Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P46425

- GSTP2_MOUSE

UniProt

P46425 - GSTP2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutathione S-transferase P 2

Gene

Gstp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cannot metabolize 1-chloro-2,4-dinitrobenzene.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81GlutathioneBy similarity
Binding sitei14 – 141GlutathioneBy similarity
Binding sitei39 – 391GlutathioneBy similarity
Binding sitei45 – 451GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: MGI

GO - Biological processi

  1. glutathione metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_189141. Detoxification of Reactive Oxygen Species.
REACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P 2 (EC:2.5.1.18)
Short name:
Gst P2
Alternative name(s):
GST YF-YF
GST class-pi
GST-piA
Gene namesi
Name:Gstp2
Synonyms:Gstpia
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:95864. Gstp2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 210209Glutathione S-transferase P 2PRO_0000185904Add
BLAST

Proteomic databases

MaxQBiP46425.
PaxDbiP46425.
PRIDEiP46425.

PTM databases

PhosphoSiteiP46425.

Expressioni

Tissue specificityi

Selectively expressed in gall bladder, colon, heart, and skeletal muscle.

Gene expression databases

BgeeiP46425.
CleanExiMM_GSTP2.
ExpressionAtlasiP46425. baseline.
GenevestigatoriP46425.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiP46425. 5 interactions.
MINTiMINT-4097004.
STRINGi10090.ENSMUSP00000038931.

Structurei

3D structure databases

ProteinModelPortaliP46425.
SMRiP46425. Positions 2-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8180GST N-terminalAdd
BLAST
Domaini83 – 204122GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 532Glutathione bindingBy similarity
Regioni65 – 662Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG05174.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115733.
HOVERGENiHBG108324.
InParanoidiP46425.
KOiK00799.
OMAiAYLNKRA.
OrthoDBiEOG7KH9M3.
PhylomeDBiP46425.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46425-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPYTIVYFP SPGRCEAMRM LLADQGQSWK EEVVTIDTWM QGLLKPTCLY
60 70 80 90 100
GQLPKFEDGD LTLYQSNAIL RHLGRSLGLY GKNQREAAQV DMVNDGVEDL
110 120 130 140 150
RGKYGTMIYR NYENGKNDYV KALPGHLKPF ETLLSQNQGG KAFIVGDQIS
160 170 180 190 200
FADYNLLDLL LIHQVLAPGC LDNFPLLSAY VARLSARPKI KAFLSSPEHV
210
NRPINGNGKQ
Length:210
Mass (Da):23,537
Last modified:January 23, 2007 - v2
Checksum:i48423B9F236C8A36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76144 Genomic DNA. No translation available.
U15654 Genomic DNA. Translation: AAA64836.1.
BC064781 mRNA. Translation: AAH64781.1.
BC094623 mRNA. Translation: AAH94623.1.
CCDSiCCDS29412.1.
PIRiA55140.
RefSeqiNP_861461.1. NM_181796.2.
UniGeneiMm.441542.

Genome annotation databases

EnsembliENSMUST00000042700; ENSMUSP00000038931; ENSMUSG00000038155.
ENSMUST00000181010; ENSMUSP00000138013; ENSMUSG00000097808.
GeneIDi14869.
KEGGimmu:14869.
UCSCiuc008fyg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76144 Genomic DNA. No translation available.
U15654 Genomic DNA. Translation: AAA64836.1 .
BC064781 mRNA. Translation: AAH64781.1 .
BC094623 mRNA. Translation: AAH94623.1 .
CCDSi CCDS29412.1.
PIRi A55140.
RefSeqi NP_861461.1. NM_181796.2.
UniGenei Mm.441542.

3D structure databases

ProteinModelPortali P46425.
SMRi P46425. Positions 2-210.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P46425. 5 interactions.
MINTi MINT-4097004.
STRINGi 10090.ENSMUSP00000038931.

PTM databases

PhosphoSitei P46425.

Proteomic databases

MaxQBi P46425.
PaxDbi P46425.
PRIDEi P46425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042700 ; ENSMUSP00000038931 ; ENSMUSG00000038155 .
ENSMUST00000181010 ; ENSMUSP00000138013 ; ENSMUSG00000097808 .
GeneIDi 14869.
KEGGi mmu:14869.
UCSCi uc008fyg.1. mouse.

Organism-specific databases

CTDi 14869.
MGIi MGI:95864. Gstp2.

Phylogenomic databases

eggNOGi NOG05174.
GeneTreei ENSGT00550000074559.
HOGENOMi HOG000115733.
HOVERGENi HBG108324.
InParanoidi P46425.
KOi K00799.
OMAi AYLNKRA.
OrthoDBi EOG7KH9M3.
PhylomeDBi P46425.
TreeFami TF105321.

Enzyme and pathway databases

Reactomei REACT_189141. Detoxification of Reactive Oxygen Species.
REACT_215316. Glutathione conjugation.

Miscellaneous databases

NextBioi 287129.
PROi P46425.
SOURCEi Search...

Gene expression databases

Bgeei P46425.
CleanExi MM_GSTP2.
ExpressionAtlasi P46425. baseline.
Genevestigatori P46425.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01268. GSTRNSFRASEP.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of two mouse PI class glutathione S-transferase genes."
    Bammler T.K., Smith C.A.D., Wolf R.C.
    Biochem. J. 298:385-390(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Two murine GSTpi genes are arranged in tandem and are differentially expressed."
    Xu X., Stambrook P.J.
    J. Biol. Chem. 269:30268-30273(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Mammary gland.

Entry informationi

Entry nameiGSTP2_MOUSE
AccessioniPrimary (citable) accession number: P46425
Secondary accession number(s): Q505C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3