P46558 (KICB1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choline kinase B1
EC=2.7.1.32

Gene names

Name:	ckb-1
ORF Names:	B0285.8

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + choline = ADP + phosphocholine.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the choline/ethanolamine kinase family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	CDP-choline pathway Inferred from electronic annotation. Source: GOC
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW choline kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Choline kinase B1		PRO_0000206232

Sequences

	Sequence		Length	Mass (Da)
	P46558 [UniParc]. Last modified March 15, 2004. Version 2. Checksum: 035F6EE53F026709	FASTA	371	42,786
	10 20 30 40 50 60 MRPIEKFFTE NAPDSDLVIE KVIEFGIDFL GGEWKNVKKN EVKVTTILGG QSNHMFHVTS 70 80 90 100 110 120 STSATPYLLR IHRQGPSHVF MDTVNFAIFS ERGLGPKLYG FFDGGRMEEF LPSRTLDSDC 130 140 150 160 170 180 ILDPEISRRV GAVYPKYHAI DVPVSKKRRC FQVMRESLKE YQDLGGGDYE IKPTTVTYSE 190 200 210 220 230 240 HPKKISMDDL YKEIDFMEKW TNELFEDTVV FCHNDLASSN ILELNSTKEL VLIDWEFGSY 250 260 270 280 290 300 NCRGFDLAMH LAETAADFRD STPPGIRISE ELTDNPPNLQ GFCEAYVDAD NKLKNRVPSN 310 320 330 340 350 360 RDLEVSNLIC ECQFFWPITQ LFWACFVMKL ALLKYNCGVD MDVQAQDRFA VYWHLKERTR 370 KIYEDLKKGT C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization." Gee P., Kent C. Biochim. Biophys. Acta 1648:33-42(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY158690 mRNA. Translation: AAN41642.1. Z34533 Genomic DNA. Translation: CAA84300.2.
PIR	T18695.
RefSeq	NP_497879.2. NM_065478.2.
UniGene	Cel.20658.
3D structure databases
ProteinModelPortal	P46558.
SMR	P46558. Positions 29-362.
ModBase	Search...
Proteomic databases
PaxDb	P46558.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	B0285.8; B0285.8; B0285.8.
GeneID	181904.
KEGG	cel:CELE_B0285.8.
UCSC	B0285.8. c. elegans.
Organism-specific databases
CTD	181904.
WormBase	B0285.8; CE33590; WBGene00000511; ckb-1.
Phylogenomic databases
eggNOG	COG0510.
GeneTree	ENSGT00530000062991.
HOGENOM	HOG000015981.
InParanoid	P46558.
OMA	DINIRAR.
Family and domain databases
InterPro	IPR026712. Cho/Etha_kinase. IPR011009. Kinase-like_dom. [Graphical view]
PANTHER	PTHR22603. PTHR22603. 1 hit.
SUPFAM	SSF56112. Kinase_like. 1 hit.
ProtoNet	Search...
Other
NextBio	915744.

Entry information

Entry name

KICB1_CAEEL

Accession

Primary (citable) accession number: P46558
Secondary accession number(s): Q8IS24

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	March 15, 2004
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project