Reviewed,
UniProtKB/Swiss-Prot P46412 (GPX3_MOUSE)
Last modified
November 25, 2008.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Glutathione peroxidase 3 EC=1.11.1.9 Alternative name(s): GSHPx-3 Short name=GPx-3 Plasma glutathione peroxidase GSHPx-P | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 226 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. |
| Catalytic activity | 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O. |
| Subunit structure | Homotetramer. |
| Subcellular location | |
| Tissue specificity | Secreted in plasma. |
| Sequence similarities | Belongs to the glutathione peroxidase family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Selenocysteine |
| Domain | Signal |
| Ligand | Selenium |
| Molecular function | Oxidoreductase Peroxidase |
Gene Ontology (GO) | |
| Biological process | hydrogen peroxide catabolic process Inferred from direct assay. Source: MGI oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW protein homotetramerizationInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | extracellular space Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | glutathione peroxidase activity Inferred from sequence or structural similarity. Source: UniProtKB selenium bindingInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 24 | 24 | Potential | ||||||
| Chain | 25 – 226 | 202 | Glutathione peroxidase 3 | PRO_0000013063 | |||||
Sites | |||||||||
| Active site | 73 | 1 | |||||||
Amino acid modifications | |||||||||
| Non-standard residue | 73 | 1 | Selenocysteine | ||||||
Experimental info | |||||||||
| Sequence conflict | 6 – 7 | 2 | RA → Q Ref.4 | ||||||
| Sequence conflict | 21 | 1 | P → A Ref.4 | ||||||
| Sequence conflict | 24 – 29 | 6 | GQEKSK → DKRSLR Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Mouse plasma glutathione peroxidase. cDNA sequence analysis and renal proximal tubular expression and secretion." Maser R.L., Magenheimer B.S., Calvet J.P. J. Biol. Chem. 269:27066-27073(1994) [PubMed: 7929449] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Kidney. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Heart, Kidney and Liver. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N and NMRI. Tissue: Colon, Kidney and Mammary tumor. |
| [4] | "Cloning of the mouse gene encoding plasma glutathione peroxidase: organization, sequence and chromosomal localization." Schwaab V., Baud E., Ghyselinck N.B., Mattei M.-G., Dufaure J.-P., Drevet J.R. Gene 167:25-31(1995) [PubMed: 8566787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U13705 mRNA. Translation: AAA62283.2. AK002219 mRNA. Translation: BAC55243.1. AK004942 mRNA. Translation: BAC55250.1. AK146760 mRNA. Translation: BAE27413.1. BC003339 mRNA. Translation: AAH03339.1. BC037027 mRNA. Translation: AAH37027.1. BC049235 mRNA. Translation: AAH49235.1. BC061950 mRNA. Translation: AAH61950.1. X84742 Genomic DNA. No translation available. | |
| PIR | A55086. |
| RefSeq | NP_001077398.1. NP_032187.2. |
| UniGene | Mm.200916 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GP1 based on UniProtKB P00435. |
| ModBase | Search... |
Protein family/group databases | |
| PeroxiBase | 3711. MmGPx03. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000018339. Mus musculus. [Contig view] |
| GeneID | 14778. |
| KEGG | mmu:14778. |
Organism-specific databases | |
| MGI | MGI:105102. Gpx3. |
Phylogenomic databases | |
| HOGENOM | P46412. |
| HOVERGEN | P46412. |
Gene expression databases | |
| CleanEx | MM_GPX3. |
| GermOnline | ENSMUSG00000018339. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000889. Glut_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| PANTHER | PTHR11592. Glut_peroxidase. 1 hit. |
| Pfam | PF00255. GSHPx. 1 hit. [Graphical view] |
| PIRSF | PIRSF000303. Glutathion_perox. 1 hit. |
| PRINTS | PR01011. GLUTPROXDASE. |
| PROSITE | PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 286887. |
| SOURCE | Search... |
Entry information
| Entry name | GPX3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P46412 Secondary accession number(s): Q5XKR0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

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