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P46430 (GSTT1_MANSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 1

EC=2.5.1.18
Alternative name(s):
GST class-theta
Gene names
Name:GST1
OrganismManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifier7130 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer Potential.

Sequence similarities

Belongs to the GST superfamily. Theta family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Glutathione S-transferase 1
PRO_0000185964

Regions

Domain1 – 8383GST N-terminal
Domain89 – 211123GST C-terminal
Region53 – 553Glutathione binding By similarity
Region67 – 693Glutathione binding By similarity

Sites

Binding site111Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P46430 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 630281A2975E56C0

FASTA21724,431
        10         20         30         40         50         60 
MVMTLYKLDA SPPARAVMMV IEALKIPDVE YIDVNLLEGS HLSEEFTKMN PQHTVPLLKD 

        70         80         90        100        110        120 
DDFLVWDSHA IAGYLVSKYG ADDSLYPTDP KKRAIVDQRL HFDSGILFPA LRGSLEPVIF 

       130        140        150        160        170        180 
WGETAFRPEC LEKVRKGYDF AEKFLTSTWM AGEEFTVADI CCVASISTMN DIIVPIDENT 

       190        200        210 
YPKLSAWLER CSQLDVYKKK NAPGNDLCKD LVASKLS 

« Hide

References

[1]"Glutathione S-transferases from larval Manduca sexta midgut: sequence of two cDNAs and enzyme induction."
Snyder M.J., Walding J.K., Feyereisen R.
Insect Biochem. Mol. Biol. 25:455-465(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Midgut.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L32091 mRNA. Translation: AAA92880.1.

3D structure databases

ProteinModelPortalP46430.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTT1_MANSE
AccessionPrimary (citable) accession number: P46430
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families