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P46456

- PURR_HAEIN

UniProt

P46456 - PURR_HAEIN

Protein

HTH-type transcriptional repressor PurR

Gene

purR

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei73 – 731CorepressorUniRule annotation
    Binding sitei188 – 1881CorepressorUniRule annotation
    Binding sitei190 – 1901CorepressorUniRule annotation
    Binding sitei219 – 2191CorepressorUniRule annotation
    Binding sitei273 – 2731CorepressorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi4 – 2320H-T-H motifUniRule annotationAdd
    BLAST
    DNA bindingi48 – 569UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
    2. purine nucleotide biosynthetic process Source: UniProtKB-UniPathway
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Purine biosynthesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    UniPathwayiUPA00488.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional repressor PurRUniRule annotation
    Alternative name(s):
    Pur regulon repressorUniRule annotation
    Purine nucleotide synthesis repressorUniRule annotation
    Gene namesi
    Name:purRUniRule annotation
    Ordered Locus Names:HI_1635
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336HTH-type transcriptional repressor PurRPRO_0000107979Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi71421.HI1635.

    Structurei

    3D structure databases

    ProteinModelPortaliP46456.
    SMRiP46456. Positions 1-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 5655HTH lacI-typeUniRule annotationAdd
    BLAST

    Domaini

    Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.UniRule annotation

    Sequence similaritiesi

    Contains 1 HTH lacI-type DNA-binding domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1609.
    KOiK03604.
    OMAiGVMRALH.
    OrthoDBiEOG6SJJMM.
    PhylomeDBiP46456.

    Family and domain databases

    Gene3Di1.10.260.40. 1 hit.
    HAMAPiMF_01277. HTH_type_PurR.
    InterProiIPR010982. Lambda_DNA-bd_dom.
    IPR028082. Peripla_BP_I.
    IPR000843. Tscrpt_reg_HTH_LacI.
    IPR023588. Tscrpt_reg_HTH_PurR.
    [Graphical view]
    PfamiPF00356. LacI. 1 hit.
    [Graphical view]
    PRINTSiPR00036. HTHLACI.
    SMARTiSM00354. HTH_LACI. 1 hit.
    [Graphical view]
    SUPFAMiSSF47413. SSF47413. 1 hit.
    SSF53822. SSF53822. 1 hit.
    PROSITEiPS00356. HTH_LACI_1. 1 hit.
    PS50932. HTH_LACI_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46456-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATIKDVAKM AGVSTTTVSH VINKTRFVAK DTEEAVLSAI KQLNYSPSAV    50
    ARSLKVNTTK SIGMIVTTSE APYFAEIIHS VEEHCYRQGY SLFCVTHKMD 100
    PEKVKNHLEM LAKKRVDGLL VMCSEYTQDS LDLLSSFSTI PMVVMDWGPN 150
    ANTDVIDDHS FDGGYLATKH LIECGHKKIG IICGELNKTT ARTRYEGFEK 200
    AMEEAKLTIN PSWVLEGAFE PEDGYECMNR LLTQEKLPTA LFCCNDVMAL 250
    GAISALTEKG LRVPEDMSII GYDDIHASRF YAPPLTTIHQ SKLRLGRQAI 300
    NILLERITHK DEGVQQYSRI DITPELIIRK SVKSIL 336
    Length:336
    Mass (Da):37,508
    Last modified:November 1, 1997 - v2
    Checksum:i75084FF974EDAE31
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23280.1.
    RefSeqiNP_439777.1. NC_000907.1.
    WP_010869264.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC23280; AAC23280; HI_1635.
    GeneIDi950319.
    KEGGihin:HI1635.
    PATRICi20192015. VBIHaeInf48452_1711.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC23280.1 .
    RefSeqi NP_439777.1. NC_000907.1.
    WP_010869264.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P46456.
    SMRi P46456. Positions 1-333.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI1635.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC23280 ; AAC23280 ; HI_1635 .
    GeneIDi 950319.
    KEGGi hin:HI1635.
    PATRICi 20192015. VBIHaeInf48452_1711.

    Phylogenomic databases

    eggNOGi COG1609.
    KOi K03604.
    OMAi GVMRALH.
    OrthoDBi EOG6SJJMM.
    PhylomeDBi P46456.

    Enzyme and pathway databases

    UniPathwayi UPA00488 .

    Family and domain databases

    Gene3Di 1.10.260.40. 1 hit.
    HAMAPi MF_01277. HTH_type_PurR.
    InterProi IPR010982. Lambda_DNA-bd_dom.
    IPR028082. Peripla_BP_I.
    IPR000843. Tscrpt_reg_HTH_LacI.
    IPR023588. Tscrpt_reg_HTH_PurR.
    [Graphical view ]
    Pfami PF00356. LacI. 1 hit.
    [Graphical view ]
    PRINTSi PR00036. HTHLACI.
    SMARTi SM00354. HTH_LACI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47413. SSF47413. 1 hit.
    SSF53822. SSF53822. 1 hit.
    PROSITEi PS00356. HTH_LACI_1. 1 hit.
    PS50932. HTH_LACI_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. White O., Clayton R.A., Kerlavage A.R., Fleischmann R.D.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.

    Entry informationi

    Entry nameiPURR_HAEIN
    AccessioniPrimary (citable) accession number: P46456
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3