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P46436 (GST1_ASCSU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 1

EC=2.5.1.18
Alternative name(s):
GST class-sigma
Gene names
Name:GST1
OrganismAscaris suum (Pig roundworm) (Ascaris lumbricoides)
Taxonomic identifier6253 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAscarididaeAscaris

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can also function as a GSH peroxidase.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Sequence similarities

Belongs to the GST superfamily. Sigma family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processmetabolic process

Non-traceable author statement Ref.1. Source: GOC

   Molecular_functionglutathione transferase activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 206205Glutathione S-transferase 1
PRO_0000185922

Regions

Domain2 – 7978GST N-terminal
Domain81 – 206126GST C-terminal
Region50 – 512Glutathione binding By similarity
Region63 – 642Glutathione binding By similarity

Sites

Binding site81Glutathione By similarity
Binding site391Glutathione By similarity
Binding site431Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P46436 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: B8366238A63DF399

FASTA20623,585
        10         20         30         40         50         60 
MPQYKLTYFD IRGLGEGARL IFHQAGVKFE DNRLKREDWP ALKPKTPFGQ LPLLEVDGEV 

        70         80         90        100        110        120 
LAQSAAIYRY LGRQFGLAGK TPMEEAQVDS IFDQFKDFMA ELRPCFRVLA GFEEGDKEKV 

       130        140        150        160        170        180 
LKEVAVPARD KHLPLLEKFL AKSGSEYMVG KSVTWADLVI TDSLASWESL IPDFLSGHLQ 

       190        200 
LKKYIEHVRE LPNIKKWIAE RPKTPY 

« Hide

References

[1]"Molecular cloning and expression of a cDNA encoding glutathione S-transferase from Ascaris suum."
Liebau E., Schoenberger O.L., Walter R.D., Henkle-Duehrsen K.J.
Mol. Biochem. Parasitol. 63:167-170(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 2-41.
[2]"Structural and functional analysis of a glutathione S-transferase from Ascaris suum."
Liebau E., Eckelt V.H., Wildenburg G., Teesdale-Spittle P., Brophy P.M., Walter R.D., Henkle-Duehrsen K.
Biochem. J. 324:659-666(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75502 mRNA. Translation: CAA53218.1.
Y10613 Genomic DNA. Translation: CAA71620.1.
PIRS38626.

3D structure databases

ProteinModelPortalP46436.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGST1_ASCSU
AccessionPrimary (citable) accession number: P46436
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 54 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families