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P46456 (PURR_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
HTH-type transcriptional repressor PurR
Alternative name(s):
Pur regulon repressor
Purine nucleotide synthesis repressor
Gene names
Name:purR
Ordered Locus Names:HI_1635
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression By similarity. HAMAP-Rule MF_01277

Pathway

Purine metabolism; purine nucleotide biosynthesis [regulation]. HAMAP-Rule MF_01277

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01277

Domain

Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization By similarity. HAMAP-Rule MF_01277

Sequence similarities

Contains 1 HTH lacI-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336HTH-type transcriptional repressor PurR HAMAP-Rule MF_01277
PRO_0000107979

Regions

Domain2 – 5655HTH lacI-type
DNA binding4 – 2320H-T-H motif By similarity
DNA binding48 – 569 By similarity

Sites

Binding site731Corepressor By similarity
Binding site1881Corepressor By similarity
Binding site1901Corepressor By similarity
Binding site2191Corepressor By similarity
Binding site2731Corepressor By similarity

Sequences

Sequence LengthMass (Da)Tools
P46456 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 75084FF974EDAE31

FASTA33637,508
        10         20         30         40         50         60 
MATIKDVAKM AGVSTTTVSH VINKTRFVAK DTEEAVLSAI KQLNYSPSAV ARSLKVNTTK 

        70         80         90        100        110        120 
SIGMIVTTSE APYFAEIIHS VEEHCYRQGY SLFCVTHKMD PEKVKNHLEM LAKKRVDGLL 

       130        140        150        160        170        180 
VMCSEYTQDS LDLLSSFSTI PMVVMDWGPN ANTDVIDDHS FDGGYLATKH LIECGHKKIG 

       190        200        210        220        230        240 
IICGELNKTT ARTRYEGFEK AMEEAKLTIN PSWVLEGAFE PEDGYECMNR LLTQEKLPTA 

       250        260        270        280        290        300 
LFCCNDVMAL GAISALTEKG LRVPEDMSII GYDDIHASRF YAPPLTTIHQ SKLRLGRQAI 

       310        320        330 
NILLERITHK DEGVQQYSRI DITPELIIRK SVKSIL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC23280.1.
RefSeqNP_439777.1. NC_000907.1.

3D structure databases

ProteinModelPortalP46456.
SMRP46456. Positions 1-333.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1635.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23280; AAC23280; HI_1635.
GeneID950319.
KEGGhin:HI1635.
PATRIC20192015. VBIHaeInf48452_1711.

Phylogenomic databases

eggNOGCOG1609.
KOK03604.
OMAGVMRALH.
OrthoDBEOG6SJJMM.
PhylomeDBP46456.

Enzyme and pathway databases

UniPathwayUPA00488.

Family and domain databases

Gene3D1.10.260.40. 1 hit.
HAMAPMF_01277. HTH_type_PurR.
InterProIPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR023588. Tscrpt_reg_HTH_PurR.
[Graphical view]
PfamPF00356. LacI. 1 hit.
[Graphical view]
PRINTSPR00036. HTHLACI.
SMARTSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePURR_HAEIN
AccessionPrimary (citable) accession number: P46456
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names