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P46437

- GST_MUSDO

UniProt

P46437 - GST_MUSDO

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Protein
Glutathione S-transferase
Gene
N/A
Organism
Musca domestica (House fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461Glutathione By similarity
Binding sitei77 – 771Glutathione By similarity
Binding sitei81 – 811Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Glutathione S-transferase
PRO_0000185919Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP46437.
SMRiP46437. Positions 39-241.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 11778GST N-terminal
Add
BLAST
Domaini119 – 241123GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 892Glutathione binding By similarity
Regioni101 – 1022Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46437-1 [UniParc]FASTAAdd to Basket

« Hide

MADEAPAAPP AEGEAPAAPA EGEAPPPAEG EAPPAEPVKN TYTLFYFNVK    50
ALAEPLRYLF AYGGIEYEDV RVTRDEWPAL KPTMPMGQMP VLEVNGKRVH 100
QSISMARFLA KTVGLCGATP WEDLQVDIVV DTINDFRLKI AVVSYEPEDE 150
IKEKKLVTLN NEVIPFYLEK LEQTVKDNDG HLALNKLTWA DVYFAGILDY 200
MNYMVKRDIL EQYPALRGVV DSVNALEPIK AWIEKRPQTE V 241
Length:241
Mass (Da):26,964
Last modified:November 1, 1995 - v1
Checksum:i6A8FBD67ADDDEDFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U02616 mRNA. Translation: AAA03434.1.
RefSeqiNP_001273827.1. NM_001286898.1.

Genome annotation databases

GeneIDi101890455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U02616 mRNA. Translation: AAA03434.1 .
RefSeqi NP_001273827.1. NM_001286898.1.

3D structure databases

ProteinModelPortali P46437.
SMRi P46437. Positions 39-241.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101890455.

Organism-specific databases

CTDi 101890455.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Franciosa H.
    Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Cooper.
    Tissue: Head.

Entry informationi

Entry nameiGST_MUSDO
AccessioniPrimary (citable) accession number: P46437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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