Reviewed,
UniProtKB/Swiss-Prot P46563 (ALF2_CAEEL)
Last modified
November 3, 2009.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Fructose-bisphosphate aldolase 2 EC=4.1.2.13 Alternative name(s): Aldolase CE-2 Short name=CE2 | ||
| Gene names |
| ||
| Organism | Caenorhabditis elegans [Complete proteome] | ||
| Taxonomic identifier | 6239 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 366 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. |
| Pathway | |
| Developmental stage | Restricted to the embryo and early larval stages. |
| Sequence similarities | Belongs to the class I fructose-bisphosphate aldolase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Ligand | Schiff base |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase glycolysisInferred from electronic annotation. Source: UniProtKB-KW locomotionInferred from mutant phenotype. Source: WormBase ovipositionInferred from mutant phenotype. Source: WormBase positive regulation of growth rateInferred from mutant phenotype. Source: WormBase |
| Molecular function | fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC identical protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| itself | 1 | EBI-314454,EBI-314454 | ||
| P91503 | 1 | EBI-314454,EBI-318873 | ||
| Q9TZA7 | 1 | EBI-314454,EBI-317106 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 366 | 366 | Fructose-bisphosphate aldolase 2 | PRO_0000216929 | |||||
Sites | |||||||||
| Active site | 191 | 1 | Proton acceptor By similarity | ||||||
| Active site | 233 | 1 | Schiff-base intermediate with dihydroxyacetone-P By similarity | ||||||
| Binding site | 60 | 1 | Substrate By similarity | ||||||
| Binding site | 150 | 1 | Substrate By similarity | ||||||
| Site | 366 | 1 | Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Caenorhabditis elegans has two isozymic forms, CE-1 and CE-2, of fructose-1,6-bisphosphate aldolase which are encoded by different genes." Inoue T., Yatsuki H., Kusakabe T., Joh K., Hori K. Arch. Biochem. Biophys. 339:226-234(1997) [PubMed: 9056253] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Bristol N2. |
| [2] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D83739 mRNA. Translation: BAA12092.1. U13070 Genomic DNA. Translation: AAC46646.1. | |
| PIR | T15951. |
| RefSeq | NP_001021240.1. |
| UniGene | Cel.18124 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FBA based on UniProtKB P07764. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:24398N. |
| IntAct | P46563. 8 interactions. |
| STRING | P46563. |
Proteomic databases | |
| PRIDE | P46563. |
Genome annotation databases | |
| Ensembl | F01F1.12a; F01F1.12a; F01F1.12; Caenorhabditis elegans. [Genome view] |
| GeneID | 175827. |
| KEGG | cel:F01F1.12. |
| UCSC | F01F1.12a. c. elegans. |
Organism-specific databases | |
| CTD | 175827. |
| WormBase | WBGene00017166. F01F1.12. |
| WormPep | F01F1.12. CE01225. [WorfDB] |
Phylogenomic databases | |
| OMA | ASICQAN. |
Enzyme and pathway databases | |
| BRENDA | 4.1.2.13. 672. |
Gene expression databases | |
| ArrayExpress | P46563. |
Family and domain databases | |
| InterPro | IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| PANTHER | PTHR11627. Aldolase_I. 1 hit. |
| Pfam | PF00274. Glycolytic. 1 hit. [Graphical view] |
| ProDom | PD001128. Aldolase_I. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00158. ALDOLASE_CLASS_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 889828. |
Entry information
| Entry name | ALF2_CAEEL | ||||||||
| Accession | Primary (citable) accession number: P46563 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


