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Protein

Glutathione S-transferase Mu 5

Gene

GSTM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

  • glutathione transferase activity Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

  • glutathione derivative biosynthetic process Source: Reactome
  • glutathione metabolic process Source: UniProtKB

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.5.1.18 2681
ReactomeiR-HSA-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 5 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 5
GSTM5-5
Gene namesi
Name:GSTM5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134201.10
HGNCiHGNC:4637 GSTM5
MIMi138385 gene
neXtProtiNX_P46439

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2949
OpenTargetsiENSG00000134201
PharmGKBiPA29027

Chemistry databases

ChEMBLiCHEMBL2819
DrugBankiDB00143 Glutathione

Polymorphism and mutation databases

BioMutaiGSTM5
DMDMi67476963

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858251 – 218Glutathione S-transferase Mu 5Add BLAST218

Proteomic databases

EPDiP46439
PaxDbiP46439
PeptideAtlasiP46439
PRIDEiP46439

PTM databases

iPTMnetiP46439
PhosphoSitePlusiP46439

Expressioni

Gene expression databases

BgeeiENSG00000134201
CleanExiHS_GSTM5
ExpressionAtlasiP46439 baseline and differential
GenevisibleiP46439 HS

Organism-specific databases

HPAiHPA055972
HPA055973

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi109204, 8 interactors
IntActiP46439, 7 interactors
STRINGi9606.ENSP00000256593

Structurei

3D structure databases

ProteinModelPortaliP46439
SMRiP46439
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 88GST N-terminalAdd BLAST87
Domaini90 – 207GST C-terminalAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 8Glutathione bindingBy similarity2
Regioni46 – 50Glutathione bindingBy similarity5
Regioni59 – 60Glutathione bindingBy similarity2
Regioni72 – 73Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated

Phylogenomic databases

eggNOGiENOG410IN5J Eukaryota
ENOG4110YU0 LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115735
HOVERGENiHBG106842
InParanoidiP46439
KOiK00799
OMAiENQVMDI
PhylomeDBiP46439
TreeFamiTF353040

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003081 GST_mu
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01267 GSTRNSFRASEM
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P46439-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMTLGYWDI RGLAHAIRLL LEYTDSSYVE KKYTLGDAPD YDRSQWLNEK
60 70 80 90 100
FKLGLDFPNL PYLIDGAHKI TQSNAILRYI ARKHNLCGET EEEKIRVDIL
110 120 130 140 150
ENQVMDNHME LVRLCYDPDF EKLKPKYLEE LPEKLKLYSE FLGKRPWFAG
160 170 180 190 200
DKITFVDFLA YDVLDMKRIF EPKCLDAFLN LKDFISRFEG LKKISAYMKS
210
SQFLRGLLFG KSATWNSK
Length:218
Mass (Da):25,675
Last modified:January 23, 2007 - v3
Checksum:i62B03FCD960FB4AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35L → M in AAA20040 (PubMed:8473333).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06509867A → T2 PublicationsCorresponds to variant dbSNP:rs17854972Ensembl.1
Natural variantiVAR_049491179L → P. Corresponds to variant dbSNP:rs2227963Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02321 mRNA Translation: AAA20040.1
AK289673 mRNA Translation: BAF82362.1
BC058881 mRNA Translation: AAH58881.1
CCDSiCCDS811.1
PIRiA46048
RefSeqiNP_000842.2, NM_000851.3
XP_005270841.1, XM_005270784.4
UniGeneiHs.75652

Genome annotation databases

EnsembliENST00000256593; ENSP00000256593; ENSG00000134201
GeneIDi2949
KEGGihsa:2949

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGSTM5_HUMAN
AccessioniPrimary (citable) accession number: P46439
Secondary accession number(s): A8K0V8, Q6PD78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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