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P46450 (LCFA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase

EC=6.2.1.3
Alternative name(s):
Long-chain acyl-CoA synthetase
Gene names
Name:fadD
Ordered Locus Names:HI_0390.1
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Subunit structure

Homodimer Probable.

Subcellular location

Membrane; Peripheral membrane protein Potential. Note: Partially membrane-associated Potential.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentMembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmembrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

long-chain fatty acid-CoA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Long-chain-fatty-acid--CoA ligase
PRO_0000193131

Sequences

Sequence LengthMass (Da)Tools
P46450 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 74BE7C8E9D711F12

FASTA56263,479
        10         20         30         40         50         60 
MEKIWFQNYP KGSEKFLDTS KYESILDMFD KAVREHPDRP AYINMGQVLT FRKLEERSRA 

        70         80         90        100        110        120 
FAAYLQNEFK LQRGDRVALM MPNLLQYPIA LFGILRAGLI AVNVNPLYTP RELELQLQDS 

       130        140        150        160        170        180 
GAVAIVVVSN FASTLEKVVF NTNVKHVILT RMGDQLSFGK RTLVNFVVKY VKKLVPKYKL 

       190        200        210        220        230        240 
PHAVTFREVL SIGKYRQYVR PEISREDLAF LQYTGGTTGV AKGAMLTHGN IITNVFQAKW 

       250        260        270        280        290        300 
IAEPFIGDHS RTRSAILALP LYHVFALTVN CLLFLELGVT AILITNPRDI EGFVKELKKY 

       310        320        330        340        350        360 
RFEAITGVNT LFNALLNNEN FKEVDFSALK LSVGGGMAIQ QSVATRWHEL TGCNIIEGYG 

       370        380        390        400        410        420 
MTECSPLIAA CPINVVKHNG TIGVPVPNTD IKIIKDDGSD AKIGEAGELW VKGDQVMRGY 

       430        440        450        460        470        480 
WQRPEATSEV LKDGWMATGD IVIMDESYSL RIVDRKKDII LVSGFNVYPN EIEDVVMLNY 

       490        500        510        520        530        540 
KVSEAVAIGV PHAVSGETIK IFVVKKDDSL TRDELRNHCR QYLTGYKVPK EIEFRDELPK 

       550        560 
TNVGKILRRV LRDEEIAKRP KH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC22049.1.
RefSeqNP_438551.1. NC_000907.1.

3D structure databases

ProteinModelPortalP46450.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0390.1.

Proteomic databases

PRIDEP46450.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC22049; AAC22049; HI_0390.1.
GeneID950680.
KEGGhin:HI0390.1.
PATRIC20189329. VBIHaeInf48452_0408.

Phylogenomic databases

eggNOGCOG0318.
KOK01897.
OMAVATRWHE.
OrthoDBEOG6MH5BV.
PhylomeDBP46450.

Family and domain databases

InterProIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLCFA_HAEIN
AccessionPrimary (citable) accession number: P46450
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names