Glutathione S-transferase 1 - Manduca sexta (Tobacco hawkmoth)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Glutathione S-transferase 1
EC=2.5.1.18

Alternative name(s):
GST class-theta

Gene names

Name:

GST1

Organism

Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)

Taxonomic identifier

7130 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Lepidoptera › Glossata › Ditrysia › Bombycoidea › Sphingidae › Sphinginae › Sphingini › Manduca

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer Potential.
Sequence similarities	Belongs to the GST superfamily. Theta family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Gene Ontology (GO)
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 217

217

Glutathione S-transferase 1

PRO_0000185964

Regions

Domain

1 – 83

83

GST N-terminal

Domain

89 – 211

123

GST C-terminal

Region

53 – 55

3

Glutathione binding By similarity

Region

67 – 69

3

Glutathione binding By similarity

Sites

Binding site

11

1

Glutathione By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P46430 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 630281A2975E56C0
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FASTA

217

24,431

        10         20         30         40         50         60 
MVMTLYKLDA SPPARAVMMV IEALKIPDVE YIDVNLLEGS HLSEEFTKMN PQHTVPLLKD 

        70         80         90        100        110        120 
DDFLVWDSHA IAGYLVSKYG ADDSLYPTDP KKRAIVDQRL HFDSGILFPA LRGSLEPVIF 

       130        140        150        160        170        180 
WGETAFRPEC LEKVRKGYDF AEKFLTSTWM AGEEFTVADI CCVASISTMN DIIVPIDENT 

       190        200        210 
YPKLSAWLER CSQLDVYKKK NAPGNDLCKD LVASKLS

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References

[1]	"Glutathione S-transferases from larval Manduca sexta midgut: sequence of two cDNAs and enzyme induction." Snyder M.J., Walding J.K., Feyereisen R. Insect Biochem. Mol. Biol. 25:455-465(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Midgut.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L32091 mRNA. Translation: AAA92880.1.
3D structure databases
ProteinModelPortal	P46430.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTT1_MANSE

Accession

Primary (citable) accession number: P46430

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families