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P46560

- KICB3_CAEEL

UniProt

P46560 - KICB3_CAEEL

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Protein

Putative choline kinase B3

Gene

ckb-3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + choline = ADP + phosphocholine.

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. choline kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_183754. Synthesis of PC.
REACT_197616. Synthesis of PE.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative choline kinase B3 (EC:2.7.1.32)
Gene namesi
Name:ckb-3
ORF Names:B0285.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiB0285.10; CE40595; WBGene00000513; ckb-3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Putative choline kinase B3PRO_0000206234Add
BLAST

Proteomic databases

PaxDbiP46560.
PRIDEiP46560.

Interactioni

Protein-protein interaction databases

BioGridi46771. 1 interaction.
STRINGi6239.B0285.10.

Structurei

3D structure databases

ProteinModelPortaliP46560.
SMRiP46560. Positions 20-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

eggNOGiCOG0510.
GeneTreeiENSGT00530000062991.
HOGENOMiHOG000015981.
InParanoidiP46560.
OMAiDINIRAR.
PhylomeDBiP46560.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequencei

Sequence statusi: Complete.

P46560-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPIEKLFVG NSLDSVAVLQ KALDFGIDFL GDEWKNVNRS EVTVTRILGG
60 70 80 90 100
QSNHMFHVTS STSATSFVLR IHREGQSQFD TDIVNFAIFS ERGLGPKLYG
110 120 130 140 150
FFEEGRMEEF LPSVTLKLND VLNTEISRKI GAAFPKYHAI NVPVSKSRRC
160 170 180 190 200
FQIMRESLHD YQALGGGDFA IFPTVVTYSE HPKSISIKDL LTEIDLLEKW
210 220 230 240 250
SIDLFENTLV FCHNDLTSSN ILQLNSTGEL VFIDWENASY NWRGYDLAMH
260 270 280 290 300
LSEAAVIRNT CPPGIVINEE LTDNPPNLQA FCEAYVDSEN KIKGLLSSNI
310 320 330 340 350
SSQVNSLIQE CKFFWPITHL FWACFIMKLG LFECNREIKL NAQAREHLAV
360
YFHLRSRSEM IYKKLSEN
Length:368
Mass (Da):41,928
Last modified:July 10, 2007 - v2
Checksum:iF8EF0B7998E4DB67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z34533, Z30973 Genomic DNA. Translation: CAA84303.2.
BK000640 mRNA. Translation: DAA05761.1.
PIRiT18698.
RefSeqiNP_497881.2. NM_065480.2.
UniGeneiCel.25604.

Genome annotation databases

EnsemblMetazoaiB0285.10; B0285.10; WBGene00000513.
GeneIDi181905.
KEGGicel:CELE_B0285.10.
UCSCiB0285.10. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z34533 , Z30973 Genomic DNA. Translation: CAA84303.2 .
BK000640 mRNA. Translation: DAA05761.1 .
PIRi T18698.
RefSeqi NP_497881.2. NM_065480.2.
UniGenei Cel.25604.

3D structure databases

ProteinModelPortali P46560.
SMRi P46560. Positions 20-323.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 46771. 1 interaction.
STRINGi 6239.B0285.10.

Proteomic databases

PaxDbi P46560.
PRIDEi P46560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0285.10 ; B0285.10 ; WBGene00000513 .
GeneIDi 181905.
KEGGi cel:CELE_B0285.10.
UCSCi B0285.10. c. elegans.

Organism-specific databases

CTDi 181905.
WormBasei B0285.10 ; CE40595 ; WBGene00000513 ; ckb-3.

Phylogenomic databases

eggNOGi COG0510.
GeneTreei ENSGT00530000062991.
HOGENOMi HOG000015981.
InParanoidi P46560.
OMAi DINIRAR.
PhylomeDBi P46560.

Enzyme and pathway databases

Reactomei REACT_183754. Synthesis of PC.
REACT_197616. Synthesis of PE.

Miscellaneous databases

NextBioi 915748.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization."
    Gee P., Kent C.
    Biochim. Biophys. Acta 1648:33-42(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiKICB3_CAEEL
AccessioniPrimary (citable) accession number: P46560
Secondary accession number(s): Q1LZ58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 10, 2007
Last modified: October 1, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3