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P46419 (GSTM1_DERPT) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase

EC=2.5.1.18
Alternative name(s):
GST class-mu
Major allergen Der p 8
P dp 15
Allergen=Der p 8
OrganismDermatophagoides pteronyssinus (European house dust mite)
Taxonomic identifier6956 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer Potential.

Subcellular location

Cytoplasm By similarity.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the GST superfamily. Mu family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   DiseaseAllergen
   Molecular functionTransferase
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Glutathione S-transferase
PRO_0000185839

Regions

Domain2 – 8988GST N-terminal
Domain91 – 207117GST C-terminal
Region8 – 92Glutathione binding By similarity
Region47 – 515Glutathione binding By similarity
Region60 – 612Glutathione binding By similarity
Region73 – 742Glutathione binding By similarity

Sites

Binding site1171Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P46419 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: EC4A739CD40FC4B4

FASTA21925,590
        10         20         30         40         50         60 
MSQPILGYWD IRGYAQPIRL LLTYSGVDFV DKRYQIGPAP DFDRSEWLNE KFNLGLDFPN 

        70         80         90        100        110        120 
LPYYIDGDMK MTQTFAILRY LGRKYKLNGS NDHEEIRISM AEQQTEDMMA AMIRVCYDAN 

       130        140        150        160        170        180 
CDKLKPDYLK SLPDCLKLMS KFVGEHAFIA GANISYVDFN LYEYLCHVKV MVPEVFGQFE 

       190        200        210 
NLKRYVERME SLPRVSDYIK KQQPKTFNAP TSKWNASYA 

« Hide

References

[1]"Cloning and characterization of a major allergen of the house dust mite, Dermatophagoides pteronyssinus, homologous with glutathione S-transferase."
O'Neill G.M., Donovan G.R., Baldo B.A.
Biochim. Biophys. Acta 1219:521-528(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S75286 mRNA. Translation: AAB32224.1.
PIRS50146.

3D structure databases

ProteinModelPortalP46419.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome322. Der p 8.
3269. Der p 8.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.5.1.18. 1873.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01267. GSTRNSFRASEM.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTM1_DERPT
AccessionPrimary (citable) accession number: P46419
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries