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P46559

- KICB2_CAEEL

UniProt

P46559 - KICB2_CAEEL

Protein

Choline kinase B2

Gene

ckb-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (15 Mar 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + choline = ADP + phosphocholine.1 Publication

    Cofactori

    Magnesium.1 Publication

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. choline kinase activity Source: WormBase

    GO - Biological processi

    1. CDP-choline pathway Source: WormBase
    2. endoplasmic reticulum unfolded protein response Source: WormBase

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    ATP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_183754. Synthesis of PC.
    REACT_197616. Synthesis of PE.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Choline kinase B2 (EC:2.7.1.32)
    Gene namesi
    Name:ckb-2
    ORF Names:B0285.9
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiB0285.9; CE33591; WBGene00000512; ckb-2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Choline kinase B2PRO_0000206233Add
    BLAST

    Proteomic databases

    PaxDbiP46559.
    PRIDEiP46559.

    Interactioni

    Protein-protein interaction databases

    BioGridi40801. 1 interaction.
    STRINGi6239.B0285.9.

    Structurei

    3D structure databases

    ProteinModelPortaliP46559.
    SMRiP46559. Positions 29-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the choline/ethanolamine kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0510.
    GeneTreeiENSGT00530000062991.
    HOGENOMiHOG000015981.
    InParanoidiP46559.
    OMAiNIRIFCE.
    OrthoDBiEOG7W41GK.
    PhylomeDBiP46559.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P46559-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAIEKFFTE KSPDSEQVLL KVIELGIDFL GGEWKNVDKS QVNVSRVHGG    50
    QSNHMFHVTS STSATPYLLR IHRQPPSQVF TDTVNLAIFS ERGLGPKLYG 100
    FFEGGRMEEF LPSKTFDVND VLVPENSRKI GAIFPLYHSI NVPVSKSRRC 150
    VHLMREWLNG YESLGGGDYE ILPTTVNYSD HPKSVSIKDL NHEIDNFEKW 200
    STEIFEHTLV FSHNDLASTN ILELNSTKEL VLIDWEFGTY NWRGFDLAMH 250
    LSETAIDYRV PFPPGIKMNG DLIDNPPNIQ IFCEAYVEAD KKLKNRSPSD 300
    PTAEVKALIQ ECQFFWPLTN LFWALSAMKH SLLKFENGVD LDVQARDRLA 350
    VYFHLKPRSQ KIYEELSKK 369
    Length:369
    Mass (Da):42,264
    Last modified:March 15, 2004 - v2
    Checksum:i24384022ED1458B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY158691 mRNA. Translation: AAN41643.1.
    Z34533 Genomic DNA. Translation: CAA84301.2.
    PIRiT18696.
    RefSeqiNP_497880.2. NM_065479.6.
    UniGeneiCel.20657.

    Genome annotation databases

    EnsemblMetazoaiB0285.9; B0285.9; WBGene00000512.
    GeneIDi175565.
    KEGGicel:CELE_B0285.9.
    UCSCiB0285.9. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY158691 mRNA. Translation: AAN41643.1 .
    Z34533 Genomic DNA. Translation: CAA84301.2 .
    PIRi T18696.
    RefSeqi NP_497880.2. NM_065479.6.
    UniGenei Cel.20657.

    3D structure databases

    ProteinModelPortali P46559.
    SMRi P46559. Positions 29-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 40801. 1 interaction.
    STRINGi 6239.B0285.9.

    Proteomic databases

    PaxDbi P46559.
    PRIDEi P46559.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai B0285.9 ; B0285.9 ; WBGene00000512 .
    GeneIDi 175565.
    KEGGi cel:CELE_B0285.9.
    UCSCi B0285.9. c. elegans.

    Organism-specific databases

    CTDi 175565.
    WormBasei B0285.9 ; CE33591 ; WBGene00000512 ; ckb-2.

    Phylogenomic databases

    eggNOGi COG0510.
    GeneTreei ENSGT00530000062991.
    HOGENOMi HOG000015981.
    InParanoidi P46559.
    OMAi NIRIFCE.
    OrthoDBi EOG7W41GK.
    PhylomeDBi P46559.

    Enzyme and pathway databases

    Reactomei REACT_183754. Synthesis of PC.
    REACT_197616. Synthesis of PE.

    Miscellaneous databases

    NextBioi 888698.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization."
      Gee P., Kent C.
      Biochim. Biophys. Acta 1648:33-42(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, COFACTOR.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiKICB2_CAEEL
    AccessioniPrimary (citable) accession number: P46559
    Secondary accession number(s): Q8IS23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: March 15, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3