Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetyl-/propionyl-coenzyme A carboxylase alpha chain

Gene

bccA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase.By similarity

Catalytic activityi

ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine.

Cofactori

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123ATPBy similarity1
Binding sitei207ATPBy similarity1
Binding sitei242ATPBy similarity1
Active sitei299By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Multifunctional enzyme
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-794-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-/propionyl-coenzyme A carboxylase alpha chain
Including the following 2 domains:
Biotin carboxylase (EC:6.3.4.14)
Biotin carboxyl carrier protein
Short name:
BCCP
Gene namesi
Name:bccA
Ordered Locus Names:ML0726
ORF Names:B1308_C1_129
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0726

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001467971 – 598Acetyl-/propionyl-coenzyme A carboxylase alpha chainAdd BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564N6-biotinyllysinePROSITE-ProRule annotationBy similarity1

Interactioni

Subunit structurei

Multimer comprised of 2 different subunits, the larger one (63/64 kDa) has biotin carboxylase and biotin carrier functions, while the smaller subunit possesses carboxyltransferase and substrate binding activity.By similarity

Protein-protein interaction databases

STRINGi272631.ML0726

Structurei

3D structure databases

ProteinModelPortaliP46392
SMRiP46392
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 452Biotin carboxylationAdd BLAST445
Domaini127 – 324ATP-graspPROSITE-ProRule annotationAdd BLAST198
Domaini522 – 598Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST77

Phylogenomic databases

eggNOGiENOG4108JIK Bacteria
COG4770 LUCA
HOGENOMiHOG000008988
KOiK11263
OMAiFVEICSH
OrthoDBiPOG091H02XZ

Family and domain databases

InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P46392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASHASSRIA KVLVANRGEI AVRVIRAARD ARLPSVAVYA EPDAEAPHVR
60 70 80 90 100
LADEAFALGG HTSAESYLDF GKILDAAAKS GANAIHPGYG FLAENADFAQ
110 120 130 140 150
AVIDAGLIWI GPSPQSIRDL GDKVTARHIA ARAQAPLVPG TPDPVKNADE
160 170 180 190 200
VVAFAKEHGV PIAIKAAFGG GGKGMKVART LEEISELYES AVREATVAFG
210 220 230 240 250
RGECFVERYL DKPRHVEAQV IADQHGNIVV AGTRDCSLQR RFQKLVEEAP
260 270 280 290 300
APFLTDAQRK EIHESAKRIC KEAHYYGAGT VEYLVGQDGL ISFLEVNTRL
310 320 330 340 350
QVEHPVTEET TGIDLVLQQF KIANGEKLEL IKDPIPCGHA IEFRINGEDA
360 370 380 390 400
GRNFLPSPGP VSKFHPPTGP GVRLDSGVET GSVIGGQFDS MLAKLIVHGA
410 420 430 440 450
TRQEALARAR RALDEFEVEG LATVIPFHRA VVSDPALIGD NNSFSVHTRW
460 470 480 490 500
IETEWNNTIE PFIDNQPLDE EDTRPQQTVI VEVDGRRLEV SLPADLALAN
510 520 530 540 550
PAGCNPAGVI RKKPKPRKRG GHTGAATSGD AVTAPMQGTV VKVAVAEGQT
560 570 580 590
VMTGDLVVVL EAMKMENPVT AHKDGIITGL AVEAGTAITQ GTVLAEIK
Length:598
Mass (Da):63,863
Last modified:April 27, 2001 - v2
Checksum:i5F2E291D7C54515D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30D → H in CAA45070 (PubMed:7909542).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63470 Genomic DNA Translation: CAA45070.1
U00012 Genomic DNA Translation: AAA85920.1
AL583919 Genomic DNA Translation: CAC30235.1
PIRiA55579
G86999
RefSeqiNP_301567.1, NC_002677.1
WP_010907891.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30235; CAC30235; CAC30235
GeneIDi909662
KEGGimle:ML0726
PATRICifig|272631.5.peg.1321

Similar proteinsi

Entry informationi

Entry nameiBCCA_MYCLE
AccessioniPrimary (citable) accession number: P46392
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: April 25, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health