLQAADVL TFKATTVPVG EDQSQHLNLL GGLAYAFNKT
210 220 230 240 250
YETEIFPIPK QLTRESHARI RSLREPEKKM SKSSGGPRSR IEITDSRSTI
260 270 280 290 300
IEKCQKAQSD NAGKVTYDKE NRLAVSNLLD LYSAVTKTQT SEIDFSNWTT
310 320 330 340 350
LDLKMNLAEA VDKRLAPIRQ KFEELQNTGE VDKVLTENGE KAREIAEKNL
360
EEIRRTIGFL
Length:360
Mass (Da):40,474
Last modified:January 25, 2012 - v3
Checksum:iE73230D906FA1E7A
GO

Sequence cautioni

The sequence CCD66656.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080774 Genomic DNA. Translation: CCD66648.1.
FO080774 Genomic DNA. Translation: CCD66656.1. Sequence problems.
AB096634 mRNA. Translation: BAC76734.1.
PIRiT15761.
RefSeqiNP_001021200.2. NM_001026029.3.
NP_001021201.1. NM_001026030.3.
UniGeneiCel.23360.
Cel.39087.

Genome annotation databases

EnsemblMetazoaiC34E10.4b; C34E10.4b; WBGene00006946.
GeneIDi175719.
KEGGicel:CELE_C34E10.4.
UCSCiC34E10.4a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080774 Genomic DNA. Translation: CCD66648.1 .
FO080774 Genomic DNA. Translation: CCD66656.1 . Sequence problems.
AB096634 mRNA. Translation: BAC76734.1 .
PIRi T15761.
RefSeqi NP_001021200.2. NM_001026029.3.
NP_001021201.1. NM_001026030.3.
UniGenei Cel.23360.
Cel.39087.

3D structure databases

ProteinModelPortali P46579.
SMRi P46579. Positions 34-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P46579. 1 interaction.
STRINGi 6239.C34E10.4a.

Proteomic databases

PaxDbi P46579.
PRIDEi P46579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C34E10.4b ; C34E10.4b ; WBGene00006946 .
GeneIDi 175719.
KEGGi cel:CELE_C34E10.4.
UCSCi C34E10.4a. c. elegans.

Organism-specific databases

CTDi 175719.
WormBasei C34E10.4a ; CE29032 ; WBGene00006946 ; wars-2.
C34E10.4b ; CE37710 ; WBGene00006946 ; wars-2.

Phylogenomic databases

eggNOGi COG5574.
GeneTreei ENSGT00510000047425.
HOGENOMi HOG000022014.
InParanoidi P46579.
OMAi SHILHRP.
OrthoDBi EOG73JKWD.

Miscellaneous databases

NextBioi 889350.
PROi P46579.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "C. elegans mitochondrial aminoacyl-tRNA synthetases."
    Ohtsuki T.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSYWM_CAEEL
AccessioniPrimary (citable) accession number: P46579
Secondary accession number(s): Q5TYM1, Q7Z259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 25, 2012
Last modified: October 29, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3