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P46450

- LCFA_HAEIN

UniProt

P46450 - LCFA_HAEIN

Protein

Long-chain-fatty-acid--CoA ligase

Gene

fadD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3)
    Alternative name(s):
    Long-chain acyl-CoA synthetase
    Gene namesi
    Name:fadD
    Ordered Locus Names:HI_0390.1
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Membrane Curated; Peripheral membrane protein Curated
    Note: Partially membrane-associated.Curated

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Long-chain-fatty-acid--CoA ligasePRO_0000193131Add
    BLAST

    Proteomic databases

    PRIDEiP46450.

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Protein-protein interaction databases

    STRINGi71421.HI0390.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP46450.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0318.
    KOiK01897.
    OMAiVATRWHE.
    OrthoDBiEOG6MH5BV.
    PhylomeDBiP46450.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P46450-1 [UniParc]FASTAAdd to Basket

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    MEKIWFQNYP KGSEKFLDTS KYESILDMFD KAVREHPDRP AYINMGQVLT    50
    FRKLEERSRA FAAYLQNEFK LQRGDRVALM MPNLLQYPIA LFGILRAGLI 100
    AVNVNPLYTP RELELQLQDS GAVAIVVVSN FASTLEKVVF NTNVKHVILT 150
    RMGDQLSFGK RTLVNFVVKY VKKLVPKYKL PHAVTFREVL SIGKYRQYVR 200
    PEISREDLAF LQYTGGTTGV AKGAMLTHGN IITNVFQAKW IAEPFIGDHS 250
    RTRSAILALP LYHVFALTVN CLLFLELGVT AILITNPRDI EGFVKELKKY 300
    RFEAITGVNT LFNALLNNEN FKEVDFSALK LSVGGGMAIQ QSVATRWHEL 350
    TGCNIIEGYG MTECSPLIAA CPINVVKHNG TIGVPVPNTD IKIIKDDGSD 400
    AKIGEAGELW VKGDQVMRGY WQRPEATSEV LKDGWMATGD IVIMDESYSL 450
    RIVDRKKDII LVSGFNVYPN EIEDVVMLNY KVSEAVAIGV PHAVSGETIK 500
    IFVVKKDDSL TRDELRNHCR QYLTGYKVPK EIEFRDELPK TNVGKILRRV 550
    LRDEEIAKRP KH 562
    Length:562
    Mass (Da):63,479
    Last modified:November 1, 1995 - v1
    Checksum:i74BE7C8E9D711F12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22049.1.
    RefSeqiNP_438551.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22049; AAC22049; HI_0390.1.
    GeneIDi950680.
    KEGGihin:HI0390.1.
    PATRICi20189329. VBIHaeInf48452_0408.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22049.1 .
    RefSeqi NP_438551.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P46450.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0390.1.

    Proteomic databases

    PRIDEi P46450.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22049 ; AAC22049 ; HI_0390.1 .
    GeneIDi 950680.
    KEGGi hin:HI0390.1.
    PATRICi 20189329. VBIHaeInf48452_0408.

    Phylogenomic databases

    eggNOGi COG0318.
    KOi K01897.
    OMAi VATRWHE.
    OrthoDBi EOG6MH5BV.
    PhylomeDBi P46450.

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. Koonin E.V., Rudd K.E.
      Submitted (SEP-1995) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiLCFA_HAEIN
    AccessioniPrimary (citable) accession number: P46450
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3