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Protein

Glutathione S-transferase Mu 5

Gene

GSTM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

  • glutathione transferase activity Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

  • glutathione derivative biosynthetic process Source: Reactome
  • glutathione metabolic process Source: UniProtKB

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.5.1.18. 2681.
ReactomeiR-HSA-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 5 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 5
GSTM5-5
Gene namesi
Name:GSTM5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4637. GSTM5.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2949.
OpenTargetsiENSG00000134201.
PharmGKBiPA29027.

Chemistry databases

ChEMBLiCHEMBL2819.
DrugBankiDB00143. Glutathione.

Polymorphism and mutation databases

BioMutaiGSTM5.
DMDMi67476963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858251 – 218Glutathione S-transferase Mu 5Add BLAST218

Proteomic databases

EPDiP46439.
PaxDbiP46439.
PeptideAtlasiP46439.
PRIDEiP46439.

PTM databases

iPTMnetiP46439.
PhosphoSitePlusiP46439.

Expressioni

Gene expression databases

BgeeiENSG00000134201.
CleanExiHS_GSTM5.
ExpressionAtlasiP46439. baseline and differential.
GenevisibleiP46439. HS.

Organism-specific databases

HPAiHPA055972.
HPA055973.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi109204. 8 interactors.
IntActiP46439. 7 interactors.
STRINGi9606.ENSP00000256593.

Structurei

3D structure databases

ProteinModelPortaliP46439.
SMRiP46439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 88GST N-terminalAdd BLAST87
Domaini90 – 207GST C-terminalAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 8Glutathione bindingBy similarity2
Regioni46 – 50Glutathione bindingBy similarity5
Regioni59 – 60Glutathione bindingBy similarity2
Regioni72 – 73Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated

Phylogenomic databases

eggNOGiENOG410IN5J. Eukaryota.
ENOG4110YU0. LUCA.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiP46439.
KOiK00799.
OMAiEIPGRMK.
PhylomeDBiP46439.
TreeFamiTF353040.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P46439-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMTLGYWDI RGLAHAIRLL LEYTDSSYVE KKYTLGDAPD YDRSQWLNEK
60 70 80 90 100
FKLGLDFPNL PYLIDGAHKI TQSNAILRYI ARKHNLCGET EEEKIRVDIL
110 120 130 140 150
ENQVMDNHME LVRLCYDPDF EKLKPKYLEE LPEKLKLYSE FLGKRPWFAG
160 170 180 190 200
DKITFVDFLA YDVLDMKRIF EPKCLDAFLN LKDFISRFEG LKKISAYMKS
210
SQFLRGLLFG KSATWNSK
Length:218
Mass (Da):25,675
Last modified:January 23, 2007 - v3
Checksum:i62B03FCD960FB4AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35L → M in AAA20040 (PubMed:8473333).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06509867A → T2 PublicationsCorresponds to variant dbSNP:rs17854972Ensembl.1
Natural variantiVAR_049491179L → P. Corresponds to variant dbSNP:rs2227963Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02321 mRNA. Translation: AAA20040.1.
AK289673 mRNA. Translation: BAF82362.1.
BC058881 mRNA. Translation: AAH58881.1.
CCDSiCCDS811.1.
PIRiA46048.
RefSeqiNP_000842.2. NM_000851.3.
XP_005270841.1. XM_005270784.4.
UniGeneiHs.75652.

Genome annotation databases

EnsembliENST00000256593; ENSP00000256593; ENSG00000134201.
GeneIDi2949.
KEGGihsa:2949.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02321 mRNA. Translation: AAA20040.1.
AK289673 mRNA. Translation: BAF82362.1.
BC058881 mRNA. Translation: AAH58881.1.
CCDSiCCDS811.1.
PIRiA46048.
RefSeqiNP_000842.2. NM_000851.3.
XP_005270841.1. XM_005270784.4.
UniGeneiHs.75652.

3D structure databases

ProteinModelPortaliP46439.
SMRiP46439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109204. 8 interactors.
IntActiP46439. 7 interactors.
STRINGi9606.ENSP00000256593.

Chemistry databases

ChEMBLiCHEMBL2819.
DrugBankiDB00143. Glutathione.

PTM databases

iPTMnetiP46439.
PhosphoSitePlusiP46439.

Polymorphism and mutation databases

BioMutaiGSTM5.
DMDMi67476963.

Proteomic databases

EPDiP46439.
PaxDbiP46439.
PeptideAtlasiP46439.
PRIDEiP46439.

Protocols and materials databases

DNASUi2949.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256593; ENSP00000256593; ENSG00000134201.
GeneIDi2949.
KEGGihsa:2949.

Organism-specific databases

CTDi2949.
DisGeNETi2949.
GeneCardsiGSTM5.
HGNCiHGNC:4637. GSTM5.
HPAiHPA055972.
HPA055973.
MIMi138385. gene.
neXtProtiNX_P46439.
OpenTargetsiENSG00000134201.
PharmGKBiPA29027.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IN5J. Eukaryota.
ENOG4110YU0. LUCA.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiP46439.
KOiK00799.
OMAiEIPGRMK.
PhylomeDBiP46439.
TreeFamiTF353040.

Enzyme and pathway databases

BRENDAi2.5.1.18. 2681.
ReactomeiR-HSA-156590. Glutathione conjugation.

Miscellaneous databases

ChiTaRSiGSTM5. human.
GenomeRNAii2949.
PROiPR:P46439.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134201.
CleanExiHS_GSTM5.
ExpressionAtlasiP46439. baseline and differential.
GenevisibleiP46439. HS.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGSTM5_HUMAN
AccessioniPrimary (citable) accession number: P46439
Secondary accession number(s): A8K0V8, Q6PD78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.