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P46431 (GSTT2_MUSDO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 2

EC=2.5.1.18
Alternative name(s):
GST class-theta
Gene names
Name:Gst2
Synonyms:Gst-2
OrganismMusca domestica (House fly)
Taxonomic identifier7370 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the GST superfamily. Theta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 210210Glutathione S-transferase 2
PRO_0000185966

Regions

Domain1 – 8080GST N-terminal
Domain87 – 208122GST C-terminal
Region50 – 523Glutathione binding By similarity
Region64 – 663Glutathione binding By similarity

Sites

Binding site91Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P46431 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: EC8ADA2B54AA2F38

FASTA21024,344
        10         20         30         40         50         60 
MDFYYLPLSA PCRSVIMTAK ALGIELNKKL LNLFEGEHLK PEFLKINPQH TIPTLVDNGF 

        70         80         90        100        110        120 
AMWESRAIMV YLVEKYGKQN DPLYPSCPKK RALINQRLYF DMGTLWKSYA DYTYPQFREN 

       130        140        150        160        170        180 
KPADPELFKK FESALEFLNI FLSQSKYAAG ETMTLADLAI LASVSTFDVV QMDLSKYEHI 

       190        200        210 
LRWYNMLKDT APGAAENWAG CLEMKKYFKK 

« Hide

References

[1]"Glutathione transferase gene family from the housefly Musca domestica."
Syvanen M., Zhou Z., Wang J.
Mol. Gen. Genet. 245:25-31(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Cornell-R.
[2]Syvanen M.
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X73574 mRNA. Translation: CAA51976.1.
PIRS70851.

3D structure databases

ProteinModelPortalP46431.
SMRP46431. Positions 1-208.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTT2_MUSDO
AccessionPrimary (citable) accession number: P46431
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families