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P46563 (ALF2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase 2

EC=4.1.2.13
Alternative name(s):
Aldolase CE-2
Short name=CE2
Gene names
Name:aldo-2
ORF Names:F01F1.12
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Developmental stage

Restricted to the embryo and early larval stages.

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Fructose-bisphosphate aldolase 2
PRO_0000216929

Sites

Active site1911Proton acceptor By similarity
Active site2331Schiff-base intermediate with dihydroxyacetone-P By similarity
Binding site601Substrate By similarity
Binding site1501Substrate By similarity
Site3661Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

Sequences

Sequence LengthMass (Da)Tools
P46563 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D6BD9D1469E69834

FASTA36638,846
        10         20         30         40         50         60 
MATVGGAFKD SLTQAQKDEL HQIALKIVQD GKGILAADES TGTIGKRLDA INLENNETNR 

        70         80         90        100        110        120 
QKYRQLLFTT PNLNQHISGV ILYEETFHQS TDKGEKFTDL LIKQGIVPGI KLDLGVVPLA 

       130        140        150        160        170        180 
GTIGEGTTQG LDKLAERAAA FKKGGCGFAK WRCVLNIGTH TPSHLGMLEN ANVLARYASI 

       190        200        210        220        230        240 
CQANGLVPIV EPEVLCDGEH DLARAQKVTE QVLAFVYKAL ADHHVYLEGT LLKPNMVTPG 

       250        260        270        280        290        300 
QSSASKASHE AIGLATVTAL RRGVPAAVPG ITFLSGGQSE LDATANLNAI NSVQLGKPWK 

       310        320        330        340        350        360 
LTFSYGRALQ ASVLKAWGGK DENIAAAQKT LLHRSKANGD ASLGKYAGED AAGAAAESLF 


VAKHSY 

« Hide

References

« Hide 'large scale' references
[1]"Caenorhabditis elegans has two isozymic forms, CE-1 and CE-2, of fructose-1,6-bisphosphate aldolase which are encoded by different genes."
Inoue T., Yatsuki H., Kusakabe T., Joh K., Hori K.
Arch. Biochem. Biophys. 339:226-234(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D83739 mRNA. Translation: BAA12092.1.
FO080705 Genomic DNA. Translation: CCD65997.1.
PIRT15951.
RefSeqNP_001021240.1. NM_001026069.5.
UniGeneCel.18124.

3D structure databases

ProteinModelPortalP46563.
SMRP46563. Positions 17-366.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid41049. 7 interactions.
DIPDIP-24398N.
IntActP46563. 4 interactions.
MINTMINT-1053227.
STRING6239.F01F1.12a.

Proteomic databases

PaxDbP46563.
PRIDEP46563.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF01F1.12a.1; F01F1.12a.1; WBGene00017166.
F01F1.12a.2; F01F1.12a.2; WBGene00017166.
GeneID175827.
KEGGcel:CELE_F01F1.12.
UCSCF01F1.12a. c. elegans.

Organism-specific databases

CTD175827.
WormBaseF01F1.12a; CE01225; WBGene00017166; aldo-2.

Phylogenomic databases

eggNOGCOG3588.
GeneTreeENSGT00390000010235.
HOGENOMHOG000220876.
InParanoidP46563.
KOK01623.
OMALIRTAKY.
PhylomeDBP46563.

Enzyme and pathway databases

UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
[Graphical view]
PANTHERPTHR11627. PTHR11627. 1 hit.
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio889828.
PROP46563.

Entry information

Entry nameALF2_CAEEL
AccessionPrimary (citable) accession number: P46563
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase