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P46412

- GPX3_MOUSE

UniProt

P46412 - GPX3_MOUSE

Protein

Glutathione peroxidase 3

Gene

Gpx3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

    Catalytic activityi

    2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731

    GO - Molecular functioni

    1. glutathione peroxidase activity Source: UniProtKB
    2. selenium binding Source: UniProtKB

    GO - Biological processi

    1. hydrogen peroxide catabolic process Source: MGI
    2. protein homotetramerization Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Enzyme and pathway databases

    ReactomeiREACT_189141. Detoxification of Reactive Oxygen Species.

    Protein family/group databases

    PeroxiBasei3711. MmGPx03.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione peroxidase 3 (EC:1.11.1.9)
    Short name:
    GPx-3
    Short name:
    GSHPx-3
    Alternative name(s):
    Plasma glutathione peroxidase
    Short name:
    GPx-P
    Short name:
    GSHPx-P
    Gene namesi
    Name:Gpx3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:105102. Gpx3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 226202Glutathione peroxidase 3PRO_0000013063Add
    BLAST

    Proteomic databases

    MaxQBiP46412.
    PaxDbiP46412.
    PRIDEiP46412.

    Expressioni

    Tissue specificityi

    Secreted in plasma.

    Gene expression databases

    BgeeiP46412.
    CleanExiMM_GPX3.
    GenevestigatoriP46412.

    Interactioni

    Subunit structurei

    Homotetramer.

    Protein-protein interaction databases

    IntActiP46412. 3 interactions.
    MINTiMINT-4096578.
    STRINGi10090.ENSMUSP00000081011.

    Structurei

    3D structure databases

    ProteinModelPortaliP46412.
    SMRiP46412. Positions 36-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutathione peroxidase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0386.
    GeneTreeiENSGT00740000115226.
    HOGENOMiHOG000277055.
    HOVERGENiHBG004333.
    InParanoidiP46412.
    KOiK00432.
    OMAiWYHRTTV.
    PhylomeDBiP46412.
    TreeFamiTF105318.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR000889. Glutathione_peroxidase.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR11592. PTHR11592. 1 hit.
    PfamiPF00255. GSHPx. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
    PRINTSiPR01011. GLUTPROXDASE.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
    PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
    PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P46412-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARILRASCL LSLLLAGFVP PGRGQEKSKT DCHGGMSGTI YEYGALTIDG    50
    EEYIPFKQYA GKYILFVNVA SYUGLTDQYL ELNALQEELG PFGLVILGFP 100
    SNQFGKQEPG ENSEILPSLK YVRPGGGFVP NFQLFEKGDV NGEKEQKFYT 150
    FLKNSCPPTA ELLGSPGRLF WEPMKIHDIR WNFEKFLVGP DGIPVMRWYH 200
    RTTVSNVKMD ILSYMRRQAA LSARGK 226
    Length:226
    Mass (Da):25,424
    Last modified:February 26, 2008 - v2
    Checksum:iD9706574929E3F86
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 72RA → Q(PubMed:8566787)Curated
    Sequence conflicti21 – 211P → A(PubMed:8566787)Curated
    Sequence conflicti24 – 296GQEKSK → DKRSLR(PubMed:8566787)Curated

    Non-standard residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-standard residuei73 – 731Selenocysteine

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13705 mRNA. Translation: AAA62283.2.
    AK002219 mRNA. Translation: BAC55243.1.
    AK004942 mRNA. Translation: BAC55250.1.
    AK146760 mRNA. Translation: BAE27413.1.
    BC003339 mRNA. Translation: AAH03339.1.
    BC037027 mRNA. Translation: AAH37027.1.
    BC049235 mRNA. Translation: AAH49235.1.
    BC061950 mRNA. Translation: AAH61950.1.
    X84742 Genomic DNA. No translation available.
    CCDSiCCDS24703.1.
    PIRiA55086.
    RefSeqiNP_032187.2. NM_008161.3.
    UniGeneiMm.200916.

    Genome annotation databases

    EnsembliENSMUST00000082430; ENSMUSP00000081011; ENSMUSG00000018339.
    GeneIDi14778.
    KEGGimmu:14778.
    UCSCiuc007iyk.2. mouse.

    Keywords - Coding sequence diversityi

    Selenocysteine

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13705 mRNA. Translation: AAA62283.2 .
    AK002219 mRNA. Translation: BAC55243.1 .
    AK004942 mRNA. Translation: BAC55250.1 .
    AK146760 mRNA. Translation: BAE27413.1 .
    BC003339 mRNA. Translation: AAH03339.1 .
    BC037027 mRNA. Translation: AAH37027.1 .
    BC049235 mRNA. Translation: AAH49235.1 .
    BC061950 mRNA. Translation: AAH61950.1 .
    X84742 Genomic DNA. No translation available.
    CCDSi CCDS24703.1.
    PIRi A55086.
    RefSeqi NP_032187.2. NM_008161.3.
    UniGenei Mm.200916.

    3D structure databases

    ProteinModelPortali P46412.
    SMRi P46412. Positions 36-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P46412. 3 interactions.
    MINTi MINT-4096578.
    STRINGi 10090.ENSMUSP00000081011.

    Protein family/group databases

    PeroxiBasei 3711. MmGPx03.

    Proteomic databases

    MaxQBi P46412.
    PaxDbi P46412.
    PRIDEi P46412.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082430 ; ENSMUSP00000081011 ; ENSMUSG00000018339 .
    GeneIDi 14778.
    KEGGi mmu:14778.
    UCSCi uc007iyk.2. mouse.

    Organism-specific databases

    CTDi 2878.
    MGIi MGI:105102. Gpx3.

    Phylogenomic databases

    eggNOGi COG0386.
    GeneTreei ENSGT00740000115226.
    HOGENOMi HOG000277055.
    HOVERGENi HBG004333.
    InParanoidi P46412.
    KOi K00432.
    OMAi WYHRTTV.
    PhylomeDBi P46412.
    TreeFami TF105318.

    Enzyme and pathway databases

    Reactomei REACT_189141. Detoxification of Reactive Oxygen Species.

    Miscellaneous databases

    ChiTaRSi GPX3. mouse.
    NextBioi 286887.
    PROi P46412.
    SOURCEi Search...

    Gene expression databases

    Bgeei P46412.
    CleanExi MM_GPX3.
    Genevestigatori P46412.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR000889. Glutathione_peroxidase.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR11592. PTHR11592. 1 hit.
    Pfami PF00255. GSHPx. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
    PRINTSi PR01011. GLUTPROXDASE.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS00460. GLUTATHIONE_PEROXID_1. 1 hit.
    PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
    PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse plasma glutathione peroxidase. cDNA sequence analysis and renal proximal tubular expression and secretion."
      Maser R.L., Magenheimer B.S., Calvet J.P.
      J. Biol. Chem. 269:27066-27073(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart, Kidney and Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N and NMRI.
      Tissue: Colon, Kidney and Mammary tumor.
    4. "Cloning of the mouse gene encoding plasma glutathione peroxidase: organization, sequence and chromosomal localization."
      Schwaab V., Baud E., Ghyselinck N.B., Mattei M.-G., Dufaure J.-P., Drevet J.R.
      Gene 167:25-31(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29.

    Entry informationi

    Entry nameiGPX3_MOUSE
    AccessioniPrimary (citable) accession number: P46412
    Secondary accession number(s): Q5XKR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3