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P46456

- PURR_HAEIN

UniProt

P46456 - PURR_HAEIN

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Protein

HTH-type transcriptional repressor PurR

Gene

purR

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731CorepressorUniRule annotation
Binding sitei188 – 1881CorepressorUniRule annotation
Binding sitei190 – 1901CorepressorUniRule annotation
Binding sitei219 – 2191CorepressorUniRule annotation
Binding sitei273 – 2731CorepressorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi4 – 2320H-T-H motifUniRule annotationAdd
BLAST
DNA bindingi48 – 569UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  2. purine nucleotide biosynthetic process Source: UniProtKB-UniPathway
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Purine biosynthesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

UniPathwayiUPA00488.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor PurRUniRule annotation
Alternative name(s):
Pur regulon repressorUniRule annotation
Purine nucleotide synthesis repressorUniRule annotation
Gene namesi
Name:purRUniRule annotation
Ordered Locus Names:HI_1635
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336HTH-type transcriptional repressor PurRPRO_0000107979Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI1635.

Structurei

3D structure databases

ProteinModelPortaliP46456.
SMRiP46456. Positions 1-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 5655HTH lacI-typeUniRule annotationAdd
BLAST

Domaini

Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.UniRule annotation

Sequence similaritiesi

Contains 1 HTH lacI-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1609.
KOiK03604.
OMAiGVMRALH.
OrthoDBiEOG6SJJMM.
PhylomeDBiP46456.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
HAMAPiMF_01277. HTH_type_PurR.
InterProiIPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR023588. Tscrpt_reg_HTH_PurR.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46456-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATIKDVAKM AGVSTTTVSH VINKTRFVAK DTEEAVLSAI KQLNYSPSAV
60 70 80 90 100
ARSLKVNTTK SIGMIVTTSE APYFAEIIHS VEEHCYRQGY SLFCVTHKMD
110 120 130 140 150
PEKVKNHLEM LAKKRVDGLL VMCSEYTQDS LDLLSSFSTI PMVVMDWGPN
160 170 180 190 200
ANTDVIDDHS FDGGYLATKH LIECGHKKIG IICGELNKTT ARTRYEGFEK
210 220 230 240 250
AMEEAKLTIN PSWVLEGAFE PEDGYECMNR LLTQEKLPTA LFCCNDVMAL
260 270 280 290 300
GAISALTEKG LRVPEDMSII GYDDIHASRF YAPPLTTIHQ SKLRLGRQAI
310 320 330
NILLERITHK DEGVQQYSRI DITPELIIRK SVKSIL
Length:336
Mass (Da):37,508
Last modified:November 1, 1997 - v2
Checksum:i75084FF974EDAE31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23280.1.
RefSeqiNP_439777.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23280; AAC23280; HI_1635.
GeneIDi950319.
KEGGihin:HI1635.
PATRICi20192015. VBIHaeInf48452_1711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23280.1 .
RefSeqi NP_439777.1. NC_000907.1.

3D structure databases

ProteinModelPortali P46456.
SMRi P46456. Positions 1-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1635.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23280 ; AAC23280 ; HI_1635 .
GeneIDi 950319.
KEGGi hin:HI1635.
PATRICi 20192015. VBIHaeInf48452_1711.

Phylogenomic databases

eggNOGi COG1609.
KOi K03604.
OMAi GVMRALH.
OrthoDBi EOG6SJJMM.
PhylomeDBi P46456.

Enzyme and pathway databases

UniPathwayi UPA00488 .

Family and domain databases

Gene3Di 1.10.260.40. 1 hit.
HAMAPi MF_01277. HTH_type_PurR.
InterProi IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR023588. Tscrpt_reg_HTH_PurR.
[Graphical view ]
Pfami PF00356. LacI. 1 hit.
[Graphical view ]
PRINTSi PR00036. HTHLACI.
SMARTi SM00354. HTH_LACI. 1 hit.
[Graphical view ]
SUPFAMi SSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEi PS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.

Entry informationi

Entry nameiPURR_HAEIN
AccessioniPrimary (citable) accession number: P46456
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3