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Protein

Prolactin

Gene

PRL

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Prolactin acts primarily on the mammary gland by promoting lactation.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Lactation

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:PRL
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome B2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30By similarityAdd BLAST30
ChainiPRO_000003291431 – 229ProlactinAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 41By similarity
Modified residuei56PhosphoserineBy similarity1
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Modified residuei64PhosphoserineBy similarity1
Disulfide bondi88 ↔ 204By similarity
Modified residuei120PhosphoserineBy similarity1
Disulfide bondi221 ↔ 229By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000013943.

Structurei

3D structure databases

ProteinModelPortaliP46403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
GeneTreeiENSGT00730000110805.
HOVERGENiHBG104895.
InParanoidiP46403.
KOiK05439.
OMAiLHCLRRD.
OrthoDBiEOG091G0O08.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46403-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNKGWSLKG SLLFLLLLLS DLLLCKSVAS LPICPSGAVN CQVSLRDLFD
60 70 80 90 100
RAVILSHYIH NLSSEMFNEF DKRYAQGRGF ITKAINSCHT SSLPTPEDKE
110 120 130 140 150
QAQQIHHEDL LNVILRVLRS WNDPLYHLVT EVRGLHEAPD AILSRAIEIE
160 170 180 190 200
EQNRRLLEGM EKIVHQVHPG VRENEVYSVW SGLPSLQMAD EDSRLFAFYN
210 220
LLHCLRRDSH KIDSYLKLLK CRIVYDSNC
Length:229
Mass (Da):26,282
Last modified:November 1, 1995 - v1
Checksum:i657347282D11E61A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25974 mRNA. Translation: AAA67295.1.
PIRiJC4631.
RefSeqiNP_001036806.1. NM_001043341.1.

Genome annotation databases

EnsembliENSFCAT00000015037; ENSFCAP00000013943; ENSFCAG00000015035.
GeneIDi751517.
KEGGifca:751517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25974 mRNA. Translation: AAA67295.1.
PIRiJC4631.
RefSeqiNP_001036806.1. NM_001043341.1.

3D structure databases

ProteinModelPortaliP46403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000013943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000015037; ENSFCAP00000013943; ENSFCAG00000015035.
GeneIDi751517.
KEGGifca:751517.

Organism-specific databases

CTDi5617.

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
GeneTreeiENSGT00730000110805.
HOVERGENiHBG104895.
InParanoidiP46403.
KOiK05439.
OMAiLHCLRRD.
OrthoDBiEOG091G0O08.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRL_FELCA
AccessioniPrimary (citable) accession number: P46403
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.