Reviewed, UniProtKB/Swiss-Prot P46434 (GST1_ONCVO)

Names and origin

Protein names

Recommended name:
    Glutathione S-transferase 1
    EC=2.5.1.18

Gene names

Name:	GST1
Synonyms:	GSTA

Organism

Onchocerca volvulus

Taxonomic identifier

6282 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Spirurida › Filarioidea › Onchocercidae › Onchocerca

Protein attributes

Sequence length	235 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the GST superfamily. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	3D-structure
Gene Ontology (GO)
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 235

›235

Glutathione S-transferase 1

PRO_0000185969

Regions

Domain

36 – 113

78

GST N-terminal

Domain

115 – 235

121

GST C-terminal

Experimental info

Non-terminal residue

1

1

Secondary structure

1

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235

Helix Strand Turn

Details...

Beta strand

38 – 46

9

Helix

47 – 49

3

Helix

50 – 59

10

Beta strand

64 – 68

5

Helix

70 – 76

7

Helix

77 – 79

3

Beta strand

80 – 83

4

Beta strand

87 – 90

4

Beta strand

93 – 96

4

Helix

98 – 108

11

Helix

116 – 141

26

Helix

145 – 156

12

Turn

157 – 159

3

Helix

160 – 172

13

Beta strand

175 – 177

3

Helix

186 – 197

12

Helix

199 – 201

3

Helix

204 – 206

3

Helix

208 – 219

12

Helix

223 – 229

7

Sequences

	Sequence		Length	Mass (Da)
	P46434-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: F28928E44102F63A	FASTA	235	26,838
	10 20 30 40 50 60 FITMNFVVEA ASSNANQAIT SENSIKPKGK LQPQMEKYTL TYFNGRGRAE VIRLLFALAN 70 80 90 100 110 120 VSYEDNRITR DEWKYLKPRT PFGHVPMLNV SGNVLGESHA IELLLGGRFG LLGTNDWEEA 130 140 150 160 170 180 KIMAVVLNID ELFQKLIPWT HEKNTTKKAE LFRNLSESDV MPFLGRYEKF LKESTTGHIV 190 200 210 220 230 GNKVSVADLT VFNMLMTLDD EVKLEEYPQL ASFVNKIGQM PGIKEWIKKR PKTYF

References

[1]	"Isolation, sequence and expression of an Onchocerca volvulus glutathione S-transferase cDNA." Liebau E., Walter R.D., Henkle-Duehrsen K. Mol. Biochem. Parasitol. 63:305-309(1994) [PubMed: 8008026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

X75029 mRNA. Translation: CAA52937.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HNL	X-ray	2.00	A/B	11-235	[»]

ModBase

Search...

Enzyme and pathway databases

BRENDA

2.5.1.18. 3103.

Family and domain databases

InterPro

IPR004045. Glutathione_S-Trfase_N.
IPR017933. Glutathione_S_Trfase/Cl_chnl_C.
IPR004046. GST_C.
IPR012335. Thioredoxin_fold.
[Graphical view]

Gene3D

G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.

Pfam

PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]

PROSITE

PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

GST1_ONCVO

Accession

Primary (citable) accession number: P46434

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	March 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)