P46510 (CAHX_FLABI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Carbonic anhydrase EC=4.2.1.1 Alternative name(s): Carbonate dehydratase
Organism	Flaveria bidentis (Coastal plain yellowtops) (Ethulia bidentis)
Taxonomic identifier	4224 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae alliance › Tageteae › Flaveria

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Subcellular location	Cytoplasm Potential.
Domain	Possesses a transit-like peptide, but it is proposed that this peptide is not removed and that therefore the enzyme stays in the cytoplasm instead of going to the chloroplast.
Sequence similarities	Belongs to the beta-class carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Zinc
Molecular function	Lyase
Gene Ontology (GO)
Biological process	carbon utilization Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Carbonic anhydrase		PRO_0000077453
Regions
	Region	1 – 109	109	Chloroplast transit peptide-like
	Compositional bias	40 – 47	8	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	P46510 [UniParc]. Last modified May 24, 2004. Version 2. Checksum: 53989F16CE4DF26C	FASTA	330	35,545
	10 20 30 40 50 60 MSAASAFAMN APSFVNASSL KKASTSARSG VLSARFTCNS SSSSSSSATP PSLIRNEPVF 70 80 90 100 110 120 AAPAPIITPN WTEDGNESYE EAIDALKKTL IEKGELEPVA ATRIDQITAQ AAAPDTKAPF 130 140 150 160 170 180 DPVERIKSGF VKFKTEKFVT NPALYDELAK GQSPKFMVFA CSDSRVCPSH VLDFQPGEAF 190 200 210 220 230 240 VVRNVANMVP PFDKTKYSGV GAAVEYAVLH LKVQEIFVIG HSRCGGIKGL MTFPDEGPHS 250 260 270 280 290 300 TDFIEDWVKV CLPAKSKVVA EHNGTHLDDQ CVLCEKEAVN VSLGNLLTYP FVRDGLRNKT 310 320 330 LALKGGHYDF VNGTFELWAL DFGLSSPTSV

References

[1]	"The nucleotide sequence of a complementary DNA encoding Flaveria bidentis carbonic anhydrase." Cavallaro A., Ludwig M., Burnell J.N. FEBS Lett. 350:216-218(1994) [PubMed: 8070567] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Leaf.
[2]	Burnell J.N. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U08398 mRNA. Translation: AAA86939.2.
PIR	S48675.
3D structure databases
ProteinModelPortal	P46510.
SMR	P46510. Positions 124-330.
ModBase	Search...
Proteomic databases
PRIDE	P46510.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	4.2.1.1. 2264.
Family and domain databases
InterPro	IPR001765. Carbonic_anhydrase. IPR015892. Carbonic_anhydrase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1050.10. CO_anhd_prok_pln. 1 hit.
PANTHER	PTHR11002. Carbonic_anhydrase. 1 hit.
Pfam	PF00484. Pro_CA. 1 hit. [Graphical view]
SMART	SM00947. Pro_CA. 1 hit. [Graphical view]
SUPFAM	SSF53056. Prok_plnt_COanhd. 1 hit.
PROSITE	PS00704. PROK_CO2_ANHYDRASE_1. 1 hit. PS00705. PROK_CO2_ANHYDRASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAHX_FLABI

Accession

Primary (citable) accession number: P46510

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	May 24, 2004
Last modified:	May 31, 2011
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program