ID   CDNB_HUMAN     STANDARD;      PRT;   198 AA.
AC   P46527;
DT   01-NOV-1995 (REL. 32, CREATED)
DT   01-NOV-1995 (REL. 32, LAST SEQUENCE UPDATE)
DT   01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE)
DE   CYCLIN-DEPENDENT KINASE INHIBITOR 1B (CYCLIN-DEPENDENT KINASE
DE   INHIBITOR P27) (P27KIP1).
GN   CDKN1B OR KIP1.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A., AND SEQUENCE OF 28-79 AND 104-152.
RC   TISSUE=KIDNEY;
RA   POLYAK K., LEE M.-H., ERDJUMENT-BROMAGE H., KOFF A., ROBERTS J.M.,
RA   TEMPST P., MASSAGUE J.;
RL   CELL 78:56-66(1994).
CC   -!- FUNCTION: INVOLVED IN G1 ARREST. MAY MEDIATE TGF BETA-INDUCED G1
CC       ARREST. BINDS TO AND INHIBITS COMPLEXES FORMED BY CYCLIN E-CDK2,
CC       CYCLIN A-CDK2, AND CYCLIN D1-CDK4.
CC   -!- SUBCELLULAR LOCATION: NUCLEAR.
CC   -!- TISSUE SPECIFICITY: EXPRESSED IN ALL TISSUES TESTED. HIGHEST
CC       LEVELS IN SKELETAL MUSCLE, LOWEST IN LIVER AND KIDNEY.
CC   -!- DOMAIN: A PEPTIDE SEQUENCE CONTAINING ONLY AA 28-79 RETAINS
CC       SUBSTANTIAL KIP1 CYCLIN A/CDK2 INHIBITORY ACTIVITY.
CC   -!- SIMILARITY: THE N-TERMINAL OF CIP1 AND KIP ARE SIMILAR.
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DR   EMBL; U10906; G516559; -.
DR   MIM; 600778; 11TH EDITION.
KW   CELL CYCLE; NUCLEAR PROTEIN.
FT   DOMAIN      153    169       NUCLEAR LOCALIZATION SIGNAL (POTENTIAL).
SQ   SEQUENCE   198 AA;  22073 MW;  600FA4AF CRC32;
     MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVDHEE LTRDLEKHCR DMEEASQRKW
     NFDFQNHKPL EGKYEWQEVE KGSLPEFYYR PPRPPKGACK VPAQESQDVS GSRPAAPLIG
     APANSEDTHL VDPKTDPSDS QTGLAEQCAG IRKRPATDDS STQNKRANRT EENVSDGSPN
     AGSVEQTPKK PGLRRRQT
//