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Protein

Glutathione S-transferase 3

Gene

GST3

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the detoxification of certain herbicides.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131GlutathioneBy similarity
Binding sitei54 – 541Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase 3 (EC:2.5.1.18)
Gene namesi
Name:GST3
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827 Componenti: Chromosome 15

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Glutathione S-transferase 3PRO_0000185873Add
BLAST

Proteomic databases

PRIDEiP46417.

Interactioni

Subunit structurei

Homodimer. degradation; (R)-lactate from methylglyoxal: step 1/2.1 Publication

Protein-protein interaction databases

STRINGi3847.GLYMA15G40290.1.

Structurei

3D structure databases

ProteinModelPortaliP46417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8280GST N-terminalAdd
BLAST
Domaini88 – 216129GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 672Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. HSP26 family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

InParanoidiP46417.
KOiK00799.
OMAiINLEVEC.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDEVVLLDT WASMYGMRAR IALAEKGVRY EYKEENLMNR SPLLLQMNPI
60 70 80 90 100
HKKIPVLIHN GKPICESAII VQYIDEVWND KSPLMPSDPY KRSQARFWVD
110 120 130 140 150
YIDKKIYDTW KKMWLSKGEE HEEGKKELIS IFKQLEETLT DKPFYGDDTF
160 170 180 190 200
GFVDLCLITF SSWFYTYETY GNFKMEEECP KLMAWVKRCM ERETVSNTLP
210
DAKKVYGLIV ELQKTLESK
Length:219
Mass (Da):25,901
Last modified:November 1, 1995 - v1
Checksum:i6A2E46B759476A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68819 mRNA. Translation: CAA48717.1.
PIRiS47177.
RefSeqiNP_001236181.1. NM_001249252.2.
UniGeneiGma.1560.

Genome annotation databases

EnsemblPlantsiGLYMA15G40290.1; GLYMA15G40290.1; GLYMA15G40290.
GeneIDi547925.
KEGGigmx:547925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68819 mRNA. Translation: CAA48717.1.
PIRiS47177.
RefSeqiNP_001236181.1. NM_001249252.2.
UniGeneiGma.1560.

3D structure databases

ProteinModelPortaliP46417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3847.GLYMA15G40290.1.

Proteomic databases

PRIDEiP46417.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiGLYMA15G40290.1; GLYMA15G40290.1; GLYMA15G40290.
GeneIDi547925.
KEGGigmx:547925.

Phylogenomic databases

InParanoidiP46417.
KOiK00799.
OMAiINLEVEC.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Koellner B., Finkelnburg B., Mayerbacher R., Paulus C., Springer B.
    Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Leaf.
  2. Cited for: CATALYTIC ACTIVITY, SUBUNIT.

Entry informationi

Entry nameiGSTX3_SOYBN
AccessioniPrimary (citable) accession number: P46417
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 24, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Was originally (Ref. 1) thought to be a glyoxalase I.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.