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Reviewed, UniProtKB/Swiss-Prot P46412 (GPX3_MOUSE)

Last modified November 25, 2008. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutathione peroxidase 3
    EC=1.11.1.9
Alternative name(s):
    GSHPx-3
      Short name=GPx-3
    Plasma glutathione peroxidase
    GSHPx-P
Gene names
Name: Gpx3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

Catalytic activity

2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.

Subunit structure

Homotetramer.

Subcellular location

Secreted.

Tissue specificity

Secreted in plasma.

Sequence similarities

Belongs to the glutathione peroxidase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 226202Glutathione peroxidase 3
PRO_0000013063

Sites

Active site731

Amino acid modifications

Non-standard residue731Selenocysteine

Experimental info

Sequence conflict6 – 72RA → Q Ref.4
Sequence conflict211P → A Ref.4
Sequence conflict24 – 296GQEKSK → DKRSLR Ref.4

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Sequences

Sequence LengthMass (Da)Tools
P46412-1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: D9706574929E3F86

FASTA22625,424
        10         20         30         40         50         60 
MARILRASCL LSLLLAGFVP PGRGQEKSKT DCHGGMSGTI YEYGALTIDG EEYIPFKQYA 

        70         80         90        100        110        120 
GKYILFVNVA SYUGLTDQYL ELNALQEELG PFGLVILGFP SNQFGKQEPG ENSEILPSLK 

       130        140        150        160        170        180 
YVRPGGGFVP NFQLFEKGDV NGEKEQKFYT FLKNSCPPTA ELLGSPGRLF WEPMKIHDIR 

       190        200        210        220 
WNFEKFLVGP DGIPVMRWYH RTTVSNVKMD ILSYMRRQAA LSARGK

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References

« Hide 'large scale' references
[1]"Mouse plasma glutathione peroxidase. cDNA sequence analysis and renal proximal tubular expression and secretion."
Maser R.L., Magenheimer B.S., Calvet J.P.
J. Biol. Chem. 269:27066-27073(1994) [PubMed: 7929449] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Heart, Kidney and Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N and NMRI.
Tissue: Colon, Kidney and Mammary tumor.
[4]"Cloning of the mouse gene encoding plasma glutathione peroxidase: organization, sequence and chromosomal localization."
Schwaab V., Baud E., Ghyselinck N.B., Mattei M.-G., Dufaure J.-P., Drevet J.R.
Gene 167:25-31(1995) [PubMed: 8566787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U13705 mRNA. Translation: AAA62283.2.
AK002219 mRNA. Translation: BAC55243.1.
AK004942 mRNA. Translation: BAC55250.1.
AK146760 mRNA. Translation: BAE27413.1.
BC003339 mRNA. Translation: AAH03339.1.
BC037027 mRNA. Translation: AAH37027.1.
BC049235 mRNA. Translation: AAH49235.1.
BC061950 mRNA. Translation: AAH61950.1.
X84742 Genomic DNA. No translation available.
PIRA55086.
RefSeqNP_001077398.1.
NP_032187.2.
UniGeneMm.200916

3D structure databases

HSSPHSSP built from PDB template 1GP1 based on UniProtKB P00435.
ModBaseSearch...

Protein family/group databases

PeroxiBase3711. MmGPx03.

Genome annotation databases

EnsemblENSMUSG00000018339. Mus musculus. [Contig view]
GeneID14778.
KEGGmmu:14778.

Organism-specific databases

MGIMGI:105102. Gpx3.

Phylogenomic databases

HOGENOMP46412.
HOVERGENP46412.

Gene expression databases

CleanExMM_GPX3.
GermOnlineENSMUSG00000018339. Mus musculus.

Family and domain databases

InterProIPR000889. Glut_peroxidase.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR11592. Glut_peroxidase. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio286887.
SOURCESearch...

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Entry information

Entry nameGPX3_MOUSE
AccessionPrimary (citable) accession number: P46412
Secondary accession number(s): Q5XKR0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 26, 2008
Last modified: November 25, 2008
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents