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P46551 (CDK12_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 12

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cell division cycle 2-related protein kinase 7
Cell division protein kinase 12
Gene names
Name:cdtl-7
ORF Names:B0285.1/B0285.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length730 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation By similarity.

Catalytic activity

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Phosphorylation at Thr-321 or Tyr-322 inactivates the enzyme By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 730730Cyclin-dependent kinase 12
PRO_0000085716

Regions

Domain313 – 605293Protein kinase
Nucleotide binding317 – 3259ATP By similarity
Compositional bias12 – 121110Arg-rich
Compositional bias100 – 17071Ser-rich
Compositional bias189 – 27587Pro-rich
Compositional bias677 – 68711His-rich

Sites

Active site4441Proton acceptor By similarity
Binding site3401ATP By similarity

Amino acid modifications

Modified residue3211Phosphothreonine By similarity
Modified residue3221Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P46551 [UniParc].

Last modified December 6, 2002. Version 4.
Checksum: E347661352F39A0B

FASTA73082,429
        10         20         30         40         50         60 
MEISPGSSTH ERDRKGSYGH RERTRSHSGS PSRFYSKDKR GSSRQGVRPR DRDSKDSISP 

        70         80         90        100        110        120 
QYKQRNWSRG GGGGGRDRGR NDFSYRKKGK DYNKRRDKRS RSRSRHRSPK RSGSSKKSKR 

       130        140        150        160        170        180 
RNSSGSSSSD LMDTSLMSEL KKHGDYGSSS KSKKKSRKRR KHSSSSSSSS GEAMDLPVSS 

       190        200        210        220        230        240 
NGMNVTAIPP PPSFNINPFQ PMFSQPPPPP LPPNSQFMTP PPRPPPAPFS IPPPSVDIHF 

       250        260        270        280        290        300 
AATASFSLSS IPPPPPQTDG GASSSKRQDP LPMPPDSKRI ATRPVITTRR GHATNRPSDS 

       310        320        330        340        350        360 
DSWYKTNLTH YTMLDQIGEG TYGQVYKAVN NLTGEQVALK RVRLENEKEG FPITAIREIK 

       370        380        390        400        410        420 
ILRQLHHKNI VRLMDIVIDD ISMDELKRTR ANFYLVFEYV DHDLIGLLES KELVDFNKDQ 

       430        440        450        460        470        480 
ICSLFKQLLE GLAYIHNTGF LHRDIKCSNI LVNNKGELKI ADLGLARLWE KESRLYTNRV 

       490        500        510        520        530        540 
ITLWYRPPEL LLGDERYGPA IDVWSTGCML GELFTRKPLF NGNNEFGQLE LISKVCGSPN 

       550        560        570        580        590        600 
VDNWPELTEL VGWNTFRMKR TYQRRIREEF EHIMPREAVD LLDKMLTLNP EKRISAKEAL 

       610        620        630        640        650        660 
NHPWIRSLEH TTVQPLKLPQ HQDCHEMWSK KQKKSARLGR QAEGSSGSGH SIRATSHPRA 

       670        680        690        700        710        720 
PTQPSTTTTK SNGSSNHHHH HHHSHHHASS LPPSGGHAPP PPPPPTQASS TSHNNHQPVP 

       730 
QSQYQSVFFK 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z34533 Genomic DNA. Translation: CAA84302.3.
PIRT18689.
T18697.
RefSeqNP_001254916.1. NM_001267987.1.
UniGeneCel.7463.

3D structure databases

ProteinModelPortalP46551.
SMRP46551. Positions 261-708.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid40795. 11 interactions.
STRING6239.B0285.1.

Proteomic databases

PaxDbP46551.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaB0285.1a; B0285.1a; WBGene00007135.
GeneID175559.
KEGGcel:CELE_B0285.1.

Organism-specific databases

CTD175559.
WormBaseB0285.1a; CE31401; WBGene00007135; cdtl-7.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00740000114964.
HOGENOMHOG000021386.
InParanoidP46551.
KOK08819.
PhylomeDBP46551.

Enzyme and pathway databases

SignaLinkP46551.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio888674.
PROP46551.

Entry information

Entry nameCDK12_CAEEL
AccessionPrimary (citable) accession number: P46551
Secondary accession number(s): P46552
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 6, 2002
Last modified: June 11, 2014
This is version 119 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase