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P46579

- SYWM_CAEEL

UniProt

P46579 - SYWM_CAEEL

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Protein
Tryptophan--tRNA ligase, mitochondrial
Gene
wars-2, wrs-2, C34E10.4
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei232 – 2321ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. tryptophan-tRNA ligase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase, mitochondrial (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:wars-2
Synonyms:wrs-2
ORF Names:C34E10.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC34E10.4a; CE29032; WBGene00006946; wars-2.
C34E10.4b; CE37710; WBGene00006946; wars-2.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 360Tryptophan--tRNA ligase, mitochondrialPRO_0000136746
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

PaxDbiP46579.
PRIDEiP46579.

Interactioni

Protein-protein interaction databases

IntActiP46579. 1 interaction.
STRINGi6239.C34E10.4a.

Structurei

3D structure databases

ProteinModelPortaliP46579.
SMRiP46579. Positions 34-359.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi39 – 479"HIGH" region
Motifi229 – 2335"KMSKS" region

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG5574.
GeneTreeiENSGT00510000047425.
HOGENOMiHOG000022014.
InParanoidiP46579.
OMAiSHILHRP.
OrthoDBiEOG73JKWD.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46579-1 [UniParc]FASTAAdd to Basket

« Hide

MIFSGKFTSH LLNYGFKPNN LRLLSTSTHP TIYFTGIQPT GIPHLGNFFG    50
SIEPWTELQN SVDKNILMML SVVDQHAISL GPLPANELRQ NTHQMTASLI 100
ACGVDPNRTL LFRQSDVPQI AQISWILGSL QTTSKLARLP QYKEKKERFK 150
KGDIPVGLLT YPLLQAADVL TFKATTVPVG EDQSQHLNLL GGLAYAFNKT 200
YETEIFPIPK QLTRESHARI RSLREPEKKM SKSSGGPRSR IEITDSRSTI 250
IEKCQKAQSD NAGKVTYDKE NRLAVSNLLD LYSAVTKTQT SEIDFSNWTT 300
LDLKMNLAEA VDKRLAPIRQ KFEELQNTGE VDKVLTENGE KAREIAEKNL 350
EEIRRTIGFL 360
Length:360
Mass (Da):40,474
Last modified:January 25, 2012 - v3
Checksum:iE73230D906FA1E7A
GO

Sequence cautioni

The sequence CCD66656.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080774 Genomic DNA. Translation: CCD66648.1.
FO080774 Genomic DNA. Translation: CCD66656.1. Sequence problems.
AB096634 mRNA. Translation: BAC76734.1.
PIRiT15761.
RefSeqiNP_001021200.2. NM_001026029.3.
NP_001021201.1. NM_001026030.3.
UniGeneiCel.23360.
Cel.39087.

Genome annotation databases

EnsemblMetazoaiC34E10.4b; C34E10.4b; WBGene00006946.
GeneIDi175719.
KEGGicel:CELE_C34E10.4.
UCSCiC34E10.4a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080774 Genomic DNA. Translation: CCD66648.1 .
FO080774 Genomic DNA. Translation: CCD66656.1 . Sequence problems.
AB096634 mRNA. Translation: BAC76734.1 .
PIRi T15761.
RefSeqi NP_001021200.2. NM_001026029.3.
NP_001021201.1. NM_001026030.3.
UniGenei Cel.23360.
Cel.39087.

3D structure databases

ProteinModelPortali P46579.
SMRi P46579. Positions 34-359.
ModBasei Search...

Protein-protein interaction databases

IntActi P46579. 1 interaction.
STRINGi 6239.C34E10.4a.

Proteomic databases

PaxDbi P46579.
PRIDEi P46579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C34E10.4b ; C34E10.4b ; WBGene00006946 .
GeneIDi 175719.
KEGGi cel:CELE_C34E10.4.
UCSCi C34E10.4a. c. elegans.

Organism-specific databases

CTDi 175719.
WormBasei C34E10.4a ; CE29032 ; WBGene00006946 ; wars-2.
C34E10.4b ; CE37710 ; WBGene00006946 ; wars-2.

Phylogenomic databases

eggNOGi COG5574.
GeneTreei ENSGT00510000047425.
HOGENOMi HOG000022014.
InParanoidi P46579.
OMAi SHILHRP.
OrthoDBi EOG73JKWD.

Miscellaneous databases

NextBioi 889350.
PROi P46579.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "C. elegans mitochondrial aminoacyl-tRNA synthetases."
    Ohtsuki T.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSYWM_CAEEL
AccessioniPrimary (citable) accession number: P46579
Secondary accession number(s): Q5TYM1, Q7Z259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 25, 2012
Last modified: June 11, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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