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Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpC

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).By similarity

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Putative anthranilate synthase component II (HI_1171), Anthranilate synthase component 2 (trpG), Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Tryptophan biosynthesis protein TrpCF (trpC)
  4. Tryptophan biosynthesis protein TrpCF (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Isomerase, Lyase, Multifunctional enzyme
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1417-MONOMER
UniPathwayiUPA00035; UER00042
UPA00035; UER00043

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan biosynthesis protein TrpCF
Including the following 2 domains:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpC
Ordered Locus Names:HI_1389.1
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001542791 – 477Tryptophan biosynthesis protein TrpCFAdd BLAST477

Proteomic databases

PRIDEiP46451

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi71421.HI1389.1

Structurei

3D structure databases

ProteinModelPortaliP46451
SMRiP46451
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 275Indole-3-glycerol phosphate synthaseAdd BLAST263
Regioni276 – 477N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST202

Sequence similaritiesi

In the N-terminal section; belongs to the TrpC family.Curated
In the C-terminal section; belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiENOG4105DK0 Bacteria
COG0134 LUCA
COG0135 LUCA
KOiK13498
OMAiYDIIGIN
PhylomeDBiP46451

Family and domain databases

CDDicd00331 IGPS, 1 hit
cd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 2 hits
HAMAPiMF_00134_B IGPS_B, 1 hit
MF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR013798 Indole-3-glycerol_P_synth
IPR001468 Indole-3-GlycerolPSynthase_CS
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00218 IGPS, 1 hit
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 2 hits
PROSITEiView protein in PROSITE
PS00614 IGPS, 1 hit

Sequencei

Sequence statusi: Complete.

P46451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMITQDFTKP IDSATVLQKI VLDKAQWVKA KEKEFPLSQF KQNIQNSDRS
60 70 80 90 100
FYDALAKGTH QKPAYILECK KASPSKGLIR AEFNLEEIAN VYKHYASAVS
110 120 130 140 150
VLTDEKYFQG NFEFLPLVRD IVSQPVLCKD FMISEYQVYL ARYYQVDAIL
160 170 180 190 200
LMLSVVNDET YRVLADLAHS LGMGVLTETS NEEEFERALA LGAKIIGVNN
210 220 230 240 250
RNLHDLTVDL NRVVELTKKY ADCIPADVRI ISESGIYNHK QIHQLQKVAH
260 270 280 290 300
GFLIGSSLMG NQDLNNAVRS VIFGENKVCG LTRAQDVKIV YENGALYGGL
310 320 330 340 350
IFAEHSKRSV SLRQAQELVT AAPLRFVGVF QNQEIDFIVK IASQLQLYAV
360 370 380 390 400
QLHGAETEAF ITALRQQLPK NTQIWKAISV NTEAQSAVDF TDDLNVDRYI
410 420 430 440 450
FDSQTANQQG GTGKTFDWSL IPENLKHKII LAGGISPNNV EQAIAQGCLG
460 470
LDLNSGVESS AGVKDQEKVR LVFNNIY
Length:477
Mass (Da):53,306
Last modified:November 1, 1995 - v1
Checksum:iB1435FAEFA24379E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC23036.1
RefSeqiNP_439543.1, NC_000907.1
WP_005693972.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC23036; AAC23036; HI_1389.1
GeneIDi950301
KEGGihin:HI1389.1
PATRICifig|71421.8.peg.1448

Entry informationi

Entry nameiTRPC_HAEIN
AccessioniPrimary (citable) accession number: P46451
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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