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P46409

- GSTMU_RABIT

UniProt

P46409 - GSTMU_RABIT

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Protein

Glutathione S-transferase Mu 1

Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Substrate By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 1 (EC:2.5.1.18)
Alternative name(s):
GST Mu I
GST class-mu
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Glutathione S-transferase Mu 1PRO_0000185837Add
BLAST

Proteomic databases

PRIDEiP46409.

Expressioni

Tissue specificityi

Well expressed in rabbit liver, brain and kidney.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021965.

Structurei

3D structure databases

ProteinModelPortaliP46409.
SMRiP46409. Positions 1-215.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8887GST N-terminalAdd
BLAST
Domaini90 – 208119GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 82Glutathione binding By similarity
Regioni46 – 505Glutathione binding By similarity
Regioni59 – 602Glutathione binding By similarity
Regioni72 – 732Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.

Phylogenomic databases

eggNOGiNOG300089.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46409-1 [UniParc]FASTAAdd to Basket

« Hide

MPMTLGYWDV RGLALPIRML LEYTDTSYEE KKYTMGDAPN YDQSKWLSEK    50
FTLGLDFPNL PYLIDGTHKL TQSNAILRYL ARKHGLCGET EEERIRVDIL 100
ENQLMDNRFQ LVNVCYSPDF EKLKPEYLKG LPEKLQLYSQ FLGSLPWFAG 150
DKITFADFLV YDVLDQNRIF VPGCLDAFPN LKDFHVRFEG LPKISAYMKS 200
SRFIRVPVFL KKATWTGI 218
Length:218
Mass (Da):25,417
Last modified:January 23, 2007 - v2
Checksum:i481EA4AB85671102
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23766 mRNA. Translation: AAA69665.1.
PIRiS65674.
RefSeqiNP_001075721.1. NM_001082252.1.
UniGeneiOcu.2029.

Genome annotation databases

GeneIDi100009073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L23766 mRNA. Translation: AAA69665.1 .
PIRi S65674.
RefSeqi NP_001075721.1. NM_001082252.1.
UniGenei Ocu.2029.

3D structure databases

ProteinModelPortali P46409.
SMRi P46409. Positions 1-215.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000021965.

Proteomic databases

PRIDEi P46409.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100009073.

Organism-specific databases

CTDi 2946.

Phylogenomic databases

eggNOGi NOG300089.
HOGENOMi HOG000115735.
HOVERGENi HBG106842.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01267. GSTRNSFRASEM.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of a cDNA for mu-class glutathione S-transferase from rabbit liver."
    Lee S.H., Lee S.H., Han J.S., Kim Y.S., Koh J.K.
    Arch. Biochem. Biophys. 318:424-429(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Purification and characterization of class mu glutathione S-transferase isozymes from rabbit hepatic tissue."
    Primiano T., Novak R.F.
    Arch. Biochem. Biophys. 301:404-410(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21.
    Tissue: Liver.

Entry informationi

Entry nameiGSTMU_RABIT
AccessioniPrimary (citable) accession number: P46409
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 13, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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