P46426 (GSTP_DIRIM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Glutathione S-transferase EC=2.5.1.18 Alternative name(s): GST class-pi
Organism	Dirofilaria immitis (Canine heartworm)
Taxonomic identifier	6287 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Spirurida › Filarioidea › Onchocercidae › Dirofilaria

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the GST superfamily. Pi family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Gene Ontology (GO)
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Glutathione S-transferase		PRO_0000185913
Regions
	Domain	1 – 78	78	GST N-terminal
	Domain	80 – 200	121	GST C-terminal
	Region	49 – 50	2	Glutathione binding By similarity
	Region	62 – 63	2	Glutathione binding By similarity
Sites
	Binding site	7	1	Glutathione By similarity
	Binding site	42	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	P46426 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 698510856385AE6B	FASTA	208	24,146
	10 20 30 40 50 60 MSYKLTYFPI RGLAEPIRLL LVDQGIKFTD EHIPKDDFVS IKSQFQFGQL PCFYDGDQQI 70 80 90 100 110 120 VQSGAILRHL ARKFNLNGEN NAETSYVDMF YEGIRDLHSK YTRMIYEAYE TQKDPFIKNI 130 140 150 160 170 180 LPQELAKLEK LLATRDNGKN FILGDKISFA DYVLFEELDV QQILDPHCLE KFPLLKAFHQ 190 200 RLGDKPKIKE YCAKRNASKM PVNGNGKQ

References

[1]	James E.R., McLean D.C., Venkatakrishnaiah L. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U14753 mRNA. Translation: AAA21585.1.
3D structure databases
ProteinModelPortal	P46426.
SMR	P46426. Positions 1-208.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR003082. GST_pi. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01268. GSTRNSFRASEP.
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTP_DIRIM

Accession

Primary (citable) accession number: P46426

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	March 6, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)