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Protein

Glucose-6-phosphate isomerase

Gene

PGI

Organism
Calanus finmarchicus (Calanus tonsus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.PROSITE-ProRule annotation

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.PROSITE-ProRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (PGI)
  3. ATP-dependent 6-phosphofructokinase (PFK)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei146 – 1461Proton donorPROSITE-ProRule annotation
Active sitei177 – 1771PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PGI
OrganismiCalanus finmarchicus (Calanus tonsus)
Taxonomic identifieri6837 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMaxillopodaCopepodaCalanoidaCalanidaeCalanus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›304›304Glucose-6-phosphate isomerasePRO_0000180542Add
BLAST

Proteomic databases

PRIDEiP46479.

Structurei

3D structure databases

ProteinModelPortaliP46479.
SMRiP46479. Positions 1-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P46479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FTTQETITNA NTAKQWFLKS AKDSKFVANH FVALSTNAKL VQEFGIDKAN
60 70 80 90 100
MFEFWDWVGG RYSLWSAIGM SIALNIGFEN FEHLLSGAHW MDNHFKSTPI
110 120 130 140 150
ERNIPVILAV LGIWYGNFYG AETQALLPYD QYMHRFAAYF QQGDMESNGK
160 170 180 190 200
YVVRAGDKVN YSTGPIVWGE PGTNGQHAFY QLIHQVPHHP CDFNSPVKSH
210 220 230 240 250
NSELRDGLHH TILLSNFLAQ TEALMKGKDR QTVEKELKAA GKSEDEIKSI
260 270 280 290 300
GPHKEFTGNR PTNSIMVDTV TPFTLGAMIA MYEHKIFTQG IIWDINSYDQ

WGVE
Length:304
Mass (Da):34,460
Last modified:November 1, 1995 - v1
Checksum:i520F95811054FCF7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei304 – 3041

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21239 mRNA. Translation: AAA85286.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21239 mRNA. Translation: AAA85286.1.

3D structure databases

ProteinModelPortaliP46479.
SMRiP46479. Positions 1-304.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP46479.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nuclear genes from the copepod Calanus finmarchicus."
    Crawford D.L.
    Mol. Mar. Biol. Biotechnol. 4:241-247(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiG6PI_CALFI
AccessioniPrimary (citable) accession number: P46479
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.