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P46448

- FDXG_HAEIN

UniProt

P46448 - FDXG_HAEIN

Protein

Formate dehydrogenase major subunit

Gene

fdxG

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Allows to use formate as major electron donor during anaerobic respiration. Subunit alpha possibly forms the active site.

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Cofactori

    Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.By similarity
    Binds 1 4Fe-4S cluster.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi50 – 501Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
    Metal bindingi53 – 531Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
    Metal bindingi57 – 571Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation
    Metal bindingi100 – 1001Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. electron carrier activity Source: InterPro
    3. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    4. molybdenum ion binding Source: InterPro

    GO - Biological processi

    1. cellular respiration Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate dehydrogenase major subunit (EC:1.2.1.2)
    Alternative name(s):
    Formate dehydrogenase subunit alpha
    Short name:
    FDH subunit alpha
    Gene namesi
    Name:fdxG
    Ordered Locus Names:HI_0006
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    Periplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    2. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Tat-type signalPROSITE-ProRule annotationAdd
    BLAST
    Chaini34 – 1028995Formate dehydrogenase major subunitPRO_0000063224Add
    BLAST

    Post-translational modificationi

    Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

    Interactioni

    Subunit structurei

    Formate dehydrogenase is a membrane-bound complex, formed by subunits alpha, beta and gamma.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 114724Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OMAiYKTFLVN.

    Family and domain databases

    InterProiIPR009010. Asp_de-COase-like_dom.
    IPR006443. Formate_DH_asu_anaerob.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR006655. Mopterin_OxRdtase_prok_CS.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    IPR006311. TAT_signal.
    [Graphical view]
    PfamiPF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    [Graphical view]
    SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF50692. SSF50692. 2 hits.
    TIGRFAMsiTIGR01553. formate-DH-alph. 1 hit.
    PROSITEiPS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P46448-1 [UniParc]FASTAAdd to Basket

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    MQVSRRKFFK ICAGGMAGTS AAMLGFAPAN VLAAPREYKL LRAFESRNTC     50
    TYCAVSCGML LYSTGKPYNS LSSHTGTNTR SKLFHIEGDP DHPVSRGALC 100
    PKGAGSLDYV NSESRSLYPQ YRAPGSDKWE RISWKDAIKR IARLMKDDRD 150
    ANFVEKDSNG KTVNRWATTG IMTASAMSNE AALLTQKWIR MLGMVPVCNQ 200
    ANTUHGPTVA SLAPSFGRGA MTNNWVDIKN ANLIIVQGGN PAEAHPVGFR 250
    WAIEAKKNGA KIIVIDPRFN RTASVADLHA PIRSGSDITF LMGVIRYLLE 300
    TNQIQHEYVK HYTNASFLID EGFKFEDGLF VGYNEEKRNY DKSKWNYQFD 350
    ENGHAKRDMT LQHPRCVINI LKEHVSRYTP EMVERITGVK QKLFLQICEE 400
    IGKTSVPNKT MTHLYALGFT EHSIGTQNIR SMAIIQLLLG NMGMPGGGIN 450
    ALRGHSNVQG TTDMGLLPMS LPGYMRLPND KDTSYDQYIN AITPKDIVPN 500
    QVNYYRHTSK FFVSMMKTFY GDNATKENGW GFDFLPKADR LYDPITHVKL 550
    MNEGKLHGWI LQGFNVLNSL PNKNKTLSGM SKLKYLVVMD PLQTESSEFW 600
    RNFGESNNVN PAEIQTEVFR LPTTCFAEEE GSIVNSGRWT QWHWKGCDQP 650
    GEALPDVDIL SMLREEMHEL YKKEGGQGIE SFEAMTWNYA QPHSPSAVEL 700
    AKELNGYALE DLYDPNGNLM YKKGQLLNGF AHLRDDGTTT SGNWLYVGQW 750
    TEKGNQTANR DNSDPSGLGC TIGWGFAWPA NRRVLYSRAS LDINGNPWDK 800
    NRQLIKWNGK NWNWFDIADY GTQPPGSDTG PFIMSAEGVG RLFAVDKIAN 850
    GPMPEHYEPV ESPIDTNPFH PNVVTDPTLR IYKEDREFIG SNKEYPFVAT 900
    TYRLTEHFHS WTAQSALNII AQPQQFVEIG EKLAAEKGIQ KGDMVKITSR 950
    RGYIKAVAVV TKRLKDLEID GRVVHHIGLP IHWNMKALNG KGNRGFSTNT 1000
    LTPSWGEAIT QTPEYKTFLV NIEKVGEA 1028
    Length:1,028
    Mass (Da):115,451
    Last modified:February 26, 2008 - v2
    Checksum:i4A2E55B78B301300
    GO

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei204 – 2041SelenocysteineCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. No translation available.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OMAi YKTFLVN.

    Family and domain databases

    InterProi IPR009010. Asp_de-COase-like_dom.
    IPR006443. Formate_DH_asu_anaerob.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR006655. Mopterin_OxRdtase_prok_CS.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    IPR006311. TAT_signal.
    [Graphical view ]
    Pfami PF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    [Graphical view ]
    SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50692. SSF50692. 2 hits.
    TIGRFAMsi TIGR01553. formate-DH-alph. 1 hit.
    PROSITEi PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
    PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiFDXG_HAEIN
    AccessioniPrimary (citable) accession number: P46448
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3