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P46551

- CDK12_CAEEL

UniProt

P46551 - CDK12_CAEEL

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Protein
Cyclin-dependent kinase 12
Gene
cdtl-7, B0285.1/B0285.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation By similarity.

Catalytic activityi

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation at Thr-321 or Tyr-322 inactivates the enzyme By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei340 – 3401ATP By similarity
Active sitei444 – 4441Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi317 – 3259ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP46551.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 12 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cell division cycle 2-related protein kinase 7
Cell division protein kinase 12
Gene namesi
Name:cdtl-7
ORF Names:B0285.1/B0285.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiB0285.1a; CE31401; WBGene00007135; cdtl-7.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 730730Cyclin-dependent kinase 12
PRO_0000085716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei321 – 3211Phosphothreonine By similarity
Modified residuei322 – 3221Phosphotyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP46551.

Interactioni

Protein-protein interaction databases

BioGridi40795. 11 interactions.
STRINGi6239.B0285.1.

Structurei

3D structure databases

ProteinModelPortaliP46551.
SMRiP46551. Positions 261-708.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini313 – 605293Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 121110Arg-rich
Add
BLAST
Compositional biasi100 – 17071Ser-rich
Add
BLAST
Compositional biasi189 – 27587Pro-rich
Add
BLAST
Compositional biasi677 – 68711His-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00740000114964.
HOGENOMiHOG000021386.
InParanoidiP46551.
KOiK08819.
PhylomeDBiP46551.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46551-1 [UniParc]FASTAAdd to Basket

« Hide

MEISPGSSTH ERDRKGSYGH RERTRSHSGS PSRFYSKDKR GSSRQGVRPR    50
DRDSKDSISP QYKQRNWSRG GGGGGRDRGR NDFSYRKKGK DYNKRRDKRS 100
RSRSRHRSPK RSGSSKKSKR RNSSGSSSSD LMDTSLMSEL KKHGDYGSSS 150
KSKKKSRKRR KHSSSSSSSS GEAMDLPVSS NGMNVTAIPP PPSFNINPFQ 200
PMFSQPPPPP LPPNSQFMTP PPRPPPAPFS IPPPSVDIHF AATASFSLSS 250
IPPPPPQTDG GASSSKRQDP LPMPPDSKRI ATRPVITTRR GHATNRPSDS 300
DSWYKTNLTH YTMLDQIGEG TYGQVYKAVN NLTGEQVALK RVRLENEKEG 350
FPITAIREIK ILRQLHHKNI VRLMDIVIDD ISMDELKRTR ANFYLVFEYV 400
DHDLIGLLES KELVDFNKDQ ICSLFKQLLE GLAYIHNTGF LHRDIKCSNI 450
LVNNKGELKI ADLGLARLWE KESRLYTNRV ITLWYRPPEL LLGDERYGPA 500
IDVWSTGCML GELFTRKPLF NGNNEFGQLE LISKVCGSPN VDNWPELTEL 550
VGWNTFRMKR TYQRRIREEF EHIMPREAVD LLDKMLTLNP EKRISAKEAL 600
NHPWIRSLEH TTVQPLKLPQ HQDCHEMWSK KQKKSARLGR QAEGSSGSGH 650
SIRATSHPRA PTQPSTTTTK SNGSSNHHHH HHHSHHHASS LPPSGGHAPP 700
PPPPPTQASS TSHNNHQPVP QSQYQSVFFK 730
Length:730
Mass (Da):82,429
Last modified:December 6, 2002 - v4
Checksum:iE347661352F39A0B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z34533 Genomic DNA. Translation: CAA84302.3.
PIRiT18689.
T18697.
RefSeqiNP_001254916.1. NM_001267987.1.
UniGeneiCel.7463.

Genome annotation databases

EnsemblMetazoaiB0285.1a; B0285.1a; WBGene00007135.
GeneIDi175559.
KEGGicel:CELE_B0285.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z34533 Genomic DNA. Translation: CAA84302.3 .
PIRi T18689.
T18697.
RefSeqi NP_001254916.1. NM_001267987.1.
UniGenei Cel.7463.

3D structure databases

ProteinModelPortali P46551.
SMRi P46551. Positions 261-708.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 40795. 11 interactions.
STRINGi 6239.B0285.1.

Proteomic databases

PaxDbi P46551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0285.1a ; B0285.1a ; WBGene00007135 .
GeneIDi 175559.
KEGGi cel:CELE_B0285.1.

Organism-specific databases

CTDi 175559.
WormBasei B0285.1a ; CE31401 ; WBGene00007135 ; cdtl-7.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00740000114964.
HOGENOMi HOG000021386.
InParanoidi P46551.
KOi K08819.
PhylomeDBi P46551.

Enzyme and pathway databases

SignaLinki P46551.

Miscellaneous databases

NextBioi 888674.
PROi P46551.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiCDK12_CAEEL
AccessioniPrimary (citable) accession number: P46551
Secondary accession number(s): P46552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 6, 2002
Last modified: June 11, 2014
This is version 119 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi