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P46559

- KICB2_CAEEL

UniProt

P46559 - KICB2_CAEEL

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Protein

Choline kinase B2

Gene
ckb-2, B0285.9
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + choline = ADP + phosphocholine.1 Publication

Cofactori

Magnesium.1 Publication

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. choline kinase activity Source: WormBase

GO - Biological processi

  1. CDP-choline pathway Source: WormBase
  2. endoplasmic reticulum unfolded protein response Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_183754. Synthesis of PC.
REACT_197616. Synthesis of PE.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline kinase B2 (EC:2.7.1.32)
Gene namesi
Name:ckb-2
ORF Names:B0285.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiB0285.9; CE33591; WBGene00000512; ckb-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Choline kinase B2PRO_0000206233Add
BLAST

Proteomic databases

PaxDbiP46559.
PRIDEiP46559.

Interactioni

Protein-protein interaction databases

BioGridi40801. 1 interaction.
STRINGi6239.B0285.9.

Structurei

3D structure databases

ProteinModelPortaliP46559.
SMRiP46559. Positions 29-356.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0510.
GeneTreeiENSGT00530000062991.
HOGENOMiHOG000015981.
InParanoidiP46559.
OMAiNIRIFCE.
OrthoDBiEOG7W41GK.
PhylomeDBiP46559.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequencei

Sequence statusi: Complete.

P46559-1 [UniParc]FASTAAdd to Basket

« Hide

MTAIEKFFTE KSPDSEQVLL KVIELGIDFL GGEWKNVDKS QVNVSRVHGG    50
QSNHMFHVTS STSATPYLLR IHRQPPSQVF TDTVNLAIFS ERGLGPKLYG 100
FFEGGRMEEF LPSKTFDVND VLVPENSRKI GAIFPLYHSI NVPVSKSRRC 150
VHLMREWLNG YESLGGGDYE ILPTTVNYSD HPKSVSIKDL NHEIDNFEKW 200
STEIFEHTLV FSHNDLASTN ILELNSTKEL VLIDWEFGTY NWRGFDLAMH 250
LSETAIDYRV PFPPGIKMNG DLIDNPPNIQ IFCEAYVEAD KKLKNRSPSD 300
PTAEVKALIQ ECQFFWPLTN LFWALSAMKH SLLKFENGVD LDVQARDRLA 350
VYFHLKPRSQ KIYEELSKK 369
Length:369
Mass (Da):42,264
Last modified:March 15, 2004 - v2
Checksum:i24384022ED1458B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY158691 mRNA. Translation: AAN41643.1.
Z34533 Genomic DNA. Translation: CAA84301.2.
PIRiT18696.
RefSeqiNP_497880.2. NM_065479.6.
UniGeneiCel.20657.

Genome annotation databases

EnsemblMetazoaiB0285.9; B0285.9; WBGene00000512.
GeneIDi175565.
KEGGicel:CELE_B0285.9.
UCSCiB0285.9. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY158691 mRNA. Translation: AAN41643.1 .
Z34533 Genomic DNA. Translation: CAA84301.2 .
PIRi T18696.
RefSeqi NP_497880.2. NM_065479.6.
UniGenei Cel.20657.

3D structure databases

ProteinModelPortali P46559.
SMRi P46559. Positions 29-356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 40801. 1 interaction.
STRINGi 6239.B0285.9.

Proteomic databases

PaxDbi P46559.
PRIDEi P46559.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0285.9 ; B0285.9 ; WBGene00000512 .
GeneIDi 175565.
KEGGi cel:CELE_B0285.9.
UCSCi B0285.9. c. elegans.

Organism-specific databases

CTDi 175565.
WormBasei B0285.9 ; CE33591 ; WBGene00000512 ; ckb-2.

Phylogenomic databases

eggNOGi COG0510.
GeneTreei ENSGT00530000062991.
HOGENOMi HOG000015981.
InParanoidi P46559.
OMAi NIRIFCE.
OrthoDBi EOG7W41GK.
PhylomeDBi P46559.

Enzyme and pathway databases

Reactomei REACT_183754. Synthesis of PC.
REACT_197616. Synthesis of PE.

Miscellaneous databases

NextBioi 888698.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization."
    Gee P., Kent C.
    Biochim. Biophys. Acta 1648:33-42(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, COFACTOR.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiKICB2_CAEEL
AccessioniPrimary (citable) accession number: P46559
Secondary accession number(s): Q8IS23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 15, 2004
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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