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Protein

Putative aldehyde dehydrogenase family 7 member A1 homolog

Gene

alh-9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei185Transition state stabilizerBy similarity1
Active sitei286Proton acceptorPROSITE-ProRule annotation1
Active sitei320NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi264 – 269NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-CEL-6798163 Choline catabolism
R-CEL-71064 Lysine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase family 7 member A1 homolog (EC:1.2.1.3)
Alternative name(s):
ALH-9
Gene namesi
Name:alh-9
ORF Names:F01F1.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF01F1.6 ; CE39486 ; WBGene00000115 ; alh-9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564991 – 531Putative aldehyde dehydrogenase family 7 member A1 homologAdd BLAST531

Proteomic databases

EPDiP46562
PaxDbiP46562
PeptideAtlasiP46562
PRIDEiP46562

PTM databases

iPTMnetiP46562

Expressioni

Gene expression databases

BgeeiWBGene00000115

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi41042, 2 interactors
DIPiDIP-25437N
IntActiP46562, 4 interactors
STRINGi6239.F01F1.6.2

Structurei

3D structure databases

ProteinModelPortaliP46562
SMRiP46562
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2453 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00760000118999
HOGENOMiHOG000271511
InParanoidiP46562
KOiK14085
OMAiDAWKVYM
OrthoDBiEOG091G058Y
PhylomeDBiP46562

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

P46562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRLLSSGMS AATLQTRMAS QLLINDSKYG FLKELGLTEN NAGVFHGKWA
60 70 80 90 100
ASGQVVQSFA PANNSPIANV QNGNVQDYEI AISEAKKAYN DWCEVPAPRR
110 120 130 140 150
GEIVRQIGDK LRTQLQNLGK LVSLEMGKIS AEGVGEVQEY VDICDYATGL
160 170 180 190 200
SRSLEGKIFP SERPGHALLE QWNPLGVVGV ISAFNFPCAV YGWNNALALV
210 220 230 240 250
TGNSVVWKPA PSTPLTAIAV TKLVEEVLVA NNVNPALCSL VCGEGDVGQA
260 270 280 290 300
LVKDKRVNLV SFTGSSEIGK IVGQQVQARF GKLLLELGGN NAIIVNEDAD
310 320 330 340 350
LNMVVPATVF AAVGTAGQRC TTTRRLIVHD KVYDQVLERL KKAYAQFESR
360 370 380 390 400
IGCPLDSNTI IGPLHNQQAV GKYKASVAEA VASGGKIEYG GKVLERDGNF
410 420 430 440 450
VLPTIVTGLK HDSPVVLRET FAPILYVLKF STLEEAIAIN NEVDQGLSSS
460 470 480 490 500
LFTTNIQNVF KWMGPKGSDC GIVNVNIPTS GAEIGGAFGG EKETGGGRES
510 520 530
GSDSWRQYMR RSTCTINYSK ELPLAQGIKF E
Length:531
Mass (Da):57,013
Last modified:May 2, 2006 - v2
Checksum:i2FEA6B882C790BBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD65988.1
PIRiT15944
RefSeqiNP_498263.2, NM_065862.3
UniGeneiCel.8090

Genome annotation databases

EnsemblMetazoaiF01F1.6.1; F01F1.6.1; WBGene00000115
F01F1.6.2; F01F1.6.2; WBGene00000115
GeneIDi175820
KEGGicel:CELE_F01F1.6
UCSCiF01F1.6.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiAL7A1_CAEEL
AccessioniPrimary (citable) accession number: P46562
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 2, 2006
Last modified: March 28, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health