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Protein

Probable 26S proteasome regulatory subunit 6B

Gene

rpt-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 209ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-195253 Degradation of beta-catenin by the destruction complex
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-4641258 Degradation of DVL
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69017 CDK-mediated phosphorylation and removal of Cdc6
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 26S proteasome regulatory subunit 6B
Gene namesi
Name:rpt-3
ORF Names:F23F12.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF23F12.6 ; CE01253 ; WBGene00004503 ; rpt-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846901 – 414Probable 26S proteasome regulatory subunit 6BAdd BLAST414

Proteomic databases

EPDiP46502
PaxDbiP46502
PeptideAtlasiP46502
PRIDEiP46502

Expressioni

Gene expression databases

BgeeiWBGene00004503

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi41143, 3 interactors
DIPiDIP-24412N
IntActiP46502, 3 interactors
STRINGi6239.F23F12.6.2

Structurei

3D structure databases

ProteinModelPortaliP46502
SMRiP46502
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0727 Eukaryota
COG1222 LUCA
GeneTreeiENSGT00550000074962
HOGENOMiHOG000225143
InParanoidiP46502
KOiK03063
OMAiLIIRNDP
OrthoDBiEOG091G07NC
PhylomeDBiP46502

Family and domain databases

InterProiView protein in InterPro
IPR005937 26S_Psome_P45-like
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
IPR035256 PSMC4
PANTHERiPTHR23073:SF8 PTHR23073:SF8, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01242 26Sp45, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

P46502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAALEEIG IAPLQENTSL RPPPLPATCV DVSSDDYIKL TTLERQLAHL
60 70 80 90 100
QVMEDYIKLE TRNLEKELLH AQEEVKRIQS VPLVIGQFLE AVDQNHAIVG
110 120 130 140 150
STTGSNYYVR VLSILDRELL KPGCSVALHK YSNALVDVLP PEADSSIQML
160 170 180 190 200
RPDEKPDISY GDIGGLDMQK QEVREAVELP LTHGELYQQI GIDPPRGVLM
210 220 230 240 250
YGPPGCGKTM LAKAVAANTA ASFIRVVGSE FVQKYLGEGP RMVRDVFRLA
260 270 280 290 300
KENSPSIIFI DEIDAIATKR FDAQTGADRE VQRILLELLN QMDGFDQSTN
310 320 330 340 350
VKVIMATNRQ DTLDPALLRP GRLDRKIEFP LPDRRQKRLV FSTVCSRMNL
360 370 380 390 400
SDDVDLEDWV ARPDKISGAD INSICQEAGM QAVRENRYVV LTKDLEKAYK
410
NVVKKDTNDF EFYK
Length:414
Mass (Da):46,358
Last modified:November 1, 1995 - v1
Checksum:i8630AFFB8A2C7F32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081210 Genomic DNA Translation: CCD69926.1
PIRiA88485
RefSeqiNP_498429.1, NM_066028.3
UniGeneiCel.10140

Genome annotation databases

EnsemblMetazoaiF23F12.6.1; F23F12.6.1; WBGene00004503
F23F12.6.2; F23F12.6.2; WBGene00004503
GeneIDi175925
KEGGicel:CELE_F23F12.6
UCSCiF23F12.6.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPRS6B_CAEEL
AccessioniPrimary (citable) accession number: P46502
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health