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P46425 (GSTP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase P 2

Short name=Gst P2
EC=2.5.1.18
Alternative name(s):
GST YF-YF
GST class-pi
GST-piA
Gene names
Name:Gstp2
Synonyms:Gstpia
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cannot metabolize 1-chloro-2,4-dinitrobenzene.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer.

Tissue specificity

Selectively expressed in gall bladder, colon, heart, and skeletal muscle.

Sequence similarities

Belongs to the GST superfamily. Pi family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutathione metabolic process

Inferred from direct assay Ref.2. Source: MGI

   Molecular_functionglutathione transferase activity

Inferred from direct assay Ref.2. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 210209Glutathione S-transferase P 2
PRO_0000185904

Regions

Domain2 – 8180GST N-terminal
Domain83 – 204122GST C-terminal
Region52 – 532Glutathione binding By similarity
Region65 – 662Glutathione binding By similarity

Sites

Binding site81Glutathione By similarity
Binding site141Glutathione By similarity
Binding site391Glutathione By similarity
Binding site451Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P46425 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 48423B9F236C8A36

FASTA21023,537
        10         20         30         40         50         60 
MPPYTIVYFP SPGRCEAMRM LLADQGQSWK EEVVTIDTWM QGLLKPTCLY GQLPKFEDGD 

        70         80         90        100        110        120 
LTLYQSNAIL RHLGRSLGLY GKNQREAAQV DMVNDGVEDL RGKYGTMIYR NYENGKNDYV 

       130        140        150        160        170        180 
KALPGHLKPF ETLLSQNQGG KAFIVGDQIS FADYNLLDLL LIHQVLAPGC LDNFPLLSAY 

       190        200        210 
VARLSARPKI KAFLSSPEHV NRPINGNGKQ 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of two mouse PI class glutathione S-transferase genes."
Bammler T.K., Smith C.A.D., Wolf R.C.
Biochem. J. 298:385-390(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Two murine GSTpi genes are arranged in tandem and are differentially expressed."
Xu X., Stambrook P.J.
J. Biol. Chem. 269:30268-30273(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X76144 Genomic DNA. No translation available.
U15654 Genomic DNA. Translation: AAA64836.1.
BC064781 mRNA. Translation: AAH64781.1.
BC094623 mRNA. Translation: AAH94623.1.
CCDSCCDS29412.1.
PIRA55140.
RefSeqNP_861461.1. NM_181796.2.
UniGeneMm.441542.

3D structure databases

ProteinModelPortalP46425.
SMRP46425. Positions 2-210.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP46425. 5 interactions.
MINTMINT-4097004.
STRING10090.ENSMUSP00000038931.

PTM databases

PhosphoSiteP46425.

Proteomic databases

MaxQBP46425.
PaxDbP46425.
PRIDEP46425.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000042700; ENSMUSP00000038931; ENSMUSG00000038155.
ENSMUST00000181010; ENSMUSP00000138013; ENSMUSG00000097808.
GeneID14869.
KEGGmmu:14869.
UCSCuc008fyg.1. mouse.

Organism-specific databases

CTD14869.
MGIMGI:95864. Gstp2.

Phylogenomic databases

eggNOGNOG05174.
GeneTreeENSGT00550000074559.
HOGENOMHOG000115733.
HOVERGENHBG108324.
InParanoidP46425.
KOK00799.
OMAAYLNKRA.
OrthoDBEOG7KH9M3.
PhylomeDBP46425.
TreeFamTF105321.

Gene expression databases

BgeeP46425.
CleanExMM_GSTP2.
GenevestigatorP46425.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01268. GSTRNSFRASEP.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio287129.
PROP46425.
SOURCESearch...

Entry information

Entry nameGSTP2_MOUSE
AccessionPrimary (citable) accession number: P46425
Secondary accession number(s): Q505C3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot