Reviewed,
UniProtKB/Swiss-Prot P46481 (AAEB_ECOLI)
Last modified
June 16, 2009.
Version 64.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: p-hydroxybenzoic acid efflux pump subunit aaeB Short name=pHBA efflux pump protein B | ||||||
| Gene names |
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| Organism | Escherichia coli (strain K12) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 83333 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 655 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Ref.3 |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. HAMAP MF_01545 |
| Induction | Positively coregulated with aaeA and aaeX by aaeR. HAMAP MF_01545 |
| Miscellaneous | Both aaeB and aaeA are required for the function of the efflux system. HAMAP MF_01545 |
| Sequence similarities | Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family. [View classification] |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transport |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | transport Inferred from electronic annotation. Source: HAMAP |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 655 | 655 | p-hydroxybenzoic acid efflux pump subunit aaeB HAMAP MF_01545 | PRO_0000210077 | |||||
Regions | |||||||||
| Topological domain | 1 – 12 | 12 | Periplasmic Potential | ||||||
| Transmembrane | 13 – 33 | 21 | Potential | ||||||
| Topological domain | 34 – 37 | 4 | Cytoplasmic Potential | ||||||
| Transmembrane | 38 – 58 | 21 | Potential | ||||||
| Topological domain | 59 – 68 | 10 | Periplasmic Potential | ||||||
| Transmembrane | 69 – 89 | 21 | Potential | ||||||
| Topological domain | 90 – 92 | 3 | Cytoplasmic Potential | ||||||
| Transmembrane | 93 – 113 | 21 | Potential | ||||||
| Topological domain | 114 – 120 | 7 | Periplasmic Potential | ||||||
| Transmembrane | 121 – 141 | 21 | Potential | ||||||
| Topological domain | 142 – 151 | 10 | Cytoplasmic Potential | ||||||
| Transmembrane | 152 – 172 | 21 | Potential | ||||||
| Topological domain | 173 – 369 | 197 | Periplasmic Potential | ||||||
| Transmembrane | 370 – 390 | 21 | Potential | ||||||
| Topological domain | 391 – 406 | 16 | Cytoplasmic Potential | ||||||
| Transmembrane | 407 – 427 | 21 | Potential | ||||||
| Topological domain | 428 – 430 | 3 | Periplasmic Potential | ||||||
| Transmembrane | 431 – 451 | 21 | Potential | ||||||
| Topological domain | 452 – 458 | 7 | Cytoplasmic Potential | ||||||
| Transmembrane | 459 – 479 | 21 | Potential | ||||||
| Topological domain | 480 – 481 | 2 | Periplasmic Potential | ||||||
| Transmembrane | 482 – 502 | 21 | Potential | ||||||
| Topological domain | 503 – 655 | 153 | Cytoplasmic Potential | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| U18997 Genomic DNA. Translation: AAA58042.1. U00096 Genomic DNA. Translation: AAC76272.1. AP009048 Genomic DNA. Translation: BAE77283.1. | |
| PIR | B65116. |
| RefSeq | AP_003782.1. NP_417707.1. |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| TCDB | 2.A.85.1.2. aromatic acid exporter (ArAE) family. |
Genome annotation databases | |
| GeneID | 947747. |
| GenomeReviews | Gene locus JW3209 in contig AP009048_GR. Gene locus b3240 in contig U00096_GR. |
| KEGG | ecj:JW3209. eco:b3240. |
Organism-specific databases | |
| EchoBASE | EB2673. |
| EcoGene | EG12822. aaeB. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P46481. |
| OMA | P46481. APQFAVE. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:G7685-MON. |
Family and domain databases | |
| HAMAP | MF_01545. [Tree] |
| InterPro | IPR006726. Fusaric_acid-R. [Graphical view] |
| Pfam | PF04632. FUSC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AAEB_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P46481 Secondary accession number(s): Q2M8X3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| SIMILARITY comments Index of protein domains and families |

Clusters with


