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P46434

- GST1_ONCVO

UniProt

P46434 - GST1_ONCVO

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Protein
Glutathione S-transferase 1
Gene
GST1, GSTA
Organism
Onchocerca volvulus
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Glutathione
Binding sitei73 – 731Glutathione
Binding sitei77 – 771Glutathione
Binding sitei85 – 851Glutathione; via amide nitrogen and carbonyl oxygen

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 1 (EC:2.5.1.18)
Gene namesi
Name:GST1
Synonyms:GSTA
OrganismiOnchocerca volvulus
Taxonomic identifieri6282 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeOnchocerca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 235›235Glutathione S-transferase 1
PRO_0000185969Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.1 Publication

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi38 – 469
Helixi47 – 493
Helixi50 – 5910
Beta strandi64 – 685
Helixi70 – 767
Helixi77 – 793
Beta strandi80 – 834
Beta strandi87 – 904
Beta strandi93 – 964
Helixi98 – 10811
Helixi116 – 14126
Helixi145 – 15612
Turni157 – 1593
Helixi160 – 17213
Beta strandi175 – 1773
Helixi186 – 19712
Helixi199 – 2013
Helixi204 – 2063
Helixi208 – 21912
Helixi223 – 2297

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HNLX-ray2.00A/B11-235[»]
ProteinModelPortaliP46434.
SMRiP46434. Positions 34-235.

Miscellaneous databases

EvolutionaryTraceiP46434.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 11378GST N-terminal
Add
BLAST
Domaini115 – 235121GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 982Glutathione binding

Sequence similaritiesi

Belongs to the GST superfamily.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P46434-1 [UniParc]FASTAAdd to Basket

« Hide

FITMNFVVEA ASSNANQAIT SENSIKPKGK LQPQMEKYTL TYFNGRGRAE    50
VIRLLFALAN VSYEDNRITR DEWKYLKPRT PFGHVPMLNV SGNVLGESHA 100
IELLLGGRFG LLGTNDWEEA KIMAVVLNID ELFQKLIPWT HEKNTTKKAE 150
LFRNLSESDV MPFLGRYEKF LKESTTGHIV GNKVSVADLT VFNMLMTLDD 200
EVKLEEYPQL ASFVNKIGQM PGIKEWIKKR PKTYF 235
Length:235
Mass (Da):26,838
Last modified:November 1, 1995 - v1
Checksum:iF28928E44102F63A
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75029 mRNA. Translation: CAA52937.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75029 mRNA. Translation: CAA52937.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HNL X-ray 2.00 A/B 11-235 [» ]
ProteinModelPortali P46434.
SMRi P46434. Positions 34-235.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P46434.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation, sequence and expression of an Onchocerca volvulus glutathione S-transferase cDNA."
    Liebau E., Walter R.D., Henkle-Duehrsen K.
    Mol. Biochem. Parasitol. 63:305-309(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of the extracellular glutathione S-transferase OvGST1 from the human pathogenic parasite Onchocerca volvulus."
    Perbandt M., Hoppner J., Burmeister C., Luersen K., Betzel C., Liebau E.
    J. Mol. Biol. 377:501-511(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 11-235 IN COMPLEX WITH GLUTATHIONE, SUBUNIT.

Entry informationi

Entry nameiGST1_ONCVO
AccessioniPrimary (citable) accession number: P46434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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