Reviewed, UniProtKB/Swiss-Prot P46429 (GST2_MANSE)

Names and origin

Protein names

Recommended name:
    Glutathione S-transferase 2
    EC=2.5.1.18
Alternative name(s):
    GST class-sigma

Gene names

Name:

GST2

Organism

Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)

Taxonomic identifier

7130 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Lepidoptera › Glossata › Ditrysia › Bombycoidea › Sphingidae › Sphinginae › Sphingini › Manduca

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Induction	By dietary chemicals.
Sequence similarities	Belongs to the GST superfamily. Sigma family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Gene Ontology (GO)
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Glutathione S-transferase 2		PRO_0000185918
Regions
	Domain	1 – 78	78	GST N-terminal
	Domain	80 – 203	124	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	P46429-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: D5EC67F119DE470D	FASTA	203	23,596
	10 20 30 40 50 60 MPKVVFHYFG AKGWARPTML LAYGGQEFED HRVEYEQWPE FKPNTPFGQM PVLEIDGKKY 70 80 90 100 110 120 AQSLAISRYL GRKYGLAGND IEEDFEIDQI VDFVNDIRAS AASVEYEQDA ANKEVKHEEN 130 140 150 160 170 180 MKNKYPFQLN KLSEIITKNN GFLALGRLTW ADFVFVGMFD YLKKMLRMPD LEEQYPIFKK 190 200 PIETVLSNPK LKAYLDSAPK KEF

References

[1]	"Glutathione S-transferases from larval Manduca sexta midgut: sequence of two cDNAs and enzyme induction." Snyder M.J., Walding J.K., Feyereisen R. Insect Biochem. Mol. Biol. 25:455-465(1995) [PubMed: 7742833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Midgut.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L32092 mRNA. Translation: AAA92881.1.
3D structure databases
SMR	P46429. Positions 1-203.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.18. 15145.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GST2_MANSE

Accession

Primary (citable) accession number: P46429

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 19, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)