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Protein

Putative choline kinase B3

Gene

ckb-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + choline = ADP + phosphocholine.

Cofactori

Mg2+By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. choline kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_287639. Synthesis of PC.
REACT_293935. Synthesis of PE.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative choline kinase B3 (EC:2.7.1.32)
Gene namesi
Name:ckb-3
ORF Names:B0285.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiB0285.10; CE40595; WBGene00000513; ckb-3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Putative choline kinase B3PRO_0000206234Add
BLAST

Proteomic databases

PaxDbiP46560.
PRIDEiP46560.

Interactioni

Protein-protein interaction databases

BioGridi46771. 1 interaction.
STRINGi6239.B0285.10.

Structurei

3D structure databases

ProteinModelPortaliP46560.
SMRiP46560. Positions 20-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

eggNOGiCOG0510.
GeneTreeiENSGT00530000062991.
HOGENOMiHOG000015981.
InParanoidiP46560.
KOiK14156.
OMAiGYDLAMH.
PhylomeDBiP46560.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequencei

Sequence statusi: Complete.

P46560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPIEKLFVG NSLDSVAVLQ KALDFGIDFL GDEWKNVNRS EVTVTRILGG
60 70 80 90 100
QSNHMFHVTS STSATSFVLR IHREGQSQFD TDIVNFAIFS ERGLGPKLYG
110 120 130 140 150
FFEEGRMEEF LPSVTLKLND VLNTEISRKI GAAFPKYHAI NVPVSKSRRC
160 170 180 190 200
FQIMRESLHD YQALGGGDFA IFPTVVTYSE HPKSISIKDL LTEIDLLEKW
210 220 230 240 250
SIDLFENTLV FCHNDLTSSN ILQLNSTGEL VFIDWENASY NWRGYDLAMH
260 270 280 290 300
LSEAAVIRNT CPPGIVINEE LTDNPPNLQA FCEAYVDSEN KIKGLLSSNI
310 320 330 340 350
SSQVNSLIQE CKFFWPITHL FWACFIMKLG LFECNREIKL NAQAREHLAV
360
YFHLRSRSEM IYKKLSEN
Length:368
Mass (Da):41,928
Last modified:July 10, 2007 - v2
Checksum:iF8EF0B7998E4DB67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34533, Z30973 Genomic DNA. Translation: CAA84303.2.
BK000640 mRNA. Translation: DAA05761.1.
PIRiT18698.
RefSeqiNP_497881.2. NM_065480.2.
UniGeneiCel.25604.

Genome annotation databases

EnsemblMetazoaiB0285.10; B0285.10; WBGene00000513.
GeneIDi181905.
KEGGicel:CELE_B0285.10.
UCSCiB0285.10. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34533, Z30973 Genomic DNA. Translation: CAA84303.2.
BK000640 mRNA. Translation: DAA05761.1.
PIRiT18698.
RefSeqiNP_497881.2. NM_065480.2.
UniGeneiCel.25604.

3D structure databases

ProteinModelPortaliP46560.
SMRiP46560. Positions 20-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46771. 1 interaction.
STRINGi6239.B0285.10.

Proteomic databases

PaxDbiP46560.
PRIDEiP46560.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0285.10; B0285.10; WBGene00000513.
GeneIDi181905.
KEGGicel:CELE_B0285.10.
UCSCiB0285.10. c. elegans.

Organism-specific databases

CTDi181905.
WormBaseiB0285.10; CE40595; WBGene00000513; ckb-3.

Phylogenomic databases

eggNOGiCOG0510.
GeneTreeiENSGT00530000062991.
HOGENOMiHOG000015981.
InParanoidiP46560.
KOiK14156.
OMAiGYDLAMH.
PhylomeDBiP46560.

Enzyme and pathway databases

ReactomeiREACT_287639. Synthesis of PC.
REACT_293935. Synthesis of PE.

Miscellaneous databases

NextBioi915748.
PROiP46560.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization."
    Gee P., Kent C.
    Biochim. Biophys. Acta 1648:33-42(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiCKB3_CAEEL
AccessioniPrimary (citable) accession number: P46560
Secondary accession number(s): Q1LZ58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 10, 2007
Last modified: April 29, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.