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P46562

- AL7A1_CAEEL

UniProt

P46562 - AL7A1_CAEEL

Protein

Putative aldehyde dehydrogenase family 7 member A1 homolog

Gene

alh-9

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (02 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei185 – 1851Transition state stabilizerBy similarity
    Active sitei286 – 2861Proton acceptorPROSITE-ProRule annotation
    Active sitei320 – 3201NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi264 – 2696NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB

    GO - Biological processi

    1. cellular aldehyde metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative aldehyde dehydrogenase family 7 member A1 homolog (EC:1.2.1.3)
    Alternative name(s):
    ALH-9
    Gene namesi
    Name:alh-9
    ORF Names:F01F1.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiF01F1.6; CE39486; WBGene00000115; alh-9.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 531531Putative aldehyde dehydrogenase family 7 member A1 homologPRO_0000056499Add
    BLAST

    Proteomic databases

    PaxDbiP46562.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    BioGridi41042. 2 interactions.
    DIPiDIP-25437N.
    IntActiP46562. 2 interactions.
    MINTiMINT-1047274.
    STRINGi6239.F01F1.6.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP46562.
    SMRiP46562. Positions 20-530.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00720000108597.
    HOGENOMiHOG000271511.
    InParanoidiP46562.
    KOiK14085.
    OMAiNAIIVFE.
    PhylomeDBiP46562.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46562-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRLLSSGMS AATLQTRMAS QLLINDSKYG FLKELGLTEN NAGVFHGKWA    50
    ASGQVVQSFA PANNSPIANV QNGNVQDYEI AISEAKKAYN DWCEVPAPRR 100
    GEIVRQIGDK LRTQLQNLGK LVSLEMGKIS AEGVGEVQEY VDICDYATGL 150
    SRSLEGKIFP SERPGHALLE QWNPLGVVGV ISAFNFPCAV YGWNNALALV 200
    TGNSVVWKPA PSTPLTAIAV TKLVEEVLVA NNVNPALCSL VCGEGDVGQA 250
    LVKDKRVNLV SFTGSSEIGK IVGQQVQARF GKLLLELGGN NAIIVNEDAD 300
    LNMVVPATVF AAVGTAGQRC TTTRRLIVHD KVYDQVLERL KKAYAQFESR 350
    IGCPLDSNTI IGPLHNQQAV GKYKASVAEA VASGGKIEYG GKVLERDGNF 400
    VLPTIVTGLK HDSPVVLRET FAPILYVLKF STLEEAIAIN NEVDQGLSSS 450
    LFTTNIQNVF KWMGPKGSDC GIVNVNIPTS GAEIGGAFGG EKETGGGRES 500
    GSDSWRQYMR RSTCTINYSK ELPLAQGIKF E 531
    Length:531
    Mass (Da):57,013
    Last modified:May 2, 2006 - v2
    Checksum:i2FEA6B882C790BBF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080705 Genomic DNA. Translation: CCD65988.1.
    PIRiT15944.
    RefSeqiNP_498263.2. NM_065862.3.
    UniGeneiCel.8090.

    Genome annotation databases

    EnsemblMetazoaiF01F1.6.1; F01F1.6.1; WBGene00000115.
    F01F1.6.2; F01F1.6.2; WBGene00000115.
    GeneIDi175820.
    KEGGicel:CELE_F01F1.6.
    UCSCiF01F1.6.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080705 Genomic DNA. Translation: CCD65988.1 .
    PIRi T15944.
    RefSeqi NP_498263.2. NM_065862.3.
    UniGenei Cel.8090.

    3D structure databases

    ProteinModelPortali P46562.
    SMRi P46562. Positions 20-530.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 41042. 2 interactions.
    DIPi DIP-25437N.
    IntActi P46562. 2 interactions.
    MINTi MINT-1047274.
    STRINGi 6239.F01F1.6.1.

    Proteomic databases

    PaxDbi P46562.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F01F1.6.1 ; F01F1.6.1 ; WBGene00000115 .
    F01F1.6.2 ; F01F1.6.2 ; WBGene00000115 .
    GeneIDi 175820.
    KEGGi cel:CELE_F01F1.6.
    UCSCi F01F1.6.1. c. elegans.

    Organism-specific databases

    CTDi 175820.
    WormBasei F01F1.6 ; CE39486 ; WBGene00000115 ; alh-9.

    Phylogenomic databases

    eggNOGi COG1012.
    GeneTreei ENSGT00720000108597.
    HOGENOMi HOG000271511.
    InParanoidi P46562.
    KOi K14085.
    OMAi NAIIVFE.
    PhylomeDBi P46562.

    Miscellaneous databases

    NextBioi 889800.
    PROi P46562.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiAL7A1_CAEEL
    AccessioniPrimary (citable) accession number: P46562
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3