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P46563

- ALF2_CAEEL

UniProt

P46563 - ALF2_CAEEL

Protein

Fructose-bisphosphate aldolase 2

Gene

aldo-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei60 – 601SubstrateBy similarity
    Binding sitei150 – 1501SubstrateBy similarity
    Active sitei191 – 1911Proton acceptorBy similarity
    Active sitei233 – 2331Schiff-base intermediate with dihydroxyacetone-PBy similarity
    Sitei366 – 3661Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase 2 (EC:4.1.2.13)
    Alternative name(s):
    Aldolase CE-2
    Short name:
    CE2
    Gene namesi
    Name:aldo-2
    ORF Names:F01F1.12
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiF01F1.12a; CE01225; WBGene00017166; aldo-2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Fructose-bisphosphate aldolase 2PRO_0000216929Add
    BLAST

    Proteomic databases

    PaxDbiP46563.
    PRIDEiP46563.

    Expressioni

    Developmental stagei

    Restricted to the embryo and early larval stages.

    Interactioni

    Protein-protein interaction databases

    BioGridi41049. 7 interactions.
    DIPiDIP-24398N.
    IntActiP46563. 4 interactions.
    MINTiMINT-1053227.
    STRINGi6239.F01F1.12a.

    Structurei

    3D structure databases

    ProteinModelPortaliP46563.
    SMRiP46563. Positions 17-366.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3588.
    GeneTreeiENSGT00390000010235.
    HOGENOMiHOG000220876.
    InParanoidiP46563.
    KOiK01623.
    OMAiLIRTAKY.
    PhylomeDBiP46563.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46563-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATVGGAFKD SLTQAQKDEL HQIALKIVQD GKGILAADES TGTIGKRLDA    50
    INLENNETNR QKYRQLLFTT PNLNQHISGV ILYEETFHQS TDKGEKFTDL 100
    LIKQGIVPGI KLDLGVVPLA GTIGEGTTQG LDKLAERAAA FKKGGCGFAK 150
    WRCVLNIGTH TPSHLGMLEN ANVLARYASI CQANGLVPIV EPEVLCDGEH 200
    DLARAQKVTE QVLAFVYKAL ADHHVYLEGT LLKPNMVTPG QSSASKASHE 250
    AIGLATVTAL RRGVPAAVPG ITFLSGGQSE LDATANLNAI NSVQLGKPWK 300
    LTFSYGRALQ ASVLKAWGGK DENIAAAQKT LLHRSKANGD ASLGKYAGED 350
    AAGAAAESLF VAKHSY 366
    Length:366
    Mass (Da):38,846
    Last modified:November 1, 1995 - v1
    Checksum:iD6BD9D1469E69834
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83739 mRNA. Translation: BAA12092.1.
    FO080705 Genomic DNA. Translation: CCD65997.1.
    PIRiT15951.
    RefSeqiNP_001021240.1. NM_001026069.5.
    UniGeneiCel.18124.

    Genome annotation databases

    EnsemblMetazoaiF01F1.12a.1; F01F1.12a.1; WBGene00017166.
    F01F1.12a.2; F01F1.12a.2; WBGene00017166.
    GeneIDi175827.
    KEGGicel:CELE_F01F1.12.
    UCSCiF01F1.12a. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83739 mRNA. Translation: BAA12092.1 .
    FO080705 Genomic DNA. Translation: CCD65997.1 .
    PIRi T15951.
    RefSeqi NP_001021240.1. NM_001026069.5.
    UniGenei Cel.18124.

    3D structure databases

    ProteinModelPortali P46563.
    SMRi P46563. Positions 17-366.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 41049. 7 interactions.
    DIPi DIP-24398N.
    IntActi P46563. 4 interactions.
    MINTi MINT-1053227.
    STRINGi 6239.F01F1.12a.

    Proteomic databases

    PaxDbi P46563.
    PRIDEi P46563.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F01F1.12a.1 ; F01F1.12a.1 ; WBGene00017166 .
    F01F1.12a.2 ; F01F1.12a.2 ; WBGene00017166 .
    GeneIDi 175827.
    KEGGi cel:CELE_F01F1.12.
    UCSCi F01F1.12a. c. elegans.

    Organism-specific databases

    CTDi 175827.
    WormBasei F01F1.12a ; CE01225 ; WBGene00017166 ; aldo-2.

    Phylogenomic databases

    eggNOGi COG3588.
    GeneTreei ENSGT00390000010235.
    HOGENOMi HOG000220876.
    InParanoidi P46563.
    KOi K01623.
    OMAi LIRTAKY.
    PhylomeDBi P46563.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Miscellaneous databases

    NextBioi 889828.
    PROi P46563.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Caenorhabditis elegans has two isozymic forms, CE-1 and CE-2, of fructose-1,6-bisphosphate aldolase which are encoded by different genes."
      Inoue T., Yatsuki H., Kusakabe T., Joh K., Hori K.
      Arch. Biochem. Biophys. 339:226-234(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiALF2_CAEEL
    AccessioniPrimary (citable) accession number: P46563
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3