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Protein

T-complex protein 1 subunit zeta

Gene

cct-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-CEL-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta
Short name:
TCP-1-zeta
Alternative name(s):
CCT-zeta
Gene namesi
Name:cct-6
ORF Names:F01F1.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF01F1.8a; CE01234; WBGene00000381; cct-6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283601 – 539T-complex protein 1 subunit zetaAdd BLAST539

Proteomic databases

EPDiP46550.
PaxDbiP46550.
PeptideAtlasiP46550.
PRIDEiP46550.

Expressioni

Gene expression databases

BgeeiWBGene00000381.
ExpressionAtlasiP46550. differential.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.By similarity

Protein-protein interaction databases

BioGridi41041. 1 interactor.
IntActiP46550. 1 interactor.
STRINGi6239.F01F1.8a.1.

Structurei

3D structure databases

ProteinModelPortaliP46550.
SMRiP46550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0359. Eukaryota.
ENOG410XQ3Q. LUCA.
GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
InParanoidiP46550.
KOiK09498.
OMAiEPMKPVD.
OrthoDBiEOG091G07CE.
PhylomeDBiP46550.

Family and domain databases

CDDicd03342. TCP1_zeta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353:SF21. PTHR11353:SF21. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIQCLNPK AELARHAAAL ELNISGARGL QDVMRSNLGP KGTLKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLHEMAIQ HPTASMIAKA STAQDDVTGD GTTSTVLLIG
110 120 130 140 150
ELLKQAESLV LEGLHPRIVT EGFEWANTKT LELLEKFKKE APVERDLLVE
160 170 180 190 200
VCRTALRTKL HQKLADHITE CVVDAVLAIR RDGEEPDLHM VEKMEMHHDS
210 220 230 240 250
DMDTTLVRGL VLDHGARHPD MPRHVKDAYI LTCNVSLEYE KTEVNSGLFY
260 270 280 290 300
KTAKEREALL AAEREFITRR VHKIIELKKK VIDNSPDGKN KGFVVINQKG
310 320 330 340 350
IDPPSLDLLA SEGILALRRA KRRNMERLQL AVGGEAVNSV DDLTPEDLGW
360 370 380 390 400
AGLVYEHSLG EEKYTFIEEC RAPKSVTLLI KGPNKHTITQ IKDAIHDGLR
410 420 430 440 450
AVFNTIVDKA VLPGAAAFEI AAYVMLKKDV ENLKGRAKLG AEAFAQALLV
460 470 480 490 500
IPKTLAVNGG YDAQETLVKL IEEKTAAGPD IAVGLDLETG GAVEPQGIWD
510 520 530
NVTVKKNSIS SATVLACNLL LVDEVMRAGM TNLKQPQPE
Length:539
Mass (Da):58,905
Last modified:November 1, 1995 - v1
Checksum:i84DE24110A03CDE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080705 Genomic DNA. Translation: CCD65990.1.
PIRiT15943.
RefSeqiNP_741153.1. NM_171135.6.
UniGeneiCel.17538.

Genome annotation databases

EnsemblMetazoaiF01F1.8a.1; F01F1.8a.1; WBGene00000381.
F01F1.8a.2; F01F1.8a.2; WBGene00000381.
GeneIDi175819.
KEGGicel:CELE_F01F1.8.
UCSCiF01F1.8a.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080705 Genomic DNA. Translation: CCD65990.1.
PIRiT15943.
RefSeqiNP_741153.1. NM_171135.6.
UniGeneiCel.17538.

3D structure databases

ProteinModelPortaliP46550.
SMRiP46550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41041. 1 interactor.
IntActiP46550. 1 interactor.
STRINGi6239.F01F1.8a.1.

Proteomic databases

EPDiP46550.
PaxDbiP46550.
PeptideAtlasiP46550.
PRIDEiP46550.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF01F1.8a.1; F01F1.8a.1; WBGene00000381.
F01F1.8a.2; F01F1.8a.2; WBGene00000381.
GeneIDi175819.
KEGGicel:CELE_F01F1.8.
UCSCiF01F1.8a.1. c. elegans.

Organism-specific databases

CTDi175819.
WormBaseiF01F1.8a; CE01234; WBGene00000381; cct-6.

Phylogenomic databases

eggNOGiKOG0359. Eukaryota.
ENOG410XQ3Q. LUCA.
GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
InParanoidiP46550.
KOiK09498.
OMAiEPMKPVD.
OrthoDBiEOG091G07CE.
PhylomeDBiP46550.

Enzyme and pathway databases

ReactomeiR-CEL-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-CEL-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiP46550.

Gene expression databases

BgeeiWBGene00000381.
ExpressionAtlasiP46550. differential.

Family and domain databases

CDDicd03342. TCP1_zeta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PANTHERiPTHR11353:SF21. PTHR11353:SF21. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCPZ_CAEEL
AccessioniPrimary (citable) accession number: P46550
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.