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Protein

Glutathione S-transferase 1

Gene

GST1

Organism
Onchocerca volvulus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42Glutathione1 Publication1
Binding sitei73Glutathione1 Publication1
Binding sitei77Glutathione1 Publication1
Binding sitei85Glutathione; via amide nitrogen and carbonyl oxygen1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1 (EC:2.5.1.18)
Gene namesi
Name:GST1
Synonyms:GSTA
OrganismiOnchocerca volvulus
Taxonomic identifieri6282 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeOnchocerca
Proteomesi
  • UP000024404 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000185969‹1 – 235Glutathione S-transferase 1Add BLAST›235

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 46Combined sources9
Helixi47 – 49Combined sources3
Helixi50 – 59Combined sources10
Beta strandi64 – 68Combined sources5
Helixi70 – 76Combined sources7
Helixi77 – 79Combined sources3
Beta strandi80 – 83Combined sources4
Beta strandi87 – 90Combined sources4
Beta strandi93 – 96Combined sources4
Helixi98 – 108Combined sources11
Helixi116 – 141Combined sources26
Helixi145 – 156Combined sources12
Turni157 – 159Combined sources3
Helixi160 – 172Combined sources13
Beta strandi175 – 177Combined sources3
Helixi186 – 197Combined sources12
Helixi199 – 201Combined sources3
Helixi204 – 206Combined sources3
Helixi208 – 219Combined sources12
Helixi223 – 229Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HNLX-ray2.00A/B11-235[»]
ProteinModelPortaliP46434.
SMRiP46434.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46434.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 113GST N-terminalAdd BLAST78
Domaini115 – 235GST C-terminalAdd BLAST121

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 98Glutathione binding2

Sequence similaritiesi

Belongs to the GST superfamily.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P46434-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FITMNFVVEA ASSNANQAIT SENSIKPKGK LQPQMEKYTL TYFNGRGRAE
60 70 80 90 100
VIRLLFALAN VSYEDNRITR DEWKYLKPRT PFGHVPMLNV SGNVLGESHA
110 120 130 140 150
IELLLGGRFG LLGTNDWEEA KIMAVVLNID ELFQKLIPWT HEKNTTKKAE
160 170 180 190 200
LFRNLSESDV MPFLGRYEKF LKESTTGHIV GNKVSVADLT VFNMLMTLDD
210 220 230
EVKLEEYPQL ASFVNKIGQM PGIKEWIKKR PKTYF
Length:235
Mass (Da):26,838
Last modified:November 1, 1995 - v1
Checksum:iF28928E44102F63A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75029 mRNA. Translation: CAA52937.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75029 mRNA. Translation: CAA52937.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HNLX-ray2.00A/B11-235[»]
ProteinModelPortaliP46434.
SMRiP46434.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP46434.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGST1_ONCVO
AccessioniPrimary (citable) accession number: P46434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.