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P46559 (KICB2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Choline kinase B2

EC=2.7.1.32
Gene names
Name:ckb-2
ORF Names:B0285.9
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + choline = ADP + phosphocholine. Ref.1

Cofactor

Magnesium. Ref.1

Sequence similarities

Belongs to the choline/ethanolamine kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Choline kinase B2
PRO_0000206233

Sequences

Sequence LengthMass (Da)Tools
P46559 [UniParc].

Last modified March 15, 2004. Version 2.
Checksum: 24384022ED1458B3

FASTA36942,264
        10         20         30         40         50         60 
MTAIEKFFTE KSPDSEQVLL KVIELGIDFL GGEWKNVDKS QVNVSRVHGG QSNHMFHVTS 

        70         80         90        100        110        120 
STSATPYLLR IHRQPPSQVF TDTVNLAIFS ERGLGPKLYG FFEGGRMEEF LPSKTFDVND 

       130        140        150        160        170        180 
VLVPENSRKI GAIFPLYHSI NVPVSKSRRC VHLMREWLNG YESLGGGDYE ILPTTVNYSD 

       190        200        210        220        230        240 
HPKSVSIKDL NHEIDNFEKW STEIFEHTLV FSHNDLASTN ILELNSTKEL VLIDWEFGTY 

       250        260        270        280        290        300 
NWRGFDLAMH LSETAIDYRV PFPPGIKMNG DLIDNPPNIQ IFCEAYVEAD KKLKNRSPSD 

       310        320        330        340        350        360 
PTAEVKALIQ ECQFFWPLTN LFWALSAMKH SLLKFENGVD LDVQARDRLA VYFHLKPRSQ 


KIYEELSKK 

« Hide

References

« Hide 'large scale' references
[1]"Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization."
Gee P., Kent C.
Biochim. Biophys. Acta 1648:33-42(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, COFACTOR.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY158691 mRNA. Translation: AAN41643.1.
Z34533 Genomic DNA. Translation: CAA84301.2.
PIRT18696.
RefSeqNP_497880.2. NM_065479.6.
UniGeneCel.20657.

3D structure databases

ProteinModelPortalP46559.
SMRP46559. Positions 28-356.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid40801. 1 interaction.
STRING6239.B0285.9.

Proteomic databases

PaxDbP46559.
PRIDEP46559.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaB0285.9; B0285.9; B0285.9.
GeneID175565.
KEGGcel:CELE_B0285.9.
UCSCB0285.9. c. elegans.

Organism-specific databases

CTD175565.
WormBaseB0285.9; CE33591; WBGene00000512; ckb-2.

Phylogenomic databases

eggNOGCOG0510.
HOGENOMHOG000015981.
InParanoidP46559.
OMANIRIFCE.
OrthoDBEOG7W41GK.
PhylomeDBP46559.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
ProtoNetSearch...

Other

NextBio888698.

Entry information

Entry nameKICB2_CAEEL
AccessionPrimary (citable) accession number: P46559
Secondary accession number(s): Q8IS23
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 15, 2004
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase