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P46562

- AL7A1_CAEEL

UniProt

P46562 - AL7A1_CAEEL

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Protein

Putative aldehyde dehydrogenase family 7 member A1 homolog

Gene

alh-9

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei185 – 1851Transition state stabilizerBy similarity
Active sitei286 – 2861Proton acceptorPROSITE-ProRule annotation
Active sitei320 – 3201NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi264 – 2696NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB

GO - Biological processi

  1. cellular aldehyde metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldehyde dehydrogenase family 7 member A1 homolog (EC:1.2.1.3)
Alternative name(s):
ALH-9
Gene namesi
Name:alh-9
ORF Names:F01F1.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiF01F1.6; CE39486; WBGene00000115; alh-9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Putative aldehyde dehydrogenase family 7 member A1 homologPRO_0000056499Add
BLAST

Proteomic databases

PaxDbiP46562.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi41042. 2 interactions.
DIPiDIP-25437N.
IntActiP46562. 2 interactions.
MINTiMINT-1047274.
STRINGi6239.F01F1.6.1.

Structurei

3D structure databases

ProteinModelPortaliP46562.
SMRiP46562. Positions 20-530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271511.
InParanoidiP46562.
KOiK14085.
OMAiNAIIVFE.
PhylomeDBiP46562.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46562 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRLLSSGMS AATLQTRMAS QLLINDSKYG FLKELGLTEN NAGVFHGKWA
60 70 80 90 100
ASGQVVQSFA PANNSPIANV QNGNVQDYEI AISEAKKAYN DWCEVPAPRR
110 120 130 140 150
GEIVRQIGDK LRTQLQNLGK LVSLEMGKIS AEGVGEVQEY VDICDYATGL
160 170 180 190 200
SRSLEGKIFP SERPGHALLE QWNPLGVVGV ISAFNFPCAV YGWNNALALV
210 220 230 240 250
TGNSVVWKPA PSTPLTAIAV TKLVEEVLVA NNVNPALCSL VCGEGDVGQA
260 270 280 290 300
LVKDKRVNLV SFTGSSEIGK IVGQQVQARF GKLLLELGGN NAIIVNEDAD
310 320 330 340 350
LNMVVPATVF AAVGTAGQRC TTTRRLIVHD KVYDQVLERL KKAYAQFESR
360 370 380 390 400
IGCPLDSNTI IGPLHNQQAV GKYKASVAEA VASGGKIEYG GKVLERDGNF
410 420 430 440 450
VLPTIVTGLK HDSPVVLRET FAPILYVLKF STLEEAIAIN NEVDQGLSSS
460 470 480 490 500
LFTTNIQNVF KWMGPKGSDC GIVNVNIPTS GAEIGGAFGG EKETGGGRES
510 520 530
GSDSWRQYMR RSTCTINYSK ELPLAQGIKF E
Length:531
Mass (Da):57,013
Last modified:May 2, 2006 - v2
Checksum:i2FEA6B882C790BBF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080705 Genomic DNA. Translation: CCD65988.1.
PIRiT15944.
RefSeqiNP_498263.2. NM_065862.3.
UniGeneiCel.8090.

Genome annotation databases

EnsemblMetazoaiF01F1.6.1; F01F1.6.1; WBGene00000115.
F01F1.6.2; F01F1.6.2; WBGene00000115.
GeneIDi175820.
KEGGicel:CELE_F01F1.6.
UCSCiF01F1.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080705 Genomic DNA. Translation: CCD65988.1 .
PIRi T15944.
RefSeqi NP_498263.2. NM_065862.3.
UniGenei Cel.8090.

3D structure databases

ProteinModelPortali P46562.
SMRi P46562. Positions 20-530.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 41042. 2 interactions.
DIPi DIP-25437N.
IntActi P46562. 2 interactions.
MINTi MINT-1047274.
STRINGi 6239.F01F1.6.1.

Proteomic databases

PaxDbi P46562.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F01F1.6.1 ; F01F1.6.1 ; WBGene00000115 .
F01F1.6.2 ; F01F1.6.2 ; WBGene00000115 .
GeneIDi 175820.
KEGGi cel:CELE_F01F1.6.
UCSCi F01F1.6.1. c. elegans.

Organism-specific databases

CTDi 175820.
WormBasei F01F1.6 ; CE39486 ; WBGene00000115 ; alh-9.

Phylogenomic databases

eggNOGi COG1012.
GeneTreei ENSGT00760000118999.
HOGENOMi HOG000271511.
InParanoidi P46562.
KOi K14085.
OMAi NAIIVFE.
PhylomeDBi P46562.

Miscellaneous databases

NextBioi 889800.
PROi P46562.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiAL7A1_CAEEL
AccessioniPrimary (citable) accession number: P46562
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 2, 2006
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3