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Protein

DNA replication and repair protein RecF

Gene

recF

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, DNA replication, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication and repair protein RecF
Gene namesi
Name:recF
Ordered Locus Names:ML0003
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0003.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385DNA replication and repair protein RecFPRO_0000196432Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0003.

Structurei

3D structure databases

ProteinModelPortaliP46391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecF family.Curated

Phylogenomic databases

eggNOGiENOG4105C3X. Bacteria.
COG1195. LUCA.
HOGENOMiHOG000269561.
KOiK03629.
OMAiKVQTFIT.
OrthoDBiEOG6HTP3X.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00365. RecF.
InterProiIPR001238. DNA-binding_RecF.
IPR018078. DNA-binding_RecF_CS.
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
[Graphical view]
PANTHERiPTHR32182:SF0. PTHR32182:SF0. 1 hit.
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00611. recf. 1 hit.
PROSITEiPS00617. RECF_1. 1 hit.
PS00618. RECF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P46391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVRHFGLRD FRSWDHVDLE LNPGRTVFFG PNGNGKTNLI EALWYSTTLS
60 70 80 90 100
SHRVGTDIPL IRAGTIRAIV STIVVNEGRE CAIDLEIAAG RANRARLNRS
110 120 130 140 150
LVRGMREVVG VLRAVLFAPE DLALVCGDPA NRRRYLDDLA TVRQPVIAAV
160 170 180 190 200
RADYDKVLRQ RTALLKSLAA ARYRSDQGVL DTLDVWDTRL AEHGAELMAA
210 220 230 240 250
RIDLVNQLAP EVEKAYQLLA PGSRTASISY RASLDIGGIA GVGSSDRALL
260 270 280 290 300
QADLLAGLST RRNVELERGI CLVGPHRDEL ELRLGDQPAK GFASHGESWS
310 320 330 340 350
LAIALRLAAY ELLRADGNEP VLLLDDVFAE LDAARCRALA TVAESAEQVL
360 370 380
VTSAAQEDIP VGWDAKWVTV DLRDSDSGRV SVVYP
Length:385
Mass (Da):42,067
Last modified:April 27, 2001 - v3
Checksum:i3EE309D7DA976D8B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti162 – 1621T → L in CAA94710 (Ref. 1) Curated
Sequence conflicti221 – 2211P → T (PubMed:8969512).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70722 Genomic DNA. Translation: CAA94710.1.
AL583917 Genomic DNA. Translation: CAC29511.1.
L39923 Genomic DNA. Translation: AAB53143.1.
PIRiC86909.
T10003.
RefSeqiNP_301131.1. NC_002677.1.
WP_010907456.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29511; CAC29511; CAC29511.
GeneIDi910262.
KEGGimle:ML0003.
PATRICi18050086. VBIMycLep78757_0003.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70722 Genomic DNA. Translation: CAA94710.1.
AL583917 Genomic DNA. Translation: CAC29511.1.
L39923 Genomic DNA. Translation: AAB53143.1.
PIRiC86909.
T10003.
RefSeqiNP_301131.1. NC_002677.1.
WP_010907456.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP46391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29511; CAC29511; CAC29511.
GeneIDi910262.
KEGGimle:ML0003.
PATRICi18050086. VBIMycLep78757_0003.

Organism-specific databases

LepromaiML0003.

Phylogenomic databases

eggNOGiENOG4105C3X. Bacteria.
COG1195. LUCA.
HOGENOMiHOG000269561.
KOiK03629.
OMAiKVQTFIT.
OrthoDBiEOG6HTP3X.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00365. RecF.
InterProiIPR001238. DNA-binding_RecF.
IPR018078. DNA-binding_RecF_CS.
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
[Graphical view]
PANTHERiPTHR32182:SF0. PTHR32182:SF0. 1 hit.
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00611. recf. 1 hit.
PROSITEiPS00617. RECF_1. 1 hit.
PS00618. RECF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Fsihi H., Salazar L., Takiff H.E., Cole S.T.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.
  3. "Gene arrangement and organization in an approximately 76 kb fragment encompassing the oriC region of the chromosome of Mycobacterium leprae."
    Fsihi H., de Rossi E., Salazar L., Cantoni R., Labo M., Riccardi G., Takiff H.E., Eiglmeier K., Bergh S., Cole S.T.
    Microbiology 142:3147-3161(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-223.

Entry informationi

Entry nameiRECF_MYCLE
AccessioniPrimary (citable) accession number: P46391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: April 13, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.