Reviewed,
UniProtKB/Swiss-Prot P46562 (AL7A1_CAEEL)
Last modified
June 16, 2009.
Version 64.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Putative aldehyde dehydrogenase family 7 member A1 homolog EC=1.2.1.3 Alternative name(s): ALH-9 | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 531 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | An aldehyde + NAD+ + H2O = an acid + NADH. |
| Subunit structure | Homotetramer By similarity. |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cellular aldehyde metabolic process Inferred from sequence or structural similarity. Source: UniProtKB oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | aldehyde dehydrogenase (NAD) activity Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 531 | 531 | Putative aldehyde dehydrogenase family 7 member A1 homolog | PRO_0000056499 | |||||
Regions | |||||||||
| Nucleotide binding | 264 – 269 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 286 | 1 | Proton acceptor By similarity | ||||||
| Active site | 320 | 1 | Nucleophile By similarity | ||||||
| Site | 185 | 1 | Transition state stabilizer By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
Cross-references
Sequence databases | |
|---|---|
| U13070 Genomic DNA. Translation: AAC46640.2. | |
| PIR | T15944. |
| RefSeq | NP_498263.2. |
| UniGene | Cel.8090 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:25437N. |
| IntAct | P46562. 2 interactions. |
Genome annotation databases | |
| Ensembl | F01F1.6. Caenorhabditis elegans. [Contig view] |
| GeneID | 175820. |
| KEGG | cel:F01F1.6. |
Organism-specific databases | |
| WormBase | WBGene00000115. alh-9. |
| WormPep | F01F1.6. CE39486. [WorfDB] |
Phylogenomic databases | |
| OMA | P46562. WNPLGVV. |
Enzyme and pathway databases | |
| BRENDA | 1.2.1.3. 672. |
Gene expression databases | |
| ArrayExpress | P46562. |
Family and domain databases | |
| InterPro | IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 889800. |
Entry information
| Entry name | AL7A1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: P46562 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

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