P46512 (CAH1_FLALI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Carbonic anhydrase 1 EC=4.2.1.1 Alternative name(s): Carbonate dehydratase 1
Organism	Flaveria linearis (Narrowleaf yellowtops)
Taxonomic identifier	4225 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae alliance › Tageteae › Flaveria

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Subunit structure	Homohexamer By similarity.
Subcellular location	Cytoplasm Potential.
Domain	Possesses a transit-like peptide, but it is proposed that this peptide is not removed and that therefore the enzyme stays in the cytoplasm instead of going to the chloroplast By similarity.
Sequence similarities	Belongs to the beta-class carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Zinc
Molecular function	Lyase
Gene Ontology (GO)
Biological process	carbon utilization Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Carbonic anhydrase 1		PRO_0000077455
Regions
	Region	1 – 109	109	Chloroplast transit peptide-like
	Compositional bias	41 – 47	7	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	P46512 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 2B71061E73C7E7CD	FASTA	330	35,574
	10 20 30 40 50 60 MSTASAFAIN APSFVNASSL KKSSTSSARS GVLSARFTCN SSSSSSSATP PSLIRNEPVF 70 80 90 100 110 120 AAPAPIITPN WTEDGNESYE EAIDALKKML IEKGELEPVA AARIDQITAQ AAAPDTKAPF 130 140 150 160 170 180 DPVERIKSGF VKFKTEKFVT NPALYDELAK GQSPKFMVFA CSDSRVCPSH VLDFQPGEAF 190 200 210 220 230 240 VVRNVANMVP PFDKTKYSGV GAAVEYAVLH LKVQEIFVIG HSRCGGIKGL MTFPDEGPHS 250 260 270 280 290 300 TDFIEDWVKV CLPAKSKVVA EHNGTHLDDQ CVQCEKEAVN VSLGNLLTYP FVRDGLRNNT 310 320 330 LALKGGHYDF VNGTFELWAL DFGLSSPTSV

References

[1]	"Molecular comparison of carbonic anhydrase from Flaveria species demonstrating different photosynthetic pathways." Ludwig M., Burnell J.N. Plant Mol. Biol. 29:353-365(1995) [PubMed: 7579185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Leaf.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U19738 mRNA. Translation: AAA86993.1.
PIR	S61883.
3D structure databases
ProteinModelPortal	P46512.
SMR	P46512. Positions 124-330.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001765. Carbonic_anhydrase. IPR015892. Carbonic_anhydrase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1050.10. CO_anhd_prok_pln. 1 hit.
PANTHER	PTHR11002. Carbonic_anhydrase. 1 hit.
Pfam	PF00484. Pro_CA. 1 hit. [Graphical view]
SMART	SM00947. Pro_CA. 1 hit. [Graphical view]
SUPFAM	SSF53056. Prok_plnt_COanhd. 1 hit.
PROSITE	PS00704. PROK_CO2_ANHYDRASE_1. 1 hit. PS00705. PROK_CO2_ANHYDRASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH1_FLALI

Accession

Primary (citable) accession number: P46512

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 31, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program