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P46459

- NSF_HUMAN

UniProt

P46459 - NSF_HUMAN

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Protein

Vesicle-fusing ATPase

Gene

NSF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Cofactori

Binds 1 magnesium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi550 – 5501MagnesiumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi505 – 5106ATPBy similarity
Nucleotide bindingi545 – 5528ATPBy similarity

GO - Molecular functioni

  1. ATPase activity, coupled Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. PDZ domain binding Source: UniProtKB
  5. protein complex binding Source: UniProtKB
  6. protein kinase binding Source: ParkinsonsUK-UCL
  7. syntaxin-1 binding Source: ParkinsonsUK-UCL

GO - Biological processi

  1. exocytosis Source: UniProtKB
  2. plasma membrane fusion Source: UniProtKB
  3. positive regulation of receptor recycling Source: UniProtKB
  4. potassium ion transport Source: Ensembl
  5. protein transport Source: UniProtKB-KW
  6. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_18422. Trafficking of GluR2-containing AMPA receptors.

Protein family/group databases

TCDBi1.F.1.1.1. the synaptosomal vesicle fusion pore (svf-pore) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-fusing ATPase (EC:3.6.4.6)
Alternative name(s):
N-ethylmaleimide-sensitive fusion protein
Short name:
NEM-sensitive fusion protein
Vesicular-fusion protein NSF
Gene namesi
Name:NSF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:8016. NSF.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: UniProt
  4. lysosomal membrane Source: UniProtKB
  5. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31793.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744Vesicle-fusing ATPasePRO_0000084563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051N6-acetyllysineBy similarity
Modified residuei259 – 2591PhosphotyrosineBy similarity
Modified residuei569 – 5691Phosphoserine; by CDK16By similarity

Post-translational modificationi

Phosphorylation at Ser-569 interferes with homohexamerization.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP46459.
PaxDbiP46459.
PRIDEiP46459.

2D gel databases

UCD-2DPAGEP46459.

PTM databases

PhosphoSiteiP46459.

Miscellaneous databases

PMAP-CutDBP46459.

Expressioni

Gene expression databases

BgeeiP46459.
CleanExiHS_NSF.
ExpressionAtlasiP46459. baseline and differential.
GenevestigatoriP46459.

Organism-specific databases

HPAiCAB009324.
CAB013645.
HPA003154.

Interactioni

Subunit structurei

Homohexamer. Interacts with GABARAP and GABARAPL2. Interacts with GRIA2. Interacts with PLK2, leading to disrupt the interaction with GRIA2. Interacts with MUSK; may regulate MUSK endocytosis and activity (By similarity). Interacts with CDK16 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GABBR1Q9UBS53EBI-712251,EBI-724156
GABBR2O758994EBI-712251,EBI-715469
GRIA2P422622EBI-712251,EBI-3909876
NAPAP549202EBI-712251,EBI-749652
PTPN9P433782EBI-712251,EBI-742898

Protein-protein interaction databases

BioGridi110960. 40 interactions.
DIPiDIP-389N.
IntActiP46459. 37 interactions.
MINTiMINT-1369243.
STRINGi9606.ENSP00000381293.

Structurei

3D structure databases

ProteinModelPortaliP46459.
SMRiP46459. Positions 1-201, 220-742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0464.
GeneTreeiENSGT00530000064085.
HOGENOMiHOG000198544.
HOVERGENiHBG000324.
InParanoidiP46459.
KOiK06027.
OMAiFKDKERS.
OrthoDBiEOG7P8P7F.
PhylomeDBiP46459.
TreeFamiTF300371.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P46459-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRSMQAAR CPTDELSLTN CAVVNEKDFQ SGQHVIVRTS PNHRYTFTLK
60 70 80 90 100
THPSVVPGSI AFSLPQRKWA GLSIGQEIEV SLYTFDKAKQ CIGTMTIEID
110 120 130 140 150
FLQKKSIDSN PYDTDKMAAE FIQQFNNQAF SVGQQLVFSF NEKLFGLLVK
160 170 180 190 200
DIEAMDPSIL KGEPATGKRQ KIEVGLVVGN SQVAFEKAEN SSLNLIGKAK
210 220 230 240 250
TKENRQSIIN PDWNFEKMGI GGLDKEFSDI FRRAFASRVF PPEIVEQMGC
260 270 280 290 300
KHVKGILLYG PPGCGKTLLA RQIGKMLNAR EPKVVNGPEI LNKYVGESEA
310 320 330 340 350
NIRKLFADAE EEQRRLGANS GLHIIIFDEI DAICKQRGSM AGSTGVHDTV
360 370 380 390 400
VNQLLSKIDG VEQLNNILVI GMTNRPDLID EALLRPGRLE VKMEIGLPDE
410 420 430 440 450
KGRLQILHIH TARMRGHQLL SADVDIKELA VETKNFSGAE LEGLVRAAQS
460 470 480 490 500
TAMNRHIKAS TKVEVDMEKA ESLQVTRGDF LASLENDIKP AFGTNQEDYA
510 520 530 540 550
SYIMNGIIKW GDPVTRVLDD GELLVQQTKN SDRTPLVSVL LEGPPHSGKT
560 570 580 590 600
ALAAKIAEES NFPFIKICSP DKMIGFSETA KCQAMKKIFD DAYKSQLSCV
610 620 630 640 650
VVDDIERLLD YVPIGPRFSN LVLQALLVLL KKAPPQGRKL LIIGTTSRKD
660 670 680 690 700
VLQEMEMLNA FSTTIHVPNI ATGEQLLEAL ELLGNFKDKE RTTIAQQVKG
710 720 730 740
KKVWIGIKKL LMLIEMSLQM DPEYRVRKFL ALLREEGASP LDFD
Length:744
Mass (Da):82,594
Last modified:September 1, 2009 - v3
Checksum:iBF545A2A0C7EC2F7
GO
Isoform 2 (identifier: P46459-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.
     739-744: Missing.

Note: No experimental confirmation available.

Show »
Length:644
Mass (Da):71,584
Checksum:iACC3C42259713D42
GO

Sequence cautioni

The sequence AAA17411.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221A → S in AAA17411. 1 PublicationCurated
Sequence conflicti22 – 221A → S in AAF70545. 1 PublicationCurated
Sequence conflicti25 – 251N → S in BAF82893. (PubMed:14702039)Curated
Sequence conflicti107 – 1071I → N in AAA17411. 1 PublicationCurated
Sequence conflicti107 – 1071I → N in AAF70545. 1 PublicationCurated
Sequence conflicti107 – 1071I → N in AAF04745. 1 PublicationCurated
Sequence conflicti130 – 1301F → Y in AAA17411. 1 PublicationCurated
Sequence conflicti130 – 1301F → Y in AAF70545. 1 PublicationCurated
Sequence conflicti130 – 1301F → Y in AAF04745. 1 PublicationCurated
Sequence conflicti154 – 1541A → S in AAA17411. 1 PublicationCurated
Sequence conflicti154 – 1541A → S in AAF70545. 1 PublicationCurated
Sequence conflicti154 – 1541A → S in AAF04745. 1 PublicationCurated
Sequence conflicti237 – 2371S → F in AAA17411. 1 PublicationCurated
Sequence conflicti237 – 2371S → F in AAF70545. 1 PublicationCurated
Sequence conflicti237 – 2371S → F in AAF04745. 1 PublicationCurated
Sequence conflicti251 – 2511K → I in AAA17411. 1 PublicationCurated
Sequence conflicti251 – 2511K → I in AAF70545. 1 PublicationCurated
Sequence conflicti251 – 2511K → I in AAF04745. 1 PublicationCurated
Sequence conflicti427 – 4271K → R in BAF82893. (PubMed:14702039)Curated
Sequence conflicti571 – 5711D → E in AAF04745. 1 PublicationCurated
Sequence conflicti639 – 6391K → M in BAF82893. (PubMed:14702039)Curated
Sequence conflicti686 – 6861F → L in AAA17411. 1 PublicationCurated
Sequence conflicti686 – 6861F → L in AAF70545. 1 PublicationCurated
Sequence conflicti686 – 6861F → L in AAF04745. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti476 – 4761T → M.
Corresponds to variant rs155733 [ dbSNP | Ensembl ].
VAR_029580

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494Missing in isoform 2. 1 PublicationVSP_056420Add
BLAST
Alternative sequencei739 – 7446Missing in isoform 2. 1 PublicationVSP_056421

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03985 mRNA. Translation: AAA17411.1. Different initiation.
AF135168 mRNA. Translation: AAF70545.1.
AF102846 mRNA. Translation: AAF04745.2.
AK290204 mRNA. Translation: BAF82893.1.
AK294001 mRNA. Translation: BAG57363.1.
AC004098 Genomic DNA. No translation available.
AC138645 Genomic DNA. No translation available.
AC138688 Genomic DNA. No translation available.
AC217769 Genomic DNA. No translation available.
AC217778 Genomic DNA. No translation available.
AC217780 Genomic DNA. No translation available.
BC030613 mRNA. Translation: AAH30613.1.
CCDSiCCDS42354.1. [P46459-1]
PIRiG01234.
RefSeqiNP_006169.2. NM_006178.3.
UniGeneiHs.431279.

Genome annotation databases

EnsembliENST00000398238; ENSP00000381293; ENSG00000073969. [P46459-1]
GeneIDi4905.
KEGGihsa:4905.
UCSCiuc002iku.3. human. [P46459-1]

Polymorphism databases

DMDMi257051048.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03985 mRNA. Translation: AAA17411.1 . Different initiation.
AF135168 mRNA. Translation: AAF70545.1 .
AF102846 mRNA. Translation: AAF04745.2 .
AK290204 mRNA. Translation: BAF82893.1 .
AK294001 mRNA. Translation: BAG57363.1 .
AC004098 Genomic DNA. No translation available.
AC138645 Genomic DNA. No translation available.
AC138688 Genomic DNA. No translation available.
AC217769 Genomic DNA. No translation available.
AC217778 Genomic DNA. No translation available.
AC217780 Genomic DNA. No translation available.
BC030613 mRNA. Translation: AAH30613.1 .
CCDSi CCDS42354.1. [P46459-1 ]
PIRi G01234.
RefSeqi NP_006169.2. NM_006178.3.
UniGenei Hs.431279.

3D structure databases

ProteinModelPortali P46459.
SMRi P46459. Positions 1-201, 220-742.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110960. 40 interactions.
DIPi DIP-389N.
IntActi P46459. 37 interactions.
MINTi MINT-1369243.
STRINGi 9606.ENSP00000381293.

Chemistry

ChEMBLi CHEMBL2311231.

Protein family/group databases

TCDBi 1.F.1.1.1. the synaptosomal vesicle fusion pore (svf-pore) family.

PTM databases

PhosphoSitei P46459.

Polymorphism databases

DMDMi 257051048.

2D gel databases

UCD-2DPAGE P46459.

Proteomic databases

MaxQBi P46459.
PaxDbi P46459.
PRIDEi P46459.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398238 ; ENSP00000381293 ; ENSG00000073969 . [P46459-1 ]
GeneIDi 4905.
KEGGi hsa:4905.
UCSCi uc002iku.3. human. [P46459-1 ]

Organism-specific databases

CTDi 4905.
GeneCardsi GC17P044668.
H-InvDB HIX0013914.
HIX0013915.
HGNCi HGNC:8016. NSF.
HPAi CAB009324.
CAB013645.
HPA003154.
MIMi 601633. gene.
neXtProti NX_P46459.
PharmGKBi PA31793.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0464.
GeneTreei ENSGT00530000064085.
HOGENOMi HOG000198544.
HOVERGENi HBG000324.
InParanoidi P46459.
KOi K06027.
OMAi FKDKERS.
OrthoDBi EOG7P8P7F.
PhylomeDBi P46459.
TreeFami TF300371.

Enzyme and pathway databases

Reactomei REACT_18422. Trafficking of GluR2-containing AMPA receptors.

Miscellaneous databases

ChiTaRSi NSF. human.
GeneWikii N-ethylmaleimide_sensitive_fusion_protein.
GenomeRNAii 4905.
NextBioi 18875.
PMAP-CutDB P46459.
PROi P46459.
SOURCEi Search...

Gene expression databases

Bgeei P46459.
CleanExi HS_NSF.
ExpressionAtlasi P46459. baseline and differential.
Genevestigatori P46459.

Family and domain databases

Gene3Di 3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and localization of a brain N-ethylmaleimide-sensitive factor involved in vesicular transport."
    Hong R., Moriyama Y., Mori H., Futai M., Yamamoto A., Tashiro Y., Fukui T., Tagaya M.
    Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Bui T.D., Lu L., Hong W.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The regulation of hNSF gene expression."
    Zhang R., Liu Z., Wu M.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum and Thalamus.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNSF_HUMAN
AccessioniPrimary (citable) accession number: P46459
Secondary accession number(s): A8K2D9
, B4DFA2, Q8N6D7, Q9UKZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3