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Protein

Probable 26S protease regulatory subunit 6B

Gene

rpt-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi202 – 2098ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-CEL-195253. Degradation of beta-catenin by the destruction complex.
R-CEL-4608870. Asymmetric localization of PCP proteins.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5668541. TNFR2 non-canonical NF-kB pathway.
R-CEL-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 26S protease regulatory subunit 6B
Gene namesi
Name:rpt-3
ORF Names:F23F12.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF23F12.6; CE01253; WBGene00004503; rpt-3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Probable 26S protease regulatory subunit 6BPRO_0000084690Add
BLAST

Proteomic databases

EPDiP46502.
PaxDbiP46502.

Interactioni

Protein-protein interaction databases

BioGridi41143. 3 interactions.
DIPiDIP-24412N.
IntActiP46502. 2 interactions.
MINTiMINT-212949.
STRINGi6239.F23F12.6.2.

Structurei

3D structure databases

ProteinModelPortaliP46502.
SMRiP46502. Positions 37-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0727. Eukaryota.
COG1222. LUCA.
GeneTreeiENSGT00550000074962.
HOGENOMiHOG000225143.
InParanoidiP46502.
KOiK03063.
OMAiELPLTQF.
PhylomeDBiP46502.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAALEEIG IAPLQENTSL RPPPLPATCV DVSSDDYIKL TTLERQLAHL
60 70 80 90 100
QVMEDYIKLE TRNLEKELLH AQEEVKRIQS VPLVIGQFLE AVDQNHAIVG
110 120 130 140 150
STTGSNYYVR VLSILDRELL KPGCSVALHK YSNALVDVLP PEADSSIQML
160 170 180 190 200
RPDEKPDISY GDIGGLDMQK QEVREAVELP LTHGELYQQI GIDPPRGVLM
210 220 230 240 250
YGPPGCGKTM LAKAVAANTA ASFIRVVGSE FVQKYLGEGP RMVRDVFRLA
260 270 280 290 300
KENSPSIIFI DEIDAIATKR FDAQTGADRE VQRILLELLN QMDGFDQSTN
310 320 330 340 350
VKVIMATNRQ DTLDPALLRP GRLDRKIEFP LPDRRQKRLV FSTVCSRMNL
360 370 380 390 400
SDDVDLEDWV ARPDKISGAD INSICQEAGM QAVRENRYVV LTKDLEKAYK
410
NVVKKDTNDF EFYK
Length:414
Mass (Da):46,358
Last modified:November 1, 1995 - v1
Checksum:i8630AFFB8A2C7F32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081210 Genomic DNA. Translation: CCD69926.1.
PIRiA88485.
RefSeqiNP_498429.1. NM_066028.3.
UniGeneiCel.10140.

Genome annotation databases

EnsemblMetazoaiF23F12.6; F23F12.6; WBGene00004503.
GeneIDi175925.
KEGGicel:CELE_F23F12.6.
UCSCiF23F12.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081210 Genomic DNA. Translation: CCD69926.1.
PIRiA88485.
RefSeqiNP_498429.1. NM_066028.3.
UniGeneiCel.10140.

3D structure databases

ProteinModelPortaliP46502.
SMRiP46502. Positions 37-414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41143. 3 interactions.
DIPiDIP-24412N.
IntActiP46502. 2 interactions.
MINTiMINT-212949.
STRINGi6239.F23F12.6.2.

Proteomic databases

EPDiP46502.
PaxDbiP46502.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF23F12.6; F23F12.6; WBGene00004503.
GeneIDi175925.
KEGGicel:CELE_F23F12.6.
UCSCiF23F12.6.1. c. elegans.

Organism-specific databases

CTDi175925.
WormBaseiF23F12.6; CE01253; WBGene00004503; rpt-3.

Phylogenomic databases

eggNOGiKOG0727. Eukaryota.
COG1222. LUCA.
GeneTreeiENSGT00550000074962.
HOGENOMiHOG000225143.
InParanoidiP46502.
KOiK03063.
OMAiELPLTQF.
PhylomeDBiP46502.

Enzyme and pathway databases

ReactomeiR-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-CEL-195253. Degradation of beta-catenin by the destruction complex.
R-CEL-4608870. Asymmetric localization of PCP proteins.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5668541. TNFR2 non-canonical NF-kB pathway.
R-CEL-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiP46502.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPRS6B_CAEEL
AccessioniPrimary (citable) accession number: P46502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.