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Protein

Protein AaeX

Gene

aaeX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:G7687-MONOMER.
ECOL316407:JW5541-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AaeXUniRule annotation
Gene namesi
Name:aaeXUniRule annotation
Synonyms:yhcR
Ordered Locus Names:b3242, JW5541
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12824. aaeX.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalUniRule annotationAdd
BLAST
Transmembranei43 – 6321HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6767Protein AaeXPRO_0000215048Add
BLAST

Proteomic databases

PaxDbiP46478.

Expressioni

Inductioni

Positively coregulated with aaeA and aaeB by AaeR.UniRule annotation1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262440. 13 interactions.
STRINGi511145.b3242.

Structurei

3D structure databases

ProteinModelPortaliP46478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AaeX family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000259373.
OMAiIYDLVWH.
OrthoDBiEOG65F8ZR.

Family and domain databases

HAMAPiMF_01546. AaeX.
InterProiIPR012451. DUF1656.
[Graphical view]
PfamiPF07869. DUF1656. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFPVIVVF GLSFPPIFFE LLLSLAIFWL VRRVLVPTGI YDFVWHPALF
60
NTALYCCLFY LISRLFV
Length:67
Mass (Da):7,847
Last modified:December 6, 2005 - v2
Checksum:iFE90E26EC56C9183
GO

Sequence cautioni

The sequence AAA58044.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58044.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76274.2.
AP009048 Genomic DNA. Translation: BAE77285.1.
PIRiD65116.
RefSeqiNP_417709.2. NC_000913.3.
WP_000051841.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76274; AAC76274; b3242.
BAE77285; BAE77285; BAE77285.
GeneIDi947751.
KEGGiecj:JW5541.
eco:b3242.
PATRICi32121910. VBIEscCol129921_3339.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58044.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76274.2.
AP009048 Genomic DNA. Translation: BAE77285.1.
PIRiD65116.
RefSeqiNP_417709.2. NC_000913.3.
WP_000051841.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP46478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262440. 13 interactions.
STRINGi511145.b3242.

Proteomic databases

PaxDbiP46478.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76274; AAC76274; b3242.
BAE77285; BAE77285; BAE77285.
GeneIDi947751.
KEGGiecj:JW5541.
eco:b3242.
PATRICi32121910. VBIEscCol129921_3339.

Organism-specific databases

EchoBASEiEB2675.
EcoGeneiEG12824. aaeX.

Phylogenomic databases

HOGENOMiHOG000259373.
OMAiIYDLVWH.
OrthoDBiEOG65F8ZR.

Enzyme and pathway databases

BioCyciEcoCyc:G7687-MONOMER.
ECOL316407:JW5541-MONOMER.

Miscellaneous databases

PROiP46478.

Family and domain databases

HAMAPiMF_01546. AaeX.
InterProiIPR012451. DUF1656.
[Graphical view]
PfamiPF07869. DUF1656. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve?"
    Van Dyk T.K., Templeton L.J., Cantera K.A., Sharpe P.L., Sariaslani F.S.
    J. Bacteriol. 186:7196-7204(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiAAEX_ECOLI
AccessioniPrimary (citable) accession number: P46478
Secondary accession number(s): Q2M8X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 6, 2005
Last modified: January 20, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.