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P46425

- GSTP2_MOUSE

UniProt

P46425 - GSTP2_MOUSE

Protein

Glutathione S-transferase P 2

Gene

Gstp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cannot metabolize 1-chloro-2,4-dinitrobenzene.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei8 – 81GlutathioneBy similarity
    Binding sitei14 – 141GlutathioneBy similarity
    Binding sitei39 – 391GlutathioneBy similarity
    Binding sitei45 – 451GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: MGI

    GO - Biological processi

    1. glutathione metabolic process Source: MGI

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    ReactomeiREACT_189141. Detoxification of Reactive Oxygen Species.
    REACT_215316. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase P 2 (EC:2.5.1.18)
    Short name:
    Gst P2
    Alternative name(s):
    GST YF-YF
    GST class-pi
    GST-piA
    Gene namesi
    Name:Gstp2
    Synonyms:Gstpia
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:95864. Gstp2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 210209Glutathione S-transferase P 2PRO_0000185904Add
    BLAST

    Proteomic databases

    MaxQBiP46425.
    PaxDbiP46425.
    PRIDEiP46425.

    PTM databases

    PhosphoSiteiP46425.

    Expressioni

    Tissue specificityi

    Selectively expressed in gall bladder, colon, heart, and skeletal muscle.

    Gene expression databases

    BgeeiP46425.
    CleanExiMM_GSTP2.
    GenevestigatoriP46425.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    IntActiP46425. 5 interactions.
    MINTiMINT-4097004.
    STRINGi10090.ENSMUSP00000038931.

    Structurei

    3D structure databases

    ProteinModelPortaliP46425.
    SMRiP46425. Positions 2-210.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8180GST N-terminalAdd
    BLAST
    Domaini83 – 204122GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni52 – 532Glutathione bindingBy similarity
    Regioni65 – 662Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Pi family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG05174.
    GeneTreeiENSGT00550000074559.
    HOGENOMiHOG000115733.
    HOVERGENiHBG108324.
    InParanoidiP46425.
    KOiK00799.
    OMAiAYLNKRA.
    OrthoDBiEOG7KH9M3.
    PhylomeDBiP46425.
    TreeFamiTF105321.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003082. GST_pi.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01268. GSTRNSFRASEP.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P46425-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPYTIVYFP SPGRCEAMRM LLADQGQSWK EEVVTIDTWM QGLLKPTCLY    50
    GQLPKFEDGD LTLYQSNAIL RHLGRSLGLY GKNQREAAQV DMVNDGVEDL 100
    RGKYGTMIYR NYENGKNDYV KALPGHLKPF ETLLSQNQGG KAFIVGDQIS 150
    FADYNLLDLL LIHQVLAPGC LDNFPLLSAY VARLSARPKI KAFLSSPEHV 200
    NRPINGNGKQ 210
    Length:210
    Mass (Da):23,537
    Last modified:January 23, 2007 - v2
    Checksum:i48423B9F236C8A36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76144 Genomic DNA. No translation available.
    U15654 Genomic DNA. Translation: AAA64836.1.
    BC064781 mRNA. Translation: AAH64781.1.
    BC094623 mRNA. Translation: AAH94623.1.
    CCDSiCCDS29412.1.
    PIRiA55140.
    RefSeqiNP_861461.1. NM_181796.2.
    UniGeneiMm.441542.

    Genome annotation databases

    EnsembliENSMUST00000042700; ENSMUSP00000038931; ENSMUSG00000038155.
    ENSMUST00000181010; ENSMUSP00000138013; ENSMUSG00000097808.
    GeneIDi14869.
    KEGGimmu:14869.
    UCSCiuc008fyg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76144 Genomic DNA. No translation available.
    U15654 Genomic DNA. Translation: AAA64836.1 .
    BC064781 mRNA. Translation: AAH64781.1 .
    BC094623 mRNA. Translation: AAH94623.1 .
    CCDSi CCDS29412.1.
    PIRi A55140.
    RefSeqi NP_861461.1. NM_181796.2.
    UniGenei Mm.441542.

    3D structure databases

    ProteinModelPortali P46425.
    SMRi P46425. Positions 2-210.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P46425. 5 interactions.
    MINTi MINT-4097004.
    STRINGi 10090.ENSMUSP00000038931.

    PTM databases

    PhosphoSitei P46425.

    Proteomic databases

    MaxQBi P46425.
    PaxDbi P46425.
    PRIDEi P46425.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042700 ; ENSMUSP00000038931 ; ENSMUSG00000038155 .
    ENSMUST00000181010 ; ENSMUSP00000138013 ; ENSMUSG00000097808 .
    GeneIDi 14869.
    KEGGi mmu:14869.
    UCSCi uc008fyg.1. mouse.

    Organism-specific databases

    CTDi 14869.
    MGIi MGI:95864. Gstp2.

    Phylogenomic databases

    eggNOGi NOG05174.
    GeneTreei ENSGT00550000074559.
    HOGENOMi HOG000115733.
    HOVERGENi HBG108324.
    InParanoidi P46425.
    KOi K00799.
    OMAi AYLNKRA.
    OrthoDBi EOG7KH9M3.
    PhylomeDBi P46425.
    TreeFami TF105321.

    Enzyme and pathway databases

    Reactomei REACT_189141. Detoxification of Reactive Oxygen Species.
    REACT_215316. Glutathione conjugation.

    Miscellaneous databases

    NextBioi 287129.
    PROi P46425.
    SOURCEi Search...

    Gene expression databases

    Bgeei P46425.
    CleanExi MM_GSTP2.
    Genevestigatori P46425.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003082. GST_pi.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01268. GSTRNSFRASEP.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of two mouse PI class glutathione S-transferase genes."
      Bammler T.K., Smith C.A.D., Wolf R.C.
      Biochem. J. 298:385-390(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Two murine GSTpi genes are arranged in tandem and are differentially expressed."
      Xu X., Stambrook P.J.
      J. Biol. Chem. 269:30268-30273(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Mammary gland.

    Entry informationi

    Entry nameiGSTP2_MOUSE
    AccessioniPrimary (citable) accession number: P46425
    Secondary accession number(s): Q505C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3