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Protein

Glutathione S-transferase P 2

Gene

Gstp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cannot metabolize 1-chloro-2,4-dinitrobenzene.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81GlutathioneBy similarity
Binding sitei14 – 141GlutathioneBy similarity
Binding sitei39 – 391GlutathioneBy similarity
Binding sitei45 – 451GlutathioneBy similarity

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_308972. Detoxification of Reactive Oxygen Species.
REACT_317599. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P 2 (EC:2.5.1.18)
Short name:
Gst P2
Alternative name(s):
GST YF-YF
GST class-pi
GST-piA
Gene namesi
Name:Gstp2
Synonyms:Gstpia
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componentsi: Chromosome 19, Unplaced

Organism-specific databases

MGIiMGI:95864. Gstp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Glutathione S-transferase P 2PRO_0000185904Add
BLAST

Proteomic databases

MaxQBiP46425.
PaxDbiP46425.
PRIDEiP46425.

PTM databases

PhosphoSiteiP46425.

Expressioni

Tissue specificityi

Selectively expressed in gall bladder, colon, heart, and skeletal muscle.

Gene expression databases

BgeeiP46425.
CleanExiMM_GSTP2.
ExpressionAtlasiP46425. baseline and differential.
GenevestigatoriP46425.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiP46425. 5 interactions.
MINTiMINT-4097004.
STRINGi10090.ENSMUSP00000038931.

Structurei

3D structure databases

ProteinModelPortaliP46425.
SMRiP46425. Positions 2-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8180GST N-terminalAdd
BLAST
Domaini83 – 204122GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 532Glutathione bindingBy similarity
Regioni65 – 662Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG05174.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115733.
HOVERGENiHBG108324.
InParanoidiP46425.
KOiK00799.
OMAiAYLNKRA.
OrthoDBiEOG7KH9M3.
PhylomeDBiP46425.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPYTIVYFP SPGRCEAMRM LLADQGQSWK EEVVTIDTWM QGLLKPTCLY
60 70 80 90 100
GQLPKFEDGD LTLYQSNAIL RHLGRSLGLY GKNQREAAQV DMVNDGVEDL
110 120 130 140 150
RGKYGTMIYR NYENGKNDYV KALPGHLKPF ETLLSQNQGG KAFIVGDQIS
160 170 180 190 200
FADYNLLDLL LIHQVLAPGC LDNFPLLSAY VARLSARPKI KAFLSSPEHV
210
NRPINGNGKQ
Length:210
Mass (Da):23,537
Last modified:January 23, 2007 - v2
Checksum:i48423B9F236C8A36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76144 Genomic DNA. No translation available.
U15654 Genomic DNA. Translation: AAA64836.1.
BC064781 mRNA. Translation: AAH64781.1.
BC094623 mRNA. Translation: AAH94623.1.
CCDSiCCDS29412.1.
PIRiA55140.
RefSeqiNP_861461.1. NM_181796.2.
UniGeneiMm.441542.

Genome annotation databases

EnsembliENSMUST00000042700; ENSMUSP00000038931; ENSMUSG00000038155.
ENSMUST00000181010; ENSMUSP00000138013; ENSMUSG00000097808.
GeneIDi14869.
KEGGimmu:14869.
UCSCiuc008fyg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76144 Genomic DNA. No translation available.
U15654 Genomic DNA. Translation: AAA64836.1.
BC064781 mRNA. Translation: AAH64781.1.
BC094623 mRNA. Translation: AAH94623.1.
CCDSiCCDS29412.1.
PIRiA55140.
RefSeqiNP_861461.1. NM_181796.2.
UniGeneiMm.441542.

3D structure databases

ProteinModelPortaliP46425.
SMRiP46425. Positions 2-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP46425. 5 interactions.
MINTiMINT-4097004.
STRINGi10090.ENSMUSP00000038931.

PTM databases

PhosphoSiteiP46425.

Proteomic databases

MaxQBiP46425.
PaxDbiP46425.
PRIDEiP46425.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042700; ENSMUSP00000038931; ENSMUSG00000038155.
ENSMUST00000181010; ENSMUSP00000138013; ENSMUSG00000097808.
GeneIDi14869.
KEGGimmu:14869.
UCSCiuc008fyg.1. mouse.

Organism-specific databases

CTDi14869.
MGIiMGI:95864. Gstp2.

Phylogenomic databases

eggNOGiNOG05174.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115733.
HOVERGENiHBG108324.
InParanoidiP46425.
KOiK00799.
OMAiAYLNKRA.
OrthoDBiEOG7KH9M3.
PhylomeDBiP46425.
TreeFamiTF105321.

Enzyme and pathway databases

ReactomeiREACT_308972. Detoxification of Reactive Oxygen Species.
REACT_317599. Glutathione conjugation.

Miscellaneous databases

NextBioi287129.
PROiP46425.
SOURCEiSearch...

Gene expression databases

BgeeiP46425.
CleanExiMM_GSTP2.
ExpressionAtlasiP46425. baseline and differential.
GenevestigatoriP46425.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of two mouse PI class glutathione S-transferase genes."
    Bammler T.K., Smith C.A.D., Wolf R.C.
    Biochem. J. 298:385-390(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Two murine GSTpi genes are arranged in tandem and are differentially expressed."
    Xu X., Stambrook P.J.
    J. Biol. Chem. 269:30268-30273(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Mammary gland.

Entry informationi

Entry nameiGSTP2_MOUSE
AccessioniPrimary (citable) accession number: P46425
Secondary accession number(s): Q505C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: May 27, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.