Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P46563

- ALF2_CAEEL

UniProt

P46563 - ALF2_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Fructose-bisphosphate aldolase 2

Gene

aldo-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601SubstrateBy similarity
Binding sitei150 – 1501SubstrateBy similarity
Active sitei191 – 1911Proton acceptorBy similarity
Active sitei233 – 2331Schiff-base intermediate with dihydroxyacetone-PBy similarity
Sitei366 – 3661Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiREACT_231555. Glycolysis.
REACT_258890. Fructose catabolism.
REACT_261547. Gluconeogenesis.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase 2 (EC:4.1.2.13)
Alternative name(s):
Aldolase CE-2
Short name:
CE2
Gene namesi
Name:aldo-2
ORF Names:F01F1.12
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiF01F1.12a; CE01225; WBGene00017166; aldo-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Fructose-bisphosphate aldolase 2PRO_0000216929Add
BLAST

Proteomic databases

PaxDbiP46563.
PRIDEiP46563.

Expressioni

Developmental stagei

Restricted to the embryo and early larval stages.

Gene expression databases

ExpressionAtlasiP46563. baseline.

Interactioni

Protein-protein interaction databases

BioGridi41049. 7 interactions.
DIPiDIP-24398N.
IntActiP46563. 4 interactions.
MINTiMINT-1053227.
STRINGi6239.F01F1.12a.

Structurei

3D structure databases

ProteinModelPortaliP46563.
SMRiP46563. Positions 17-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
InParanoidiP46563.
KOiK01623.
OMAiLIRTAKY.
PhylomeDBiP46563.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46563-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATVGGAFKD SLTQAQKDEL HQIALKIVQD GKGILAADES TGTIGKRLDA
60 70 80 90 100
INLENNETNR QKYRQLLFTT PNLNQHISGV ILYEETFHQS TDKGEKFTDL
110 120 130 140 150
LIKQGIVPGI KLDLGVVPLA GTIGEGTTQG LDKLAERAAA FKKGGCGFAK
160 170 180 190 200
WRCVLNIGTH TPSHLGMLEN ANVLARYASI CQANGLVPIV EPEVLCDGEH
210 220 230 240 250
DLARAQKVTE QVLAFVYKAL ADHHVYLEGT LLKPNMVTPG QSSASKASHE
260 270 280 290 300
AIGLATVTAL RRGVPAAVPG ITFLSGGQSE LDATANLNAI NSVQLGKPWK
310 320 330 340 350
LTFSYGRALQ ASVLKAWGGK DENIAAAQKT LLHRSKANGD ASLGKYAGED
360
AAGAAAESLF VAKHSY
Length:366
Mass (Da):38,846
Last modified:November 1, 1995 - v1
Checksum:iD6BD9D1469E69834
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83739 mRNA. Translation: BAA12092.1.
FO080705 Genomic DNA. Translation: CCD65997.1.
PIRiT15951.
RefSeqiNP_001021240.1. NM_001026069.5.
UniGeneiCel.18124.

Genome annotation databases

EnsemblMetazoaiF01F1.12a.1; F01F1.12a.1; WBGene00017166.
F01F1.12a.2; F01F1.12a.2; WBGene00017166.
GeneIDi175827.
KEGGicel:CELE_F01F1.12.
UCSCiF01F1.12a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83739 mRNA. Translation: BAA12092.1 .
FO080705 Genomic DNA. Translation: CCD65997.1 .
PIRi T15951.
RefSeqi NP_001021240.1. NM_001026069.5.
UniGenei Cel.18124.

3D structure databases

ProteinModelPortali P46563.
SMRi P46563. Positions 17-366.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 41049. 7 interactions.
DIPi DIP-24398N.
IntActi P46563. 4 interactions.
MINTi MINT-1053227.
STRINGi 6239.F01F1.12a.

Proteomic databases

PaxDbi P46563.
PRIDEi P46563.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F01F1.12a.1 ; F01F1.12a.1 ; WBGene00017166 .
F01F1.12a.2 ; F01F1.12a.2 ; WBGene00017166 .
GeneIDi 175827.
KEGGi cel:CELE_F01F1.12.
UCSCi F01F1.12a. c. elegans.

Organism-specific databases

CTDi 175827.
WormBasei F01F1.12a ; CE01225 ; WBGene00017166 ; aldo-2.

Phylogenomic databases

eggNOGi COG3588.
GeneTreei ENSGT00390000010235.
HOGENOMi HOG000220876.
InParanoidi P46563.
KOi K01623.
OMAi LIRTAKY.
PhylomeDBi P46563.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
Reactomei REACT_231555. Glycolysis.
REACT_258890. Fructose catabolism.
REACT_261547. Gluconeogenesis.

Miscellaneous databases

NextBioi 889828.
PROi P46563.

Gene expression databases

ExpressionAtlasi P46563. baseline.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view ]
PANTHERi PTHR11627. PTHR11627. 1 hit.
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Caenorhabditis elegans has two isozymic forms, CE-1 and CE-2, of fructose-1,6-bisphosphate aldolase which are encoded by different genes."
    Inoue T., Yatsuki H., Kusakabe T., Joh K., Hori K.
    Arch. Biochem. Biophys. 339:226-234(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiALF2_CAEEL
AccessioniPrimary (citable) accession number: P46563
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3