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P46450

- LCFA_HAEIN

UniProt

P46450 - LCFA_HAEIN

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Protein

Long-chain-fatty-acid--CoA ligase

Gene

fadD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
Alternative name(s):
Long-chain acyl-CoA synthetase
Gene namesi
Name:fadD
Ordered Locus Names:HI_0390.1
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Membrane Curated; Peripheral membrane protein Curated
Note: Partially membrane-associated.Curated

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Long-chain-fatty-acid--CoA ligasePRO_0000193131Add
BLAST

Proteomic databases

PRIDEiP46450.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi71421.HI0390.1.

Structurei

3D structure databases

ProteinModelPortaliP46450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0318.
KOiK01897.
OMAiVATRWHE.
OrthoDBiEOG6MH5BV.
PhylomeDBiP46450.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46450-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKIWFQNYP KGSEKFLDTS KYESILDMFD KAVREHPDRP AYINMGQVLT
60 70 80 90 100
FRKLEERSRA FAAYLQNEFK LQRGDRVALM MPNLLQYPIA LFGILRAGLI
110 120 130 140 150
AVNVNPLYTP RELELQLQDS GAVAIVVVSN FASTLEKVVF NTNVKHVILT
160 170 180 190 200
RMGDQLSFGK RTLVNFVVKY VKKLVPKYKL PHAVTFREVL SIGKYRQYVR
210 220 230 240 250
PEISREDLAF LQYTGGTTGV AKGAMLTHGN IITNVFQAKW IAEPFIGDHS
260 270 280 290 300
RTRSAILALP LYHVFALTVN CLLFLELGVT AILITNPRDI EGFVKELKKY
310 320 330 340 350
RFEAITGVNT LFNALLNNEN FKEVDFSALK LSVGGGMAIQ QSVATRWHEL
360 370 380 390 400
TGCNIIEGYG MTECSPLIAA CPINVVKHNG TIGVPVPNTD IKIIKDDGSD
410 420 430 440 450
AKIGEAGELW VKGDQVMRGY WQRPEATSEV LKDGWMATGD IVIMDESYSL
460 470 480 490 500
RIVDRKKDII LVSGFNVYPN EIEDVVMLNY KVSEAVAIGV PHAVSGETIK
510 520 530 540 550
IFVVKKDDSL TRDELRNHCR QYLTGYKVPK EIEFRDELPK TNVGKILRRV
560
LRDEEIAKRP KH
Length:562
Mass (Da):63,479
Last modified:November 1, 1995 - v1
Checksum:i74BE7C8E9D711F12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22049.1.
RefSeqiNP_438551.1. NC_000907.1.
WP_005693780.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC22049; AAC22049; HI_0390.1.
GeneIDi950680.
KEGGihin:HI0390.1.
PATRICi20189329. VBIHaeInf48452_0408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC22049.1 .
RefSeqi NP_438551.1. NC_000907.1.
WP_005693780.1. NC_000907.1.

3D structure databases

ProteinModelPortali P46450.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI0390.1.

Proteomic databases

PRIDEi P46450.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC22049 ; AAC22049 ; HI_0390.1 .
GeneIDi 950680.
KEGGi hin:HI0390.1.
PATRICi 20189329. VBIHaeInf48452_0408.

Phylogenomic databases

eggNOGi COG0318.
KOi K01897.
OMAi VATRWHE.
OrthoDBi EOG6MH5BV.
PhylomeDBi P46450.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. Koonin E.V., Rudd K.E.
    Submitted (SEP-1995) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiLCFA_HAEIN
AccessioniPrimary (citable) accession number: P46450
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3