L-lactate dehydrogenase [cytochrome] - Haemophilus influenzae

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Reviewed, UniProtKB/Swiss-Prot P46454 (LLDD_HAEIN)

Last modified January 19, 2010. Version 69. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
L-lactate dehydrogenase [cytochrome]
EC=1.1.2.3

Gene names

Name:	lldD
Ordered Locus Names:	HI1739.1

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H⁺. HAMAP MF_01559

Cofactor

FMN By similarity. HAMAP MF_01559

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

Ontologies

Keywords
Ligand	FMN Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro L-lactate dehydrogenase (cytochrome) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

381

L-lactate dehydrogenase [cytochrome] HAMAP MF_01559

PRO_0000206339

Regions

Domain

380

FMN hydroxy acid dehydrogenase

Nucleotide binding

25

FMN By similarity

Sites

Active site

1

Proton acceptor By similarity

Binding site

1

Substrate Potential

Binding site

1

FMN By similarity

Binding site

1

FMN By similarity

Binding site

1

Substrate By similarity

Binding site

1

FMN By similarity

Binding site

1

Substrate By similarity

Binding site

1

FMN By similarity

Binding site

1

Substrate Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P46454-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: E1BC62B0A1A6482D
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381

41,965

        10         20         30         40         50         60 
MIISSASDYR EAARRRVPPF MFHYADGGSY AEQTLARNVS DLENIALRQR VLKDMSELDT 

        70         80         90        100        110        120 
SIELFGEKLS MPTILAPVGA CGMYARRGEV QAAQAADNKG VPFTLSTVSI CPIEEVAPAI 

       130        140        150        160        170        180 
KRPMWFQLYV LKDRGFMKNA LERAKAAGCS TLVFTVDMPT PGARYRDMHS GMSGPYKEIR 

       190        200        210        220        230        240 
RVLQGFTHPF WAYDVGIKGK PHTLGNVSTY MGRQIGLDDY IGWLTENFDP SISWKDLEWI 

       250        260        270        280        290        300 
REFWEGPMVI KGILDPEDAK DAVRFGADGI VVSNHGGRQL DGVLSSARAL PPIADAVKGD 

       310        320        330        340        350        360 
IKIIADSGIR NGLDIVRMLA LGADATMLGR AFVYALGAEG RQGVENMLDI FKKEMHVAMT 

       370        380 
LTSNRTIADI KPEALVDLSK L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
[2]	Koonin E.V., Rudd K.E. Submitted (SEP-1995) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC23385.1.
PIR	T09429.
RefSeq	NP_439882.1.
3D structure databases
SMR	P46454. Positions 1-376.
ModBase	Search...
Genome annotation databases
GeneID	950543.
GenomeReviews	Gene locus HI1739.1 in contig L42023_GR.
KEGG	hin:HI1739.1.
NMPDR	fig\|71421.1.peg.1652.
TIGR	HI1739.1.
Phylogenomic databases
HOGENOM	HBG517781.
OMA	WIREFWE.
Enzyme and pathway databases
BioCyc	HINF71421:HI_1739.1-MONOMER.
BRENDA	1.1.2.3. 109.
Family and domain databases
HAMAP	MF_01559. L-lact_dehydr. [Tree]
InterPro	IPR012133. a-Hydoxy_acid_DH_FMN. IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR008259. FMN_hydac_DH_AS. IPR020920. L-lactate_DHase_cyt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01070. FMN_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITE	PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LLDD_HAEIN

Accession

Primary (citable) accession number: P46454

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 19, 2010
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents