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Protein

Glutathione S-transferase

Gene
N/A
Organism
Dermatophagoides pteronyssinus (European house dust mite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51GlutathioneBy similarity1
Binding sitei117SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BRENDAi2.5.1.18. 1873.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:2.5.1.18)
Alternative name(s):
GST class-mu
Major allergen Der p 8
P dp 15
Allergen: Der p 8
OrganismiDermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifieri6956 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei322. Der p 8.
3269. Der p 8.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858391 – 219Glutathione S-transferaseAdd BLAST219

Interactioni

Subunit structurei

Homodimer.Curated

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 12Combined sources8
Turni13 – 15Combined sources3
Helixi16 – 25Combined sources10
Beta strandi30 – 34Combined sources5
Turni39 – 41Combined sources3
Helixi45 – 48Combined sources4
Turni49 – 52Combined sources4
Beta strandi61 – 66Combined sources6
Beta strandi69 – 73Combined sources5
Helixi74 – 84Combined sources11
Helixi92 – 116Combined sources25
Helixi121 – 143Combined sources23
Beta strandi151 – 153Combined sources3
Helixi157 – 171Combined sources15
Helixi173 – 176Combined sources4
Helixi180 – 190Combined sources11
Helixi195 – 201Combined sources7
Beta strandi205 – 208Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q5QX-ray1.93A/B1-219[»]
ProteinModelPortaliP46419.
SMRiP46419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 89GST N-terminalAdd BLAST88
Domaini91 – 207GST C-terminalAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 9Glutathione bindingBy similarity2
Regioni44 – 47Glutathione bindingBy similarity4
Regioni60 – 61Glutathione bindingBy similarity2
Regioni73 – 74Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQPILGYWD IRGYAQPIRL LLTYSGVDFV DKRYQIGPAP DFDRSEWLNE
60 70 80 90 100
KFNLGLDFPN LPYYIDGDMK MTQTFAILRY LGRKYKLNGS NDHEEIRISM
110 120 130 140 150
AEQQTEDMMA AMIRVCYDAN CDKLKPDYLK SLPDCLKLMS KFVGEHAFIA
160 170 180 190 200
GANISYVDFN LYEYLCHVKV MVPEVFGQFE NLKRYVERME SLPRVSDYIK
210
KQQPKTFNAP TSKWNASYA
Length:219
Mass (Da):25,590
Last modified:November 1, 1995 - v1
Checksum:iEC4A739CD40FC4B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75286 mRNA. Translation: AAB32224.1.
PIRiS50146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75286 mRNA. Translation: AAB32224.1.
PIRiS50146.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q5QX-ray1.93A/B1-219[»]
ProteinModelPortaliP46419.
SMRiP46419.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei322. Der p 8.
3269. Der p 8.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.5.1.18. 1873.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTM1_DERPT
AccessioniPrimary (citable) accession number: P46419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.