P46559 (KICB2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choline kinase B2
EC=2.7.1.32

Gene names

Name:	ckb-2
ORF Names:	B0285.9

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + choline = ADP + phosphocholine. Ref.1
Cofactor	Magnesium. Ref.1
Sequence similarities	Belongs to the choline/ethanolamine kinase family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW choline kinase activity Inferred from direct assay Ref.1. Source: WormBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	Choline kinase B2		PRO_0000206233

Sequences

	Sequence		Length	Mass (Da)
	P46559 [UniParc]. Last modified March 15, 2004. Version 2. Checksum: 24384022ED1458B3	FASTA	369	42,264
	10 20 30 40 50 60 MTAIEKFFTE KSPDSEQVLL KVIELGIDFL GGEWKNVDKS QVNVSRVHGG QSNHMFHVTS 70 80 90 100 110 120 STSATPYLLR IHRQPPSQVF TDTVNLAIFS ERGLGPKLYG FFEGGRMEEF LPSKTFDVND 130 140 150 160 170 180 VLVPENSRKI GAIFPLYHSI NVPVSKSRRC VHLMREWLNG YESLGGGDYE ILPTTVNYSD 190 200 210 220 230 240 HPKSVSIKDL NHEIDNFEKW STEIFEHTLV FSHNDLASTN ILELNSTKEL VLIDWEFGTY 250 260 270 280 290 300 NWRGFDLAMH LSETAIDYRV PFPPGIKMNG DLIDNPPNIQ IFCEAYVEAD KKLKNRSPSD 310 320 330 340 350 360 PTAEVKALIQ ECQFFWPLTN LFWALSAMKH SLLKFENGVD LDVQARDRLA VYFHLKPRSQ KIYEELSKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization." Gee P., Kent C. Biochim. Biophys. Acta 1648:33-42(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, COFACTOR.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY158691 mRNA. Translation: AAN41643.1. Z34533 Genomic DNA. Translation: CAA84301.2.
PIR	T18696.
RefSeq	NP_497880.2. NM_065479.6.
UniGene	Cel.20657.
3D structure databases
ProteinModelPortal	P46559.
SMR	P46559. Positions 29-356.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.B0285.9.
Proteomic databases
PaxDb	P46559.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	B0285.9; B0285.9; B0285.9.
GeneID	175565.
KEGG	cel:CELE_B0285.9.
UCSC	B0285.9. c. elegans.
Organism-specific databases
CTD	175565.
WormBase	B0285.9; CE33591; WBGene00000512; ckb-2.
Phylogenomic databases
eggNOG	COG0510.
GeneTree	ENSGT00530000062991.
HOGENOM	HOG000015981.
InParanoid	P46559.
OMA	NIRIFCE.
Family and domain databases
InterPro	IPR026712. Cho/Etha_kinase. IPR011009. Kinase-like_dom. [Graphical view]
PANTHER	PTHR22603. PTHR22603. 1 hit.
SUPFAM	SSF56112. Kinase_like. 1 hit.
ProtoNet	Search...
Other
NextBio	888698.

Entry information

Entry name

KICB2_CAEEL

Accession

Primary (citable) accession number: P46559
Secondary accession number(s): Q8IS23

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	March 15, 2004
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project