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P46434

- GST1_ONCVO

UniProt

P46434 - GST1_ONCVO

Protein

Glutathione S-transferase 1

Gene

GST1

Organism
Onchocerca volvulus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421Glutathione1 Publication
    Binding sitei73 – 731Glutathione1 Publication
    Binding sitei77 – 771Glutathione1 Publication
    Binding sitei85 – 851Glutathione; via amide nitrogen and carbonyl oxygen1 Publication

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase 1 (EC:2.5.1.18)
    Gene namesi
    Name:GST1
    Synonyms:GSTA
    OrganismiOnchocerca volvulus
    Taxonomic identifieri6282 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeOnchocerca

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 235›235Glutathione S-transferase 1PRO_0000185969Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    Secondary structure

    1
    235
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi38 – 469
    Helixi47 – 493
    Helixi50 – 5910
    Beta strandi64 – 685
    Helixi70 – 767
    Helixi77 – 793
    Beta strandi80 – 834
    Beta strandi87 – 904
    Beta strandi93 – 964
    Helixi98 – 10811
    Helixi116 – 14126
    Helixi145 – 15612
    Turni157 – 1593
    Helixi160 – 17213
    Beta strandi175 – 1773
    Helixi186 – 19712
    Helixi199 – 2013
    Helixi204 – 2063
    Helixi208 – 21912
    Helixi223 – 2297

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HNLX-ray2.00A/B11-235[»]
    ProteinModelPortaliP46434.
    SMRiP46434. Positions 34-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP46434.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 11378GST N-terminalAdd
    BLAST
    Domaini115 – 235121GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni97 – 982Glutathione binding

    Sequence similaritiesi

    Belongs to the GST superfamily.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF14497. GST_C_3. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P46434-1 [UniParc]FASTAAdd to Basket

    « Hide

    FITMNFVVEA ASSNANQAIT SENSIKPKGK LQPQMEKYTL TYFNGRGRAE    50
    VIRLLFALAN VSYEDNRITR DEWKYLKPRT PFGHVPMLNV SGNVLGESHA 100
    IELLLGGRFG LLGTNDWEEA KIMAVVLNID ELFQKLIPWT HEKNTTKKAE 150
    LFRNLSESDV MPFLGRYEKF LKESTTGHIV GNKVSVADLT VFNMLMTLDD 200
    EVKLEEYPQL ASFVNKIGQM PGIKEWIKKR PKTYF 235
    Length:235
    Mass (Da):26,838
    Last modified:November 1, 1995 - v1
    Checksum:iF28928E44102F63A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75029 mRNA. Translation: CAA52937.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75029 mRNA. Translation: CAA52937.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HNL X-ray 2.00 A/B 11-235 [» ]
    ProteinModelPortali P46434.
    SMRi P46434. Positions 34-235.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P46434.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF14497. GST_C_3. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, sequence and expression of an Onchocerca volvulus glutathione S-transferase cDNA."
      Liebau E., Walter R.D., Henkle-Duehrsen K.
      Mol. Biochem. Parasitol. 63:305-309(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus."
      Perbandt M., Hoppner J., Burmeister C., Luersen K., Betzel C., Liebau E.
      J. Mol. Biol. 377:501-511(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 11-235 IN COMPLEX WITH GLUTATHIONE, SUBUNIT.

    Entry informationi

    Entry nameiGST1_ONCVO
    AccessioniPrimary (citable) accession number: P46434
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3