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P46423 (GSTF_HYOMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase

EC=2.5.1.18
Alternative name(s):
25 kDa auxin-binding protein
GST class-phi
OrganismHyoscyamus muticus (Egyptian henbane)
Taxonomic identifier35626 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeHyoscyameaeHyoscyamus

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Sequence similarities

Belongs to the GST superfamily. Phi family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Biological processAuxin signaling pathway
   Molecular functionTransferase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processauxin-activated signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Glutathione S-transferase
PRO_0000185854

Regions

Domain1 – 8282GST N-terminal
Domain89 – 212124GST C-terminal
Region40 – 412Glutathione binding By similarity
Region53 – 542Glutathione binding By similarity
Region66 – 672Glutathione binding By similarity

Sites

Binding site111Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P46423 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 9FFDB1A6A4582AD8

FASTA21223,677
        10         20         30         40         50         60 
MGMKLHGPAM SPAVMRVIAT LKEKDLDFEL VPVNMQAGDH KKEPFITLNP FGQVPAFEDG 

        70         80         90        100        110        120 
DLKLFESRAI TQYIAHTYAD KGNQLLANDP KKMAIMSVWM EVESQKFDPV ASKLTFEIVI 

       130        140        150        160        170        180 
KPMLGMVTDD AAVAENEEKL GKVLDVYESR LKDSKYLGGD SFTLADLHHA PAMNYLMGTK 

       190        200        210 
VKSLFDSRPH VSAWCADILA RPAWSKAIEY KQ 

« Hide

References

[1]"A soluble auxin-binding protein from Hyoscyamus muticus is a glutathione S-transferase."
Bilang J., Macdonald H., King P.J., Sturm A.
Plant Physiol. 102:29-34(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78203 mRNA. Translation: CAA55039.1.

3D structure databases

ProteinModelPortalP46423.
SMRP46423. Positions 2-206.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTF_HYOMU
AccessionPrimary (citable) accession number: P46423
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families