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P46437 (GST_MUSDO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase

EC=2.5.1.18
Alternative name(s):
GST class-sigma
OrganismMusca domestica (House fly)
Taxonomic identifier7370 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the GST superfamily. Sigma family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 241241Glutathione S-transferase
PRO_0000185919

Regions

Domain40 – 11778GST N-terminal
Domain119 – 241123GST C-terminal
Region88 – 892Glutathione binding By similarity
Region101 – 1022Glutathione binding By similarity

Sites

Binding site461Glutathione By similarity
Binding site771Glutathione By similarity
Binding site811Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P46437 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 6A8FBD67ADDDEDFA

FASTA24126,964
        10         20         30         40         50         60 
MADEAPAAPP AEGEAPAAPA EGEAPPPAEG EAPPAEPVKN TYTLFYFNVK ALAEPLRYLF 

        70         80         90        100        110        120 
AYGGIEYEDV RVTRDEWPAL KPTMPMGQMP VLEVNGKRVH QSISMARFLA KTVGLCGATP 

       130        140        150        160        170        180 
WEDLQVDIVV DTINDFRLKI AVVSYEPEDE IKEKKLVTLN NEVIPFYLEK LEQTVKDNDG 

       190        200        210        220        230        240 
HLALNKLTWA DVYFAGILDY MNYMVKRDIL EQYPALRGVV DSVNALEPIK AWIEKRPQTE 


V 

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References

[1]Franciosa H.
Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Cooper.
Tissue: Head.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U02616 mRNA. Translation: AAA03434.1.
RefSeqNP_001273827.1. NM_001286898.1.

3D structure databases

ProteinModelPortalP46437.
SMRP46437. Positions 39-241.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101890455.

Organism-specific databases

CTD101890455.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGST_MUSDO
AccessionPrimary (citable) accession number: P46437
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families