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P46417 (GSTX3_SOYBN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase 3

EC=2.5.1.18
Gene names
Name:GST3
OrganismGlycine max (Soybean) (Glycine hispida) [Reference proteome]
Taxonomic identifier3847 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the detoxification of certain herbicides.

Catalytic activity

RX + glutathione = HX + R-S-glutathione. Ref.2

Subunit structure

Homodimer. degradation; (R)-lactate from methylglyoxal: step 1/2. Ref.2

Sequence similarities

Belongs to the GST superfamily. HSP26 family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Caution

Was originally (Ref.1) thought to be a glyoxalase I.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Glutathione S-transferase 3
PRO_0000185873

Regions

Domain3 – 8280GST N-terminal
Domain88 – 216129GST C-terminal
Region66 – 672Glutathione binding By similarity

Sites

Binding site131Glutathione By similarity
Binding site541Glutathione; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P46417 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 6A2E46B759476A8C

FASTA21925,901
        10         20         30         40         50         60 
MSDEVVLLDT WASMYGMRAR IALAEKGVRY EYKEENLMNR SPLLLQMNPI HKKIPVLIHN 

        70         80         90        100        110        120 
GKPICESAII VQYIDEVWND KSPLMPSDPY KRSQARFWVD YIDKKIYDTW KKMWLSKGEE 

       130        140        150        160        170        180 
HEEGKKELIS IFKQLEETLT DKPFYGDDTF GFVDLCLITF SSWFYTYETY GNFKMEEECP 

       190        200        210 
KLMAWVKRCM ERETVSNTLP DAKKVYGLIV ELQKTLESK 

« Hide

References

[1]Koellner B., Finkelnburg B., Mayerbacher R., Paulus C., Springer B.
Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Leaf.
[2]"Cloning and characterization of glyoxalase I from soybean."
Skipsey M., Andrews C.J., Townson J.K., Jepson I., Edwards R.
Arch. Biochem. Biophys. 374:261-268(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CATALYTIC ACTIVITY, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X68819 mRNA. Translation: CAA48717.1.
PIRS47177.
RefSeqNP_001236181.1. NM_001249252.2.
UniGeneGma.1560.

3D structure databases

ProteinModelPortalP46417.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP46417.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsGLYMA15G40290.1; GLYMA15G40290.1; GLYMA15G40290.
GeneID547925.
KEGGgmx:547925.

Phylogenomic databases

OMARCMERET.

Gene expression databases

GenevestigatorP46417.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTX3_SOYBN
AccessionPrimary (citable) accession number: P46417
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families