P46425 (GSTP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase P 2
Short name=Gst P2
EC=2.5.1.18

Alternative name(s):
GST YF-YF
GST class-pi
GST-piA

Gene names

Name:	Gstp2
Synonyms:	Gstpia

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cannot metabolize 1-chloro-2,4-dinitrobenzene.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer.
Tissue specificity	Selectively expressed in gall bladder, colon, heart, and skeletal muscle.
Sequence similarities	Belongs to the GST superfamily. Pi family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutathione metabolic process Inferred from direct assay Ref.2. Source: MGI
Molecular_function	glutathione transferase activity Inferred from direct assay Ref.2. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 210	209	Glutathione S-transferase P 2		PRO_0000185904
Regions
	Domain	2 – 81	80	GST N-terminal
	Domain	83 – 204	122	GST C-terminal
	Region	52 – 53	2	Glutathione binding By similarity
	Region	65 – 66	2	Glutathione binding By similarity
Sites
	Binding site	8	1	Glutathione By similarity
	Binding site	14	1	Glutathione By similarity
	Binding site	39	1	Glutathione By similarity
	Binding site	45	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	P46425 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 48423B9F236C8A36	FASTA	210	23,537
	10 20 30 40 50 60 MPPYTIVYFP SPGRCEAMRM LLADQGQSWK EEVVTIDTWM QGLLKPTCLY GQLPKFEDGD 70 80 90 100 110 120 LTLYQSNAIL RHLGRSLGLY GKNQREAAQV DMVNDGVEDL RGKYGTMIYR NYENGKNDYV 130 140 150 160 170 180 KALPGHLKPF ETLLSQNQGG KAFIVGDQIS FADYNLLDLL LIHQVLAPGC LDNFPLLSAY 190 200 210 VARLSARPKI KAFLSSPEHV NRPINGNGKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of two mouse PI class glutathione S-transferase genes." Bammler T.K., Smith C.A.D., Wolf R.C. Biochem. J. 298:385-390(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Two murine GSTpi genes are arranged in tandem and are differentially expressed." Xu X., Stambrook P.J. J. Biol. Chem. 269:30268-30273(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ. Tissue: Liver.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo and Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X76144 Genomic DNA. No translation available. U15654 Genomic DNA. Translation: AAA64836.1. BC064781 mRNA. Translation: AAH64781.1. BC094623 mRNA. Translation: AAH94623.1.
IPI	IPI00283531.
PIR	A55140.
RefSeq	NP_861461.1. NM_181796.2.
UniGene	Mm.441542.
3D structure databases
ProteinModelPortal	P46425.
SMR	P46425. Positions 2-210.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000038931.
PTM databases
PhosphoSite	P46425.
Proteomic databases
PaxDb	P46425.
PRIDE	P46425.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000042700; ENSMUSP00000038931; ENSMUSG00000038155. ENSMUST00000181010; ENSMUSP00000138013; ENSMUSG00000097808.
GeneID	14869.
KEGG	mmu:14869.
UCSC	uc008fyg.1. mouse.
Organism-specific databases
CTD	14869.
MGI	MGI:95864. Gstp2.
Phylogenomic databases
eggNOG	NOG05174.
GeneTree	ENSGT00550000074559.
HOGENOM	HOG000115733.
HOVERGEN	HBG108324.
InParanoid	P46425.
KO	K00799.
OMA	ERPNIKA.
OrthoDB	EOG48SGTZ.
Gene expression databases
Bgee	P46425.
CleanEx	MM_GSTP2.
Genevestigator	P46425.
GermOnline	ENSMUSG00000038155. Mus musculus.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR003082. GST_pi. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01268. GSTRNSFRASEP.
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	287129.
SOURCE	Search...

Entry information

Entry name

GSTP2_MOUSE

Accession

Primary (citable) accession number: P46425
Secondary accession number(s): Q505C3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program