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P46459

- NSF_HUMAN

UniProt

P46459 - NSF_HUMAN

Protein

Vesicle-fusing ATPase

Gene

NSF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 3 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi550 – 5501MagnesiumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi505 – 5106ATPBy similarity
    Nucleotide bindingi545 – 5528ATPBy similarity

    GO - Molecular functioni

    1. ATPase activity, coupled Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. PDZ domain binding Source: UniProtKB
    5. protein binding Source: UniProtKB
    6. protein complex binding Source: UniProtKB
    7. protein kinase binding Source: ParkinsonsUK-UCL
    8. syntaxin-1 binding Source: ParkinsonsUK-UCL

    GO - Biological processi

    1. exocytosis Source: UniProtKB
    2. plasma membrane fusion Source: UniProtKB
    3. positive regulation of receptor recycling Source: UniProtKB
    4. potassium ion transport Source: Ensembl
    5. protein transport Source: UniProtKB-KW
    6. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_18422. Trafficking of GluR2-containing AMPA receptors.

    Protein family/group databases

    TCDBi1.F.1.1.1. the synaptosomal vesicle fusion pore (svf-pore) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicle-fusing ATPase (EC:3.6.4.6)
    Alternative name(s):
    N-ethylmaleimide-sensitive fusion protein
    Short name:
    NEM-sensitive fusion protein
    Vesicular-fusion protein NSF
    Gene namesi
    Name:NSF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:8016. NSF.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. extracellular vesicular exosome Source: UniProt
    4. lysosomal membrane Source: UniProtKB
    5. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31793.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 744744Vesicle-fusing ATPasePRO_0000084563Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei105 – 1051N6-acetyllysineBy similarity
    Modified residuei259 – 2591PhosphotyrosineBy similarity
    Modified residuei569 – 5691Phosphoserine; by CDK16By similarity

    Post-translational modificationi

    Phosphorylation at Ser-569 interferes with homohexamerization.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP46459.
    PaxDbiP46459.
    PRIDEiP46459.

    2D gel databases

    UCD-2DPAGEP46459.

    PTM databases

    PhosphoSiteiP46459.

    Miscellaneous databases

    PMAP-CutDBP46459.

    Expressioni

    Gene expression databases

    ArrayExpressiP46459.
    BgeeiP46459.
    CleanExiHS_NSF.
    GenevestigatoriP46459.

    Organism-specific databases

    HPAiCAB009324.
    CAB013645.
    HPA003154.

    Interactioni

    Subunit structurei

    Homohexamer. Interacts with GABARAP and GABARAPL2. Interacts with GRIA2. Interacts with PLK2, leading to disrupt the interaction with GRIA2. Interacts with MUSK; may regulate MUSK endocytosis and activity By similarity. Interacts with CDK16 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GABBR1Q9UBS53EBI-712251,EBI-724156
    GABBR2O758994EBI-712251,EBI-715469
    GRIA2P422622EBI-712251,EBI-3909876
    NAPAP549202EBI-712251,EBI-749652
    PTPN9P433782EBI-712251,EBI-742898

    Protein-protein interaction databases

    BioGridi110960. 38 interactions.
    DIPiDIP-389N.
    IntActiP46459. 37 interactions.
    MINTiMINT-1369243.
    STRINGi9606.ENSP00000381293.

    Structurei

    3D structure databases

    ProteinModelPortaliP46459.
    SMRiP46459. Positions 1-201, 220-742.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0464.
    HOGENOMiHOG000198544.
    HOVERGENiHBG000324.
    InParanoidiP46459.
    KOiK06027.
    OMAiFKDKERS.
    OrthoDBiEOG7P8P7F.
    PhylomeDBiP46459.
    TreeFamiTF300371.

    Family and domain databases

    Gene3Di3.10.330.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR009010. Asp_de-COase-like_dom.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR004201. Cdc48_dom2.
    IPR029067. CDC48_domain_2-like.
    IPR003338. CDC4_N-term_subdom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 2 hits.
    PF02933. CDC48_2. 1 hit.
    PF02359. CDC48_N. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    SM01072. CDC48_2. 1 hit.
    SM01073. CDC48_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF54585. SSF54585. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P46459-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGRSMQAAR CPTDELSLTN CAVVNEKDFQ SGQHVIVRTS PNHRYTFTLK    50
    THPSVVPGSI AFSLPQRKWA GLSIGQEIEV SLYTFDKAKQ CIGTMTIEID 100
    FLQKKSIDSN PYDTDKMAAE FIQQFNNQAF SVGQQLVFSF NEKLFGLLVK 150
    DIEAMDPSIL KGEPATGKRQ KIEVGLVVGN SQVAFEKAEN SSLNLIGKAK 200
    TKENRQSIIN PDWNFEKMGI GGLDKEFSDI FRRAFASRVF PPEIVEQMGC 250
    KHVKGILLYG PPGCGKTLLA RQIGKMLNAR EPKVVNGPEI LNKYVGESEA 300
    NIRKLFADAE EEQRRLGANS GLHIIIFDEI DAICKQRGSM AGSTGVHDTV 350
    VNQLLSKIDG VEQLNNILVI GMTNRPDLID EALLRPGRLE VKMEIGLPDE 400
    KGRLQILHIH TARMRGHQLL SADVDIKELA VETKNFSGAE LEGLVRAAQS 450
    TAMNRHIKAS TKVEVDMEKA ESLQVTRGDF LASLENDIKP AFGTNQEDYA 500
    SYIMNGIIKW GDPVTRVLDD GELLVQQTKN SDRTPLVSVL LEGPPHSGKT 550
    ALAAKIAEES NFPFIKICSP DKMIGFSETA KCQAMKKIFD DAYKSQLSCV 600
    VVDDIERLLD YVPIGPRFSN LVLQALLVLL KKAPPQGRKL LIIGTTSRKD 650
    VLQEMEMLNA FSTTIHVPNI ATGEQLLEAL ELLGNFKDKE RTTIAQQVKG 700
    KKVWIGIKKL LMLIEMSLQM DPEYRVRKFL ALLREEGASP LDFD 744
    Length:744
    Mass (Da):82,594
    Last modified:September 1, 2009 - v3
    Checksum:iBF545A2A0C7EC2F7
    GO
    Isoform 2 (identifier: P46459-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-94: Missing.
         739-744: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:644
    Mass (Da):71,584
    Checksum:iACC3C42259713D42
    GO

    Sequence cautioni

    The sequence AAA17411.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221A → S in AAA17411. 1 PublicationCurated
    Sequence conflicti22 – 221A → S in AAF70545. 1 PublicationCurated
    Sequence conflicti25 – 251N → S in BAF82893. (PubMed:14702039)Curated
    Sequence conflicti107 – 1071I → N in AAA17411. 1 PublicationCurated
    Sequence conflicti107 – 1071I → N in AAF70545. 1 PublicationCurated
    Sequence conflicti107 – 1071I → N in AAF04745. 1 PublicationCurated
    Sequence conflicti130 – 1301F → Y in AAA17411. 1 PublicationCurated
    Sequence conflicti130 – 1301F → Y in AAF70545. 1 PublicationCurated
    Sequence conflicti130 – 1301F → Y in AAF04745. 1 PublicationCurated
    Sequence conflicti154 – 1541A → S in AAA17411. 1 PublicationCurated
    Sequence conflicti154 – 1541A → S in AAF70545. 1 PublicationCurated
    Sequence conflicti154 – 1541A → S in AAF04745. 1 PublicationCurated
    Sequence conflicti237 – 2371S → F in AAA17411. 1 PublicationCurated
    Sequence conflicti237 – 2371S → F in AAF70545. 1 PublicationCurated
    Sequence conflicti237 – 2371S → F in AAF04745. 1 PublicationCurated
    Sequence conflicti251 – 2511K → I in AAA17411. 1 PublicationCurated
    Sequence conflicti251 – 2511K → I in AAF70545. 1 PublicationCurated
    Sequence conflicti251 – 2511K → I in AAF04745. 1 PublicationCurated
    Sequence conflicti427 – 4271K → R in BAF82893. (PubMed:14702039)Curated
    Sequence conflicti571 – 5711D → E in AAF04745. 1 PublicationCurated
    Sequence conflicti639 – 6391K → M in BAF82893. (PubMed:14702039)Curated
    Sequence conflicti686 – 6861F → L in AAA17411. 1 PublicationCurated
    Sequence conflicti686 – 6861F → L in AAF70545. 1 PublicationCurated
    Sequence conflicti686 – 6861F → L in AAF04745. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti476 – 4761T → M.
    Corresponds to variant rs155733 [ dbSNP | Ensembl ].
    VAR_029580

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9494Missing in isoform 2. 1 PublicationVSP_056420Add
    BLAST
    Alternative sequencei739 – 7446Missing in isoform 2. 1 PublicationVSP_056421

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03985 mRNA. Translation: AAA17411.1. Different initiation.
    AF135168 mRNA. Translation: AAF70545.1.
    AF102846 mRNA. Translation: AAF04745.2.
    AK290204 mRNA. Translation: BAF82893.1.
    AK294001 mRNA. Translation: BAG57363.1.
    AC004098 Genomic DNA. No translation available.
    AC138645 Genomic DNA. No translation available.
    AC138688 Genomic DNA. No translation available.
    AC217769 Genomic DNA. No translation available.
    AC217778 Genomic DNA. No translation available.
    AC217780 Genomic DNA. No translation available.
    BC030613 mRNA. Translation: AAH30613.1.
    CCDSiCCDS42354.1.
    PIRiG01234.
    RefSeqiNP_006169.2. NM_006178.3.
    UniGeneiHs.431279.

    Genome annotation databases

    EnsembliENST00000225282; ENSP00000225282; ENSG00000073969.
    ENST00000398238; ENSP00000381293; ENSG00000073969.
    GeneIDi4905.
    KEGGihsa:4905.
    UCSCiuc002iku.3. human.

    Polymorphism databases

    DMDMi257051048.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03985 mRNA. Translation: AAA17411.1 . Different initiation.
    AF135168 mRNA. Translation: AAF70545.1 .
    AF102846 mRNA. Translation: AAF04745.2 .
    AK290204 mRNA. Translation: BAF82893.1 .
    AK294001 mRNA. Translation: BAG57363.1 .
    AC004098 Genomic DNA. No translation available.
    AC138645 Genomic DNA. No translation available.
    AC138688 Genomic DNA. No translation available.
    AC217769 Genomic DNA. No translation available.
    AC217778 Genomic DNA. No translation available.
    AC217780 Genomic DNA. No translation available.
    BC030613 mRNA. Translation: AAH30613.1 .
    CCDSi CCDS42354.1.
    PIRi G01234.
    RefSeqi NP_006169.2. NM_006178.3.
    UniGenei Hs.431279.

    3D structure databases

    ProteinModelPortali P46459.
    SMRi P46459. Positions 1-201, 220-742.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110960. 38 interactions.
    DIPi DIP-389N.
    IntActi P46459. 37 interactions.
    MINTi MINT-1369243.
    STRINGi 9606.ENSP00000381293.

    Chemistry

    ChEMBLi CHEMBL2311231.

    Protein family/group databases

    TCDBi 1.F.1.1.1. the synaptosomal vesicle fusion pore (svf-pore) family.

    PTM databases

    PhosphoSitei P46459.

    Polymorphism databases

    DMDMi 257051048.

    2D gel databases

    UCD-2DPAGE P46459.

    Proteomic databases

    MaxQBi P46459.
    PaxDbi P46459.
    PRIDEi P46459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225282 ; ENSP00000225282 ; ENSG00000073969 .
    ENST00000398238 ; ENSP00000381293 ; ENSG00000073969 .
    GeneIDi 4905.
    KEGGi hsa:4905.
    UCSCi uc002iku.3. human.

    Organism-specific databases

    CTDi 4905.
    GeneCardsi GC17P044668.
    H-InvDB HIX0013914.
    HIX0013915.
    HGNCi HGNC:8016. NSF.
    HPAi CAB009324.
    CAB013645.
    HPA003154.
    MIMi 601633. gene.
    neXtProti NX_P46459.
    PharmGKBi PA31793.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0464.
    HOGENOMi HOG000198544.
    HOVERGENi HBG000324.
    InParanoidi P46459.
    KOi K06027.
    OMAi FKDKERS.
    OrthoDBi EOG7P8P7F.
    PhylomeDBi P46459.
    TreeFami TF300371.

    Enzyme and pathway databases

    Reactomei REACT_18422. Trafficking of GluR2-containing AMPA receptors.

    Miscellaneous databases

    ChiTaRSi NSF. human.
    GeneWikii N-ethylmaleimide_sensitive_fusion_protein.
    GenomeRNAii 4905.
    NextBioi 18875.
    PMAP-CutDB P46459.
    PROi P46459.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P46459.
    Bgeei P46459.
    CleanExi HS_NSF.
    Genevestigatori P46459.

    Family and domain databases

    Gene3Di 3.10.330.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR009010. Asp_de-COase-like_dom.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR004201. Cdc48_dom2.
    IPR029067. CDC48_domain_2-like.
    IPR003338. CDC4_N-term_subdom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 2 hits.
    PF02933. CDC48_2. 1 hit.
    PF02359. CDC48_N. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    SM01072. CDC48_2. 1 hit.
    SM01073. CDC48_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF54585. SSF54585. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and localization of a brain N-ethylmaleimide-sensitive factor involved in vesicular transport."
      Hong R., Moriyama Y., Mori H., Futai M., Yamamoto A., Tashiro Y., Fukui T., Tagaya M.
      Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. Bui T.D., Lu L., Hong W.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The regulation of hNSF gene expression."
      Zhang R., Liu Z., Wu M.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cerebellum and Thalamus.
    5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNSF_HUMAN
    AccessioniPrimary (citable) accession number: P46459
    Secondary accession number(s): A8K2D9
    , B4DFA2, Q8N6D7, Q9UKZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 145 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3