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P46558

- KICB1_CAEEL

UniProt

P46558 - KICB1_CAEEL

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Protein

Choline kinase B1

Gene
ckb-1, B0285.8
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + choline = ADP + phosphocholine.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. choline kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_183754. Synthesis of PC.
REACT_197616. Synthesis of PE.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline kinase B1 (EC:2.7.1.32)
Gene namesi
Name:ckb-1
ORF Names:B0285.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiB0285.8; CE33590; WBGene00000511; ckb-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Choline kinase B1PRO_0000206232Add
BLAST

Proteomic databases

PaxDbiP46558.
PRIDEiP46558.

Interactioni

Protein-protein interaction databases

BioGridi46770. 1 interaction.
STRINGi6239.B0285.8.

Structurei

3D structure databases

ProteinModelPortaliP46558.
SMRiP46558. Positions 29-362.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0510.
GeneTreeiENSGT00530000062991.
HOGENOMiHOG000015981.
InParanoidiP46558.
OMAiISAFRNE.
PhylomeDBiP46558.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequencei

Sequence statusi: Complete.

P46558-1 [UniParc]FASTAAdd to Basket

« Hide

MRPIEKFFTE NAPDSDLVIE KVIEFGIDFL GGEWKNVKKN EVKVTTILGG    50
QSNHMFHVTS STSATPYLLR IHRQGPSHVF MDTVNFAIFS ERGLGPKLYG 100
FFDGGRMEEF LPSRTLDSDC ILDPEISRRV GAVYPKYHAI DVPVSKKRRC 150
FQVMRESLKE YQDLGGGDYE IKPTTVTYSE HPKKISMDDL YKEIDFMEKW 200
TNELFEDTVV FCHNDLASSN ILELNSTKEL VLIDWEFGSY NCRGFDLAMH 250
LAETAADFRD STPPGIRISE ELTDNPPNLQ GFCEAYVDAD NKLKNRVPSN 300
RDLEVSNLIC ECQFFWPITQ LFWACFVMKL ALLKYNCGVD MDVQAQDRFA 350
VYWHLKERTR KIYEDLKKGT C 371
Length:371
Mass (Da):42,786
Last modified:March 15, 2004 - v2
Checksum:i035F6EE53F026709
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY158690 mRNA. Translation: AAN41642.1.
Z34533 Genomic DNA. Translation: CAA84300.2.
PIRiT18695.
RefSeqiNP_497879.2. NM_065478.2.
UniGeneiCel.20658.

Genome annotation databases

EnsemblMetazoaiB0285.8; B0285.8; WBGene00000511.
GeneIDi181904.
KEGGicel:CELE_B0285.8.
UCSCiB0285.8. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY158690 mRNA. Translation: AAN41642.1 .
Z34533 Genomic DNA. Translation: CAA84300.2 .
PIRi T18695.
RefSeqi NP_497879.2. NM_065478.2.
UniGenei Cel.20658.

3D structure databases

ProteinModelPortali P46558.
SMRi P46558. Positions 29-362.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 46770. 1 interaction.
STRINGi 6239.B0285.8.

Proteomic databases

PaxDbi P46558.
PRIDEi P46558.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0285.8 ; B0285.8 ; WBGene00000511 .
GeneIDi 181904.
KEGGi cel:CELE_B0285.8.
UCSCi B0285.8. c. elegans.

Organism-specific databases

CTDi 181904.
WormBasei B0285.8 ; CE33590 ; WBGene00000511 ; ckb-1.

Phylogenomic databases

eggNOGi COG0510.
GeneTreei ENSGT00530000062991.
HOGENOMi HOG000015981.
InParanoidi P46558.
OMAi ISAFRNE.
PhylomeDBi P46558.

Enzyme and pathway databases

Reactomei REACT_183754. Synthesis of PC.
REACT_197616. Synthesis of PE.

Miscellaneous databases

NextBioi 915744.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization."
    Gee P., Kent C.
    Biochim. Biophys. Acta 1648:33-42(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiKICB1_CAEEL
AccessioniPrimary (citable) accession number: P46558
Secondary accession number(s): Q8IS24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 15, 2004
Last modified: September 3, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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