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Protein

T-complex protein 1 subunit zeta

Gene

cct-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-390471 Association of TriC/CCT with target proteins during biosynthesis
R-CEL-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta
Short name:
TCP-1-zeta
Alternative name(s):
CCT-zeta
Gene namesi
Name:cct-6
ORF Names:F01F1.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF01F1.8a ; CE01234 ; WBGene00000381 ; cct-6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283601 – 539T-complex protein 1 subunit zetaAdd BLAST539

Proteomic databases

EPDiP46550
PaxDbiP46550
PeptideAtlasiP46550
PRIDEiP46550

Expressioni

Gene expression databases

BgeeiWBGene00000381
ExpressionAtlasiP46550 baseline and differential

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi41041, 1 interactor
IntActiP46550, 1 interactor
STRINGi6239.F01F1.8a.1

Structurei

3D structure databases

ProteinModelPortaliP46550
SMRiP46550
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0359 Eukaryota
ENOG410XQ3Q LUCA
GeneTreeiENSGT00550000074743
HOGENOMiHOG000226733
InParanoidiP46550
KOiK09498
OMAiMQHKTDT
OrthoDBiEOG091G07CE
PhylomeDBiP46550

Family and domain databases

CDDicd03342 TCP1_zeta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012722 Chap_CCT_zeta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02347 chap_CCT_zeta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

P46550-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIQCLNPK AELARHAAAL ELNISGARGL QDVMRSNLGP KGTLKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLHEMAIQ HPTASMIAKA STAQDDVTGD GTTSTVLLIG
110 120 130 140 150
ELLKQAESLV LEGLHPRIVT EGFEWANTKT LELLEKFKKE APVERDLLVE
160 170 180 190 200
VCRTALRTKL HQKLADHITE CVVDAVLAIR RDGEEPDLHM VEKMEMHHDS
210 220 230 240 250
DMDTTLVRGL VLDHGARHPD MPRHVKDAYI LTCNVSLEYE KTEVNSGLFY
260 270 280 290 300
KTAKEREALL AAEREFITRR VHKIIELKKK VIDNSPDGKN KGFVVINQKG
310 320 330 340 350
IDPPSLDLLA SEGILALRRA KRRNMERLQL AVGGEAVNSV DDLTPEDLGW
360 370 380 390 400
AGLVYEHSLG EEKYTFIEEC RAPKSVTLLI KGPNKHTITQ IKDAIHDGLR
410 420 430 440 450
AVFNTIVDKA VLPGAAAFEI AAYVMLKKDV ENLKGRAKLG AEAFAQALLV
460 470 480 490 500
IPKTLAVNGG YDAQETLVKL IEEKTAAGPD IAVGLDLETG GAVEPQGIWD
510 520 530
NVTVKKNSIS SATVLACNLL LVDEVMRAGM TNLKQPQPE
Length:539
Mass (Da):58,905
Last modified:November 1, 1995 - v1
Checksum:i84DE24110A03CDE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080705 Genomic DNA Translation: CCD65990.1
PIRiT15943
RefSeqiNP_741153.1, NM_171135.6
UniGeneiCel.17538

Genome annotation databases

EnsemblMetazoaiF01F1.8a.1; F01F1.8a.1; WBGene00000381
F01F1.8a.2; F01F1.8a.2; WBGene00000381
GeneIDi175819
KEGGicel:CELE_F01F1.8
UCSCiF01F1.8a.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTCPZ_CAEEL
AccessioniPrimary (citable) accession number: P46550
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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