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P46429 (GST2_MANSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 2

EC=2.5.1.18
Alternative name(s):
GST class-sigma
Gene names
Name:GST2
OrganismManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifier7130 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Induction

By dietary chemicals.

Sequence similarities

Belongs to the GST superfamily. Sigma family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Glutathione S-transferase 2
PRO_0000185918

Regions

Domain1 – 7878GST N-terminal
Domain80 – 203124GST C-terminal
Region49 – 502Glutathione binding By similarity
Region62 – 632Glutathione binding By similarity

Sites

Binding site81Glutathione By similarity
Binding site381Glutathione By similarity
Binding site421Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P46429 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D5EC67F119DE470D

FASTA20323,596
        10         20         30         40         50         60 
MPKVVFHYFG AKGWARPTML LAYGGQEFED HRVEYEQWPE FKPNTPFGQM PVLEIDGKKY 

        70         80         90        100        110        120 
AQSLAISRYL GRKYGLAGND IEEDFEIDQI VDFVNDIRAS AASVEYEQDA ANKEVKHEEN 

       130        140        150        160        170        180 
MKNKYPFQLN KLSEIITKNN GFLALGRLTW ADFVFVGMFD YLKKMLRMPD LEEQYPIFKK 

       190        200 
PIETVLSNPK LKAYLDSAPK KEF 

« Hide

References

[1]"Glutathione S-transferases from larval Manduca sexta midgut: sequence of two cDNAs and enzyme induction."
Snyder M.J., Walding J.K., Feyereisen R.
Insect Biochem. Mol. Biol. 25:455-465(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Midgut.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L32092 mRNA. Translation: AAA92881.1.

3D structure databases

ProteinModelPortalP46429.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGST2_MANSE
AccessionPrimary (citable) accession number: P46429
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families