Reviewed,
UniProtKB/Swiss-Prot P46539 (PYRD_BACCL)
Last modified
November 25, 2008.
Version 60.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dihydroorotate dehydrogenase, catalytic subunit EC=1.3.3.1 Alternative name(s): Dihydroorotate oxidase DHOdehase Short name=DHODase Short name=DHOD | ||
| Gene names |
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| Organism | Bacillus caldolyticus | ||
| Taxonomic identifier | 1394 [NCBI] | ||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 313 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-dihydroorotate + O(2) = orotate + H(2)O(2). |
| Cofactor | Binds 1 FMN per subunit By similarity. |
| Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 4/6. |
| Subunit structure | Heterotetramer of 2 pyrK and 2 pyrD subunits By similarity. |
| Subcellular location | CytoplasmBy similarity. |
| Sequence similarities | Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. |
Ontologies
Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | FMN Flavoprotein |
| Molecular function | Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | 'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro UMP biosynthetic processInferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: HAMAP |
| Molecular function | dihydroorotate oxidase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Molecular characterization of pyrimidine biosynthesis genes from the thermophile Bacillus caldolyticus." Ghim S.Y., Nielsen P., Neuhard J. Microbiology 140:479-491(1994) [PubMed: 7516791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 405 / IFO 15313 / YP-T. |
Cross-references
Sequence databases | |
|---|---|
| X73308 Genomic DNA. Translation: CAA51741.1. | |
| PIR | I40171. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EP2 based on UniProtKB P54322. |
| ModBase | Search... |
Family and domain databases | |
| HAMAP | MF_00224. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR012135. DHO_DHase_1_2. IPR005720. DHO_DHase_1_core. IPR001295. Dihydroorotate_DHase_core. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF01180. DHO_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF000164. DHO_oxidase. 1 hit. |
| TIGRFAMs | TIGR01037. pyrD_sub1_fam. 1 hit. |
| PROSITE | PS00911. DHODEHASE_1. 1 hit. PS00912. DHODEHASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PYRD_BACCL | ||||||||
| Accession | Primary (citable) accession number: P46539 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


