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Protein

Fructose-bisphosphate aldolase 2

Gene

aldo-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601SubstrateBy similarity
Binding sitei150 – 1501SubstrateBy similarity
Active sitei191 – 1911Proton acceptorBy similarity
Active sitei233 – 2331Schiff-base intermediate with dihydroxyacetone-PBy similarity
Sitei366 – 3661Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase 2 (EC:4.1.2.13)
Alternative name(s):
Aldolase CE-2
Short name:
CE2
Gene namesi
Name:aldo-2
ORF Names:F01F1.12
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF01F1.12a; CE01225; WBGene00017166; aldo-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Fructose-bisphosphate aldolase 2PRO_0000216929Add
BLAST

Proteomic databases

PaxDbiP46563.
PRIDEiP46563.

Expressioni

Developmental stagei

Restricted to the embryo and early larval stages.

Gene expression databases

ExpressionAtlasiP46563. baseline.

Interactioni

Protein-protein interaction databases

BioGridi41049. 7 interactions.
DIPiDIP-24398N.
IntActiP46563. 4 interactions.
MINTiMINT-1053227.
STRINGi6239.F01F1.12a.

Structurei

3D structure databases

ProteinModelPortaliP46563.
SMRiP46563. Positions 17-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
InParanoidiP46563.
KOiK01623.
OMAiLHRSKAN.
PhylomeDBiP46563.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVGGAFKD SLTQAQKDEL HQIALKIVQD GKGILAADES TGTIGKRLDA
60 70 80 90 100
INLENNETNR QKYRQLLFTT PNLNQHISGV ILYEETFHQS TDKGEKFTDL
110 120 130 140 150
LIKQGIVPGI KLDLGVVPLA GTIGEGTTQG LDKLAERAAA FKKGGCGFAK
160 170 180 190 200
WRCVLNIGTH TPSHLGMLEN ANVLARYASI CQANGLVPIV EPEVLCDGEH
210 220 230 240 250
DLARAQKVTE QVLAFVYKAL ADHHVYLEGT LLKPNMVTPG QSSASKASHE
260 270 280 290 300
AIGLATVTAL RRGVPAAVPG ITFLSGGQSE LDATANLNAI NSVQLGKPWK
310 320 330 340 350
LTFSYGRALQ ASVLKAWGGK DENIAAAQKT LLHRSKANGD ASLGKYAGED
360
AAGAAAESLF VAKHSY
Length:366
Mass (Da):38,846
Last modified:October 31, 1995 - v1
Checksum:iD6BD9D1469E69834
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83739 mRNA. Translation: BAA12092.1.
FO080705 Genomic DNA. Translation: CCD65997.1.
PIRiT15951.
RefSeqiNP_001021240.1. NM_001026069.5.
UniGeneiCel.18124.

Genome annotation databases

EnsemblMetazoaiF01F1.12a.1; F01F1.12a.1; WBGene00017166.
F01F1.12a.2; F01F1.12a.2; WBGene00017166.
GeneIDi175827.
KEGGicel:CELE_F01F1.12.
UCSCiF01F1.12a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83739 mRNA. Translation: BAA12092.1.
FO080705 Genomic DNA. Translation: CCD65997.1.
PIRiT15951.
RefSeqiNP_001021240.1. NM_001026069.5.
UniGeneiCel.18124.

3D structure databases

ProteinModelPortaliP46563.
SMRiP46563. Positions 17-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41049. 7 interactions.
DIPiDIP-24398N.
IntActiP46563. 4 interactions.
MINTiMINT-1053227.
STRINGi6239.F01F1.12a.

Proteomic databases

PaxDbiP46563.
PRIDEiP46563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF01F1.12a.1; F01F1.12a.1; WBGene00017166.
F01F1.12a.2; F01F1.12a.2; WBGene00017166.
GeneIDi175827.
KEGGicel:CELE_F01F1.12.
UCSCiF01F1.12a. c. elegans.

Organism-specific databases

CTDi175827.
WormBaseiF01F1.12a; CE01225; WBGene00017166; aldo-2.

Phylogenomic databases

eggNOGiCOG3588.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
InParanoidiP46563.
KOiK01623.
OMAiLHRSKAN.
PhylomeDBiP46563.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Miscellaneous databases

NextBioi889828.
PROiP46563.

Gene expression databases

ExpressionAtlasiP46563. baseline.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Caenorhabditis elegans has two isozymic forms, CE-1 and CE-2, of fructose-1,6-bisphosphate aldolase which are encoded by different genes."
    Inoue T., Yatsuki H., Kusakabe T., Joh K., Hori K.
    Arch. Biochem. Biophys. 339:226-234(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiALF2_CAEEL
AccessioniPrimary (citable) accession number: P46563
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: October 31, 1995
Last modified: March 31, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.