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P46392

- BCCA_MYCLE

UniProt

P46392 - BCCA_MYCLE

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Protein
Acetyl-/propionyl-coenzyme A carboxylase alpha chain
Gene
bccA, ML0726, B1308_C1_129
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase By similarity.

Catalytic activityi

ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

Cofactori

Biotin.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231ATP By similarity
Binding sitei207 – 2071ATP By similarity
Binding sitei242 – 2421ATP By similarity
Active sitei299 – 2991 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. biotin carboxylase activity Source: UniProtKB-EC
  3. metal ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-5080-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-/propionyl-coenzyme A carboxylase alpha chain
Including the following 2 domains:
Biotin carboxylase (EC:6.3.4.14)
Biotin carboxyl carrier protein
Short name:
BCCP
Gene namesi
Name:bccA
Ordered Locus Names:ML0726
ORF Names:B1308_C1_129
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Acetyl-/propionyl-coenzyme A carboxylase alpha chain
PRO_0000146797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei564 – 5641N6-biotinyllysine By similarity

Interactioni

Subunit structurei

Multimer comprised of 2 different subunits, the larger one (63/64 kDa) has biotin carboxylase and biotin carrier functions, while the smaller subunit possesses carboxyltransferase and substrate binding activity By similarity.

Protein-protein interaction databases

STRINGi272631.ML0726.

Structurei

3D structure databases

ProteinModelPortaliP46392.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 452445Biotin carboxylation
Add
BLAST
Domaini127 – 324198ATP-grasp
Add
BLAST
Domaini530 – 59768Biotinyl-binding
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.

Phylogenomic databases

eggNOGiCOG4770.
HOGENOMiHOG000008988.
KOiK11263.
OMAiVCFSGHA.
OrthoDBiEOG6CVV6Z.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46392-1 [UniParc]FASTAAdd to Basket

« Hide

MASHASSRIA KVLVANRGEI AVRVIRAARD ARLPSVAVYA EPDAEAPHVR    50
LADEAFALGG HTSAESYLDF GKILDAAAKS GANAIHPGYG FLAENADFAQ 100
AVIDAGLIWI GPSPQSIRDL GDKVTARHIA ARAQAPLVPG TPDPVKNADE 150
VVAFAKEHGV PIAIKAAFGG GGKGMKVART LEEISELYES AVREATVAFG 200
RGECFVERYL DKPRHVEAQV IADQHGNIVV AGTRDCSLQR RFQKLVEEAP 250
APFLTDAQRK EIHESAKRIC KEAHYYGAGT VEYLVGQDGL ISFLEVNTRL 300
QVEHPVTEET TGIDLVLQQF KIANGEKLEL IKDPIPCGHA IEFRINGEDA 350
GRNFLPSPGP VSKFHPPTGP GVRLDSGVET GSVIGGQFDS MLAKLIVHGA 400
TRQEALARAR RALDEFEVEG LATVIPFHRA VVSDPALIGD NNSFSVHTRW 450
IETEWNNTIE PFIDNQPLDE EDTRPQQTVI VEVDGRRLEV SLPADLALAN 500
PAGCNPAGVI RKKPKPRKRG GHTGAATSGD AVTAPMQGTV VKVAVAEGQT 550
VMTGDLVVVL EAMKMENPVT AHKDGIITGL AVEAGTAITQ GTVLAEIK 598
Length:598
Mass (Da):63,863
Last modified:April 27, 2001 - v2
Checksum:i5F2E291D7C54515D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301D → H in CAA45070. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63470 Genomic DNA. Translation: CAA45070.1.
U00012 Genomic DNA. Translation: AAA85920.1.
AL583919 Genomic DNA. Translation: CAC30235.1.
PIRiA55579.
G86999.
RefSeqiNP_301567.1. NC_002677.1.
WP_010907891.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30235; CAC30235; CAC30235.
GeneIDi909662.
KEGGimle:ML0726.
PATRICi18052750. VBIMycLep78757_1321.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X63470 Genomic DNA. Translation: CAA45070.1 .
U00012 Genomic DNA. Translation: AAA85920.1 .
AL583919 Genomic DNA. Translation: CAC30235.1 .
PIRi A55579.
G86999.
RefSeqi NP_301567.1. NC_002677.1.
WP_010907891.1. NC_002677.1.

3D structure databases

ProteinModelPortali P46392.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272631.ML0726.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30235 ; CAC30235 ; CAC30235 .
GeneIDi 909662.
KEGGi mle:ML0726.
PATRICi 18052750. VBIMycLep78757_1321.

Organism-specific databases

Lepromai ML0726.

Phylogenomic databases

eggNOGi COG4770.
HOGENOMi HOG000008988.
KOi K11263.
OMAi VCFSGHA.
OrthoDBi EOG6CVV6Z.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci RETL1328306-WGS:GSTH-5080-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view ]
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Lipid synthesis in mycobacteria: characterization of the biotin carboxyl carrier protein genes from Mycobacterium leprae and M. tuberculosis."
    Norman E., de Smet K.A.L., Stoker N.G., Ratledge C., Wheeler P.R., Dale J.W.
    J. Bacteriol. 176:2525-2531(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiBCCA_MYCLE
AccessioniPrimary (citable) accession number: P46392
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: September 3, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3