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Protein

p-hydroxybenzoic acid efflux pump subunit AaeA

Gene

aaeA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Forms an efflux pump with AaeB.UniRule annotation1 Publication

GO - Molecular functioni

GO - Biological processi

  • carboxylic acid transport Source: EcoliWiki
  • transport Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7686-MONOMER.
ECOL316407:JW3210-MONOMER.
MetaCyc:G7686-MONOMER.

Protein family/group databases

TCDBi8.A.1.7.1. the membrane fusion protein (mfp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
p-hydroxybenzoic acid efflux pump subunit AaeAUniRule annotation
Short name:
pHBA efflux pump protein AUniRule annotation
Gene namesi
Name:aaeAUniRule annotation
Synonyms:yhcQ
Ordered Locus Names:b3241, JW3210
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12823. aaeA.

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310p-hydroxybenzoic acid efflux pump subunit AaeAPRO_0000201850Add
BLAST

Proteomic databases

PaxDbiP46482.
PRIDEiP46482.

Expressioni

Inductioni

Positively coregulated with aaeB and aaeX by AaeR.UniRule annotation1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262447. 214 interactions.
DIPiDIP-12289N.
IntActiP46482. 2 interactions.
MINTiMINT-1252694.
STRINGi511145.b3241.

Structurei

3D structure databases

ProteinModelPortaliP46482.
SMRiP46482. Positions 44-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105Y49. Bacteria.
COG1566. LUCA.
HOGENOMiHOG000112073.
InParanoidiP46482.
KOiK15548.
OMAiRRENKRN.
PhylomeDBiP46482.

Family and domain databases

HAMAPiMF_01544. AaeA. 1 hit.
InterProiIPR022871. PHBA_efflux_pump_AaeA.
IPR006143. RND_pump_MFP.
[Graphical view]
TIGRFAMsiTIGR01730. RND_mfp. 1 hit.

Sequencei

Sequence statusi: Complete.

P46482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLIRKFSR TAITVVLVIL AFIAIFNAWV YYTESPWTRD ARFSADVVAI
60 70 80 90 100
APDVSGLITQ VNVHDNQLVK KGQILFTIDQ PRYQKALEEA QADVAYYQVL
110 120 130 140 150
AQEKRQEAGR RNRLGVQAMS REEIDQANNV LQTVLHQLAK AQATRDLAKL
160 170 180 190 200
DLERTVIRAP ADGWVTNLNV YTGEFITRGS TAVALVKQNS FYVLAYMEET
210 220 230 240 250
KLEGVRPGYR AEITPLGSNK VLKGTVDSVA AGVTNASSTR DDKGMATIDS
260 270 280 290 300
NLEWVRLAQR VPVRIRLDNQ QENIWPAGTT ATVVVTGKQD RDESQDSFFR
310
KMAHRLREFG
Length:310
Mass (Da):34,775
Last modified:November 1, 1995 - v1
Checksum:i6E0232D459DC2757
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58043.1.
U00096 Genomic DNA. Translation: AAC76273.1.
AP009048 Genomic DNA. Translation: BAE77284.1.
PIRiC65116.
RefSeqiNP_417708.1. NC_000913.3.
WP_000854021.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76273; AAC76273; b3241.
BAE77284; BAE77284; BAE77284.
GeneIDi947748.
KEGGiecj:JW3210.
eco:b3241.
PATRICi32121908. VBIEscCol129921_3338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58043.1.
U00096 Genomic DNA. Translation: AAC76273.1.
AP009048 Genomic DNA. Translation: BAE77284.1.
PIRiC65116.
RefSeqiNP_417708.1. NC_000913.3.
WP_000854021.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP46482.
SMRiP46482. Positions 44-239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262447. 214 interactions.
DIPiDIP-12289N.
IntActiP46482. 2 interactions.
MINTiMINT-1252694.
STRINGi511145.b3241.

Protein family/group databases

TCDBi8.A.1.7.1. the membrane fusion protein (mfp) family.

Proteomic databases

PaxDbiP46482.
PRIDEiP46482.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76273; AAC76273; b3241.
BAE77284; BAE77284; BAE77284.
GeneIDi947748.
KEGGiecj:JW3210.
eco:b3241.
PATRICi32121908. VBIEscCol129921_3338.

Organism-specific databases

EchoBASEiEB2674.
EcoGeneiEG12823. aaeA.

Phylogenomic databases

eggNOGiENOG4105Y49. Bacteria.
COG1566. LUCA.
HOGENOMiHOG000112073.
InParanoidiP46482.
KOiK15548.
OMAiRRENKRN.
PhylomeDBiP46482.

Enzyme and pathway databases

BioCyciEcoCyc:G7686-MONOMER.
ECOL316407:JW3210-MONOMER.
MetaCyc:G7686-MONOMER.

Miscellaneous databases

PROiP46482.

Family and domain databases

HAMAPiMF_01544. AaeA. 1 hit.
InterProiIPR022871. PHBA_efflux_pump_AaeA.
IPR006143. RND_pump_MFP.
[Graphical view]
TIGRFAMsiTIGR01730. RND_mfp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAAEA_ECOLI
AccessioniPrimary (citable) accession number: P46482
Secondary accession number(s): Q2M8X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.