P46478 (AAEX_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein AaeX

Gene names

Name:	aaeX
Synonyms:	yhcR
Ordered Locus Names:	b3242, JW5541

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	67 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Potential HAMAP MF_01546.
Induction	Positively coregulated with aaeA and aaeB by AaeR. Ref.3
Sequence similarities	Belongs to the AaeX family.
Sequence caution	The sequence AAA58044.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 67	67	Protein AaeX HAMAP MF_01546		PRO_0000215048
Regions
	Transmembrane	3 – 23	21	Helical; Potential
	Transmembrane	43 – 63	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P46478 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: FE90E26EC56C9183	FASTA	67	7,847
	10 20 30 40 50 60 MSLFPVIVVF GLSFPPIFFE LLLSLAIFWL VRRVLVPTGI YDFVWHPALF NTALYCCLFY LISRLFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve?" Van Dyk T.K., Templeton L.J., Cantera K.A., Sharpe P.L., Sariaslani F.S. J. Bacteriol. 186:7196-7204(2004) [PubMed: 15489430] [Abstract] Cited for: REGULATION. Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18997 Genomic DNA. Translation: AAA58044.1. Different initiation. U00096 Genomic DNA. Translation: AAC76274.2. AP009048 Genomic DNA. Translation: BAE77285.1.
PIR	D65116.
RefSeq	NP_417709.2. NC_000913.2.
3D structure databases
ProteinModelPortal	P46478.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000000600; EBESCP00000000600; EBESCG00000000501. EBESCT00000017833; EBESCP00000017124; EBESCG00000016889.
GeneID	947751.
GenomeReviews	Gene locus JW5541 in contig AP009048_GR. Gene locus b3242 in contig U00096_GR.
KEGG	ecj:JW5541. eco:b3242.
PATRIC	32121910. VBIEscCol129921_3339.
Organism-specific databases
EchoBASE	EB2675.
EcoGene	EG12824. aaeX.
Phylogenomic databases
eggNOG	NOG06923.
GeneTree	EBGT00050000008993.
HOGENOM	HBG468898.
OMA	FCCLFYL.
ProtClustDB	PRK11594.
Enzyme and pathway databases
BioCyc	EcoCyc:G7687-MONOMER.
Gene expression databases
Genevestigator	P46478.
Family and domain databases
HAMAP	MF_01546. AaeX. [Tree]
InterPro	IPR012451. DUF1656. [Graphical view]
Pfam	PF07869. DUF1656. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AAEX_ECOLI

Accession

Primary (citable) accession number: P46478
Secondary accession number(s): Q2M8X1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	December 6, 2005
Last modified:	January 25, 2012
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program