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Protein

Glutathione S-transferase 4

Gene

Gst4

Organism
Musca domestica (House fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 4 (EC:2.5.1.18)
Alternative name(s):
GST class-theta
Gene namesi
Name:Gst4
Synonyms:Gst-4
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca
Proteomesi
  • UP000095301 Componenti: Whole Genome Shotgun Assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859681 – 210Glutathione S-transferase 4Add BLAST210

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP46433.
SMRiP46433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 80GST N-terminalAdd BLAST80
Domaini87 – 208GST C-terminalAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 52Glutathione bindingBy similarity3
Regioni64 – 66Glutathione bindingBy similarity3

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P46433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFYYLPLSA PCRSVLMTAK ALGIELNKKL LKLFEGGHLK PEFLKINPQH
60 70 80 90 100
TIPTLVDNGF ALWESRAIMV YLVEKYGKQD DPLYPSCPKK RALINQRLYF
110 120 130 140 150
DMGTLYQGFA NYFYPQFKEK KPADPELFKK FEVTLDFLNT FLSESKYAAG
160 170 180 190 200
DSLTLADLAL LASVSTFEAV NIDVSKYEHI ARWYALVKET APGADENWAG
210
ALEMKTLIPK
Length:210
Mass (Da):23,909
Last modified:November 1, 1995 - v1
Checksum:i58B2CABB7AB6FACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73576 mRNA. Translation: CAA51978.1.
PIRiS51568.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGSTT4_MUSDO
AccessioniPrimary (citable) accession number: P46433
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 10, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families