Reviewed, UniProtKB/Swiss-Prot P46417 (LGUL_SOYBN)

Names and origin

Protein names	Recommended name:     Lactoylglutathione lyase     EC=4.4.1.5 Alternative name(s):     Methylglyoxalase     Aldoketomutase     Glyoxalase I
Organism	Glycine max (Soybean)
Taxonomic identifier	3847 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Phaseoleae › Glycine

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
Catalytic activity	(R)-S-lactoylglutathione = glutathione + methylglyoxal.
Pathway	Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.
Sequence similarities	Belongs to the GST superfamily. HSP26 family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Lyase
Gene Ontology (GO)
Molecular function	lactoylglutathione lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Lactoylglutathione lyase		PRO_0000185873
Regions
	Domain	3 – 82	80	GST N-terminal
	Domain	88 – 216	129	GST C-terminal

Sequences

	Sequence		Length	Mass (Da)
	P46417-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 6A2E46B759476A8C	FASTA	219	25,901
	10 20 30 40 50 60 MSDEVVLLDT WASMYGMRAR IALAEKGVRY EYKEENLMNR SPLLLQMNPI HKKIPVLIHN 70 80 90 100 110 120 GKPICESAII VQYIDEVWND KSPLMPSDPY KRSQARFWVD YIDKKIYDTW KKMWLSKGEE 130 140 150 160 170 180 HEEGKKELIS IFKQLEETLT DKPFYGDDTF GFVDLCLITF SSWFYTYETY GNFKMEEECP 190 200 210 KLMAWVKRCM ERETVSNTLP DAKKVYGLIV ELQKTLESK

References

[1]	Koellner B., Finkelnburg B., Mayerbacher R., Paulus C., Springer B. Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Leaf.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X68819 mRNA. Translation: CAA48717.1.
PIR	S47177.
UniGene	Gma.31882
3D structure databases
HSSP	HSSP built from PDB template 1GWC based on UniProtKB O04941.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.4.1.5. 299.
Gene expression databases
Genevestigator	P46417.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LGUL_SOYBN

Accession

Primary (citable) accession number: P46417

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	October 13, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)