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P46487

- MDHM_EUCGU

UniProt

P46487 - MDHM_EUCGU

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Protein

Malate dehydrogenase, mitochondrial

Gene
MDH
Organism
Eucalyptus gunnii (Cider gum)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671NAD By similarity
Binding sitei114 – 1141Substrate By similarity
Binding sitei120 – 1201Substrate By similarity
Binding sitei127 – 1271NAD By similarity
Binding sitei152 – 1521Substrate By similarity
Binding sitei186 – 1861Substrate By similarity
Active sitei210 – 2101Proton acceptor By similarity
Binding sitei261 – 2611NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 477NAD By similarity
Nucleotide bindingi150 – 1523NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
Gene namesi
Name:MDH
OrganismiEucalyptus gunnii (Cider gum)
Taxonomic identifieri3933 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMyrtalesMyrtaceaeEucalyptus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727Mitochondrion Reviewed predictionAdd
BLAST
Chaini28 – 347320Malate dehydrogenase, mitochondrialPRO_0000018626Add
BLAST

Proteomic databases

PRIDEiP46487.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP46487.
SMRiP46487. Positions 36-344.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46487-1 [UniParc]FASTAAdd to Basket

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MRASMLRLIR SRSSSAAPRP HLLRRAYGSE SVPERKVAVL GAAGGIGQPL    50
ALLMKLNPLV SQLALYDIAG TPGVAADVGH INTRSEVAGY VGEEQLGQAL 100
EGSDVVIIPA GVPRKPGMTR DDLFNINAGI VKSLCTAIAK YCPNAVVNMI 150
SNPVNSTVPI AAEIFKKAGT YNEKKLLGVT TLDVVRAKTF YAGKAKVPVE 200
EVNVPVVGGH AGITILPLFS QAVPKANLAD EDIKALTKRT QDGGTEVVEA 250
KAGKGSATLS MAYAGALFAD ACLKGLNGVP DVVECSFVQS SIITELPFFA 300
SKVKLGKNGV EEVLELGPMS DYEKQGLEIL IPELKASIEK GIKFANQ 347
Length:347
Mass (Da):36,462
Last modified:November 1, 1995 - v1
Checksum:i450F8254CCC84789
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78800 mRNA. Translation: CAA55383.1.
PIRiS44167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78800 mRNA. Translation: CAA55383.1 .
PIRi S44167.

3D structure databases

ProteinModelPortali P46487.
SMRi P46487. Positions 36-344.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P46487.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a cDNA encoding mitochondrial malate dehydrogenase from Eucalyptus."
    Poeydomenge O., Boudet A.M., Grima-Pettenati J., Marolda M.
    Plant Physiol. 107:1455-1456(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiMDHM_EUCGU
AccessioniPrimary (citable) accession number: P46487
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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