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P46562 (AL7A1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative aldehyde dehydrogenase family 7 member A1 homolog
EC=1.2.1.3
Alternative name(s):
ALH-9
Gene names
Name:alh-9
ORF Names:F01F1.6
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processcellular aldehyde metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular functionaldehyde dehydrogenase (NAD) activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 531531Putative aldehyde dehydrogenase family 7 member A1 homolog
PRO_0000056499

Regions

Nucleotide binding264 – 2696NAD By similarity

Sites

Active site2861Proton acceptor By similarity
Active site3201Nucleophile By similarity
Site1851Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
P46562 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: 2FEA6B882C790BBF

FASTA53157,013
        10         20         30         40         50         60 
MNRLLSSGMS AATLQTRMAS QLLINDSKYG FLKELGLTEN NAGVFHGKWA ASGQVVQSFA 

        70         80         90        100        110        120 
PANNSPIANV QNGNVQDYEI AISEAKKAYN DWCEVPAPRR GEIVRQIGDK LRTQLQNLGK 

       130        140        150        160        170        180 
LVSLEMGKIS AEGVGEVQEY VDICDYATGL SRSLEGKIFP SERPGHALLE QWNPLGVVGV 

       190        200        210        220        230        240 
ISAFNFPCAV YGWNNALALV TGNSVVWKPA PSTPLTAIAV TKLVEEVLVA NNVNPALCSL 

       250        260        270        280        290        300 
VCGEGDVGQA LVKDKRVNLV SFTGSSEIGK IVGQQVQARF GKLLLELGGN NAIIVNEDAD 

       310        320        330        340        350        360 
LNMVVPATVF AAVGTAGQRC TTTRRLIVHD KVYDQVLERL KKAYAQFESR IGCPLDSNTI 

       370        380        390        400        410        420 
IGPLHNQQAV GKYKASVAEA VASGGKIEYG GKVLERDGNF VLPTIVTGLK HDSPVVLRET 

       430        440        450        460        470        480 
FAPILYVLKF STLEEAIAIN NEVDQGLSSS LFTTNIQNVF KWMGPKGSDC GIVNVNIPTS 

       490        500        510        520        530 
GAEIGGAFGG EKETGGGRES GSDSWRQYMR RSTCTINYSK ELPLAQGIKF E

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FO080705 Genomic DNA. Translation: CCD65988.1.
PIRT15944.
RefSeqNP_498263.2. NM_065862.2.
UniGeneCel.8090.

3D structure databases

ProteinModelPortalP46562.
SMRP46562. Positions 20-530.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-25437N.
IntActP46562. 1 interaction.
MINTMINT-1047274.
STRINGP46562.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF01F1.6.1; F01F1.6.1; F01F1.6.
F01F1.6.2; F01F1.6.2; F01F1.6.
GeneID175820.
KEGGcel:F01F1.6.
UCSCF01F1.6.1. c. elegans.

Organism-specific databases

CTD175820.
WormBaseF01F1.6; CE39486; WBGene00000115; alh-9.

Phylogenomic databases

eggNOGmeNOG04426.
GeneTreeEMGT00050000005689.
HOGENOMHBG752218.
InParanoidP46562.
OMACDYATGL.
PhylomeDBP46562.

Gene expression databases

ArrayExpressP46562.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK14085.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. False negative.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio889800.

Entry information

Entry nameAL7A1_CAEEL
AccessionPrimary (citable) accession number: P46562
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 2, 2006
Last modified: January 25, 2012
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

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