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Protein

Glutathione S-transferase U5

Gene

GSTU5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC). May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  • glutathione binding Source: TAIR
  • glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • response to oxidative stress Source: TAIR
  • toxin catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processDetoxification, Stress response

Enzyme and pathway databases

BioCyciARA:AT2G29450-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U5 (EC:2.5.1.18)
Short name:
AtGSTU5
Alternative name(s):
AtGSTU1
GST class-tau member 5
Glutathione S-transferase 103-1A
Gene namesi
Name:GSTU5
Synonyms:GSTU1
Ordered Locus Names:At2g29450
ORF Names:F16P2.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G29450
TAIRilocus:2043032 AT2G29450

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858601 – 224Glutathione S-transferase U5Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP46421

Expressioni

Inductioni

By auxin.

Gene expression databases

ExpressionAtlasiP46421 baseline and differential
GenevisibleiP46421 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G29450.1

Structurei

3D structure databases

ProteinModelPortaliP46421
SMRiP46421
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 84GST N-terminalAdd BLAST80
Domaini89 – 217GST C-terminalAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 16Glutathione bindingBy similarity2
Regioni41 – 42Glutathione bindingBy similarity2
Regioni55 – 56Glutathione bindingBy similarity2
Regioni68 – 69Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated

Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
HOGENOMiHOG000125749
InParanoidiP46421
KOiK00799
OMAiNYMAERV
OrthoDBiEOG09360KSR
PhylomeDBiP46421

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P46421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKEEVKLL GIWASPFSRR VEMALKLKGI PYEYVEEILE NKSPLLLALN
60 70 80 90 100
PIHKKVPVLV HNGKTILESH VILEYIDETW PQNPILPQDP YERSKARFFA
110 120 130 140 150
KLVDEQIMNV GFISMARADE KGREVLAEQV RELIMYLEKE LVGKDYFGGK
160 170 180 190 200
TVGFLDFVAG SLIPFCLERG WEGIGLEVIT EEKFPEFKRW VRNLEKVEIV
210 220
KDCVPPREEH VEHMNYMAER VRSS
Length:224
Mass (Da):26,000
Last modified:November 1, 1995 - v1
Checksum:iBA2F5C06B94FFCC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89216 Genomic DNA Translation: CAA61504.1
U30489 Genomic DNA Translation: AAA74019.1
D44465 mRNA Translation: BAA07917.1
AF144382 mRNA Translation: AAD34992.1
AC004561 Genomic DNA Translation: AAC95193.1
CP002685 Genomic DNA Translation: AEC08255.1
AY062676 mRNA Translation: AAL32754.1
BT001228 mRNA Translation: AAN65115.1
AY088413 mRNA Translation: AAM65950.1
PIRiS66354
RefSeqiNP_180506.1, NM_128499.5
UniGeneiAt.19941

Genome annotation databases

EnsemblPlantsiAT2G29450.1; AT2G29450.1; AT2G29450
GeneIDi817494
GrameneiAT2G29450.1; AT2G29450.1; AT2G29450
KEGGiath:AT2G29450

Similar proteinsi

Entry informationi

Entry nameiGSTU5_ARATH
AccessioniPrimary (citable) accession number: P46421
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome