P46419 (GSTM1_DERPT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Glutathione S-transferase EC=2.5.1.18 Alternative name(s): GST class-mu Major allergen Der p 8 P dp 15 Allergen=Der p 8
Organism	Dermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifier	6956 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Psoroptidia › Analgoidea › Pyroglyphidae › Dermatophagoidinae › Dermatophagoides

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer Potential.
Subcellular location	Cytoplasm By similarity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the GST superfamily. Mu family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Disease	Allergen
Molecular function	Transferase
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Glutathione S-transferase		PRO_0000185839
Regions
	Domain	2 – 89	88	GST N-terminal
	Domain	91 – 207	117	GST C-terminal
	Region	8 – 9	2	Glutathione binding By similarity
	Region	47 – 51	5	Glutathione binding By similarity
	Region	60 – 61	2	Glutathione binding By similarity
	Region	73 – 74	2	Glutathione binding By similarity
Sites
	Binding site	117	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P46419 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: EC4A739CD40FC4B4	FASTA	219	25,590
	10 20 30 40 50 60 MSQPILGYWD IRGYAQPIRL LLTYSGVDFV DKRYQIGPAP DFDRSEWLNE KFNLGLDFPN 70 80 90 100 110 120 LPYYIDGDMK MTQTFAILRY LGRKYKLNGS NDHEEIRISM AEQQTEDMMA AMIRVCYDAN 130 140 150 160 170 180 CDKLKPDYLK SLPDCLKLMS KFVGEHAFIA GANISYVDFN LYEYLCHVKV MVPEVFGQFE 190 200 210 NLKRYVERME SLPRVSDYIK KQQPKTFNAP TSKWNASYA

References

[1]

"Cloning and characterization of a major allergen of the house dust mite, Dermatophagoides pteronyssinus, homologous with glutathione S-transferase." O'Neill G.M., Donovan G.R., Baldo B.A. Biochim. Biophys. Acta 1219:521-528(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	S75286 mRNA. Translation: AAB32224.1.
PIR	S50146.
3D structure databases
ProteinModelPortal	P46419.
ModBase	Search...
Protein family/group databases
Allergome	322. Der p 8. 3269. Der p 8.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.18. 1873.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR003081. GST_mu. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01267. GSTRNSFRASEM.
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTM1_DERPT

Accession

Primary (citable) accession number: P46419

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)