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P46425

- GSTP2_MOUSE

UniProt

P46425 - GSTP2_MOUSE

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Protein
Glutathione S-transferase P 2
Gene
Gstp2, Gstpia
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cannot metabolize 1-chloro-2,4-dinitrobenzene.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81Glutathione By similarity
Binding sitei14 – 141Glutathione By similarity
Binding sitei39 – 391Glutathione By similarity
Binding sitei45 – 451Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: MGI

GO - Biological processi

  1. glutathione metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_189141. Detoxification of Reactive Oxygen Species.
REACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P 2 (EC:2.5.1.18)
Short name:
Gst P2
Alternative name(s):
GST YF-YF
GST class-pi
GST-piA
Gene namesi
Name:Gstp2
Synonyms:Gstpia
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:95864. Gstp2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 210209Glutathione S-transferase P 2
PRO_0000185904Add
BLAST

Proteomic databases

MaxQBiP46425.
PaxDbiP46425.
PRIDEiP46425.

PTM databases

PhosphoSiteiP46425.

Expressioni

Tissue specificityi

Selectively expressed in gall bladder, colon, heart, and skeletal muscle.

Gene expression databases

BgeeiP46425.
CleanExiMM_GSTP2.
GenevestigatoriP46425.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiP46425. 5 interactions.
MINTiMINT-4097004.
STRINGi10090.ENSMUSP00000038931.

Structurei

3D structure databases

ProteinModelPortaliP46425.
SMRiP46425. Positions 2-210.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8180GST N-terminal
Add
BLAST
Domaini83 – 204122GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 532Glutathione binding By similarity
Regioni65 – 662Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.

Phylogenomic databases

eggNOGiNOG05174.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115733.
HOVERGENiHBG108324.
InParanoidiP46425.
KOiK00799.
OMAiAYLNKRA.
OrthoDBiEOG7KH9M3.
PhylomeDBiP46425.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46425-1 [UniParc]FASTAAdd to Basket

« Hide

MPPYTIVYFP SPGRCEAMRM LLADQGQSWK EEVVTIDTWM QGLLKPTCLY    50
GQLPKFEDGD LTLYQSNAIL RHLGRSLGLY GKNQREAAQV DMVNDGVEDL 100
RGKYGTMIYR NYENGKNDYV KALPGHLKPF ETLLSQNQGG KAFIVGDQIS 150
FADYNLLDLL LIHQVLAPGC LDNFPLLSAY VARLSARPKI KAFLSSPEHV 200
NRPINGNGKQ 210
Length:210
Mass (Da):23,537
Last modified:January 23, 2007 - v2
Checksum:i48423B9F236C8A36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76144 Genomic DNA. No translation available.
U15654 Genomic DNA. Translation: AAA64836.1.
BC064781 mRNA. Translation: AAH64781.1.
BC094623 mRNA. Translation: AAH94623.1.
CCDSiCCDS29412.1.
PIRiA55140.
RefSeqiNP_861461.1. NM_181796.2.
UniGeneiMm.441542.

Genome annotation databases

EnsembliENSMUST00000042700; ENSMUSP00000038931; ENSMUSG00000038155.
ENSMUST00000181010; ENSMUSP00000138013; ENSMUSG00000097808.
GeneIDi14869.
KEGGimmu:14869.
UCSCiuc008fyg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76144 Genomic DNA. No translation available.
U15654 Genomic DNA. Translation: AAA64836.1 .
BC064781 mRNA. Translation: AAH64781.1 .
BC094623 mRNA. Translation: AAH94623.1 .
CCDSi CCDS29412.1.
PIRi A55140.
RefSeqi NP_861461.1. NM_181796.2.
UniGenei Mm.441542.

3D structure databases

ProteinModelPortali P46425.
SMRi P46425. Positions 2-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P46425. 5 interactions.
MINTi MINT-4097004.
STRINGi 10090.ENSMUSP00000038931.

PTM databases

PhosphoSitei P46425.

Proteomic databases

MaxQBi P46425.
PaxDbi P46425.
PRIDEi P46425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042700 ; ENSMUSP00000038931 ; ENSMUSG00000038155 .
ENSMUST00000181010 ; ENSMUSP00000138013 ; ENSMUSG00000097808 .
GeneIDi 14869.
KEGGi mmu:14869.
UCSCi uc008fyg.1. mouse.

Organism-specific databases

CTDi 14869.
MGIi MGI:95864. Gstp2.

Phylogenomic databases

eggNOGi NOG05174.
GeneTreei ENSGT00550000074559.
HOGENOMi HOG000115733.
HOVERGENi HBG108324.
InParanoidi P46425.
KOi K00799.
OMAi AYLNKRA.
OrthoDBi EOG7KH9M3.
PhylomeDBi P46425.
TreeFami TF105321.

Enzyme and pathway databases

Reactomei REACT_189141. Detoxification of Reactive Oxygen Species.
REACT_215316. Glutathione conjugation.

Miscellaneous databases

NextBioi 287129.
PROi P46425.
SOURCEi Search...

Gene expression databases

Bgeei P46425.
CleanExi MM_GSTP2.
Genevestigatori P46425.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01268. GSTRNSFRASEP.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of two mouse PI class glutathione S-transferase genes."
    Bammler T.K., Smith C.A.D., Wolf R.C.
    Biochem. J. 298:385-390(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Two murine GSTpi genes are arranged in tandem and are differentially expressed."
    Xu X., Stambrook P.J.
    J. Biol. Chem. 269:30268-30273(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Mammary gland.

Entry informationi

Entry nameiGSTP2_MOUSE
AccessioniPrimary (citable) accession number: P46425
Secondary accession number(s): Q505C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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