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Protein

Excitatory amino acid transporter 1

Gene

SLC1A3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-210455. Astrocytic Glutamate-Glutamine Uptake And Metabolism.
R-BTA-210500. Glutamate Neurotransmitter Release Cycle.
R-BTA-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 1
Alternative name(s):
Sodium-dependent glutamate/aspartate transporter 1
Short name:
GLAST-1
Solute carrier family 1 member 3
Gene namesi
Name:SLC1A3
Synonyms:EAAT1, GLAST, GLAST1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747CytoplasmicSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14523HelicalSequence analysisAdd
BLAST
Topological domaini146 – 23792ExtracellularSequence analysisAdd
BLAST
Transmembranei238 – 26023HelicalSequence analysisAdd
BLAST
Transmembranei281 – 30222HelicalSequence analysisAdd
BLAST
Transmembranei319 – 34022HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Excitatory amino acid transporter 1PRO_0000202056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei512 – 5121PhosphoserineBy similarity

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP46411.
PRIDEiP46411.

Expressioni

Gene expression databases

BgeeiENSBTAG00000018245.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024287.

Structurei

3D structure databases

ProteinModelPortaliP46411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiP46411.
KOiK05614.
OMAiFKTSYEK.
OrthoDBiEOG091G0UCE.
TreeFamiTF315206.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSNGEEAR LGGRMERFQQ GVRKRTLLAK KKVQNITKED VKSYLFRNAF
60 70 80 90 100
VLLTVTAVIV GTILGFTLRP YRMSYREVKY FSFPGELLMR MLQMLVLPLI
110 120 130 140 150
ISSLVTGMAA LDSKASGKMG MRAVVYYMTT TIIAVVIGII IVIIIHPGKG
160 170 180 190 200
TKENMHREGK IVQVTAADAF LDLIRNMFPP NLVEACFKQF KTNYEKRSFK
210 220 230 240 250
VPIQPNETLV GAVINNVSEA METLTRITEE LVPVPGSVNG VNALGLVVFS
260 270 280 290 300
MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP LGILFLIAGK
310 320 330 340 350
IVEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG
360 370 380 390 400
GLLQALITAL GTSSSSATLP ITFKCLEENN GVDKRVTRFV LPVGATINMD
410 420 430 440 450
GTALYEALAA IFIAQVNNFE LNFGQIITIS ITATAASIGA AGIPQAGLVT
460 470 480 490 500
MVIVLTSVGL PTDDITLIIA VDWFLDRLRT TTNVLGDSLG AGIVEHLSRH
510 520 530 540
ELKNRDVEMG NSVIEENEMK KPYQLISQES EIEKSMDSET KM
Length:542
Mass (Da):59,591
Last modified:November 1, 1995 - v1
Checksum:iF23810DB5DC016D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82056 mRNA. Translation: BAA11527.1.
BC120125 mRNA. Translation: AAI20126.1.
RefSeqiNP_777025.1. NM_174600.2.
UniGeneiBt.361.

Genome annotation databases

EnsembliENSBTAT00000024287; ENSBTAP00000024287; ENSBTAG00000018245.
GeneIDi282354.
KEGGibta:282354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82056 mRNA. Translation: BAA11527.1.
BC120125 mRNA. Translation: AAI20126.1.
RefSeqiNP_777025.1. NM_174600.2.
UniGeneiBt.361.

3D structure databases

ProteinModelPortaliP46411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024287.

Proteomic databases

PaxDbiP46411.
PRIDEiP46411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024287; ENSBTAP00000024287; ENSBTAG00000018245.
GeneIDi282354.
KEGGibta:282354.

Organism-specific databases

CTDi6507.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiP46411.
KOiK05614.
OMAiFKTSYEK.
OrthoDBiEOG091G0UCE.
TreeFamiTF315206.

Enzyme and pathway databases

ReactomeiR-BTA-210455. Astrocytic Glutamate-Glutamine Uptake And Metabolism.
R-BTA-210500. Glutamate Neurotransmitter Release Cycle.
R-BTA-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Gene expression databases

BgeeiENSBTAG00000018245.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 2 hits.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEAA1_BOVIN
AccessioniPrimary (citable) accession number: P46411
Secondary accession number(s): Q0VCK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.