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P46433

- GSTT4_MUSDO

UniProt

P46433 - GSTT4_MUSDO

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Protein
Glutathione S-transferase 4
Gene
Gst4, Gst-4
Organism
Musca domestica (House fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 4 (EC:2.5.1.18)
Alternative name(s):
GST class-theta
Gene namesi
Name:Gst4
Synonyms:Gst-4
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Glutathione S-transferase 4
PRO_0000185968Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP46433.
SMRiP46433. Positions 1-205.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8080GST N-terminal
Add
BLAST
Domaini87 – 208122GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 523Glutathione binding By similarity
Regioni64 – 663Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46433-1 [UniParc]FASTAAdd to Basket

« Hide

MDFYYLPLSA PCRSVLMTAK ALGIELNKKL LKLFEGGHLK PEFLKINPQH    50
TIPTLVDNGF ALWESRAIMV YLVEKYGKQD DPLYPSCPKK RALINQRLYF 100
DMGTLYQGFA NYFYPQFKEK KPADPELFKK FEVTLDFLNT FLSESKYAAG 150
DSLTLADLAL LASVSTFEAV NIDVSKYEHI ARWYALVKET APGADENWAG 200
ALEMKTLIPK 210
Length:210
Mass (Da):23,909
Last modified:November 1, 1995 - v1
Checksum:i58B2CABB7AB6FACE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73576 mRNA. Translation: CAA51978.1.
PIRiS51568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X73576 mRNA. Translation: CAA51978.1 .
PIRi S51568.

3D structure databases

ProteinModelPortali P46433.
SMRi P46433. Positions 1-205.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Glutathione transferase gene family from the housefly Musca domestica."
    Syvanen M., Zhou Z., Wang J.
    Mol. Gen. Genet. 245:25-31(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Cornell-R.

Entry informationi

Entry nameiGSTT4_MUSDO
AccessioniPrimary (citable) accession number: P46433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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