Reviewed, UniProtKB/Swiss-Prot P46548 (NMT_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable glycylpeptide N-tetradecanoyltransferase
    EC=2.3.1.97
Alternative name(s):
    Peptide N-myristoyltransferase
    Myristoyl-CoA:protein N-myristoyltransferase
      Short name=NMT

Gene names

ORF Names:

T17E9.2

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins By similarity.
Catalytic activity	Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the NMT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-terminal protein myristoylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycylpeptide N-tetradecanoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Probable glycylpeptide N-tetradecanoyltransferase		PRO_0000064229

Sequences

	Sequence		Length	Mass (Da)
	P46548-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 5A639808F7DDA38E	FASTA	450	50,889
	10 20 30 40 50 60 MSHGHSHDGA PCGGHHGDDG AGGSRPSVND VQALVDQLRL AGVDVSNMPN IPTAPRDMDE 70 80 90 100 110 120 ARSKSFQFWS TQPVPQMDET VPADVNCAIE ENIALDKVRA EPFSLPAGFR WSNVDLSDEE 130 140 150 160 170 180 QLNELYNLLT RNYVEDDDSM FRFDYSADFL KWALQVPGFR PEWHCGVRAD SNNRLLAFIG 190 200 210 220 230 240 AVPQTVRVYD KTVNMVEINF LCVHKNLRSR RVAPVLIREI TRRVNVTGIF QAAFTAGIVI 250 260 270 280 290 300 PKPVSVCRYY HRSLNPRKLI DVRFSHLSAK MTMARTIKLY KLPEETATRN LREMKSTDVP 310 320 330 340 350 360 QVFKLLTTSL KQYSLAPVYN SEEELAHALV PKKGVVYSYV AENQNGKITD FVSFYSLPST 370 380 390 400 410 420 VMGHTTHKTI YAAYLYYYVA GSVTPKQLIN DSLILANREK FDVFNALDLM HNEKIFSDLK 430 440 450 FGKGDGNLQY YLYNWKCADM KPSQIGLVLQ

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U11280 Genomic DNA. Translation: AAA19436.1.
PIR	D88474.
RefSeq	NP_498326.1.
UniGene	Cel.17437
3D structure databases
HSSP	HSSP built from PDB template 1IYL based on UniProtKB P30418.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:24373N.
STRING	P46548.
Proteomic databases
PRIDE	P46548.
Genome annotation databases
Ensembl	T17E9.2a; T17E9.2a; T17E9.2; Caenorhabditis elegans. [Genome view] T17E9.2b; T17E9.2b; T17E9.2; Caenorhabditis elegans. [Genome view]
GeneID	175861.
Organism-specific databases
CTD	175861.
WormBase	WBGene00020549. T17E9.2.
WormPep	T17E9.2. CE01406. [WorfDB]
Enzyme and pathway databases
BRENDA	2.3.1.97. 672.
Gene expression databases
ArrayExpress	P46548.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000903. Myristoyl_trans. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 2 hits.
PANTHER	PTHR11377. Myristoyl_trans. 1 hit.
Pfam	PF01233. NMT. 1 hit. PF02799. NMT_C. 1 hit. [Graphical view]
PIRSF	PIRSF015892. N-myristl_transf. 1 hit.
PROSITE	PS00975. NMT_1. 1 hit. PS00976. NMT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	890024.

Entry information

Entry name

NMT_CAEEL

Accession

Primary (citable) accession number: P46548

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	September 1, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project