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Protein

p-hydroxybenzoic acid efflux pump subunit AaeB

Gene

aaeB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate.UniRule annotation1 Publication

GO - Biological processi

  • carboxylic acid transport Source: EcoliWiki
  • transport Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7685-MONOMER.
ECOL316407:JW3209-MONOMER.
MetaCyc:G7685-MONOMER.

Protein family/group databases

TCDBi2.A.85.1.2. the aromatic acid exporter (arae) family.

Names & Taxonomyi

Protein namesi
Recommended name:
p-hydroxybenzoic acid efflux pump subunit AaeBUniRule annotation
Short name:
pHBA efflux pump protein BUniRule annotation
Gene namesi
Name:aaeBUniRule annotation
Synonyms:yhcP
Ordered Locus Names:b3240, JW3209
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12822. aaeB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12PeriplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Topological domaini34 – 37CytoplasmicSequence analysis4
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21
Topological domaini59 – 68PeriplasmicSequence analysis10
Transmembranei69 – 89HelicalUniRule annotationAdd BLAST21
Topological domaini90 – 92CytoplasmicSequence analysis3
Transmembranei93 – 113HelicalUniRule annotationAdd BLAST21
Topological domaini114 – 120PeriplasmicSequence analysis7
Transmembranei121 – 141HelicalUniRule annotationAdd BLAST21
Topological domaini142 – 151CytoplasmicSequence analysis10
Transmembranei152 – 172HelicalUniRule annotationAdd BLAST21
Topological domaini173 – 369PeriplasmicSequence analysisAdd BLAST197
Transmembranei370 – 390HelicalUniRule annotationAdd BLAST21
Topological domaini391 – 406CytoplasmicSequence analysisAdd BLAST16
Transmembranei407 – 427HelicalUniRule annotationAdd BLAST21
Topological domaini428 – 430PeriplasmicSequence analysis3
Transmembranei431 – 451HelicalUniRule annotationAdd BLAST21
Topological domaini452 – 458CytoplasmicSequence analysis7
Transmembranei459 – 479HelicalUniRule annotationAdd BLAST21
Topological domaini480 – 481PeriplasmicSequence analysis2
Transmembranei482 – 502HelicalUniRule annotationAdd BLAST21
Topological domaini503 – 655CytoplasmicSequence analysisAdd BLAST153

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002100771 – 655p-hydroxybenzoic acid efflux pump subunit AaeBAdd BLAST655

Proteomic databases

PaxDbiP46481.
PRIDEiP46481.

Expressioni

Inductioni

Positively coregulated with aaeA and aaeX by AaeR.UniRule annotation1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4263393. 383 interactors.
IntActiP46481. 2 interactors.
STRINGi511145.b3240.

Structurei

3D structure databases

ProteinModelPortaliP46481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107Z11. Bacteria.
COG1289. LUCA.
HOGENOMiHOG000268026.
InParanoidiP46481.
KOiK03468.
OMAiMMAKDFL.
PhylomeDBiP46481.

Family and domain databases

HAMAPiMF_01545. AaeB. 1 hit.
InterProiIPR006726. PHBA_efflux_AaeB/fusaric-R.
IPR023706. PHBA_efflux_pump_AaeB.
[Graphical view]
PANTHERiPTHR30509:SF10. PTHR30509:SF10. 2 hits.
PfamiPF04632. FUSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIFSIANQH IRFAVKLATA IVLALFVGFH FQLETPRWAV LTAAIVAAGT
60 70 80 90 100
AFAAGGEPYS GAIRYRGFLR IIGTFIGCIA GLVIIIAMIR APLLMILVCC
110 120 130 140 150
IWAGFCTWIS SLVRIENSYA WGLAGYTALI IVITIQPEPL LTPQFAVERC
160 170 180 190 200
SEIVIGIVCA IMADLLFSPR SIKQEVDREL ESLLVAQYQL MQLCIKHGDG
210 220 230 240 250
EVVDKAWGDL VRRTTALQGM RSNLNMESSR WARANRRLKA INTLSLTLIT
260 270 280 290 300
QSCETYLIQN TRPELITDTF REFFDTPVET AQDVHKQLKR LRRVIAWTGE
310 320 330 340 350
RETPVTIYSW VAAATRYQLL KRGVISNTKI NATEEEILQG EPEVKVESAE
360 370 380 390 400
RHHAMVNFWR TTLSCILGTL FWLWTGWTSG SGAMVMIAVV TSLAMRLPNP
410 420 430 440 450
RMVAIDFIYG TLAALPLGLL YFLVIIPNTQ QSMLLLCISL AVLGFFLGIE
460 470 480 490 500
VQKRRLGSMG ALASTINIIV LDNPMTFHFS QFLDSALGQI VGCVLAFTVI
510 520 530 540 550
LLVRDKSRDR TGRVLLNQFV SAAVSAMTTN VARRKENHLP ALYQQLFLLM
560 570 580 590 600
NKFPGDLPKF RLALTMIIAH QRLRDAPIPV NEDLSAFHRQ MRRTADHVIS
610 620 630 640 650
ARSDDKRRRY FGQLLEELEI YQEKLRIWQA PPQVTEPVNR LAGMLHKYQH

ALTDS
Length:655
Mass (Da):73,591
Last modified:November 1, 1995 - v1
Checksum:i6C559FC19C276656
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58042.1.
U00096 Genomic DNA. Translation: AAC76272.1.
AP009048 Genomic DNA. Translation: BAE77283.1.
PIRiB65116.
RefSeqiNP_417707.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC76272; AAC76272; b3240.
BAE77283; BAE77283; BAE77283.
GeneIDi947747.
KEGGiecj:JW3209.
eco:b3240.
PATRICi32121906. VBIEscCol129921_3337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58042.1.
U00096 Genomic DNA. Translation: AAC76272.1.
AP009048 Genomic DNA. Translation: BAE77283.1.
PIRiB65116.
RefSeqiNP_417707.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP46481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263393. 383 interactors.
IntActiP46481. 2 interactors.
STRINGi511145.b3240.

Protein family/group databases

TCDBi2.A.85.1.2. the aromatic acid exporter (arae) family.

Proteomic databases

PaxDbiP46481.
PRIDEiP46481.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76272; AAC76272; b3240.
BAE77283; BAE77283; BAE77283.
GeneIDi947747.
KEGGiecj:JW3209.
eco:b3240.
PATRICi32121906. VBIEscCol129921_3337.

Organism-specific databases

EchoBASEiEB2673.
EcoGeneiEG12822. aaeB.

Phylogenomic databases

eggNOGiENOG4107Z11. Bacteria.
COG1289. LUCA.
HOGENOMiHOG000268026.
InParanoidiP46481.
KOiK03468.
OMAiMMAKDFL.
PhylomeDBiP46481.

Enzyme and pathway databases

BioCyciEcoCyc:G7685-MONOMER.
ECOL316407:JW3209-MONOMER.
MetaCyc:G7685-MONOMER.

Miscellaneous databases

PROiP46481.

Family and domain databases

HAMAPiMF_01545. AaeB. 1 hit.
InterProiIPR006726. PHBA_efflux_AaeB/fusaric-R.
IPR023706. PHBA_efflux_pump_AaeB.
[Graphical view]
PANTHERiPTHR30509:SF10. PTHR30509:SF10. 2 hits.
PfamiPF04632. FUSC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAEB_ECOLI
AccessioniPrimary (citable) accession number: P46481
Secondary accession number(s): Q2M8X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.