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P46434 (GST1_ONCVO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 1

EC=2.5.1.18
Gene names
Name:GST1
Synonyms:GSTA
OrganismOnchocerca volvulus
Taxonomic identifier6282 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeOnchocerca

Protein attributes

Sequence length235 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity. Ref.2

Sequence similarities

Belongs to the GST superfamily.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical term3D-structure
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 235›235Glutathione S-transferase 1
PRO_0000185969

Regions

Domain36 – 11378GST N-terminal
Domain115 – 235121GST C-terminal
Region97 – 982Glutathione binding

Sites

Binding site421Glutathione
Binding site731Glutathione
Binding site771Glutathione
Binding site851Glutathione; via amide nitrogen and carbonyl oxygen

Experimental info

Non-terminal residue11

Secondary structure

................................... 235
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P46434 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: F28928E44102F63A

FASTA23526,838
        10         20         30         40         50         60 
FITMNFVVEA ASSNANQAIT SENSIKPKGK LQPQMEKYTL TYFNGRGRAE VIRLLFALAN 

        70         80         90        100        110        120 
VSYEDNRITR DEWKYLKPRT PFGHVPMLNV SGNVLGESHA IELLLGGRFG LLGTNDWEEA 

       130        140        150        160        170        180 
KIMAVVLNID ELFQKLIPWT HEKNTTKKAE LFRNLSESDV MPFLGRYEKF LKESTTGHIV 

       190        200        210        220        230 
GNKVSVADLT VFNMLMTLDD EVKLEEYPQL ASFVNKIGQM PGIKEWIKKR PKTYF 

« Hide

References

[1]"Isolation, sequence and expression of an Onchocerca volvulus glutathione S-transferase cDNA."
Liebau E., Walter R.D., Henkle-Duehrsen K.
Mol. Biochem. Parasitol. 63:305-309(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus."
Perbandt M., Hoppner J., Burmeister C., Luersen K., Betzel C., Liebau E.
J. Mol. Biol. 377:501-511(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 11-235 IN COMPLEX WITH GLUTATHIONE, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75029 mRNA. Translation: CAA52937.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2HNLX-ray2.00A/B11-235[»]
ProteinModelPortalP46434.
SMRP46434. Positions 34-235.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP46434.

Entry information

Entry nameGST1_ONCVO
AccessionPrimary (citable) accession number: P46434
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references